This research considers the interplay among new technologies – mostly digital –, new ventures, and the new emerging city contexts leading to support the urban transformation to improve quality of ...life. The need to provide public services in an efficient and more performative way led to consider such a challenge as a business opportunity for new ventures, thus inspiring the infusion of new technologies in start-ups and spinoffs created to offer public services. City governments lack the right knowledge and resources to do that, thus stimulating and partnering new ventures is a way to achieve a successful city transformation. Several case studies show this new dynamic and the potential improvements to be further achieved, thus mirroring the business opportunity caught by new ventures and the support new technologies can offer to citizens and other city’s stakeholders.
BackgroundMost SARS-CoV-2 rapid antigen detection tests (RADTs) validation studies have been performed on specimens from COVID-19 patients and negative controls or from mostly symptomatic ...individuals. Herein we evaluated the diagnostic accuracy of AFIAS COVID-19 Ag, hereinafter denominated as AFIAS, during a COVID-19 screening program surveillance testing conducted among personnel of an Italian military airport.MethodsNasopharyngeal swabs (NPSs) were collected from study participants and were analysed by both AFIAS and RT-PCR assay. A questionnaire collecting demographic and exposure data were administered to all participants. AFIAS accuracy parameters including Cohen's kappa (K) were determined.ResultsOverall, from November 2020 to April 2021, 1294 (NPSs) were collected from 1183 participants (88.6% males, 11.4% females; mean age were 41.3, median age 42). Forty-nine NPSs (3.78%) were positive by RT-PCR, while 54 NPSs were positive by AFIAS. Overall baseline sensitivity, specificity, positive and negative predictive values were 0.633, 0.981, 0.574, 0.985, respectively and K was 0.585 (moderate). AFIAS sensitivity tended to be higher for NPSs with higher viral load. A higher sensitivity (0.944) compared to the overall baseline sensitivity (0.633) was also found for NPSs from participants with COVID-19 compatible symptoms, for which K was 0.891 (almost perfect). Instead, AFIAS sensitivity was quite poor for NPSs from asymptomatic participants. Most false negative NPSs in this group had moderate viral load.ConclusionOverall, AFIAS showed high specificity but only moderate sensitivity, mainly because of the high proportion of asymptomatic participants. However, AFIAS showed good sensitivity for NPSs with high viral load and nearly optimal accuracy parameters for NPSs from participants with COVID-19 compatible symptoms. Thus, taking into consideration its performance features, this test can be useful for COVID-19 case identification and management as well as for infection control.
Most SARS-CoV-2 rapid antigen detection tests (RADTs) validation studies have been performed on specimens from COVID-19 patients and negative controls or from mostly symptomatic individuals. Herein ...we evaluated the diagnostic accuracy of AFIAS COVID-19 Ag, hereinafter denominated as AFIAS, during a COVID-19 screening program surveillance testing conducted among personnel of an Italian military airport.
Nasopharyngeal swabs (NPSs) were collected from study participants and were analysed by both AFIAS and RT-PCR assay. A questionnaire collecting demographic and exposure data were administered to all participants. AFIAS accuracy parameters including Cohen's kappa (K) were determined.
Overall, from November 2020 to April 2021, 1294 (NPSs) were collected from 1183 participants (88.6% males, 11.4% females; mean age were 41.3, median age 42). Forty-nine NPSs (3.78%) were positive by RT-PCR, while 54 NPSs were positive by AFIAS. Overall baseline sensitivity, specificity, positive and negative predictive values were 0.633, 0.981, 0.574, 0.985, respectively and K was 0.585 (moderate). AFIAS sensitivity tended to be higher for NPSs with higher viral load. A higher sensitivity (0.944) compared to the overall baseline sensitivity (0.633) was also found for NPSs from participants with COVID-19 compatible symptoms, for which K was 0.891 (almost perfect). Instead, AFIAS sensitivity was quite poor for NPSs from asymptomatic participants. Most false negative NPSs in this group had moderate viral load.
Overall, AFIAS showed high specificity but only moderate sensitivity, mainly because of the high proportion of asymptomatic participants. However, AFIAS showed good sensitivity for NPSs with high viral load and nearly optimal accuracy parameters for NPSs from participants with COVID-19 compatible symptoms. Thus, taking into consideration its performance features, this test can be useful for COVID-19 case identification and management as well as for infection control.
