Polycythemia vera (PV) is mainly characterized by elevated blood cell counts, thrombotic as well as hemorrhagic predisposition, a variety of symptoms, and cumulative risks of fibrotic progression ...and/or leukemic evolution over time. Major changes to its diagnostic criteria were made in the 2016 revision of the World Health Organization (WHO) classification, with both hemoglobin and hematocrit diagnostic thresholds lowered to 16.5 g/dL and 49% for men, and 16 g/dL and 48% for women, respectively. The main reason leading to these changes was represented by the recognition of a new entity, namely the so-called "masked PV", as individuals suffering from this condition have a worse outcome, possibly owing to missed or delayed diagnoses and lower intensity of treatment. Thrombotic risk stratification is of crucial importance to evaluate patients' prognosis at diagnosis. Currently, patients are stratified into a low-risk group, in the case of younger age (<60 years) and no previous thromboses, and a high-risk group, in the case of patients older than 60 years and/or with a previous thrombotic complication. Furthermore, even though they have not yet been formally included in a scoring system, generic cardiovascular risk factors, particularly hypertension, smoking, and leukocytosis, contribute to the thrombotic overall risk. In the absence of agents proven to modify its natural history and prevent progression, PV management has primarily been focused on minimizing the thrombotic risk, representing the main cause of morbidity and mortality. When cytoreduction is necessary, conventional therapies include hydroxyurea as a first-line treatment and ruxolitinib and interferon in resistant/intolerant cases. Each therapy, however, is burdened by specific drawbacks, underlying the need for improved strategies. Currently, the therapeutic landscape for PV is still expanding, and includes several molecules that are under investigation, like long-acting pegylated interferon alpha-2b, histone deacetylase inhibitors, and murine double minute 2 (MDM2) inhibitors.
Imaging disdrometers are widely used in field campaigns to provide information on the shape of hydrometeors, together with the diameter and the fall velocity, which can be used to derive information ...on the shape-size relations of hydrometeors. However, due to their higher price compared to laser disdrometers, their use is limited to scientific research purposes. The 3D stereo (3DS) is a commercial imaging disdrometer recently made available by Thies Clima and on which there are currently no scientific studies in the literature. The most innovative feature of the 3DS is its ability in capturing images of the particles passing through the measurement volume, crucial to provide an accurate classification of hydrometeors based on information about their shape, especially in the case of solid precipitation. In this paper. the performance of the new device is analyzed by comparing 3DS with the Laser Precipitation Monitor (LPM) from the same manufacturer, which is a known laser disdrometer used in many research works. The data used in this paper were obtained from measurements of the two instruments carried out at the Casale Calore site in L'Aquila during the CORE-LAQ (Combined Observations of Radar Experiments in L'Aquila) campaign. The objective of the comparison analysis is to analyze the differences between the two disdrometers in terms of hydrometeor classification, number and falling speed of particles, precipitation intensity, and total cumulative precipitation on an event basis. As regards the classification of precipitation, the two instruments are in excellent agreement in identifying rain and snow; greater differences are observed in the case of particles in mixed phase (rain and snow) or frozen phase (hail). Due to the different measurement area of the two disdrometers, the 3DS generally detects more particles than the LPM. The performance differences also depend on the size of the hydrometeors and are more significant in the case of small particles, i.e., D < 1 mm. In the case of rain events, the two instruments are in agreement with respect to the terminal velocity in still air predicted by the Gunn and Kinzer model for drops with a diameter of less than 3 mm, while, for larger particles, terminal velocity is underestimated by both the disdrometers. The agreement between the two instruments in terms of total cumulative precipitation per event is very good. Regarding the 3DS ability to capture images of hydrometeors, the raw data provide, each minute, from one to four images of single particles and information on their size and type. Their number and coarse resolution make them suitable to support only qualitative analysis of the shape of precipitating particles.
Sorption heat storage system performance heavily depends on the operating temperature. It is found that testing temperatures reported in literature vary widely. In respect to the building application ...for space heating, reported testing temperatures are often outside of application scope and at times even incomplete. This has led to application performance overestimation and prevents sound comparison between reports. This issue is addressed in this paper and a remedy pursued by proposing a static temperature and vapor pressure-based testing guideline for building-integrated sorption heat storage systems. By following this guideline, comparable testing results in respect to temperature gain, power and energy density will be possible, in turn providing a measure for evaluation of progress.
ixpeobssim is a simulation and analysis framework specifically developed for the Imaging X-ray Polarimetry Explorer (IXPE). Given a source model and the response functions of the telescopes, it is ...designed to produce realistic simulated observations, in the form of event lists in FITS format, containing a strict superset of the information included in the publicly released IXPE data products. The core simulation capabilities are complemented by a full suite of post-processing applications which support the spatial, spectral, and temporal models needed for analysis of typical polarized X-ray sources, allowing for the implementation of complex, polarization-aware analysis pipelines, and facilitating the interoperation with the standard visualization and analysis tools traditionally in use by the X-ray community. Although much of the framework is specific to IXPE, the modular nature of the underlying implementation makes it potentially straightforward to adapt it to different missions with polarization capabilities.
