Pain is experienced by the vast majority of patients living with Parkinson's disease. It is most often of nociceptive origin, but may also be ascribed to neuropathic (radicular or central) or ...miscellaneous sources. The recently validated King's Parkinson's Disease Pain Scale is based on 7 domains including musculoskeletal pain, chronic body pain (central or visceral), fluctuation-related pain, nocturnal pain, oro-facial pain, pain with discolouration/oedema/swelling, and radicular pain. The basal ganglia integrate incoming nociceptive information and contribute to coordinated motor responses in pain avoidance and nocifensive behaviors. In Parkinson's disease, nigral and extra-nigral pathology, involving cortical areas, brainstem nuclei, and spinal cord, may contribute to abnormal central nociceptive processing in patients experiencing pain or not. The dopamine deficit lowers multimodal pain thresholds that are amenable to correction following levodopa dosing. Functional brain imaging with positron emission tomography following administration of H215O revealed abnormalities in the sensory discriminative processing of pain (insula/SII), as well as in the affective motivational processing of pain (anterior cingulate cortex, prefrontal cortex). Pain management is dependent on efforts invested in diagnostic accuracy to distinguish nociceptive from neuropathic pain. Treatment requires an integrated approach including strategies to lessen levodopa-related response fluctuations, in addition to other pharmacological and non-pharmacological options such as deep brain stimulation and rehabilitation.
•Pain is common at all stages in Parkinson’s disease, even as a premotor manifestation.•It is heterogeneous and falls under nociceptive, neuropathic, and miscellaneous sources.•Nigral and extra-nigral pathology may contribute to abnormal information processing in medial and lateral pain systems.•Dopamine deficit lowers multimodal pain thresholds that may be corrected following levodopa dosing.•Treatment requires an interdisciplinary approach in addition to strategies to lessen motor response fluctuations.
The increasing atmospheric nitrous oxide (N2O) concentration stems from the development of agriculture. However, N2O emissions from global rice‐based ecosystems have not been explicitly and ...systematically quantified. Therefore, this study aims to estimate the spatiotemporal magnitudes of the N2O emissions from global rice‐based ecosystems and determine different contribution factors by improving a process‐based biogeochemical model, TRIPLEX‐GHG v2.0. Model validation suggested that the modeled N2O agreed well with field observations under varying management practices at daily, seasonal, and annual steps. Simulated N2O emissions from global rice‐based ecosystems exhibited significant increasing trends from 0.026 ± 0.0013 to 0.18 ± 0.003 TgN yr−1 from 1910 to 2020, with ∼69.5% emissions attributed to the rice‐growing seasons. Irrigated rice ecosystems accounted for a majority of global rice N2O emissions (∼76.9%) because of their higher N2O emission rates than rainfed systems. Regarding spatial analysis, Southern China, Northeast India, and Southeast Asia are hotspots for rice‐based N2O emissions. Experimental scenarios revealed that N fertilizer is the largest global rice‐N2O source, especially since the 1960s (0.047 ± 0.010 TgN yr−1, 35.24%), while the impact of expanded irrigation plays a minor role. Overall, this study provides a better understanding of the rice‐based ecosystem in the global agricultural N2O budget; further, it quantitively demonstrated the central role of N fertilizer in rice‐based N2O emissions by including rice crop calendars, covering non‐rice growing seasons, and differentiating the effects of various water regimes and input N forms. Our findings emphasize the significance of co‐management of N fertilizer and water regimes in reducing the net climate impact of global rice cultivation.
Plain Language Summary
Nitrous oxide (N2O) is a greenhouse gas with ∼300 times greater effect on climate warming than carbon dioxide. Global croplands represent the largest source of anthropogenic N2O emissions. However, the contribution of global rice‐based cropping ecosystems to the N2O budget remains largely uncertain because of inconsistent observed results. Inspired by the increasing availability of reliable global data sets, we improved and applied a process‐based biogeochemical model by describing the dynamics of various microbial activities to simulate N2O emissions from rice‐based ecosystems on a global scale. Model simulations showed that 0.18 million tons of N2O‐N were emitted from global rice‐based N2O emissions in the 2010s, which was five times larger than that in the 1910s. In the context of regional contribution, southern China, northern India, and Southeast Asia are responsible for more than 80% of the total emissions during 1910–2020. Results suggest that N fertilizer is the most important rice‐N2O source quantitively and that increasing irrigation exerts a buffering effect. This study confirmed the potential mitigating effect of co‐managing N fertilizer and irrigation on mitigating rice‐based N2O emissions globally.
Key Points
N2O emissions from global rice‐based ecosystem increased from 0.026 to 0.18 TgN yr−1 between 1910 and 2020
Irrigated rice‐based ecosystems showed larger N2O fluxes than rainfed rice globally due to higher N fertilizer use and frequent aerations
N fertilizer represents the largest N2O source, and co‐management of N fertilizer and flooding regimes is important for mitigation
The main goal of this study was to review current studies on the state of the art of wood constructions with a particular focus on energy efficiency, which could serve as a valuable source of ...information for both industry and scholars. This review begins with an overview of the role of materials in wood buildings to improve energy performance, covering structural and insulation materials that have already been successfully used in the market for general applications over the years. Subsequently, studies of different wood building systems (i.e., wood-frame, post-and-beam, mass timber and hybrid constructions) and energy efficiency are discussed. This is followed by a brief introduction to strategies to increase the energy efficiency of constructions. Finally, remarks and future research opportunities for wood buildings are highlighted. Some general recommendations for developing more energy-efficient wood buildings are identified in the literature and discussed. There is a lack of emerging construction concepts for wood-frame and post-and-beam buildings and a lack of design codes and specifications for mass timber and hybrid buildings. From the perspective of the potential environmental benefits of these systems as a whole, and their effects on energy efficiency and embodied energy in constructions, there are barriers that need to be considered in the future.
