ABSTRACT
We present the discovery of NGTS-7Ab, a high-mass brown dwarf transiting an M dwarf with a period of 16.2 h, discovered as part of the Next Generation Transit Survey (NGTS). This is the ...shortest period transiting brown dwarf around a main or pre-main sequence star to date. The M star host (NGTS-7A) has an age of roughly 55 Myr and is in a state of spin–orbit synchronization, which we attribute to tidal interaction with the brown dwarf acting to spin-up the star. The host star is magnetically active and shows multiple flares across the NGTS and follow-up light curves, which we use to probe the flare–star-spot phase relation. The host star also has an M star companion at a separation of 1.13 arcsec with very similar proper motion and systemic velocity, suggesting that the NGTS-7 system is a hierarchical triple. The combination of tidal synchronisation and magnetic braking is expected to drive on-going decay of the brown dwarf orbit, with a remaining lifetime of only 5–10 Myr.
In recent years, scientific literature has demonstrated numerous improvements in physical, vocational, and emotional outcomes from an intradialytic exercise program for end-stage renal disease ...patients. Despite documented benefits, most dialysis clinics have not moved to incorporate exercise for their patients. This could be due to many factors including lack of patient interest and/or the lack of information on how to get an exercise program started. This article describes how the University of Virginia Renal Services incorporated an exercise program and has found success with adherence to the program from staff and patients. With proper commitment from administration and staff, an exercise program for ESRD patients can become a reality and a standard treatment of care for dialysis patients.
We present the discovery of NGTS-7Ab, a high mass brown dwarf transiting an M dwarf with a period of 16.2 hours, discovered as part of the Next Generation Transit Survey (NGTS). This is the shortest ...period transiting brown dwarf around a main or pre-main sequence star to date. The M star host (NGTS-7A) has an age of roughly 55 Myr and is in a state of spin-orbit synchronisation, which we attribute to tidal interaction with the brown dwarf acting to spin up the star. The host star is magnetically active and shows multiple flares across the NGTS and follow up lightcurves, which we use to probe the flare-starspot phase relation. The host star also has an M star companion at a separation of 1.13 arcseconds with very similar proper motion and systemic velocity, suggesting the NGTS-7 system is a hierarchical triple. The combination of tidal synchronisation and magnetic braking is expected to drive ongoing decay of the brown dwarf orbit, with a remaining lifetime of only 5-10 Myr.
Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care and retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants ...including patients with stage 1-5 CKD and healthy controls, we identify five metabolites, including 5-methoxytryptophan (5-MTP), whose levels strongly correlate with clinical markers of kidney disease. 5-MTP levels decrease with progression of CKD, and in mouse kidneys after unilateral ureteral obstruction (UUO). Treatment with 5-MTP ameliorates renal interstitial fibrosis, inhibits IκB/NF-κB signaling, and enhances Keap1/Nrf2 signaling in mice with UUO or ischemia/reperfusion injury, as well as in cultured human kidney cells. Overexpression of tryptophan hydroxylase-1 (TPH-1), an enzyme involved in 5-MTP synthesis, reduces renal injury by attenuating renal inflammation and fibrosis, whereas TPH-1 deficiency exacerbates renal injury and fibrosis by activating NF-κB and inhibiting Nrf2 pathways. Together, our results suggest that TPH-1 may serve as a target in the treatment of CKD.
We present strong-lensing models as well as mass and magnification maps for the cores of the six Hubble Space Telescope (HST) Frontier Fields galaxy clusters. Our parametric lens models are ...constrained by the locations and redshifts of multiple image systems of lensed background galaxies. We use a combination of photometric redshifts and spectroscopic redshifts of the lensed background sources obtained by us (for A2744 and AS1063), collected from the literature, or kindly provided by the lensing community. Using our results, we (1) compare the derived mass distribution of each cluster to its light distribution, (2) quantify the cumulative magnification power of the HST Frontier Fields clusters, (3) describe how our models can be used to estimate the magnification and image multiplicity of lensed background sources at all redshifts and at any position within the cluster cores, and (4) discuss systematic effects and caveats resulting from our modeling methods. We specifically investigate the effect of the use of spectroscopic and photometric redshift constraints on the uncertainties of the resulting models. We find that the photometric redshift estimates of lensed galaxies are generally in excellent agreement with spectroscopic redshifts, where available. However, the flexibility associated with relaxed redshift priors may cause the complexity of large-scale structure that is needed to account for the lensing signal to be underestimated. Our findings thus underline the importance of spectroscopic arc redshifts, or tight photometric redshift constraints, for high precision lens models. All products from our best-fit lens models (magnification, convergence, shear, deflection field) and model simulations for estimating errors are made available via the Mikulski Archive for Space Telescopes.
Eurobond Market Extends Issuance Spree This article was prepared by Adam Bradbery, Geoffrey T. Smith, Nicholas Elliott, Henry E. Teitelbaum, George P. Bayliss, Dan Weeks and Axel Bugge Of the Capital Markets Report
Wall Street journal. Europe,
09/1994
Newspaper Article
The Eurobond market's main focus Tuesday was a 500 billion-lire ($318.9 million) offering from the European Investment Bank of 11.45% three-year Eurobonds via joint lead underwriters Banca di Roma, ...Deutsche Bank (London) and IMI Bank (Luxembourg). IMI Bank was also chosen as the counterparty responsible for swapping 300 billion lire into floating-rate assets. While many potential investors waited on the sidelines ahead of the Italian budget law ruling set for Sept. 30, IMI syndicate officials said this deal represented important commitment to the lire market from a highly rated issuer. In trading, the 6.375% Tobl of 1999 eased 0.02 to 97.70, yielding 6.95 % vs. 6.94%, the 6.75% Bund due 2004 was at 94.79, up 0.19, yielding 7.51% vs. 7.54%, and the 6.25% Bund due 2024 was at 79.98, up 0.19, yielding 7.96% vs. 7.98%. Liffe's December Bund future climbed to 89.17, up 0.17, with the DTB December Bobl future was at 95.40, up 0.01.
