To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis.
Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. ...Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale NIHSS ≤ 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS ≤ 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale mRS ≤ 2) and excellent functional outcome (mRS ≤ 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS ≥ 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS ≥ 4 points from baseline or death within 36 hours, and 3-month death.
Adjusted multivariate analysis showed that statin use in the acute phase was associated with neurologic improvement (odds ratio OR 1.68, 95% confidence interval CI 1.26-2.25; p < 0.001), major neurologic improvement (OR 1.43, 95% CI 1.11-1.85; p = 0.006), favorable functional outcome (OR 1.63, 95% CI 1.18-2.26; p = 0.003), and a reduced risk of neurologic deterioration (OR: 0.31, 95% CI 0.19-0.53; p < 0.001) and death (OR 0.48, 95% CI 0.28-0.82; p = 0.007).
Statin use in the acute phase of stroke after IV thrombolysis may positively influence short- and long-term outcome.
Ventuno proposte di lettura Bettoni, Antonella; Calzolaio, Simone; Car, Ronald ...
Giornale di storia costituzionale,
2016., 20160101
31
Journal Article
Recenzirano
Mauro BUSSANI (a cura di) Il diritto italiano in Europa (1861-2014). Scienza, giurisprudenza, legislazione Annuario di diritto comparato e di studi legislativi 2014 Napoli, Edizioni Scientifiche ...Italiane, 2014, pp. 754 ISSN 20399871, Euro 125
Venti proposte de lettura Barbisan, A. Cura Di Benedetta; Bettoni, Antonella; Car, Ronald ...
Giornale di storia costituzionale,
01/2017
33
Journal Article
Primary Vulvar Nocardiosis Gallo, Angelo; Bettoni, Gaia; Trezzi, Gaetano ...
Obstetrics and gynecology (New York. 1953),
2006-September, Letnik:
108, Številka:
3, Part 2 Suppl
Journal Article
Recenzirano
BACKGROUND:Nocardiosis is an uncommon disease, and the primary skin infection is usually at the site of a recent injury. Nocardia is a saprophytic bacterium of the soil belonging to the order ...Actinomycetales.
CASE:A 68-year-old woman presented with a painful, hard, dark reddish lesion located in the right hemivulva. She had been treated by radiotherapy for a vulvar leiomyosarcoma arising from the left Bartholin gland at the age of 45. Pathology results demonstrated nocardial infection, initially advanced despite antibiotic therapy. The necrosis extended to and involved the ischiopubic bone, requiring extensive surgical treatment. We performed a radical vulvectomy with partial pubic bone excision to remove the necrotic tissue. A transverse gracilis-myocutaneous free flap was used for vulvar reconstruction. Wound necrosis recurrence required a rectus abdominis myocutaneous flap reconstruction, with an excellent final result.
CONCLUSION:This is the first report of primary vulvar nocardiosis. This infection may simulate advanced vulvar carcinoma requiring extensive surgical treatment.
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