Derivatives of the new class of 3-hydroxy-4-phenyl-5-oxo-pyrazolines were optimized towards both herbicidal activity on key annual grass weed species and selectivity in small grain cereal crops. The ...generic structure can be separated into three parts for the analysis of the structure–activity relationships, namely the aryl, the dione with its prodrug forms and the hydrazine moiety. Each area appears to play distinct and different roles in overall expression of biological performance which is further beneficially influenced by adjuvant response and safener action. Pinoxaden
6, a novel graminicide for use in wheat and barley incorporating a 1,4,5oxadiazepane ring, eventually emerged as a development candidate from the discovery and optimization process.
Display omitted
The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine ...receptor (RyR) and their insecticidal activity in the greenhouse is presented, as well as structure activity relationship considerations.
1?4,2,4,6-thiatriazines were identified as a novel class of herbicides. Their interesting effects on plants as well as their uncommon structures incited further studies. In addition to the initial ...sulfodiimine based preparation method, a flexible synthetic route was designed giving access to a larger array of compounds. The poor initial biological activity was improved and compounds with very high herbicidal activity were identified. Thiatriazines have been found to be unique and very potent inhibitors of the biosynthesis of cellulose, which is a major component of the plant cell wall. While the precise biochemical site of thiatriazine action is not yet known, they are known to induce the formation of a non-crystalline ?-1,4-glucan, as opposed to previously described herbicides which inhibit cellulose biosynthesis. Studies on the uptake, translocation and metabolism of a representative thiatriazine provided evidence for crop selectivity on the basis of differential rates of metabolism in various plant species.
PDF
