Multiligament knee injuries are defined as injuries to at least two of the four major ligaments in the knee: anterior cruciate ligament, posterior cruciate ligament, lateral collateral ligament (and ...posterolateral corner) and medial collateral ligament (and posteromedial corner). Multiple ligament knee injuries that results from high energy trauma, may have nerve and vascular injuries, therefore neurovascular examination with clear documentation of capillary refill time, distal pulses, function of all lower limb compartments and common peroneal and tibial nerve function should be performed. Before definitive treatment performed, we have to classified the multiligament injury according to the energy of the injury and the anatomic injured structures. MRI still recommended to know about the ligaments injury. The goal and our priority treatment is to obtain functional stability of the knee without the loss of motion or stiffnes that can lead to longterm pain, weakness, and the subsequent osteoarthritis.
An Anterior Cruciate Ligament (ACL) tear is the most common ligamentous injury of the knees. ACL reconstruction restore stability and kinematics of the knee joint, by improving knee stability. There ...are so many surgical techniques in ACL reconstruction. One of the most common technique is Single Bundle ACL reconstruction with the hamstring autograft. A good knowledge about operating technique and step by step approach are crucial for successfully procedure. The first step is patient positioning, including the leg holder should be placed proximal enough to allow full knee flexion and extension during procedure, it should be checked before starting the procedure. The second step is graft harvest, the autograft is prepared from the affected knee hamstring muscles, make a proper identification of the Gracilis and Semitendinosus tendon. The third step is portal placement, make a good native ACL attachment identification. Fourth step is femoral tunnel creation, avoid posterior wall blowout. Fifth step is tibial tunnel creation, remaining ACL fibers should be a landmark of the native ACL insertion site. Preserve the meniscal root insertion to prevent iatrogenic meniscus root avulsion. Sixth step is fixation, cycle the knee several times while applying traction to remove any slack out of the graft and to make sure there is non-impingement when fix the graft.
Epidermolysis bullosa (EB) is a genetically inherited disease characterized by recurrent bullae and erosions on the skin with numerous signs of dental caries and poor oral hygiene. The aim of this ...study was to investigate the general clinical and oral findings of patients with EB.
In this prospective study, the clinical and oral findings and family history of 26 cases with EB were evaluated. The type of EB, gender, age, parental consanguinity, dental caries, oral findings, distribution of lesions and presence of associated anomalies, clinical and oral findings correlated with gender were recorded.
All 26 patients with EB had a history of consanguinity and siblings with EB to varying degrees. In our study, malnutrition, anemia and growth retardation, gastrointestinal system complications, hair thinning, hand and nail deformity, ocular problems and renal disease (in one case) were observed with variable frequencies. When the intraoral findings of the patients were investigated, extensive dental caries in all EB types, enamel hypoplasia in junctional EB (JEB) and the presence of tooth-root to be extracted in dystrophic EB (DEB), intraoral bullae and lesions, ankyloglossia, vestibular sulcus insufficiency, microstomia and maxillary atrophy were observed. Three cases had restorative treatment and one case had prosthetic rehabilitation.
Oral involvement can be seen with varying frequencies depending on the type of EB and the severity of the disease. It may result from delayed oral and dental rehabilitation due to physical disabilities, limitations and more pressing medical problems. Microstomy, pain from mucosal lesions, and restricted access to the mouth can be caused by poor oral hygiene. Oral complications and caloric needs of individuals with EB should be determined, and individual prophylaxis should be applied to prevent caries formation and protect teeth.
