Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document ...aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future. The recommendations for action of the consensus workshop are the results of combined clinical experience, shared research expertise, and a review of the literature. They highlight the need to act early to prevent CKD and other related noncommunicable diseases later in life by reducing low birth weight, small for gestational age, prematurity, and low nephron numbers at birth through coordinated interventions. Meeting the current unmet needs would help to define the most cost-effective strategies and to optimize interventions to limit or interrupt the developmental programming cycle of CKD later in life, especially in the poorest part of the world.
Diabetes is an established risk factor for colorectal cancer. However, colorectal cancer is a heterogeneous disease and it is not well understood whether diabetes is more strongly associated with ...some tumor molecular subtypes than others. A better understanding of the association between diabetes and colorectal cancer according to molecular subtypes could provide important insights into the biology of this association. We used data on lifestyle and clinical characteristics from the Colorectal Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), including 9756 colorectal cancer cases (with tumor marker data) and 9985 controls, to evaluate associations between reported diabetes and risk of colorectal cancer according to molecular subtypes. Tumor markers included BRAF and KRAS mutations, microsatellite instability and CpG island methylator phenotype. In the multinomial logistic regression model, comparing colorectal cancer cases to cancer‐free controls, diabetes was positively associated with colorectal cancer regardless of subtype. The highest OR estimate was found for BRAF‐mutated colorectal cancer, n = 1086 (ORfully adj: 1.67, 95% confidence intervals CI: 1.36‐2.05), with an attenuated association observed between diabetes and colorectal cancer without BRAF‐mutations, n = 7959 (ORfully adj: 1.33, 95% CI: 1.19‐1.48). In the case only analysis, BRAF‐mutation was differentially associated with diabetes (Pdifference = .03). For the other markers, associations with diabetes were similar across tumor subtypes. In conclusion, our study confirms the established association between diabetes and colorectal cancer risk, and suggests that it particularly increases the risk of BRAF‐mutated tumors.
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Diabetes is a well‐known risk factor for colorectal cancer, but colorectal cancer varies widely among patients. To better understand the association between diabetes and particular molecular subtypes of colorectal cancer, these authors analyzed data from 9,756 colorectal cancer cases and 9,985 controls. They found that diabetes appears to increase the risk of tumors with BRAF mutations, which generally have poorer outcomes. The large pooled dataset allowed detection of even small variations among subtypes, but the study also was not able to account for some potentially relevant factors, such as metformin use.
The practice of human and veterinary medicine is based on the science of anatomy and dissection courses are still irreplaceable in the teaching of anatomy. Embalming is required to preserve body ...donors, for which process formaldehyde (FA) is the most frequently used and well characterized biocidal substance. Since January 2016, a new occupational exposure limit (OEL) for FA of 0.37mg/m3 issued by the European Committee on Hazardous Substances is obligatory since FA has been classified as a human 1B carcinogen. The anatomical institutes in the German-speaking region are called upon to consolidate efforts to reduce use of FA in anatomical curricula and body donations. As a result, the Anatomische Gesellschaft (AG) has formed a “Working Group for Reduction of Formaldehyde Exposure in Dissection Courses” tasked with discussion and recommendation of measures to reduce FA. Based on the assessment of the Working Group, the AG has issued an official opinion to the effect that, at this point in time, embalming of body donors without FA completely is not feasible. Therefore, a combination of approaches are to be used to reduce FA exposure, including technical and structural (architectural) adaptations, modification of protocols for fixation and preservation as well as organizational measures. One structural measure considered unavoidable is the integration of air supply and exhaust of individual dissecting tables into the ventilation system of the anatomy building. To embalm human body donors, intra-arterial perfusion fixation with up to 4% FA and a total fluid volume of 150mL/kg body weight will suffice. For animals where body weights and biology of bodies vary widely (i.e. special needs of fixation for ruminants, large animals as horses) perfusion fixation with up to 4% FA and a quantity of fixative solution of 10–15% of the body weight may be required. Preservation of body donors in storage (immersion) can be done with 40% ethanol or in a full bath preservation containing up to 2% FA. Corpse humidification in the dissecting room is possible with 2% phenoxyethanol, in each case without FA. In veterinary anatomy, microbiological burden is often higher and therefore might lead to a need of FA in long-time storage. Compliance with the current OEL in all institutes would appear to be feasible in combination with various organizational measures.
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of root s = 7 TeV ...corresponding to an integrated luminosity of 38 pb(-1). Jets are reconstructed with the anti-k(t) algorithm with distance parameters R = 0.4 or R = 0.6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT >= 20 GeV and pseudorapidities vertical bar eta vertical bar < 4.5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2.5 % in the central calorimeter region (vertical bar eta vertical bar < 0.8) for jets with 60 <= p(T) < 800 GeV, and is maximally 14 % for p(T) < 30 GeV in the most forward region 3.2 <= vertical bar eta vertical bar < 4.5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon p(T), the sum of the transverse momenta of tracks associated to the jet, or a system of low-p(T) jets recoiling against a high-p(T) jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-p(T) jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined.