In industrialized areas of the world, including Europe, Hepatitis E Virus (HEV) is considered an emerging pathogen. In fact, autochthonous cases caused by HEV genotype 3 (HEV-3) are increasingly ...reported. Several studies described the human HEV-3 subtypes and strains circulating in West Europe countries; in contrast, very little is known about the HEV strains responsible for acute hepatitis E in countries of East Europe/Balkans, such as Bulgaria.
Anti-HEV IgM positive serum samples (n = 103) from acute hepatitis cases (2013-2015) from all over Bulgaria were analysed for HEV RNA by Real-Time PCR. Viremia was detected in 90/103 samples. A fragment of the viral genome (ORF-2 region) was amplified by nested PCR from 76/90 viremic samples, leading to a sequence in 64 of them. Genotyping by phylogenetic analysis with standard reference sequences showed HEV-1 in 1/64 cases, HEV-3 in 63/64. Subtyping of HEV-3 sequences showed 3e (39/63, 62%), 3f (n = 15/63, 24%) and 3c (n = 8/63, 13%) subtypes; in one case the sequence subtype was uncertain and classified as 3hi. In the phylogenetic tree, most 3e sequences grouped in two well distinct clusters (A and B), each one with very low intragroup genetic distances. In contrast, 3f and 3c were interspersed with reference sequences and showed lower tendency to cluster and/or higher intragroup distances. Geographically, while 3f and 3c were scattered throughout the country, 3e was restricted to the South-West area, with most cases in two towns about 40 kilometres apart from each other.
Most acute hepatitis E cases in Bulgaria are caused by HEV-3, subtypes 3e, 3f and 3c. Circulation of 3e appears quite different from 3f and 3c, with 3e restricted to the South-West area while 3f and 3c diffused over the country. The factors underlying the observed molecular and geographical differences remain to be investigated.
A4A relationships Polese, Francesco; Pels, Jaqueline; Tronvoll, Bård ...
Journal of service theory and practice,
01/2017, Letnik:
27, Številka:
5
Journal Article
Recenzirano
Purpose
The purpose of this paper is to investigate the characteristics of actors that allow them to relate to others actors in the system through shared intentionality (orientation) and the nature ...of the A4A relationship and the results that such interactions bring to the emergent system based on this shared purpose (finality).
Design/methodology/approach
The topic is approached by theoretical analysis and conceptual development of three integrative frameworks: the sociological perspective, service-dominant logic and a particular perspective of system thinking: the viable system approach (vSa).
Findings
The A4A relationships involve value co-creation based on actors integrating their resources and acting with intentionality to obtain value by providing benefits to other parties and by belonging to the emergent viable system; actor acts for other actors directly involved in the relationship generating positive effects for the whole system in which it is contextualized.
Research limitations/implications
Future empirical research might better support findings.
Social implications
Many social implications deriving from an augmented role of actors engaged within social relationships in co-creation exchanges. From the title of the paper A4A over on the manuscript describes numerous social inferences of actors in co-creation.
Originality/value
A4A is a relationship formed by actors that interact for the benefit of the whole system in which are involved. They find own benefit from the benefit created for the system in which they live and act. In A4A relationships the value of the single actor comes from the participation to the viability of the whole system.
We introduce the notion of local completeness in abstract interpretation and define a logic for proving both the correctness and incorrectness of some program specification. Abstract interpretation ...is extensively used to design sound-by-construction program analyses that over-approximate program behaviours. Completeness of an abstract interpretation A for all possible programs and inputs would be an ideal situation for verifying correctness specifications, because the analysis can be done compositionally and no false alert will arise. Our first result shows that the class of programs whose abstract analysis on A is complete for all inputs has a severely limited expressiveness. A novel notion of local completeness weakens the above requirements by considering only some specific, rather than all, program inputs and thus finds wider applicability. In fact, our main contribution is the design of a proof system, parameterized by an abstraction A, that, for the first time, combines over- and under-approximations of program behaviours. Thanks to local completeness, in a provable triple ⊢A P c Q, the assertion Q is an under-approximation of the strongest post-condition postc(P) such that the abstractions in A of Q and postc(P) coincide. This means that Q is never too coarse, namely, under mild assumptions, the abstract interpretation of c does not yield false alerts for the input P iff Q has no alert. Thus, ⊢A P c Q not only ensures that all the alerts raised in Q are true ones, but also that if Q does not raise alerts then c is correct.