We present a new simulation framework, based on the Python programming language and specifically developed for the Imaging X-ray Polarimetry Explorer (IXPE) mission. Starting from an arbitrary source ...model (including morphological, temporal, spectral and polarimetric information), this framework uses the instrument response functions to produce fast and realistic observation-simulations. The generated event lists can be directly fed into the standard X-ray visualization and analysis tools, including XSPEC—which make this framework a useful tool not only for simulating observations of astronomical sources, but also to develop and test end-to-end analysis chains. We will give an overview of the basic architecture of the software and we will present a few physically interesting case studies in the context of the IXPE mission.
Abstract
Imaging X-ray Polarimetry Explorer (IXPE) is a Small Explorer mission by NASA and Agenzia Spaziale Italiana, launched on 2021 December 9, dedicated to investigating X-ray polarimetry ...allowing angular-, time-, and energy-resolved observations in the 2–8 keV energy band. IXPE is in the science observation phase since 2022 January; it is comprised of three identical telescopes with grazing-incidence mirrors, each one having in the focal plane a gas pixel detector. In this paper, we present a possible guideline to obtain an optimal background selection in polarimetric analysis, and a rejection strategy to remove instrumental background. This work is based on the analysis of IXPE observations, aiming to improve as much as possible the polarimetric sensitivity. In particular, the developed strategies have been applied
as a case study
to the IXPE observation of the 4U 0142+61 magnetar.
The article estimates energy flexibility provided to the electricity grid by integration of long-term thermal energy storage in buildings. To this end, a liquid sorption storage combined with a ...compression heat pump is studied for a single-family home. This combination acts as a double-stage heat pump comprised of a thermal and an electrical stage. It lowers the temperature lift to be overcome by the electrical heat pump and thus increases its coefficient of performance. A simplified model is used to quantify seasonal energy flexibility by means of electric load shifting evaluated with a monthly resolution. Results are presented for unlimited and limited storage capacity leading to a total seasonal electric load shift of 631.8 kWh/a and 181.7 kWh/a, respectively. This shift, referred to as virtual battery effect, provided through long-term thermal energy storage is large compared to typical electric battery capacities installed in buildings. This highlights the significance of building-integrated long-term thermal energy storage for provision of energy flexibility to the electricity grid and hence for the integration of renewables in our energy system.
Abstract
Imaging X-ray Polarimetry Explorer (IXPE) is a Small Explorer mission that was launched at the end of 2021 to measure the polarization of X-ray emission from tens of astronomical sources. ...Its focal-plane detectors are based on the Gas Pixel Detector, which measures the polarization by imaging photoelectron tracks in a gas mixture and reconstructing their initial directions. The quality of the single track, and then the capability of correctly determining the original direction of the photoelectron, depends on many factors, e.g., whether the photoelectron is emitted at low or high inclination with respect to the collection plane or the occurrence of a large Coulomb scattering close to the generation point. The reconstruction algorithm used by IXPE to obtain the photoelectron emission direction also calculates several properties of the shape of the tracks that characterize the process. In this paper we compare several such properties and identify the best one to weight each track on the basis of the reconstruction accuracy. We demonstrate that significant improvement in sensitivity can be achieved with this approach and for this reason it will be the baseline for IXPE data analysis.
In situ measurements of precipitation are typically obtained by tipping bucket or weighing rain gauges or by disdrometers using different measurement principles. One of the most critical aspects of ...their operational use is the calibration, which requires the characterization of instrument responses both in laboratory and in real conditions. Another important issue with in situ measurements is the coverage. Dense networks are desirable, but the installation and maintenance costs can be unaffordable with most of the commercial conventional devices. This work presents the development of a prototype of an impact rain gauge based on a very low-cost piezoelectric sensor. The sensor was developed by assembling off-the-shelf and reused components following an easy prototyping approach; the calibration of the relationship between the different properties of the voltage signal, as sampled by the rain drop impact, and rainfall intensity was established using machine-learning methods. The comparison with 1-minute rainfall obtained by a co-located commercial disdrometer highlights the fairly good performance of the low-cost sensor in monitoring and characterizing rainfall events.
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