Fortunately, the Ebola outbreak has been controlled. In this final report, data on the duration of the persistence of Ebola virus in semen are provided.
IntroductionYouth living with type 2 diabetes display increased risk of cardiovascular disease (CVD). It is unclear if regular physical activity (PA) modifies this risk.Research design and methodsWe ...compared CVD risk factors in a cross-sectional study of 164 youth with type 2 diabetes stratified according to weekly vigorous-intensity PA. Outcomes were hemoglobin A1c (HbA1c), ambulatory blood pressure (BP; ambulatory 24-hour readings), plasma lipoproteins, and albuminuria. The main exposure, vigorous-intensity PA, was quantified with the Adolescent Physical Activity Recall Questionnaire.ResultsYouth were 15±3 years, and 78% lived rurally and 68% were female, with a mean body mass index (BMI) Z-score of 2.4±1.1 and a mean HbA1c of 9.6% ±2.6%. Youth who participated in regular vigorous-intensity PA (40%; n=67) achieved nearly twice the dose of PA than peers who did not (62 vs 34 metabolic equivalent score-hour/week, p=0.001). After adjusting for duration of diabetes, BMI Z-score, sex, and smoking, youth who engaged in vigorous-intensity PA displayed lower HbA1c (9.1% vs 9.9%, p=0.052), diastolic BP (70 mm Hg vs 73 mm Hg, p=0.002), diastolic load (20% vs 26%, p=0.023), and mean arterial pressure (87.3 mm Hg vs 90.3 mm Hg, p<0.01), compared with youth who did not. Compared with youth who did not participate in regular vigorous-intensity PA, those who did also displayed lower odds of albuminuria after adjusting for duration of diabetes, sex, smoking, rural residence, and BMI Z-score (adjusted OR: 0.40, 95% CI 0.19 to 0.84).ConclusionsAmong youth with type 2 diabetes, participation in vigorous-intensity PA is associated with lower CVD risk.
The aim of this study was to assess the impacts of the COVID-19 pandemic on adolescents and young adults living with type 2 diabetes (T2D) involved in the national Improving Renal Complications in ...Adolescents with T2D through REsearch (iCARE) study.
The Environmental influences on Child Health Outcomes (ECHO) COVID-19 Questionnaire developed by the National Institutes of Health ECHO COVID-19 Task Force was administered to participants (n=85) from the iCARE study between June 2020 and October 2020. Children 12 years old (via parent report) and adolescents and young adults ≥13 years old (via self-report) participated. The questionnaire assessed the impact of the pandemic on health-care appointments, lifestyle, internet use, social connections and mental health.
Participants were 17.0±3.1 (range, 12 to 27) years of age and predominantly female (61.3%). During the pandemic, 69.4% were able to attend their health-care appointments by telephone or virtual platforms, 31.7% ate more, 45.1% slept more and 29.3% spent less time on physical activities. There was an increase in internet use for both educational (42.0%) and noneducational purposes (54.9%). Participants felt less socially connected (64.6%). Participants also felt sometimes (59.2%), often (19.7%) and very often (6.7%) satisfied with their lives.
Our study revealed that the COVID-19 pandemic has had various impacts on the daily lives of adolescents and young adults living with T2D. Future research should include longitudinal studies of the health burden of the COVID-19 pandemic on this population, with a more in-depth evaluation of mental health outcomes and clinical outcomes.
L’objectif de la présente étude était d’évaluer les répercussions de la pandémie de la COVID-19 sur la vie des adolescents et des jeunes adultes atteints du diabète de type 2 (DT2) qui ont participé à l’étude nationale Improving Renal Complications in Adolescents with T2D through REsearch (iCARE).
Les participants (n = 85) de l’étude iCARE ont rempli le questionnaire Environmental influences on Child Health Outcomes (ECHO) sur la COVID-19 élaboré par le groupe de travail de l’ECHO sur la COVID-19 des National Institutes of Health entre juin 2020 et octobre 2020. Les enfants de 12 ans (déclaration par le parent) et les adolescents et les jeunes adultes ≥ 13 ans (autodéclaration) y ont participé. Le questionnaire a permis d’évaluer les répercussions de la pandémie sur les rendez-vous en soins de santé, le mode de vie, l’utilisation de l’internet, les liens sociaux et la santé mentale.
