The advantages of the new imaging techniques such as optical coherence tomography (OCT) and OCT‐angiography (OCT‐A) have decreased the use of fluorescein angiography (FA) and indocyanine green ...angiography (ICG) in the diagnosis and management of uveitis. The aim of this talk is to highlight the need of using FA and ICG (including wide field and ultra‐wide field devices) in the diagnosis and follow‐up of uveitis patients.
Diagnosing the subretinal fluid Salas, Ester Carreño
Acta ophthalmologica (Oxford, England),
December 2022, 2022-12-00, 20221201, Letnik:
100, Številka:
S275
Journal Article
Recenzirano
Case presentation and interactive discussion with the other speakers and attendees regarding cases presenting with subretinal fluid as the main feature.
AimTo standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis.MethodsMembers of the International Uveitis Study Group, of the American ...Uveitis Society and of the Sociedad Panamericana de Infermedades Oculares that choose to participate responded to an online questionnaire about their preferred terminology when reporting on OCT-A findings in uveitis. The response of individuals with several publications on OCT-A (experts) was compared with uveitis specialists (users) who have less than five publications on the field of uveitis and OCT-A.ResultsA total of 108 uveitis specialists who participated in the survey were included in the analysis. Of those, 23 were considered OCT-A ‘experts’. There was an agreement in both groups for the definition of wide-field (WF)-OCT-A, and definition of neovascularisation in uveitis. Moreover, there was a difference in the responses in other areas, such as quantification of ischaemia, definition of ‘large’ areas of ischaemia or terms to describe decreased OCT-A signal from different causes. There was an unanimous need of ‘users’ and ‘experts’ to distinguish size of decreased OCT-A signal in uveitis, to implement a quantitative measurement of decreased flow specifically for WF-OCT-A and to use different terms for different causes of decreased OCT-A signal.ConclusionsWhile there was considerable agreement in the terminology used by all uveitis experts, significant differences in terminology were noted between ‘users’ and ‘experts’. These differences indicate the need for standardisation of nomenclature among all uveitis specialists both for the purpose of reporting and in clinical use.
, one of the most frequently inherited retinal dystrophy (IRD)-causing genes, implies a high phenotypic variability. This study aims to analyze the
mutational spectrum in one of the largest cohorts ...worldwide, and to describe novel pathogenic variants and genotype-phenotype correlations. A study of 220 patients from 103 families recruited from a database of 5000 families. A molecular diagnosis was performed using classical molecular approaches and next-generation sequencing. Common haplotypes were ascertained by analyzing single-nucleotide polymorphisms. We identified 56 variants, including 11 novel variants. Most of them were missense variants (64%) and were located in the D2-loop protein domain (77%). The most frequently occurring variants were p.Gly167Ser, p.Gly208Asp and p.Pro221_Cys222del. Haplotype analysis revealed a shared region in families carrying p.Leu41Pro or p.Pro221_Cys222del. Patients with retinitis pigmentosa presented an earlier disease onset. We describe the largest cohort of IRD families associated with
from a single center. Most variants were located in the D2-loop domain, highlighting its importance in interacting with other proteins. Our work suggests a likely founder effect for the variants p.Leu41Pro and p.Pro221_Cys222del in our Spanish cohort. Phenotypes with a primary rod alteration presented more severe affectation. Finally, the high phenotypic variability in
hinders the possibility of drawing genotype-phenotype correlations.
What are the options when anti‐TNK‐alpha therapy fails? What it is the evidence for these alternatives. The presentation will cover current evidence in non‐anti‐TNF‐alpha biologic therapy and new ...molecules with a potential role in the treatment of non‐infectious uveitis.
The presentation will focus in the relevant tests and investigations for the safe use of biologic therapy in non‐infectious uveitis. Biologic therapy when used appropriately in the treatment of ...non‐infectious uveitis is a very safe alternative, but some considerations are needed to take into account before starting treatment.
Herpetic retinits… Who is the guilty one? Carreño, Ester
Acta ophthalmologica (Oxford, England),
December 2019, 2019-12-00, 20191201, Letnik:
97, Številka:
S263
Journal Article
Recenzirano
The presentation will cover the approach for the diagnosis and treatment of herpetic retinitis. It will provide with a practical approach on when and what to suspect and how to handle a potential ...visual threatening such as herpetic retinitis.
Beware the cat! Toxoplasma & co Carreño, Ester
Acta ophthalmologica (Oxford, England),
December 2019, 2019-12-00, 20191201, Letnik:
97, Številka:
S263
Journal Article
Recenzirano
Ocular toxoplasmosis is the most common posterior uveitis. However atypical forms, such as those associated with severe occlusive vasculitis or mimicking acute retinal necrosis are a diagnostic ...challenge. The aim of this presentation id to help in the management and diagnosis of classic toxoplasma chorioretinitis and its more atypical presentations.
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