European guideline (EuroGuiDerm) on atopic eczema: part I – systemic therapy Wollenberg, A.; Kinberger, M.; Arents, B. ...
JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology,
September 2022, Letnik:
36, Številka:
9
Journal Article
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The evidence‐ and consensus‐based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were ...held between December 2020 and July 2021. Twenty‐nine experts (including clinicians and patient representatives) from 12 European countries participated. This first part of the guideline includes general information on its scope and purpose, the health questions covered, target users and a methods section. It also provides guidance on which patients should be treated with systemic therapies, as well as recommendations and detailed information on each systemic drug. The systemic treatment options discussed in the guideline comprise conventional immunosuppressive drugs (azathioprine, ciclosporin, glucocorticosteroids, methotrexate and mycophenolate mofetil), biologics (dupilumab, lebrikizumab, nemolizumab, omalizumab and tralokinumab) and janus kinase inhibitors (abrocitinib, baricitinib and upadacitinib). Part two of the guideline will address avoidance of provocation factors, dietary interventions, immunotherapy, complementary medicine, educational interventions, occupational and psychodermatological aspects, patient perspective and considerations for paediatric, adolescent, pregnant and breastfeeding patients.
Trissolcus japonicus
Ashmead (Hymenoptera: Scelionidae) is an endoparasitoid of the eggs of the brown marmorated stink bug,
Halyomorpha halys
Stål (Hemiptera: Pentatomidae), a major agricultural pest ...native to China, Japan, South Korea and Taiwan. We used CLIMEX to estimate the potential global distribution of
T. japonicus
with particular reference to New Zealand. In its native range the model predicts the presence, or a potential expansion, of
T. japonicus
into most of humid-subtropical and humid-continental areas. Globally, the model projects that many temperate, Mediterranean and subtropical areas could suit the establishment of
T. japonicus
. In New Zealand, the north appears moderately to highly suitable for
T. japonicus
, while southern regions are mostly marginal. The risk posed by
T. japonicus
to non-target species in New Zealand is predicted to vary between different non-targets. CLIMEX projections of the potential distribution of
T. japonicus
provide guidance for release sites of this parasitoid if approved for importation and release in New Zealand.
The evidence‐ and consensus‐based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were ...held between December 2020 and July 2021. Twenty‐nine experts (including clinicians and patient representatives) from 12 European countries participated. This second part of the guideline includes recommendations and detailed information on basic therapy with emollients and moisturizers, topical anti‐inflammatory treatment, antimicrobial and antipruritic treatment and UV phototherapy. Furthermore, this part of the guideline covers techniques for avoiding provocation factors, as well as dietary interventions, immunotherapy, complementary medicine and educational interventions for patients with atopic eczema and deals with occupational and psychodermatological aspects of the disease. It also contains guidance on treatment for paediatric and adolescent patients and pregnant or breastfeeding women, as well as considerations for patients who want to have a child. A chapter on the patient perspective is also provided. The first part of the guideline, published separately, contains recommendations and guidance on systemic treatment with conventional immunosuppressive drugs, biologics and janus kinase (JAK) inhibitors, as well as information on the scope and purpose of the guideline, and a section on guideline methodology.
This evidence‐ and consensus‐based guideline on the treatment of psoriasis vulgaris was developed following the EuroGuiDerm Guideline and Consensus Statement Development Manual. The first part of the ...guideline includes general information on the scope and purpose, health questions covered, target users and strength/limitations of the guideline. Suggestions for disease severity grading and treatment goals are provided. It presents the general treatment recommendations as well as detailed management and monitoring recommendations for the individual drugs. The treatment options discussed in this guideline are as follows: acitretin, ciclosporin, fumarates, methotrexate, adalimumab, apremilast, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, secukinumab, tildrakizumab and ustekinumab.
What people eat affects public health and human wellbeing, agricultural production, and environmental sustainability. This paper explores the heterogeneity of food consumption patterns in an ...ecologically and culturally diverse country. Using a latent class approach (which creates clusters of individuals with homogeneous characteristics), we analyse a food questionnaire (from the National Health and Nutrition Survey) applied across Mexico. We identify four clusters of food consumption (staple, prudent, high meat and low fruit) and find that belonging to these clusters is determined by socioeconomic, demographic (age, sex) and geographic (region, urban/rural) characteristics. Maize and pulses tend to constitute a larger proportion of the diet of poor, rural populations living in the south, while urban populations eat more varied foods, including ingredients whose production systems tend to exert more pressure on natural resources (for instance, meat). Despite the importance given in the literature to the Mexican gastronomy and its diverse traditional regional diets, we find that only 6% of the population adopts a food consumption pattern resembling the traditional Mexican diet. Instead, most of the Mexican population has a food consumption pattern resembling a western diet, which is problematic in terms of public health and environmental sustainability.
Moringa plants have an extensive range of bioactive compounds that can be obtained from different vegetative structures, such as leaves, seeds, stems and pod husks. These bioactive molecules include ...carbohydrates, phenolic compounds, oils and fatty acids, proteins and functional peptides and have great potential to be used in several formulations of food products. This report collects recent information concerning bioactive molecules in other species of the Moringaceae family, different from Moringa oleifera. Thus, this document aims to describe these bioactive compounds and their functional properties on foodstuffs. In addition, more suitable methodologies applied for their extraction and characterization are reviewed. Finally, an overview of patents required to protect Moringa-derived products and processes is provided.
