After many years of development of securities market, our securities market standard system is increasingly sound. But there are also many problems, such as the disclosure of accounting information ...of listed companies. It has not formed an accurate and fast system to systematize the disclosure of accounting information in the securities market, which leads to the low efficiency of the securities market. On the other hand, it is of great significance to construct the long-term mechanism of accounting supervision to perfect the national supervision system, strengthen the ability of risk management and control, optimize the quality of accounting information and standardize the market economic order. In a series of important meetings, China proposed that accounting supervision, auditing supervision and statistical supervision should be included as an important part of the national supervision system. Therefore, it can be seen that the construction of longterm mechanism of financial and accounting supervision is the most urgent and top priority to consolidate the foundation of China’s supervision system. In this paper, through the analysis of Luckin coffee incident, put forward the optimization strategy to build a long-term mechanism of accounting supervision in the new era.
In this study, the effects of different fine aggregates on the properties of polyethylene fiber engineered cementitious composite (PE-ECC) were systematically investigated. The PE-ECCs were prepared ...with four fine aggregates, respectively. Furthermore, their flowability, compressive strength, and uniaxial tensile properties were studied experimentally and comparatively analyzed by microscopic techniques including X-ray diffraction (XRD), scanning electron microscope (SEM), energy-dispersive spectroscopy (EDS), and mercury intrusion porosimetry (MIP). The results showed that all the different types of fine aggregates exhibited little effect on the flowability of PE-ECC, but a greater effect on the compressive strength, uniaxial tensile strength, and ultimate tensile strain. PE-ECC prepared from untreated desert sand showed the best comprehensive performance, with compressive strength, uniaxial tensile strength, and ultimate tensile strain of 47.92 MPa, 6.26 MPa, and 3.638%, respectively. Moreover, it was found that the ultra-fine particles in the desert sand promoted the hydration reaction of cement and produced more C–S–H gels. The pore structures of ECC prepared with different aggregates exhibited obvious fractal characteristics, and the fractal dimension ranged from 2.8 to 2.9. The fractal dimension showed a strong correlation with parameters including ultimate tensile strain and pore structure, and the larger the fractal dimension, the smaller the ultimate tensile strain, porosity, and average pore size of ECC.
From a theoretical point of view, promoting the construction of ecological civilization has a positive effect on reducing carbon emissions. However, ecological civilization construction has rich ...connotations, and the mechanism of its impact on carbon emissions is relatively complex, with regional differences. Therefore, it is necessary to further explore the influence mechanism of ecological civilization construction on carbon emissions. In order to investigate the mechanism of the effect of the construction of ecological civilization on carbon emissions. 30 provinces, cities, and autonomous regions in China were used as research objects. Based on the perspective of configuration, use the fuzzy set qualitative comparative analysis method (fsQCA), from the six dimensions of ecological civilization construction to study the configuration path of ecological civilization construction affecting carbon emissions. The findings show that the antecedent variables are related to each other and there are three types of paths to achieve low-carbon emissions, eco-economy-driven type with eco-economic construction as a key factor; eco-environmental protection type with a focus on eco-environmental protection; and land space optimization type that enhances the rational use of land resources. Comparing the low-carbon emission group pathway with the non-low-carbon emission group pathway illustrates that eco-logical management alone cannot effectively curb carbon emissions. The study explores how to promote the construction of ecological civilization and help reduce carbon emissions accordingly. To provide direction for the direction of ecological civilization construction in different regions.
ObjectiveTo identify the risk factors related to lifestyle behaviors that affect the incidence of lung cancer, to build a lung cancer risk prediction model to identify, in the population, individuals ...who are at high risk, and to facilitate the early detection of lung cancer. MethodsThe data used in the study were obtained from the UK Biobank, a database that contains information collected from 502 389 participants between March 2006 and October 2010. Based on domestic and international guidelines for lung cancer screening and high-quality research literature on lung cancer risk factors, high-risk population identification criteria were determined. Univariate Cox regression was performed to screen for risk factors of lung cancer and a multifactor lung cancer risk prediction model was constructed using Cox proportional hazards regression. Based on the comparison of Akaike information criterion and Schoenfeld residual test results, the optimal fitted model assuming proportional hazards was selected. The multiple
The clinical outcomes of single-level anterior cervical discectomy and fusion (ACDF) with the Zero-profile (Zero-p) were evaluated in comparison with the anterior cervical cage-plate construct (CPC).
...We performed a systematic search covering PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Medline, China National Knowledge Infrastructure (NCKI), Wan Fang Database, and Wei Pu Database. Articles focused on single-level ACDF or data of the single - level that can be extracted were included, and articles that did not directly compare Zero-p and CPC were excluded. Twenty-seven studies were included with a total of 1866 patients, 931 in the Zero-p group and 935 in the CPC group. All outcomes were analyzed using Review Manager 5.4.
The meta-analysis outcomes indicated that operative time (WMD = - 12.47, 95% CI (- 16.89, - 8.05), P < 0.00001), intraoperative blood loss (WMD = - 13.30, 95% CI (- 18.83, - 7.78), P < 0.00001), risk of adjacent segment degeneration (ASD) (OR 0.31, 95% CI (0.20, 0.48), P < 0.0001), risk of dysphagia of short-term (OR 0.40, 95% CI (0.30, 0.54), P < 0.0001), medium-term (OR 0.31, 95% CI (0.20, 0.49), P < 0.0001), and long-term (OR 0.29, 95% CI (0.17, 0.51), P < 0.0001) of Zero-p group were significantly lower. The JOA score of Zero-p group at the final follow-up was significantly higher (WMD = - 0.17, 95% CI (- 0.32, - 0.03), P = 0.02). There were no significant differences in length of stay (LOS), Neck Disability Index (NDI), Visual Analogue Score (VAS), fusion rate, segmental Cobb angle, cervical Cobb angle, prevertebral soft tissue thickness (PSTT), SF-36, subsidence, implant failure, and hoarseness between the two groups. This study was registered with PROSPERO, CRD42022347146.
