A brief review of the recent results on the hadronic cross section measurements with the CMD-3 detector at the
e
+
e
−
collider VEPP-2000 is given. Focus is made on the processes with charged kaons ...in multihadron events, which have a strong impact on strange meson spectroscopy and form factors that are important ingredients in the Dalitz plot analysis. Experimental data relevant to the topic are presented from the broad energy range covered by VEPP-2000 and compared to earlier measurements by the different collaborations. The analysis is based on the integrated luminosity of about 100 pb
−1
collected in 2011, 2012 and 2017.
A search for the process
e
+
e
−
→
D
*0
(2007) has been performed with the CMD-3 detector at the VEPP-2000
e
+
e
−
-collider. Two main decay modes of the
D
*0
(2007) decay,
D
0
π
0
and
D
0
γ, ...followed by
D
0
→
K
+
π
−
π
+
π
−
are used in this analysis. With an integrated luminosity of 3.7 pb
−1
collected at the center-of-mass energy E
c.m.
=2006.62 MeV our preliminary upper limit is B
D*
0
→
e
+
e
−
<1.6× 10
−6
at 90%C.L.
The cross section of the process
e
+
e
−
→ π
+
π
−
π
+
π
−
has been measured using an integrated luminosity of 17 pb
−1
collected with the CMD-3 detector in the center-of-mass energy range 650-1000 ...MeV. High-precision measurements of various hadronic cross sections are of great interest in relation with the problem of the muon anomalous magnetic moment g-2. This measurement can be also used to test the relation between the cross section of
e
+
e
−
→ π
+
π
−
π
+
π
−
and the spectral function for the τ
−
→ π
−
π
0
π
0
π
0
decay predicted by the conservation of vector current (CVC).
BACKGROUND.
There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to ...determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).
AIM.
To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.
MATERIALS AND METHODS.
AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight (n=2139), overweight (n=2931) and obese (n=2666).
RESULTS.
A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p<0.001), serum C-reactive protein over 100 mg/l (p<0.001), and the need for targeted therapy (p<0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval CI: 1,13–3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30–2,30).The patients with the 1st and 2nd degree obesity, undergoing the inpatient treatment, tended to have a higher probability of a mortality rate. While in case of morbid obesity patients this tendency is the most significant (odds ratio — 1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p<0,001).Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 years
CONCLUSION.
Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.
Aim.
To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the ...AKTIV register.
Material and methods.
The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months.
Results.
According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure.
Conclusion.
According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period.
New cryptogamic records. 13 Kotkova, V. M.; Afonina, O. M.; Alverdiyeva, S. M. ...
Novosti sistematiki nizs̆ih rastenij,
3/2024, Letnik:
58, Številka:
1
Journal Article
Recenzirano
First records for Russia of one colorless chrysophyte species, five species of desmid algae, and two species of lichens, first record for Georgia of one freshwater green alga, first record for the ...Republic of Kazakhstan of one yellow-green alga, first records for the Republic of Belarus of three species of myxomycetes, first record for the Republic of Azerbaijan of one species of lichens, and first records for regions of Russia: two species of siphonous yellow-green alga for the Krasnodar Territory and Nenets Autonomous Okrug, some species of basidiomycetes for the Arkhangelsk, Kemerovo, Kurgan, Novosibirsk, Omsk, Tyumen regions, Altai Territory, and Republic of Altai, four species of lichenicolous fungi for Samara and Tver regions, some species of lichens for the republics of Karelia and Tuva, Tver Region, and Altai Territory, some species of mosses for St. Petersburg, Kursk, Irkutsk, Voronezh regions, Republic of North Ossetia – Alania, and Kamchatka Territory are presented. The data on their localities, habitats, distribution are provided. The specimens are kept in the herbaria ALTB, BAK, GSU, IBIW, LE, MSK-F, NSK, OMSK, SMR, SVER, TBI, TOB, VU, YSU, in the Algae collection of the Department of Mycology and Algology of Biological faculty of Moscow State University, or Vaucheria collection of the Laboratory for Algology at the Papanin Institute for Biology of Inland Waters of the Russian Academy of Sciences. Sequences of ITS1-5.8S-ITS2 fungal nrDNA regions of some specimens have been deposited in the GenBank.
Aim
To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis ...of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.
Material and methods
The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients’ privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).
Results
The analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).
Conclusion
In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity.
The aim of this study is to gain an insight into the physical phenomena underlying the spontaneous ignition of hydrogen following a sudden release from high-pressure storage and transition to ...sustained jet fire. The modelling and large-eddy simulation (LES) of the spontaneous ignition dynamics in a tube with a non-inertial rupture disk separating the high-pressure hydrogen storage and the atmosphere is described. Numerical experiments confirmed that due to the stagnation conditions a chemical reaction first commences in the tube boundary layer, and subsequently propagates throughout the tube cross-section. The dynamics of flame formation outside the tube, simulated by the LES model, has reproduced the combustion patterns, including vortex induced “flame separation”, which have been experimentally observed by high-speed photography. It is concluded that the LES model can be applied for hydrogen safety engineering, e.g. for the development of innovative pressure relief devices.
Existing Monte-Carlo generators with radiative corrections to the
e
+
e
-
→π
+
π
-
process are usually developed under the assumption that pions can be treated as pointlike particles. We study the
e
...+
e
-
→π
+
π
-
γ
process with final-state radiation and test this assumption using simulated events from the MCGPJ generator based on the scalar QED hypothesis. In order to increase a fraction of events with FSR, the analysis was performed in the energy region to the left from the
ρ
-meson peak (660÷785 MeV) that is based on the integrated luminosity of about 8.4 pb
-1
. The experimental data for the photon energy spectrum agree with the simulation results at 1% level.
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