Um eine stationare Platzierung, insbesondere die anschlieende Integration, erfolgreich gestalten zu konnen, braucht es ein Kooperationsbundnis zwischen den Kindern resp. Jugendlichen mit den Eltern ...und den professionellen Mitarbeitenden der Sozialen Arbeit. Der konsequente Miteinbezug von Eltern und Familie in einen stationaren Platzierungsprozess innerhalb der Kinder- und Jugendhilfe bringt jedoch einige Herausforderungen fur den professionellen Alltag. Wie wichtig der Miteinbezug von Eltern und Familie in diesen Prozess sind und welche Konsequenzen dies auf die Prozesse, Strukturen sowie die Kultur des stationaren Alltags hat, wird mit einer qualitativen Untersuchung herausgearbeitet und als Thesenkatalogs aufgezeigt. Anhand von konkreten und in der Praxis erprobten Methoden werden zusatzlich im Vorwort Vorschlage fur die konkrete Umsetzung in den stationaren Alltag gemacht.
A search for squarks and gluinos in events containing jets, missing transverse momentum and no electrons or muons is presented. The data were recorded in 2011 by the ATLAS experiment in root s = 7 ...TeV proton-proton collisions at the Large Hadron Collider. No excess above the Standard Model background expectation is observed in 1.04 fb(-1) of data. Gluino and squark masses below 700 GeV and 875 GeV respectively are excluded at the 95% confidence level in simplified models containing only squarks of the first two generations, a gluino octet and a massless neutralino. The exclusion limit increases to 1075 GeV for squarks and gluinos of equal mass. In MSUGRA/CMSSM models with tan beta = 10, A(0) = 0 and mu > 0, squarks and gluinos of equal mass are excluded for masses below 950 GeV. These limits extend the region of supersymmetric parameter space excluded by previous measurements.
A search for diphoton events with large missing transverse momentum has been performed using 1.07 fb(-1) of proton-proton collision data at root s = 7 TeV recorded with the ATLAS detector. No excess ...of events was observed above the Standard Model prediction and 95% Confidence Level (CL) upper limits are set on the production cross section for new physics. The limits depend on each model parameter space and vary as follows: sigma < (22-129) fb in the context of a generalised model of gauge-mediated supersymmetry breaking (GGM) with a bino-like lightest neutralino, sigma < (27-91) fb in the context of a minimal model of gauge-mediated supersymmetry breaking (SPS8), and sigma < (15-27) fb in the context of a specific model with one universal extra dimension (UED). A 95% CL lower limit of 805 GeV, for bino masses above 50 GeV, is set on the GGM gluino mass. Lower limits of 145 TeV and 1.23 TeV are set on the SPS8 breaking scale Lambda and on the UED compactification scale 1/R, respectively. These limits provide the most stringent tests of these models to date.
This Letter presents a search for contact interactions in the dielectron and dimuon channels using data from proton-proton collisions produced by the LHC at,root s = 7 TeV and recorded by the ATLAS ...detector. The data sample, collected in 2011, corresponds to an integrated luminosity of 1.08 and 1.21 fb(-1) in the e(+)e(-) and mu(+)mu(-) channels, respectively. No significant deviations from the standard model are observed. Using a Bayesian approach with a prior flat in 1/A(2), the following 95% CL lower limits are placed on the energy scale of llqq contact interactions: A(-) > 10.1 TeV (A(+) > 9.4 TeV) in the electron channel and A(-) > 8.0 TeV (A(+) > 7.0 TeV) in the muon channel for constructive (destructive) interference in the left-left isoscalar contact interaction model. Limits are also provided for a prior flat in 1/A(4).
Cross-border integration is the central management issue for banks that expand internationally, and this is especially true in Central and Eastern Europe, where the pace of internationalisation ...through mergers and acquisitions has been rapid. A critical challenge in cross-border integration is aligning a multinational company's formal organizational structure with the distribution of capabilities across its subsidiary units, and this issue is explored by tracking the co-evolution of organizational structure and capabilities during the internationalisation of a large banking network into this region. Our focus is the Vienna head office of Bank Austria Creditanstalt, which was acquired first by HypoVereinsbank (Germany) and then UniCredit (Italy). Despite its formal role being downgraded during these changes, the unit continued to develop its distinctive capabilities. The key insight our article offers is that managing cross-border integration is not simply about recognizing the value of the distinctive capabilities of individual units and designing formal structures that successfully align with them. It is also about understanding the need for dynamic interaction between formal corporate structure and individual units' desires to retain power and influence, which have significant implications for the development of their organizational capabilities.
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