This study focuses on the development of advanced water-resistant bio-based membranes with enhanced vapour permeability for use within building envelopes. Building walls are vulnerable to moisture ...damage and mold growth due to water penetration, built-in moisture, and interstitial condensation. In this work, breathable composite membranes were prepared using micro-fibrillated cellulose fiber (CF) and polylactic acid (PLA). The chemical composition and physical structure of CF is responsible for its hydrophilic nature, which affects its compatibility with polymers and consequently its performance in the presence of excessive moisture conditions. To enhance the dispersibility of CF in the PLA polymer, the fibers were treated with an organic phosphoric acid ester-based surfactant. The hygroscopic properties of the PLA-CF composites were improved after surfactant treatment and the membranes were resistant to water yet permeable to vapor. Morphological examination of the surface showed better interfacial adhesion and enhanced dispersion of CF in the PLA matrix. Thermal analysis revealed that the surfactant treatment of CF enhanced the glass transition temperature and thermal stability of the composite samples. These bio-based membranes have immense potential as durable, eco-friendly, weather resistant barriers for the building industry as they can adapt to varying humidity conditions, thus allowing entrapped water vapor to pass through and escape the building, eventually prolonging the building life.
Wood is a living material with a dimensional stability problem. White spruce wood is a Canadian non-permeable wood that is used for siding applications. To improve this property, white spruce wood ...was treated with organosilanes sol-gel treatment with different moisture content (oven dried, air dried, and green wood). No major morphological changes were observed after treatment. However, organosilanes were impregnated into the cell wall without densifying the wood and without modifying the wood structure. Si-O-C chemical bonds between organosilanes and wood and Si-O-Si bonds were confirmed by FTIR and NMR, showing the condensation of organosilanes. The green wood (41% moisture content) showed only 26% dimensional stability due to the presence of too much water for organosilanes treatment. With a moisture content of 14%-18% (oven dried or air dried wood), the treatment was adapted to obtain the best improvement in dimensional stability of 35% and a 25% reduction of water vapor sorption. Finally, impregnation with organosilanes combined with the appropriate heat treatment improved the dimensional stability of white spruce wood by up to 35%. This treated Canadian wood could be an interesting option to validate for siding application in Canada.
Steel and concrete are traditionally used as structural materials for non-residential and multi-housing buildings. However, wood can meet the same structural property requirements, and a variety of ...multi-story buildings have recently been built all over the world using this key material. In this study, the main motivations and barriers to wood adoption for structural uses in non-residential buildings are highlighted, based on an analysis of grey literature concerning some well-known buildings and on scientific literature. The motivations found were linked to sustainability, lack of expertise, costs, rapidity of erection, and aesthetic of wooden structures. In contrast, the barriers preventing its use encompass building code implementation, technology transfer, costs, material durability and other technical aspects, culture of the industry, and material availability. Furthermore, an analysis of non-residential timber building meeting minutes for nine projects is also presented to support the identification of problems and concerns related to site assembly issues, the conception of the building, the scheduling, and stakeholders’ relationships. With a better understanding of the expectations and challenges concerning wood usage in non-residential construction projects, companies will be able to adapt their business models and use the resource even more in the future to develop innovative structures.
A novel sandwich-structured composite was developed from the surface layers of polyhydroxyalkanoate (PHA) and the interlayer of polylactic acid (PLA)/cellulose microfibers (CMF) composite. Moreover, ...CMF was chemically modified via a sol-gel process to improve the compatibility between the natural reinforcement and the polymer matrix. According to the obtained results, the modified CMF exhibited a highly hydrophobic characteristic (contact angel value of approximately 118°), and they were homogeneously dispersed in the PLA matrix. The results of the thermogravimetric analysis indicated that the sandwich composites reinforced with the modified CMF showed improvement in thermal stability. Regarding the mechanical properties, the incorporation of the natural reinforcement into sandwich composites increased the values of tensile modulus and strength of materials. The water vapor permeability of sandwich composites increased with the addition of untreated fibers; however, the composites reinforced with the modified CMF showed superior barrier performance than that of untreated CMF. In addition, a durability test was performed to determine the effect of accelerated aging on the properties of sandwich composites. The results demonstrated that the mechanical and barrier properties of composites incorporated with untreated CMF decreased after the accelerated aging, whereas the composites reinforced with the modified CMF experienced the least change.
The energy efficiency of buildings is well documented. However, to improve standards of energy efficiency, the embodied energy of materials included in the envelope is also increasing. Natural fibers ...like wood and hemp are used to make low environmental impact insulation products. Technical characterizations of five bio-based materials are described and compared to a common, traditional, synthetic-based insulation material, i.e., expanded polystyrene. The study tests the thermal conductivity and the vapor transmission performance, as well as the combustibility of the material. Achieving densities below 60 kg/m3, wood and hemp batt insulation products show thermal conductivity in the same range as expanded polystyrene (0.036 kW/mK). The vapor permeability depends on the geometry of the internal structure of the material. With long fibers are intertwined with interstices, vapor can diffuse and flow through the natural insulation up to three times more than with cellular synthetic (polymer) -based insulation. Having a short ignition times, natural insulation materials are highly combustible. On the other hand, they release a significantly lower amount of smoke and heat during combustion, making them safer than the expanded polystyrene. The behavior of a bio-based building envelopes needs to be assessed to understand the hygrothermal characteristics of these nontraditional materials which are currently being used in building systems.
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