Lipoid proteinosis (LP) is a rare autosomal recessive disorder characterized by the accumulation of hyaline-like material in the skin, oral mucosa, larynx, and brain. This study aimed to evaluate the ...dermatological findings and treatment responses of patients diagnosed with LP.OBJECTIVESLipoid proteinosis (LP) is a rare autosomal recessive disorder characterized by the accumulation of hyaline-like material in the skin, oral mucosa, larynx, and brain. This study aimed to evaluate the dermatological findings and treatment responses of patients diagnosed with LP.This retrospective study included 41 patients diagnosed with LP at our clinic between May 2018 and January 2023. The diagnosis of LP was established in 22 patients by detecting mutations in the ECM1 gene. In comparison, in 19 patients, it was based on typical clinical findings and histopathological examination of lesioned skin. Clinical and demographic data such as dermatological findings, treatments received, and responses to treatment were recorded from patient files.METHODSThis retrospective study included 41 patients diagnosed with LP at our clinic between May 2018 and January 2023. The diagnosis of LP was established in 22 patients by detecting mutations in the ECM1 gene. In comparison, in 19 patients, it was based on typical clinical findings and histopathological examination of lesioned skin. Clinical and demographic data such as dermatological findings, treatments received, and responses to treatment were recorded from patient files.All patients exhibited skin thickening and acneiform scars. The most commonly observed additional dermatological findings were moniliform blepharosis (60.9%), varioliform scars (29.2%), waxy papules and plaques (24.3%), and blisters with crusts (19.5%). Verrucous lesions, diffuse yellow plaques, and scarring alopecia were observed in adult patients, while hypopigmented lesions and blisters with crusts were seen in the pediatric age group. The most frequently used treatments were acitretin (14.6%) and systemic steroids (9.7%). No improvement in skin lesions was observed in patients treated with acitretin, whereas complete resolution of blisters with crusts was noted in patients treated with systemic steroids.RESULTSAll patients exhibited skin thickening and acneiform scars. The most commonly observed additional dermatological findings were moniliform blepharosis (60.9%), varioliform scars (29.2%), waxy papules and plaques (24.3%), and blisters with crusts (19.5%). Verrucous lesions, diffuse yellow plaques, and scarring alopecia were observed in adult patients, while hypopigmented lesions and blisters with crusts were seen in the pediatric age group. The most frequently used treatments were acitretin (14.6%) and systemic steroids (9.7%). No improvement in skin lesions was observed in patients treated with acitretin, whereas complete resolution of blisters with crusts was noted in patients treated with systemic steroids.In addition to the existing literature on dermatological manifestations of LP, hypopigmented lesions and atrophoderma vermiculatum-like lesions can also be observed in these patients. We believe that short-term systemic steroid therapy for vesiculobullous lesions can be considered for treatment. We think prospective studies with more patients and requiring long-term follow-up are needed regarding the effectiveness of acitretin treatment.CONCLUSIONSIn addition to the existing literature on dermatological manifestations of LP, hypopigmented lesions and atrophoderma vermiculatum-like lesions can also be observed in these patients. We believe that short-term systemic steroid therapy for vesiculobullous lesions can be considered for treatment. We think prospective studies with more patients and requiring long-term follow-up are needed regarding the effectiveness of acitretin treatment.
In recent years, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV) and C reactive protein (CRP) have been shown to be important indicators of systemic ...inflammation. Studies have shown that NLR, PLR, MPV and CRP are higher in psoriasis patients than in the control group.
To investigate the NLR, PLR, MPV and serum CRP levels in patients who were treated with biological agents for psoriasis.
In our study, 75 patients who were followed up and had a diagnosis of psoriasis vulgaris and took a biological agent therapy between January 2014 and December 2017 in the Dermatology Clinic of the Dicle University Medical Faculty Hospital were evaluated before treatment, and 3 and 6 months after treatment.
Neutrophil count, lymphocyte count, thrombocyte count, NLR, PLR, MPV and CRP values before the biological agent treatment were statistically higher than the values at 3 and 6 months of treatment. There was no statistically significant difference between pre-treatment neutrophil, lymphocyte, leukocyte, platelet, NLR, PLR, MPV, CRP values and values at 3 and 6 months after treatment when we compared four different biological agents.
It was seen that NLR, PLR, MPV and CRP values decreased independently of the type of the biological agent used in our study. Therefore, we think that these parameters can be used to evaluate the effects of biological agent treatment on systemic inflammation in psoriasis patients and to monitor the course of the disease.
Purpose: Since the discovery of the ABO blood group, the potential role of blood groups in infectious diseases has been investigated. Some viral infections, despite viral contact, do not occur or are ...not symptomatic due to ABO blood groups. It is known that not all patients in contact with HPV develop clinical disease. To our knowledge, the relationship between ABO-Rh groups and anogenital wart has not been investigated previously.
Materials and Methods: 96 patients with anogenital wart and 286 sexually active patients with blood group records were included in this study. Age, sex and blood groups of the patient and control groups were retrospectively analyzed. The results were analyzed statistically.
