A very short, effective and widely applicable synthesis of substituted 1-carbo-1λ
4
-1,2,4,6-thiatriazines is presented. The first step consisting of replacing the chlorine atom at the sulfur of ...trichlorothiatriazine by a carbon atom is described for the first time.
Collagen is a biological macromolecule capable of second harmonic generation, allowing label-free detection in tissues; in addition, molecular orientation can be determined from the polarization ...dependence of the second harmonic signal. Previously we reported that in-plane orientation of collagen fibrils could be determined by modulating the polarization angle of the laser during scanning. We have now extended this method so that out-of-plane orientation angles can be determined at the same time, allowing visualization of the 3-dimensional structure of collagenous tissues. This approach offers advantages compared with other methods for determining out-of-plane orientation. First, the orientation angles are directly calculated from the polarimetry data obtained in a single scan, while other reported methods require data from multiple scans, use of iterative optimization methods, application of fitting algorithms, or extensive post-optical processing. Second, our method does not require highly specialized instrumentation, and thus can be adapted for use in almost any nonlinear optical microscopy setup. It is suitable for both basic and clinical applications. We present three-dimensional images of structurally complex collagenous tissues that illustrate the power of such 3-dimensional analyses to reveal the architecture of biological structures.
Hypogammaglobulinemia (serum IgG levels < 7.0 g/L) has been associated with increased risk of COPD exacerbations but has not yet been shown to predict hospitalizations.
To determine the relationship ...between hypogammaglobulinemia and the risk of hospitalization in patients with COPD.
Serum IgG levels were measured on baseline samples from four COPD cohorts (n = 2,259): Azithromycin for Prevention of AECOPD (MACRO, n = 976); Simvastatin in the Prevention of AECOPD (STATCOPE, n = 653), Long-Term Oxygen Treatment Trial (LOTT, n = 354), and COPD Activity: Serotonin Transporter, Cytokines and Depression (CASCADE, n = 276). IgG levels were determined by immunonephelometry (MACRO; STATCOPE) or mass spectrometry (LOTT; CASCADE). The effect of hypogammaglobulinemia on COPD hospitalization risk was evaluated using cumulative incidence functions for this outcome and deaths (competing risk). Fine-Gray models were performed to obtain adjusted subdistribution hazard ratios (SHR) related to IgG levels for each study and then combined using a meta-analysis. Rates of COPD hospitalizations per person-year were compared according to IgG status.
The overall frequency of hypogammaglobulinemia was 28.4%. Higher incidence estimates of COPD hospitalizations were observed among participants with low IgG levels compared with those with normal levels (Gray's test, P < .001); pooled SHR (meta-analysis) was 1.29 (95% CI, 1.06-1.56, P = .01). Among patients with prior COPD admissions (n = 757), the pooled SHR increased to 1.58 (95% CI, 1.20-2.07, P < .01). The risk of COPD admissions, however, was similar between IgG groups in patients with no prior hospitalizations: pooled SHR = 1.15 (95% CI, 0.86-1.52, P =.34). The hypogammaglobulinemia group also showed significantly higher rates of COPD hospitalizations per person-year: 0.48 ± 2.01 vs 0.29 ± 0.83, P < .001.
Hypogammaglobulinemia is associated with a higher risk of COPD hospital admissions.
To describe the prevalence of cerebral palsy (CP) at age 2 years in infants born before 33 weeks of gestation and to analyze the fetal neuroprotective effect of the antenatal administration of ...magnesium sulfate (MgSO4) treatment on CP.
Preterm infants born before 33 weeks of gestation and discharged from the Rouen University Hospital's Neonatal Intensive Care Unit between 2007 and 2015 were included. At age 2 years, pediatricians of the perinatal network of Eure and Seine-Maritime counties administered standardized questionnaires analyzing motor, cognitive, and behavioral items, derived from the Denver and Amiel-Tison scales. A routine protocol based on MgSO4 infusion was introduced in 2010. The primary outcome measure was the occurrence of CP according to the Surveillance of Cerebral Palsy in Europe network definition.
A total of 1759 very preterm infants were included, among whom 138 (7.8%) died and 148 (9.1%) were lost to follow-up. Assuming that those lost to follow-up had no CP, at 2 years, 55 of 1621 infants (3.4%; 95% CI, 2.6%-4.4%) had CP. After statistical adjustment for birth term and antenatal corticosteroid use, a significant decrease in CP was observed after implementation of a protocol of MgSO4 administration in mothers before imminent preterm birth at <33 weeks of gestation (aOR, 0.53; 95% CI, 0.29-0.98; P = .04).
The prevalence of CP at 2 years after very preterm birth was low. The implementation of a neuroprotective protocol with MgSO4 was associated with reduced CP occurrence; however, several relevant limitations must be considered for interpretation.