Zero-p group reduced operative time, intraoperative blood loss, JOA score at follow-up and reduced the incidence of dysphagia and postoperative ASD, but the two devices had the same efficacy in restoring the cervical curvature, preventing the cage subsidence, and in postoperative VAS, NDI, LOS, PSTT, SF-36, fusion rate, implant failure, and hoarseness in single-level ACDF. The use of Zero-p in single-level ACDF was recommended.
In elderly patients infected with the Omicron variant, disease progression to severe infection can result in poor outcomes. This study aimed to identify risk and protective factors associated with ...disease progression to severe infection and viral clearance time in elderly Omicron-infected patients.
Shanghai Fourth People's Hospital, School of Medicine, Tongji University, was officially designated to provide treatment to patients with COVID-19. This study was conducted on confirmed Omicron cases admitted to the hospital between 10 April 2022 and 21 June 2022. In total, 1,568 patients aged 65 years or older were included. We conducted a retrospective, observational study using logistic regression to analyze risk and protective factors for the development of severe disease and Cox proportional hazards regression models to analyze factors influencing viral clearance time.
Aged over 80 years, having 2 or more comorbidities, combined cerebrovascular disease, chronic neurological disease, and mental disorders were associated with the development of severe disease, and full vaccination was a protective factor. Furthermore, aged over 80 years, combined chronic respiratory disease, chronic renal disease, cerebrovascular disease, mental disorders, and high viral load were associated with prolonged viral clearance time, and full vaccination was a protective factor.
This study analyzed risk factors for progression to severe infection and prolonged viral clearance time in hospitalized elderly Omicron-infected patients. Aged patients with comorbidities had a higher risk of developing severe infection and had longer viral clearance, while vaccination protected them against the Omicron infection.
Dengue fever is the most common mosquito-borne viral disease and is caused by the dengue virus (DENV). There is still a lack of efficient drugs against DENV infection, so it is urgent to develop new ...inhibitors for future clinical use. Our previous research indicated the role of VEGFR2/AMPK in regulating cellular metabolism during DENV infection, while acetyl-CoA carboxylase (ACC) is located downstream of AMPK and plays a crucial role in mediating cellular lipid synthesis; therefore, we speculated that an ACC inhibitor could serve as an antiviral agent against DENV. Luckily, we found that CP640186, a reported noncompetitive ACC inhibitor, significantly inhibited DENV proliferation, and CP640186 clearly reduced DENV2 proliferation at an early stage with an EC
of 0.50 μM. A mechanism study indicated that CP640186 inhibited ACC activation and destroyed the cellular lipid environment for viral proliferation. In the DENV2 infection mice model, oral CP640186 administration (10 mg/kg/day) significantly improved the mice survival rate after DENV2 infection. In summary, our research suggests that lipid synthesis plays an important role during DENV2 proliferation and indicates that CP640186 is a promising drug candidate against DNEV2 in the future.
Remotely sensed light imagery provides a unique perspective for high-frequency human activity monitoring. NASA has developed the Black Marble, a daily nighttime light (NTL) product from the Visible ...Infrared Imaging Radiometer Suite (VIIRS) nighttime images by correcting environmental effects (i.e., atmospheric, lunar, and stray light effects). However, variation and uncertainty remain in the daily lunar-BRDF corrected NTL product and hinder its quantitative applications. To better understand the uncertainty across multiple spatial and temporal scales, this study proposed a spatial–temporal hierarchical analysis strategy to separate uncertainties from different sources, and evaluated the effects of multiple factors on daily NTL time series. The experiments conducted on two populous regions show that: (1) The daily NTL in Northern America has variations up to 50% of the annual average, which is stronger than in East Asia, with variations up to 25%. (2) The variation in seasonality is stronger in Northern America, whereas the variation related to day-to-day changing factors is stronger in East Asia. (3) Generalized linear models are built to capture the relationship between daily NTL and influential factors in each grid, revealing that approximately 25%∼50% of the daily variations can be explained by environmental factors, observational factors, and seasonality. (4) Environmental factors and observational conditions show spatially varying impacts on NTL. Specifically, aerosol exhibit opposite impacts on rural and urban areas; significant impacts of moonlight are mainly distributed in rural areas; the impact of satellite viewing angle is less pronounced and frequent in East Asian cities compared to those in North America. This research revealed the essential knowledge about variations of satellite-derived NTL and will benefit the processing and utilization of daily NTL products.
High-accuracy indoor positioning is a prerequisite to satisfy the increasing demands of position-based services in complex indoor scenes. Current indoor visual-positioning methods mainly include ...image retrieval-based methods, visual landmarks-based methods, and learning-based methods. To better overcome the limitations of traditional methods such as them being labor-intensive, of poor accuracy, and time-consuming, this paper proposes a novel indoor-positioning method with automated red, green, blue and depth (RGB-D) image database construction. First, strategies for automated database construction are developed to reduce the workload of manually selecting database images and ensure the requirements of high-accuracy indoor positioning. The database is automatically constructed according to the rules, which is more objective and improves the efficiency of the image-retrieval process. Second, by combining the automated database construction module, convolutional neural network (CNN)-based image-retrieval module, and strict geometric relations-based pose estimation module, we obtain a high-accuracy indoor-positioning system. Furthermore, in order to verify the proposed method, we conducted extensive experiments on the public indoor environment dataset. The detailed experimental results demonstrated the effectiveness and efficiency of our indoor-positioning method.
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