The SARS-CoV-2 pandemic has seriously affected the population in Turkey. Since the beginning, phylogenetic analysis has been necessary to monitor public health measures against COVID-19 disease. In ...any case, the analysis of spike (S) and nucleocapsid (N) gene mutations was crucial in determining their potential impact on viral spread. We screened S and N regions to detect usual and unusual substitutions, whilst also investigating the clusters among a patient cohort resident in Kahramanmaraş city, in a restricted time span. Sequences were obtained by Sanger methods and genotyped by the PANGO Lineage tool. Amino acid substitutions were annotated comparing newly generated sequences to the NC_045512.2 reference sequence. Clusters were defined using phylogenetic analysis with a 70% cut-off. All sequences were classified as Delta. Eight isolates carried unusual mutations on the S protein, some of them located in the S2 key domain. One isolate displayed the unusual L139S on the N protein, while few isolates carried the T24I and A359S N substitutions able to destabilize the protein. Phylogeny identified nine monophyletic clusters. This study provided additional information about SARS-CoV-2 epidemiology in Turkey, suggesting local transmission of infection in the city by several transmission routes, and highlighting the necessity to improve the power of sequencing worldwide.
The article describes the social technology’s role in the TCM attractiveness from the retailers’ perspective. The exploratory research experience in Sweden during different periods between 2012 and ...2016 includes contributions of the literature, direct interviews and analysis of the TCM’s websites. The state-of-the-art of social commerce perception by managers and retailers is defined, and specific evidences are given through research. An interpretation of the concept of attractiveness of the TCM is presented to explain how social commerce could affect this property. Dissonance between opinions and statements of TCM stakeholders are discussed, and the will to use social commerce to increase opportunities for TCM is, in general, declared by retailers, but it is not realized in practice in management activities. A comparative empirical exploration between different countries could be conducted in future. This paper explores the actual situation in the use of website sustaining that the social commerce and the social networks are able to go beyond the supporting of commerce activity and they are able to support the TCM attractiveness and place attachment.
Assigning a satisfactory truly concurrent semantics to Petri nets with confusion and distributed decisions is a long standing problem, especially if one wants to resolve decisions by drawing from ...some probability distribution. Here we propose a general solution based on a recursive, static decomposition of (occurrence) nets in loci of decision, called structural branching cells (s-cells). Each s-cell exposes a set of alternatives, called transactions. Our solution transforms a given Petri net into another net whose transitions are the transactions of the s-cells and whose places are those of the original net, with some auxiliary structure for bookkeeping. The resulting net is confusion-free, and thus conflicting alternatives can be equipped with probabilistic choices, while nonintersecting alternatives are purely concurrent and their probability distributions are independent. The validity of the construction is witnessed by a tight correspondence with the recursively stopped configurations of Abbes and Benveniste. Some advantages of our approach are that: i) s-cells are defined statically and locally in a compositional way; ii) our resulting nets faithfully account for concurrency.
In European countries, autochthonous acute hepatitis E cases are caused by Hepatitis E Virus (HEV) genotype 3 and are usually observed as sporadic cases. In mid/late September 2019, a hepatitis E ...outbreak caused by HEV genotype 3 was recognized by detection of identical/highly similar HEV sequences in some hepatitis E cases from two Italian regions, Abruzzo and Lazio, with most cases from this latter region showing a link with Abruzzo. Overall, 47 cases of HEV infection were finally observed with onsets from 8 June 2019 to 6 December 2019; they represent a marked increase as compared with just a few cases in the same period of time in the past years and in the same areas. HEV sequencing was successful in 35 cases. The phylogenetic analysis of the viral sequences showed 30 of them grouped in three distinct molecular clusters, termed A, B, and C: strains in cluster A and B were of subtype 3e and strains in cluster C were of subtype 3f. No strains detected in Abruzzo in the past years clustered with the strains involved in the present outbreak. The outbreak curve showed partially overlapped temporal distribution of the three clusters. Analysis of collected epidemiological data identified pork products as the most likely source of the outbreak. Overall, the findings suggest that the outbreak might have been caused by newly and almost simultaneously introduced strains not previously circulating in this area, which are possibly harbored by pork products or live animals imported from outside Abruzzo. This possibility deserves further studies in this area in order to monitor the circulation of HEV in human cases as well as in pigs and wild boars.
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