Abstract
Aims
Modifiable cardiovascular risk factors (RFs) play a key role in the development of coronary artery disease. We evaluated 20-year trends in RF prevalence among young adults hospitalized ...with acute coronary syndromes (ACS) in Switzerland.
Methods and results
Data were analysed from the Acute Myocardial Infarction in Switzerland (AMIS) Plus registry from 2000 to 2019. Young patients were defined as those aged <50 years. Among 58 028 ACS admissions, 7073 (14.1%) were young (median 45.6 years, IQR 42.0–48.0), of which 91.6% had at least one modifiable RF and 59.0% had at least two RFs. Smoking was the most prevalent RF (71.4%), followed by dyslipidaemia (57.3%), hypertension (35.9%), obesity (21.7%), and diabetes (10.1%). Compared with older patients, young patients were more likely to be obese (21.7% vs. 17.4%, P < 0.001) and active smokers (71.4% vs. 33.9%, P < 0.001). Among young patients, between 2000 and 2019, there was a significant increase in the prevalence of hypertension from 29.0% to 51.3% and obesity from 21.2% to 27.1% (both Ptrend < 0.001) but a significant decrease in active smoking from 72.5% to 62.5% (Ptrend = 0.02). There were no significant changes in the prevalence of diabetes (Ptrend = 0.32) or dyslipidaemia (Ptrend = 0.067).
Conclusion
Young ACS patients in Switzerland exhibit a high prevalence of RFs and are more likely than older patients to be obese and smokers. Between 2000 and 2019, RF prevalence either increased or remained stable, except for smoking which decreased but still affected approximately two-thirds of young patients in 2019. Public health initiatives targeting RFs in young adults in Switzerland are warranted.
Lay Summary
We evaluated the prevalence of risk factors (RFs) among young patients admitted with ACS in Switzerland between 2000 and 2019.
Young ACS patients in Switzerland exhibited a high prevalence of RFs.
There was a significant increase in the prevalence of hypertension and obesity.
Despite a significant decrease, active smoking remained the most prevalent RF.
These findings strongly suggest that public health initiatives targeting RFs in young adults in Switzerland are warranted.
Graphical Abstract
Graphical Abstract
Hypogammaglobulinemia (serum IgG levels < 7.0 g/L) has been associated with increased risk of COPD exacerbations but has not yet been shown to predict hospitalizations.
To determine the relationship ...between hypogammaglobulinemia and the risk of hospitalization in patients with COPD.
Serum IgG levels were measured on baseline samples from four COPD cohorts (n = 2,259): Azithromycin for Prevention of AECOPD (MACRO, n = 976); Simvastatin in the Prevention of AECOPD (STATCOPE, n = 653), Long-Term Oxygen Treatment Trial (LOTT, n = 354), and COPD Activity: Serotonin Transporter, Cytokines and Depression (CASCADE, n = 276). IgG levels were determined by immunonephelometry (MACRO; STATCOPE) or mass spectrometry (LOTT; CASCADE). The effect of hypogammaglobulinemia on COPD hospitalization risk was evaluated using cumulative incidence functions for this outcome and deaths (competing risk). Fine-Gray models were performed to obtain adjusted subdistribution hazard ratios (SHR) related to IgG levels for each study and then combined using a meta-analysis. Rates of COPD hospitalizations per person-year were compared according to IgG status.
The overall frequency of hypogammaglobulinemia was 28.4%. Higher incidence estimates of COPD hospitalizations were observed among participants with low IgG levels compared with those with normal levels (Gray’s test, P < .001); pooled SHR (meta-analysis) was 1.29 (95% CI, 1.06-1.56, P = .01). Among patients with prior COPD admissions (n = 757), the pooled SHR increased to 1.58 (95% CI, 1.20-2.07, P < .01). The risk of COPD admissions, however, was similar between IgG groups in patients with no prior hospitalizations: pooled SHR = 1.15 (95% CI, 0.86-1.52, P =.34). The hypogammaglobulinemia group also showed significantly higher rates of COPD hospitalizations per person-year: 0.48 ± 2.01 vs 0.29 ± 0.83, P < .001.
Hypogammaglobulinemia is associated with a higher risk of COPD hospital admissions.
Johnny Hallyday à l'Olympia Weiss, George (1921-2010). Auteur ou responsable intellectuel; Vesta, Gisèle. Auteur ou responsable intellectuel; Stoller, Mike (1933-....). Auteur ou responsable intellectuel ...