Speculation on Timing of World Bank Issue Steals the Spotlight From Belgian Offering This article was prepared by Allison Bisbey, Adam Bradbery, George Bayliss, Dan Weeks, Geoffrey T. Smith, Chui-Ling Tam, Henry E. Teitelbaum And Eric Van Zant of the Dow Jones Capital Markets Report
Wall Street journal. Europe,
09/1994
Newspaper Article
Belgium's one-billion-mark ($646.7 million) five-year issue won't be priced until early today, a move designed to let more Asian-Pacific accounts have a look at the deal, according to a syndicate ...official at Dresdner Bank AG, which is joint lead-managing the offering with Swiss Bank Corp. The bonds are being marketed in line with expectations at an indicated yield margin of 25 basis points over the 6 1/4% German note due in 1999. The 6% note due 1999 was unchanged at 89 11/32, yielding 8.71%, while the 6.75% bond maturing 2004 fell 4/32 to 85 24/32 for a yield of 8.90%, up from 8.87%. The 8.75% bond of 2017 fell 4/32 to 100 7/32 as its yield rose to 8.71% from 8.70%. The 6.375% note maturing 1999 ended at 97.19, down 0.11, while its yield rose to 7.08% from 7.06%. The 6.75% bond due 2004 slid 0.17 to 93.33; its yield rose to 7.59% from 7.56%. The 6.25% bond due 2024 ended 0.11 lower at 80.39 as its yield edged up to 8.00% from 7.99%.
Markets Plummet on U.S. Production News This article was prepared by Adam Bradbery, Gene Colter, Nicholas Elliott, Geoffrey T. Smith, Henry E. Teitelbaum, Eric Van Zant, George P. Bayliss, Dan Weeks and Axel Bugge Of Dow Jones Capital Markets Report
Wall Street journal. Europe,
09/1994
Newspaper Article
The 6.375% note due 1999 was down 0.66 point to 96.83, to yield 7.17%. The 6.75% Bund maturing 2004 dropped 1.24 point to 93.66, to yield 7.69%. The 6.25% Bund maturing 2024 plummeted 1.63 point to ...79.43, for a yield of 8.10%. The 6% note due 1999 was down 18/32 to 89 11/32, for a yield of 8.70%, while the 6.75% bond due 2004 dropped 1 8/32 to 85 11/32, to yield 8.95%. The 8.75% bond maturing 2017 dropped 1 20/32 to 100, yielding 8.74%. The 7% note due 1999 was down 0.46 point to 96.78, to yield 7.79%, while the 6.75% bond maturing 2004 was down 0.86 point to 90.28, to yield 8.2%. The 6% bond maturing 2025 was down 1.18 point to 71.44, yielding 8.69%.
Borrowers Are Wary of Sensitive Markets This article was prepared by Nicholas Elliott, Adam Bradbery, Geoffrey T. Smith, Henry E. Teitelbaum, George P. Bayliss, Dan Weeks, Allison Bisbey and Axel Bugge Of the Dow Jones Capital Markets Report
Wall Street journal. Europe,
05/1994
Newspaper Article
The 6% bond due 1999 fell 10/32 to 93 16/32 to yield 7.53%. The 6.75% bond due 2004 slid 21/32 to 91 16/32 to yield 7.95%, and the 9% bond due 2008 fell 23/32 to 108 to yield 8.04%. The 8.5% bond due ...1997 dropped 0.35 point to 99.55 to yield 8.87%. The 8.5% bond due 2004 slid 0.75 point to 95.35 to yield 9.44%. The 9% bond due 2023 dropped 1.25 point to 93.15 to yield 9.94%. The 5.75% bond due 1999 sank 0.49 point to 99.29, to yield 5.92%. The 6.25% bond due 2004 tumbled 0.59 point to 97.96, to yield 6.53%. The 6.25% bond due 2024 fell 1.03 points to 88.56, to yield 7.19%.
Eurobond Jitters Persist Despite Calm Week This article was prepared by Allison Bisbey, Axel Bugge, Nicholas Elliott, George P. Bayliss, Dan Weeks, Chui-Ling Tam, Henry E. Teitelbaum and Eric Van Zant Of the Dow Jones Capital Markets Report
Wall Street journal. Europe,
04/1994
Newspaper Article
Still, underwriters were somewhat heartened by a week that saw modest gains or little change in European government bond markets. Hopes that poor economic performance will encourage the Bundesbank to ...lower its 6.75% Lombard rate, if not its 5.25% discount rate, helped German government bonds gain 0.25% in local currency terms in the week ended Thursday. According to the Salomon Brothers world government bond index, French government bonds fell a minute 0.04% in local currency terms in the same period, while U.K. gilts lost an unthreatening 0.11%. U.S. Treasurys lost 0.37% in the same time. Though the figures aren't bullish, they point to a further decoupling of European bonds from the rising-yield trend in the U.S. Interest floats at the three-month London interbank offered rate for pounds plus 25 basis points. The bonds mature in December 2028, but are expected to have an average life of 3.51 years, assuming a 20% repayment rate to match the expected duration of the mortgages. The bonds are callable at par from March 2001, with the coupon stepping up to Libor plus 70 basis points if the bonds aren't called.
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