Hip dislocation remains a significant complication following total hip arthroplasty, even though its incidence has decreased. While closed reduction is typically performed for early dislocations, ...delayed or chronic dislocations often necessitate acetabular or femoral component revision.
This document describes the treatment of hip dislocation in a 56-year-old patient through pelvic osteotomy without component revision. An acetabular component malposition was identified, exhibiting an 80-degree inclination and 20-degree cup anteversion. Owing to limited bone stock, a modified Stoppa approach was used for pelvic osteotomy to reduce acetabular inclination. The patient displayed remarkable clinical improvement, achieving a Harris Hip Score of 85 at the two-year check-up with no signs of dislocation.
Recurrent hip dislocation is difficult to manage. It frequently necessitates component revision, presenting a challenge due to issues with cup extraction and limited bone stock. Preoperative detection of loosened components is crucial. If it goes undetected, the extraction process can result in bone loss, potentially leading to pelvic insufficiency.
Successful revisions of hip arthroplasties can be achieved with geometric modifications to the pelvis.
•Despite numerous technological advances, hip dislocation remains an essential sequela of THA.•The most challenging aspect of surgical treatment is removing the acetabular cup or femoral stem.•The patient presented to us due to a fourth hip dislocation that had occurred one month previously•We assessed our patient with insufficient acetabular walls and whether ring and cage reconstruction would be needed.•Pelvic osteotomy serves as a geometrical alteration for restoring normal biomechanics without component loosening.
Highlights • Several inhibitors of apoptosis (IAPs) mediate immune signaling through their ubiquitin ligase function. • Additional IAPs control immunity through the regulation of the inflammasome. • ...The IAPs contribute to immunity and immune disorders, such as inflammatory bowel disease (IBD). • X-chromosome-linked IAP (XIAP) deficiency is now recognized as a monogenic cause of severe Crohn's-like disease.
The 1-(1-benzofuran-2yl)-3-(4-hydroxyphenyl)propen-1-one (compound 1) from the reaction between 1-(1-benzofuran-2-yl) ethanone and 4-hydroxybenzaldehyde was firstly synthesized. And secondly, we ...synthesized 4-3-(1-benzofuran-2-yl)-3-oxoprop-1-en-1-yl phenyl chloroacetate (compound 2) as the result of the reaction between the compound 1 and chloroacetyl chloride. The monomer was prepared by the reaction of compound 2 and sodium methacrylate. The monomer was polymerized using the free radicalic polymerization method (FRP). The structure characterization of the polymer was determined utilizing 1H,13C- NMR and FT-IR techniques. Thermal behaviour of the homopolymer was studied by measurements of TGA and DSC. For thermal decomposition kinetics of homopolymer, Flynn-Wall-Ozawa method was applied to thermogravimetry curves. The dielectric measurements were studied using the impedance analyzer technique at a frequency which varied between 100 Hz and 20 kHz Hz depending on the alternating current (AC) conductivities. The dielectric parameters such as dielectric constant and dielectric loss are changed with the temperature.
•Polymer synthesized for the first time.•The dielectric and thermal properties investigated.•Chalcone side group polymer was synthesized.
INTRODUCTION|This study was an evaluation of intravitreal injections of ranibizumab (IVR) and aflibercept (IVA) administered to the corneal endothelium.¤METHODS|Thirty eyes of 30 patients made up the ...IVR injection group and 30 eyes of another 30 patients were recruited as the IVA injection group. Specular microscopy results before the injection, on the 1st, 7th, and 30th days were examined. Central corneal thickness (CCT), endothelial cell density (CD), coefficient of variation (CV), and hexagonality (HEX) values were recorded.¤RESULTS|No difference was seen between the groups with respect to gender (p=0.057). No significant difference was seen in CCT measurements in the IVR or the IVA group (p=0.08, p=0.16, respectively). Nor was a significant difference seen in the IVR group in terms of CD (p=0.85); however, a statistically significant difference was detected in the IVA group (p=0.03). Furthermore, no significant difference was seen in the IVR or the IVA group with regard to CV (p=0.12, p=0.17, respectively), and no significant difference was seen in the IVA group with respect to HEX values between measurements intervals (p>0.05); however, a significant difference was found in the IVR group (p=0.02).¤DISCUSSION AND CONCLUSION|Neither IVR nor IVA affected the CCT or CV values. The CD did not change significantly in the IVR group, whereas in the IVA group, the CD values of the first day after the injection were high, although they had returned to normal on the 30th day. In the IVR group, a statistically significant difference was seen in terms of the HEX values.¤
•The Au/Anthraquinone/p-Si/Al device has been fabricated using electrocemical method.•It was seen that the anthraquinone film increased the barrier height of the Au/p-Si/Al device.•The I–V ...measurements were performed at various temperatures.
