No copper needed: In recent years, a large number of metal-free click reactions have been reported based on thiol-ene radical additions, Diels-Alder reactions, and Michael additions. In this ...Minireview, special attention is given to the advantages and limitations of the different methods to evaluate whether they have the potential to surpass the overwhelming success of the copper(I)-catalyzed azide-alkyne cycloaddition.The overwhelming success of click chemistry encouraged researchers to develop alternative "spring-loaded" chemical reactions for use in different fields of chemistry. Initially, the copper(I)-catalyzed azide-alkyne cycloaddition was the only click reaction. In recent years, metal-free 3+2 cycloaddition reactions, Diels-Alder reactions, and thiol-alkene radical addition reactions have come to the fore as click reactions because of their simple synthetic procedures and high yields. Furthermore, these metal-free reactions have wide applicability and are physiologically compatible. These and other alternative click reactions expand the opportunities for synthesizing small organic compounds as well as tailor-made macromolecules and bioconjugates. This Minireview discusses the success and applicability of new, in particular metal-free, click reactions.
Glycopolymers are becoming more and more important in understanding biological interactions due to their unique recognition properties. Macromolecules with different chain lengths, compositions and ...architectures provide enormous diversity in the formation of primary and secondary structures that have a major effect on multivalent binding to lectins. It is crucial to control the precise structure of macromolecules to achieve specific and selective carbohydrate‐lectin binding. The use of advanced synthesis techniques to prepare well‐defined glycopolymers and selected advanced analytical techniques to study multivalent interactions are highlighted in this Feature Article.
Glycopolymers have unique recognition properties and can be used in various bioapplications. The well‐defined structures of glycopolymers effect their binding to proteins significantly. It is crucial to gain absolute control over their structure to control specific carbohydrate–lectin interactions. These interactions can be best determined by advanced techniques, QCM and SPR.
Obituary – Prof. Dr. Yusuf Yagci (1952–2023) Becer, C. Remzi
Macromolecular rapid communications.,
June 2023, 2023-Jun, 2023-06-00, 20230601, Letnik:
44, Številka:
12
Journal Article
Multiblock copolymers (MBCs) are an emerging class of synthetic polymers that exhibit different macromolecular architectures and behaviours to those of homopolymers or di/triblock copolymers. Owing ...to the rapidly expanding field of synthetic methodologies applied in the field of polymer chemistry, sequenced controlled MBCs are becoming the new functional materials of this decade. MBCs can now be synthesised with precision and control unlike before and yet some of the synthetic limitations remain a challenge. In this review article, we summarise the various synthetic methodologies that have been reported to date with recent advances in different polymerisation techniques and applications.
Multiblock copolymers (MBCs) are an emerging class of synthetic polymers that exhibit different macromolecular architectures and behaviours to those of homopolymers or di/triblock copolymers.
The demand for petroleum dependent chemicals and materials has been increasing despite the dwindling of their fossil resources. As the dead-end of petroleum based industry has started to appear, ...today's modern society has to implement alternative energy and valuable chemical resources immediately. Owing to the importance of lignocellulosic biomass being the most abundant and bio-renewable biomass on earth, this critical review provides insights into the potential of lignocellulosic biomass as an alternative platform to fossil resources. In this context, over 200 value-added compounds, which can be derived from lignocellulosic biomass by various treatment methods, are presented with their references. Lignocellulosic biomass based polymers and their commercial importance are also reported mainly in the frame of these compounds. This review article aims to draw the map of lignocellulosic biomass derived chemicals and their synthetic polymers, and to reveal the scope of this map in today's modern chemical and polymer industry.
The ongoing research activities in the field of lignocellulosic biomass for production of value-added chemicals and polymers that can be utilized to replace petroleum-based materials are reviewed.
Cyclodextrins (CDs) are a family of cyclic oligosaccharides with a hydrophilic exterior surface and a nonpolar cavity interior, therefore, CDs can form inclusion complexes through noncovalent ...interactions with a broad range of hydrophobic guests. CD derivatives and CD-based polymers find important uses in different fields such as pharmacy, cosmetics, biomedicine, textiles, and food domain due to their unique properties during the past decade. Hence, in this review, functionalised CDs and CD-based polymers are classified and discussed according to their synthetic approaches comprehensively to help polymer chemists for the development of new CD-based materials for different types of applications.
A toolbox of cyclodextrin derivatives, synthetic strategies for the preparation of cyclodextrin-polymer conjugates using various polymerisation techniques and representative applications of such conjugates are discussed.
Recent advances in polymer science make it possible to create single chain polymer nanoparticles (SCNPs), which can mimic the folding of natural macromolecules, such as protein and nucleic acid, in ...terms of their native and functional state. Even though considerable progress has been done during the last years, the synthesis of relatively controlled SCNPs with a good folding accuracy is still challenging due to lack of appropriate chemical synthesis techniques. Different types of SCNPs are developed with enhanced properties and used for various applications, e.g., delivery systems, imaging agents, and nanomedicine. As it is believed that SCNPs are so crucial to elucidate single chain technology, in this review, recent developments in SCNPs are discussed comprehensively according to their synthetic approaches to keep readers updated on this important research field. First, selective point folding methods are classified and highlighted, and then repeat unit folding routes are discussed with exciting examples.
Single chain nanoparticles are the latest challenge of polymer scientists. Being able to analyze individual chains and advanced synthesis techniques allows creation of new materials with unprecedented properties. This review article highlights the most important work that is carried out on single chain nanoparticles.
From drug delivery to nanoreactors and protocells, polymersomes have gained considerable interest from researchers due to their novel applications. However, one of the main challenges is the ...selection of the most appropriate synthetic route. It is crucial to consider factors such as desired application, functionalisation, and environment of the polymersome when designing a synthetic route. This review will explore the current scope of polymersome synthesis and preparation methods, and will conclude by highlighting the most recent reports on polymersome related systems such as virus-like nanoparticles. From the choice of monomers, to polymerisation techniques, and to preparation methods used, we aim for this review to be utilised as a tutorial guide for the synthesis of a range of polymersomes, each with varying characteristics and applications.
From drug delivery to nanoreactors and protocells, polymersomes have gained considerable interest from researchers due to their novel applications.
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