1962
Audio Recording
Provider: - Institution: - Data provided by Europeana Collections- Comprend : LA BAGARRE ("Trouble") / J. LEIBER - M. STOLLER - VLINE et BUGGY ; Johnny HALLYDAY - STATICS / R. PRINCE ; les GOLDEN ...STRINGS - C'EST LE MASHED POTATOES (Little bitty pretty one") / R. BIRD - JIL et JAN ; Johnny HALLYDAY - COMME L'ETE DERNIER ("Dancin' party") / K. MANN - Dave APPELL et G. VESTA ; Johnny HALLYDAY - VIENS DANSER LE TWIST ("Let's twist again") / Kal MANN - Dave APPELL et G. GOSSET ; Johnny HALLYDAY - MASHED POPATOES : madison / ROZIER ; les GOLDEN STRINGS - TOUT BAS, TOUT BAS, TOUT BAS ("Apron strings") / G. WEISS - A. SCHROEDER - G. GARVARENTZ et C. NICOLAS ; Johnny HALLYDAY - C'EST TELLEMENT BON ("I got a woman") / R. CHARLES et Claude DUFRESNE ; Johnny HALLYDAY - LAISSEZ-NOUS TWISTER ("Twisting the night away") / Sam COOKE et A. PASCAL ; Johnny HALLYDAY - ELLE EST TERRIBLE ("Something else") / SHEELEY - COCHRANE - JIL et JAN ; Johnny HALLYDAY - L'IDOLE DES JEUNES ("Teenage idol") / Jack LEWIS et Ralph BERNET ; Johnny HALLYDAY - C'EST UNE FILLE COMME TOI / G. GARVARENTZ - C. NICOLAS et N. ROUX ; Johnny HALLYDAY - DANS UN JARDIN D'AMOUR ("Garden of love") / Gene PITNEY et JIL et JAN ; Johnny HALLYDAY - SERRE LA MAIN D'UN FOU ("Shake the hand of a fool") / Margie SINGLETON - JIL et JAN ; Johnny HALLYDAY - PAS CETTE CHANSON ("Don't play that song") / Ahmet ERTEGUN - Betty NELSON et R. BERNET ; Johnny HALLYDAY - RETIENS LA NUIT / Charles AZNAVOUR et G. GARVARENTZ ; Johnny HALLYDAY- BnF-Partenariats, Collection sonore - Believe- Contient une table des matières- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
DANSE-PARTY CHEZ MYLENE DEMONGEOT Verchuren, André (1920-2013). Auteur ou responsable intellectuel; Troxel, G.. Auteur ou responsable intellectuel; Tiomkin, Dimitri (1894-1979). Auteur ou responsable intellectuel ...
1959
Audio Recording
Provider: - Institution: - Data provided by Europeana Collections- Titre uniforme : Come softly to me- Titre uniforme : Rio bravo- Titre uniforme : Kansas city- Titre uniforme : Margie- Titre ...uniforme : La Chanson d'Orphée- Titre uniforme : Vacaciones- Titre uniforme : Tout doux, tout doucement = Come softly to me- Titre uniforme : Margie- Titre uniforme : La Chanson d'Orphée- Titre uniforme : Quiet village- Comprend : PAS DE PITIE : du film "RIO BRAVO" - boléro / D. TIOMKIN - M. DABADIE - M. CAPEZ ; Trumpet Boy et sa Trompette succès - LA CHANSON D'ORPHEE : du film "ORFEU NEGRO" - boléro / L. BONFA - G. GHESTEM - A. MARIA - M. CAMUS - F. LLENAS ; Trumpet Boy et sa Trompette succès - QUIET VILLAGE - batucada / Les BAXTER ; Francis BAY et son Orch. - QUIMBOMBO : cha cha cha / GRINAN ; Raoul ZEQUEIRA et orch. - LE TANGO DE L'ASSASSIN / J. LUBIN - F. BONIFAY - J. HOURDEAUX ; Tito FUGGI et orch. - VACACIONES - tango / G. GOMEZ - R. DESBOIS - P. DENONCIN ; Tito FUGGI et orch. - TOUT DOUX, TOUT DOUCEMENT - calypso-merengue / TROXEL - CHRISTOPHER - ELLYS ; Trumpet Boy et sa Trompette succès - CARNAVAL SAMBA : du film "ORFEU NEGRO" / A.C. JOBIM - M. CAMUS - F. LLENAS ; Trumpet Boy et sa Trompette succès - A SAN CRISTINA : cha cha cha / F. BUSCAGLIONE - L. CHIOSSO - I. LARUE ; Raoul ZEQUEIRA et orch. - KANSAS CITY - rock / LIEBER - STOLLER ; Trumpet Boy et sa Trompette succès - MARGIE - rock / CONRAD - ROBINSON ; Trumpet Boy et sa Trompette succès - LE TANGO NOUS INVITE / VERCHUREN - GRELBIN ; Tito FUGGI et orch. - MON COPAIN D'ESPAGNE : paso-doble / RIFFARD ; Tito FUGGI et orch. - JE VOUDRAIS : slow / COQUATRIX - SALVET ; Claude BOLLING et orch. - ENCHANTED : slow / B. RAM ; Claude BOLLING et orch.- BnF-Partenariats, Collection sonore - Believe- Contient une table des matières- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
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