Results: In terms of ABO blood groups, 41 (42.7%) patients had A, 21 (21.9%) patients had B, 11 (11.5%) patients had AB, 23 (23.9%) patients had 0 blood groups in the patient group. In the control group, there were 126 (44.1%) individuals A, 46 (16.1%) individuals B, 30 (10.5) individuals AB, 84 (29.3) individuals had 0 blood group. The difference between the groups was not significant. In terms of Rh groups, 85 (88.5%) patients were Rh (+) and 11(11.5%) patients were Rh (-). In the control group, 240 (83.9%) individuals were Rh (+) and 46 (16.1%) were Rh (-). The difference between the groups was not.
Conclusion: There was no relationship between ABO-Rh groups and anogenital wart development. To clarify whether anogenital wart development is easy in some blood groups, further studies are needed in different races and geographic regions.
The use of liposomal amphotericin B (L‐AmB) in the treatment of cutaneous leishmaniasis (CL) is increasing. However, few data are available regarding the efficacy and safety of L‐AmB in pediatric CL ...patients. Our aim in this study is to evaluate the efficacy and safety of L‐AmB in pediatric CL patients. Pediatric patients admitted to a tertiary training and research hospital in a hyperendemic region for CL between January 2019 and May 2021 and receiving L‐AmB therapy for CL were included in this retrospective study. L‐AmB treatment was administered as 3 mg/kg for 5 consecutive days and on the 10th day, in a total of 6 doses (18 mg/kg total dose). A total of 52 pediatric patients who received L‐AmB therapy for CL were included in the study. In the follow‐up 3 months after L‐AmB treatment, 16 (31%) patients showed complete clinical recovery, while treatment failure was detected in 36 (69%) patients. In conclusion, considering the low treatment success rate in our study, we think that the L‐AmB dose used in our study is not an appropriate treatment option for the treatment of pediatric CL patients. However, we think that prospective studies with a large number of patients treated with higher doses of L‐AmB and in whom the causative agents of CL were determined are needed.
Abstract Background Our objective in this study is to determine the atypical clinical presentations of cutaneous leishmaniasis (CL) patients diagnosed in Şanlıurfa province. Methods This ...retrospective study included 213 patients with atypical clinical presentations among 1751 patients diagnosed with CL between October 2019 and August 2022 in Şanlıurfa Oriental Boil Diagnosis and Treatment Center located in an endemic region for CL. Results We found the prevalence of atypical CL to be 12.1%. The most common atypical lesions were lupoid 21 (9.8%), erysipeloid 16 (7.5%), impetiginous 16 (7.5%), recidivan 15 (7%), eczematous 15 (7%), ecthyma-like 13 (6.1%), pyoderma gangrenous-like 12 (5.6%), and sporotrichoid 12 (5.6%). Other lesions with atypical clinical presentations: chalazion-like, verrucous, dental sinus-like, psoriasiform, zosteriform, lymphoma-like, juvenile xanthogranuloma-like, volcano-like, paronychial, basal cell carcinoma-like, squamous cell carcinoma-like, herpes labialis-like, keratoacanthoma-like, chancriform, annular, lichenoid, mastocitoma-like, keloidal, epidermoid cyst-like, kaposi sarcoma-like, scar leishmaniasis, granulomatous cheilitis-like, mycetoma-like, molluscum contagiosum-like, discoid lupus erythematosus-like, and dermatofibroma-like. Conclusions In addition to the atypical clinical presentations previously reported, we also defined dermatofibroma-like, Kaposi sarcoma-like, dental sinus-like, juvenile xanthogranuloma-like, mastocytoma-like, and epidermoid cyst-like. It should be kept in mind that CL can clinically mimic many infectious, inflammatory, and neoplastic diseases, which should be considered in the differential diagnosis of long-term non-healing lesions, especially in endemic areas. Key message What is already known on this subject: CL is known as the great imitator disease in dermatology. What this study adds: In addition to the atypical clinical presentations previously reported, we also defined dermatofibroma-like, Kaposi sarcoma-like, dental sinus-like, juvenile xanthogranuloma-like, mastocytoma-like, and epidermoid cyst-like. How this study might affect research, practice, or policy: CL can clinically mimic many infectious, inflammatory and neoplastic diseases, which should be considered in the differential diagnosis of long-term non-healing lesions, especially in endemic areas.
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