•Constitutional mismatch repair deficiency syndrome should be considered in children with acute leukemia and characteristic skin lesions.•The high mutation burden of CMMRD-related cancers contributes ...to treatment resistance, necessitating individualized treatment strategies.
Identity propagation in N-tier systems Patel, A.; McRoberts, M.; Crenshaw, M.
MILCOM 2009 - 2009 IEEE Military Communications Conference,
2009-Oct.
Conference Proceeding
While SOA promises great benefits in productivity and flexibility, the tools for securing these systems continue to lag behind. The ideal of SOA security is to provide trusted containers and ...frameworks that enforce policies established during deployment, and remove security logic and policy from application code completely. Standards such as WS-Security address some of the issues, but enterprise systems don't stop and start with Web services. In an N-tier the user is authenticated at the client platform, and this authentication will ultimately determine access to resources in back-end data stores. The challenge is to create a framework for the end-to-end propagation of user credentials across N-tiers, which doesn't rely on custom security code within applications. This paper will describe a working prototype framework that propagates user credentials through Web application, web service and database tiers, and applies label-based access control (LBAC) policies within the database. The paper will also outline known gaps in web and SOA standards, and directions for future work.
At the Third Turner Resource Network Symposium, a working group presented the results of collaborative discussions about the importance of autopsy in Turner syndrome (TS). Considerable gaps in ...understanding the causes of death in TS can only be closed by more frequent death investigations and autopsies. The presentation included an overview of autopsy methods, strategies for utilizing autopsy, and biobanking to address research questions about TS, and the role of palliative care in the context of autopsy. This review highlights strategies to promote autopsy and tissue donation, culminating with an action plan to increase autopsy rates in the TS community.
In discussing their holographic installation "Choice and Circumstance," which was designed as a collaboration, the authors examine the concept development, technical production and finished artwork. ...The installation is composed of white-light reflection holograms set against large-format photographic murals. Conceived as an installation in four parts, or tableaux, the work chronicles emotional response through gesture and suggestion. Drawing on current social and political attitudes, "Choice and Circumstance" endeavors to visualize some specific complexities of timeless relevance.
Hundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of ...cell lines is currently impractical, and such experiments are often difficult to control. Here we report a method called PRISM that allows pooled screening of mixtures of cancer cell lines by labeling each cell line with 24-nucleotide barcodes. PRISM revealed the expected patterns of cell killing seen in conventional (unpooled) assays. In a screen of 102 cell lines across 8,400 compounds, PRISM led to the identification of BRD-7880 as a potent and highly specific inhibitor of aurora kinases B and C. Cell line pools also efficiently formed tumors as xenografts, and PRISM recapitulated the expected pattern of erlotinib sensitivity in vivo.
This work describes a new specific, sensitive, and rapid stable isotope dilution method for the simultaneous detection of the organophosphorus nerve agents (OPNAs) tabun (GA), sarin (GB), soman (GD), ...cyclosarin (GF), VR, VX, and VM adducts to tyrosine (Tyr). Serum, plasma, and lysed whole blood samples (50 μL) were prepared by protein precipitation followed by digestion with Pronase. Specific Tyr adducts were isolated from the digest by a single solid phase extraction (SPE) step, and the analytes were separated by reversed-phase ultra high performance liquid chromatography (UHPLC) gradient elution in less than 2 min. Detection was performed on a triple quadrupole tandem mass spectrometer using time-triggered selected reaction monitoring (SRM) in positive electrospray ionization (ESI) mode. The calibration range was characterized from 0.100−50.0 ng/mL for GB– and VR–Tyr and 0.250–50.0 ng/mL for GA–, GD–, GF–, and VX/VM–Tyr (R 2 ≥ 0.995). Inter- and intra-assay precision had coefficients of variation of ≤17 and ≤10%, respectively, and the measured concentration accuracies of spiked samples were within 15% of the targeted value for multiple spiking levels. The limit of detection was calculated to be 0.097, 0.027, 0.018, 0.074, 0.023, and 0.083 ng/mL for GA–, GB–, GD–, GF–, VR–, and VX/VM–Tyr, respectively. A convenience set of 96 serum samples with no known nerve agent exposure was screened and revealed no baseline values or potential interferences. This method provides a simple and highly specific diagnostic tool that may extend the time postevent that a confirmation of nerve agent exposure can be made with confidence.
Having a child with ASD can impact many aspects and quality of family life, including the marital relationship, siblings, and extended family, and can lead to social isolation (Myers et al. 2009). ...Educators can play a significant role in helping to foster, develop, and maintain these relationships (Sad & Gurbuzturk 2013; Rodriguez, Blatz, & Elbaum 2014), which in turn is likely to have a positive impact on the quality of life for families of children with ASD (Hsiao et al. 2017) and student success (Garbacz et al. 2015). ...elementary general education teachers have indicated not feeling sufficiently involved in selecting IEP goals and feeling like the only whole-team decision at IEP meetings was educational placement (Lee-Tarver 2006). (See "Strategies in Action" on page 51 for more information on sending home materials in multiple languages.) * sharing online resources that families can access to learn more about learning differences and IEPs.
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