Slovene Idylls Ivan Cankar; Klančar, A. J.; Noyes, George R.
The Slavonic and East European review (1928),
04/1935, Letnik:
13, Številka:
39
Journal Article
A new type of axially chiral sulfonic acid was developed. The synthesis is based on cheap commercially available materials and a practical method for optical resolution via diastereomeric salt ...formation, which can provide both enantiomers. Eleven benzoimidazolylnaphthalenesulfonic acids were prepared and four of them were isolated as pure and stable atropisomers. Moreover, several of these sulfonic acids were transformed into triflyl imides to further expand the range of dissociation constants.
Benzimidazoles are frequently used in medicinal chemistry. Their anticancer effect is among the most prominent biological activities exhibited by this scaffold. Although numerous benzimidazole ...derivatives have been synthesized, possible atropisomerism of ortho -substituted 1-phenylbenzimidazoles has been largely overlooked. The aim of this research was to synthesize a small library of novel atropisomeric benzimidazole derivatives and explore their biological activity in various cancer and normal human cell lines. The new unique structural motif provides an interesting 3D architecture with axial chirality, which further contributes to molecular complexity and specificity. Racemates and their separated atropisomers arrested the cell cycle, caused apoptosis, and affected microtubule organization in cancer cells in vitro at different intensities. Moreover, this phenomenon was also verified by the inhibition of endothelial cell migration. These results showed that (+)-atropisomers, especially 5n , exhibit a stronger effect and show promise as agents for cancer therapy.
Republika Slovenija je 1.5.2004 vstopila v EU. Ob tem je trošarinski sistem nadgradila tako, da je na področju harmoniziranih trošarin v celoti usklajen s pravnim redom EU. Vstop v EU se je odražal ...tudi na področju pobiranja dajatev, ki postanejo pravica Skupnosti v trenutku knjiženja terjatev v poslovne knjige, država članica pa zadrži 25 % tradicionalnih lastnih sredstev Skupnosti za stroške pobiranja teh dajatev. Po navedenem dejanju so trošarine postale najpomembnejše dajatve, ki jih v državni proračun vplača Carinska uprava Republike Slovenije. Pri primerjavi stopenj trošarin na trošarinske izdelke med izbranimi državami članicami EU lahko ugotovimo, da Republika Slovenija sodi med države z nižjimi stopnjami trošarin na tobačne izdelke, etilni alkohol in vmesne pijače. Treba bi bilo zvišati predvsem trošarine na tobačne izdelke ter alkohol in alkoholne pijače kar bi prispevalo k povečanju proračunskih sredstev, razlog za zvišanje pa je tudi zdravstveni vidik. Naša država bi lahko sledila zgledu Republike Hrvaške in uvedla trošarine na nekatere neharmonizirane trošarinske izdelke.
Correction for ‘Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality’ by Jana Pospíšilová et al. , Org. Biomol. Chem. , 2024, ...https://doi.org/10.1039/d4ob00863d.
Our paper is based on four country samples – Bulgaria, Czech Republic, Slovakia, and Slovenia. All these countries are new EU member states, where the (official) goal of the health-finance system is ...to guarantee universal and equal access to health services. In the first part the country studies describe the evolution of new health-finance systems in selected countries as well as the pros and cons of national solutions. The core part of this paper discusses two important health-financing
issues – the decision about how to fund health services and particularly the decision about the relations of public and private funding of health care. We propose two core conclusions: first, because the mode of financing does not have a clear impact on outcomes of the health-care system, the decisions of CEE countries to switch from general taxation to social-insurance systems are based mainly on political rationality; second, introducing pluralistic social health insurance during early phases of transition is too risky.
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