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•Moringa is a source of bioactive compounds with relevance for food industry.•Carbohydrates reported in M. oleifera are reviewed by the first time.•Bioactive compounds from Moringaceae family different to M. oleifera are reviewed.•LC and GC–MS are the most suitable methods for identification of bioactive molecules.
Revisiting Proxima with ESPRESSO Suárez Mascareño, A.; Faria, J. P.; Figueira, P. ...
Astronomy & astrophysics,
07/2020, Letnik:
639
Journal Article
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Context.
The discovery of Proxima b marked one of the most important milestones in exoplanetary science in recent years. Yet the limited precision of the available radial velocity data and the ...difficulty in modelling the stellar activity calls for a confirmation of the Earth-mass planet.
Aims.
We aim to confirm the presence of Proxima b using independent measurements obtained with the new ESPRESSO spectrograph, and refine the planetary parameters taking advantage of its improved precision.
Methods.
We analysed 63 spectroscopic ESPRESSO observations of Proxima (Gl 551) taken during 2019. We obtained radial velocity measurements with a typical radial velocity photon noise of 26 cm s
−1
. We combined these data with archival spectroscopic observations and newly obtained photometric measurements to model the stellar activity signals and disentangle them from planetary signals in the radial velocity (RV) data. We ran a joint Markov chain Monte Carlo analysis on the time series of the RV and full width half maximum of the cross-correlation function to model the planetary and stellar signals present in the data, applying Gaussian process regression to deal with the stellar activity signals.
Results.
We confirm the presence of Proxima b independently in the ESPRESSO data and in the combined ESPRESSO+ HARPS+UVES dataset. The ESPRESSO data on its own shows Proxima b at a period of 11.218 ± 0.029 days, with a minimum mass of 1.29 ± 0.13
M
⊕
. In the combined dataset we measure a period of 11.18427 ± 0.00070 days with a minimum mass of 1.173 ± 0.086
M
⊕
. We get a clear measurement of the stellar rotation period (87 ± 12 d) and its induced RV signal, but no evidence of stellar activity as a potential cause for the 11.2 days signal. We find some evidence for the presence of a second short-period signal, at 5.15 days with a semi-amplitude of only 40 cm s
−1
. If caused by a planetary companion, it would correspond to a minimum mass of 0.29 ± 0.08
M
⊕
. We find that forthe case of Proxima, the full width half maximum of the cross-correlation function can be used as a proxy for the brightness changes and that its gradient with time can be used to successfully detrend the RV data from part of the influence of stellar activity. The activity-induced RV signal in the ESPRESSO data shows a trend in amplitude towards redder wavelengths. Velocities measured using the red end of the spectrograph are less affected by activity, suggesting that the stellar activity is spot dominated. This could be used to create differential RVs that are activity dominated and can be used to disentangle activity-induced and planetary-induced signals. The data collected excludes the presence of extra companions with masses above 0.6
M
⊕
at periods shorter than 50 days.
Background The present study examined whether the learning benefits of an external focus of attention (i.e. on the movement effect) relative to an internal focus (i.e. on the movement), found ...previously in non‐disabled children and adults would also be found in children with intellectual disabilities (IDs).
Methods Participants (n = 24; average age: 12.2 years) with mild intellectual deficiency (IQ = 51–69) practiced throwing beanbags at a target. In the external focus group, participants were instructed to direct their attention to the movement of the beanbag, while in the internal focus group, participants were asked to direct their attention to the movement of their hand. The practice phase consisted of 40 trials, and attentional focus reminders were given after every third trial. Learning was assessed 1 day later by retention and transfer (greater target distance) tests, each consisting of 10 trials. No focus reminders were given on that day.
Results The external focus group demonstrated more effective learning than the internal focus group, as evidenced by more accurate tosses on the transfer test.
Conclusions The present findings show that instructions that induce an external focus of attention can enhance motor learning in children with IDs.
We present basic statistics for all supernovae discovered by the All-Sky Automated Survey for SuperNovae (ASAS-SN) during its first year-and-a-half of operations, spanning 2013 and 2014. We also ...present the same information for all other bright (mV less than or equal to 17), spectroscopically confirmed supernovae discovered from 2014 May 1 through the end of 2014, providing a comparison to the ASAS-SN sample starting from the point where ASAS-SN became operational in both hemispheres. In addition, we present collected redshifts and near-UV through IR magnitudes, where available, for all host galaxies of the bright supernovae in both samples. This work represents a comprehensive catalogue of bright supernovae and their hosts from multiple professional and amateur sources, allowing for population studies that were not previously possible because the all-sky emphasis of ASAS-SN redresses many previously existing biases. In particular, ASAS-SN systematically finds bright supernovae closer to the centres of host galaxies than either other professional surveys or amateurs, a remarkable result given ASAS-SN's poorer angular resolution. This is the first of a series of yearly papers on bright supernovae and their hosts that will be released by the ASAS-SN team.