The current–voltage measurements of the Au/Anthraquinone/p-Si/Al junction device have been carried out in the temperature range of 80–280K. It has been observed that the anthraquinone film increases the effective barrier height of the Au/p-Si/Al by influencing the space charge region of p-Si from 0.77eV to 0.85eV at 280K. The current–voltage measurements of the Au/Anthraquinone/p-Si/Al junction device show a decrease of the barrier height and an increase in the ideality factor at low temperatures. The dependence of the ideality factor and barrier height on temperature has been attributed the spatial inhomogeneity in the interface. The non-linearity behavior has been seen in the Richardson plots and the values of activation energy (Ea) and the Richardson constant (A∗) has been determined as 0.08eV and 3.19×10−8Acm−2K−2 from the slope and the intercept at ordinate of the linear region of Richardson plot, respectively. The values of the series resistance obtained from Cheung functions are strongly temperature-dependent.
Many transcription factors are known to control transcription at several promoters, while others are only active at a few places. However, due to their importance in controlling cellular functions, ...aberrant transcription factor function and inappropriate gene regulation have been shown to play a causal role in a large number of diseases and developmental disorders. Inflammatory bowel disease (IBD) is characterized by a chronically inflamed mucosa caused by dysregulation of the intestinal immune homeostasis. The aetiology of IBD is thought to be a combination of genetic and environmental factors, including luminal bacteria. The
Caudal-related homeobox transcription factor 2 (CDX2) is critical in early intestinal differentiation and has been implicated as a master regulator of the intestinal homeostasis and permeability in adults. When expressed, CDX2 modulates a diverse set of processes including cell proliferation, differentiation, cell adhesion, migration, and tumorigenesis. In addition to these critical cellular processes, there is increasing evidence for linking CDX2 to intestinal inflammation. The aim of the present paper was to review the current knowledge of CDX2 in regulation of the intestinal homeostasis and further to reveal its potential role in inflammation.
► CDX2 regulates intestinal homeostasis. ► Altered CDX2 expression triggers inflammation. ► CDX2 is a downstream target of inflammatory cytokines.
Its nickel complex and a polyacrylate with side chain the Schiff base obtained from the condensation reaction of 4-hydroxybenzaldehide and p-toluidine, have been synthesized. The three-component ...composites were prepared using the polyacrylate, poly4-((p-tolylimino) methyl) phenyl acrylate, its Ni-complex, and aminated MWCNT at three different percent (2%, 8% and 15% by wt). For characterization, FT-IR, 1H-NMR, SEM-EDX, SEM images and VSM (vibrating sample magnetometer) were used. The specific magnetic susceptibility for the Ni-complex is calculated as 3.0 × 10
−8
m
3
/kg from the slope of VSM straight line and the Ni-complex shows paramagnetic property. Thermal stabilities of the composites decreased compared with the polymer and Ni-complex. The AC conductivities of the samples increased with increasing frequency and increasing temperature. Frequency exponent of the equation connecting the AC conductivity to angular frequency was calculated as between 1.06 and 0.86 at 298 K and between 0.97 and 0.71 at 320 K, for all samples. Log σ
ac
vs 1000/T straight lines were generated above and below the T
g
temperature and the activation energies were calculated from the slopes as the values between 0.097 and 0.331 eV below Tg and the values between 1.134 and 0.768 eV above T
g
.
The objective of this study was to describe the distribution pattern of cerebellar hemispheric tentorial bridging (CHTB) veins on the tentorial surface in a case series of perimedian or paramedian ...supracerebellar approaches and to describe a novel technique to preserve these veins.
A series of 141 patients with various pathological processes in different locations was operated on via perimedian or paramedian supracerebellar approaches by the senior author from July 2006 through October 2022 and was retrospectively evaluated. During surgery, the number and locations of all CHTB veins were recorded to establish a distribution map on the tentorial surface, divided into nine zones. Patients were classified into four groups according to the surgical technique used to manage CHTB veins: 1) group 1 consisted of CHTB veins preserved without intervention during surgery or no CHTB veins found in the surgical route; 2) group 2 included CHTB veins coagulated during surgery; 3) group 3 included CHTB veins preserved with arachnoid and/or tentorial dissection from the cerebellar or tentorial surface, respectively; and 4) group 4 comprised CHTB veins preserved using a novel tentorial cut technique.
Overall, 141 patients were included in the study. Of these 141 patients, 38 were in group 1 (27%), 32 in group 2 (22.7%), 47 in group 3 (33.3%), and 24 in group 4 (17%). The total number of CHTB veins encountered was 207 during surgeries on one side. According to the distribution zones of the tentorium, zone 5 had the highest density of CHTB veins, while zone 7 had the lowest. Of the patients in group 4, 6 underwent the perimedian supracerebellar approach and 18 had the paramedian supracerebellar approach. There were 39 CHTB veins on the surface of the 24 cerebellar hemispheres in group 4. The tentorial cut technique was performed for 27 of 39 CHTB veins. Twelve veins were not addressed because they did not present any obstacles during approaches. During surgery, no complications were observed due to the tentorial cut technique.
Because there is no way to determine whether a CHTB vein can be sacrificed without complications, it is important to protect these veins in supracerebellar approaches. This new tentorial cut technique in perimedian or paramedian supracerebellar approaches makes it possible to preserve CHTB veins encountered during supracerebellar surgeries.
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