Les participants avaient 17,0 ± 3,1 (étendue, de 12 à 27) ans et étaient principalement des femmes (61,3 %). Durant la pandémie, 69,4 % étaient en mesure de participer à leurs rendez-vous en soins de santé par téléphone ou via les plateformes virtuelles, 31,7 % mangeaient plus, 45,1 % dormaient plus et 29,3 % passaient moins de temps à faire des activités physiques. Il y a eu une augmentation de l’utilisation de l’internet à des fins éducatives (42,0 %) ou non éducatives (54,9 %). Les participants se sentaient moins connectés socialement (64,6 %). Les participants se sentaient aussi parfois (59,2 %), souvent (19,7 %) et très souvent (6,7 %) satisfaits de leur vie.
Notre étude a révélé que la pandémie de la COVID-19 a eu des répercussions variées sur la vie quotidienne des adolescents et des jeunes adultes atteints du DT2. Des recherches subséquentes devraient inclure des études longitudinales sur le fardeau en santé de la pandémie de la COVID-19 sur cette population, et une évaluation plus poussée des résultats en matière de santé mentale et des résultats cliniques.
Our aim in this study was to describe the clinical and social characteristics of 2 Canadian cohorts of adolescents with diabetes.
Participants from the Improving renal Complications in Adolescents ...with type 2 diabetes through REsearch (iCARE) study (n=322) and the Early Determinants of Cardio-Renal Disease in Youth With Type 1 Diabetes (n=199) study were compared.
Adolescents were 10 to 18 years of age (mean ± standard deviation: 14.8±2.4 years). The T2DM cohort had a shorter duration of diabetes. Both groups had glycated hemoglobin levels above target. The type 2 diabetes (T2D) cohort was comprised of predominantly Indigenous youth. The type 1 diabetes (T1D) cohort was 58.3% European/Caucasian, with a high proportion (41.7%) of visible minority groups (Afro-Caribbean, Asian/Pacific Islander, Hispanic). The prevalence of obesity, hypertension, left ventricular hypertrophy, albuminuria and hyperfiltration was higher in the T2D cohort. The T1D cohort was more socially and economically advantaged in all 4 dimensions of health inequality.
There are significant differences in clinical and social characteristics of adolescents with T2D and T1D in Canada. Both have inadequate glycemic control with evidence of onset and progression of diabetes-related complications.
L’objectif de notre étude était de décrire les caractéristiques cliniques et sociales de 2 cohortes canadiennes d’adolescents diabétiques.
Nous avons comparé les participants à l’étude Improving renal Complications in Adolescents with type 2 diabetes through REsearch (iCARE) (n = 322) et les participants à l’étude Early Determinants of Cardio-Renal Disease in Youth With Type 1 Diabetes (n = 199).
Les adolescents avaient de 10 à 18 ans (moyenne ± écart type : 14,8 ± 2,4 ans). La cohorte atteinte du diabète de type 2 (DT2) souffrait du diabète depuis moins longtemps. Les 2 groupes avaient des concentrations d’hémoglobine glyquée au-dessus des valeurs visées. La cohorte atteinte du DST2 était majoritairement composée de personnes autochtones. La cohorte atteinte du diabète de type 1 (DT1) était composée de 58,3 % d’Européens blancs, dont une forte proportion (41,7 %) de groupes des minorités visibles (Afro-Antillais, Asiatiques/insulaires du Pacifique, Hispaniques). La prévalence de l’obésité, de l’hypertension, de l’hypertrophie ventriculaire gauche, de l’albuminurie et de l’hyperfiltration était plus élevée dans la cohorte atteinte du DT2. La cohorte atteinte du DT1 était plus socialement et économiquement favorisée dans les 4 dimensions des inégalités en santé.
Il existe des différences significatives entre les caractéristiques cliniques et sociales des adolescents atteints du DT2 et celles des adolescents atteints du DT1 au Canada. Les 2 cohortes ont une mauvaise régulation de la glycémie qui se manifeste par l’apparition et la progression des complications liées au diabète.
The clinical, virologic, and immunologic findings in a female Ebola virus disease patient are described. During the long-term follow-up, Ebola virus RNA was detectable in vaginal fluid before 36 days ...after symptom onset, with nearly an identical genome sequence as in acute phase blood. Ebola-specific T cells retained activation at 56 days after disease onset.
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