Dusty star-forming galaxies at high redshift (1 < z < 3) represent the most intense star-forming regions in the universe. Key aspects to these processes are the gas heating and cooling mechanisms, ...and although it is well known that these galaxies are gas-rich, little is known about the gas excitation conditions. Only a few detailed radiative transfer studies have been carried out owing to a lack of multiple line detections per galaxy. Here we examine these processes in a sample of 24 strongly lensed star-forming galaxies identified by the Planck satellite (LPs) at z ∼ 1.1-3.5. We analyze 162 CO rotational transitions (ranging from Jup = 1 to 12) and 37 atomic carbon fine-structure lines (C i) in order to characterize the physical conditions of the gas in the sample of LPs. We simultaneously fit the CO and C i lines and the dust continuum emission, using two different non-LTE, radiative transfer models. The first model represents a two-component gas density, while the second assumes a turbulence-driven lognormal gas density distribution. These LPs are among the most gas-rich, IR-luminous galaxies ever observed ( L L IR ( 8 − 1000 m ) ∼ 10 13 − 14.6 L ; 〈 LMISM 〉 = (2.7 1.2) × 1012 M , with L ∼ 10-30 the average lens magnification factor). Our results suggest that the turbulent interstellar medium present in the LPs can be well characterized by a high turbulent velocity dispersion ( 〈 ΔVturb 〉 ∼ 100 km s−1) and ratios of gas kinetic temperature to dust temperature 〈 Tkin/Td 〉 ∼ 2.5, sustained on scales larger than a few kiloparsecs. We speculate that the average surface density of the molecular gas mass and IR luminosity, M ISM ∼ 103-4 M pc−2 and L IR ∼ 1011-12 L kpc−2, arise from both stellar mechanical feedback and a steady momentum injection from the accretion of intergalactic gas.
The mass–metallicity relation revisited with CALIFA Sánchez, S. F.; Barrera-Ballesteros, J. K.; Sánchez-Menguiano, L. ...
Monthly Notices of the Royal Astronomical Society,
08/2017, Letnik:
469, Številka:
2
Journal Article
Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall ...survival of 6%. There are promising results using prophylactic HIPEC in this group of patients, and it is estimated that up to 26% of all T4 colon cancer could benefit from this treatment with a minimal morbidity. Adjuvant HIPEC is effective to avoid the possibility of peritoneal seeding after surgical resection. Taking into account these results and the cumulative experience in HIPEC use, we will lead a randomized controlled trial to determine the effectiveness and safety of adjuvant treatment with HIPEC vs. standard treatment in patients with colon cancer at high risk of peritoneal recurrence (pT4).
The aim of this study is to determine the effectiveness and safety of adjuvant HIPEC in preventing the development of PC in patients with colon cancer with a high risk of peritoneal recurrence (cT4). This study will be carried out in 15 Spanish HIPEC centres. Eligible for inclusion are patients who underwent curative resection for cT4NxM0 stage colon cancer. After resection of the primary tumour, 200 patients will be randomized to adjuvant HIPEC followed by routine adjuvant systemic chemotherapy in the experimental arm, or to systemic chemotherapy only in the control arm. Adjuvant HIPEC will be performed simultaneously after the primary resection. Mitomycin C will be used as chemotherapeutic agent, for 60 min at 42-43 °C. Primary endpoint is loco-regional control (LC) in months and the rate of loco-regional control (%LC) at 12 months and 36 months after resection.
We assumed that adjuvant HIPEC will reduce the expected absolute risk of peritoneal recurrence from 36% to 18% at 36 months for T4 colon-rectal carcinoma.
NCT02614534 ( clinicaltrial.gov ) Nov-2015.
•Nine real-world problems that concerns the planning of bus services are solved.•The problem is modeled as a variant of the Open Vehicle Routing Problem.•The objective is to minimize the makespan ...instead of the total cost.•A competitive multi-start algorithm is proposed.•A specific local search for the considered problem is proposed.
The aim of this paper is to solve a real-world problem proposed by an international company operating in Spain and modeled as a variant of the Open Vehicle Routing Problem in which the makespan, i.e., the maximum time spent on the vehicle by one person, must be minimized. A competitive multi-start algorithm, able to obtain high quality solutions within reasonable computing time is proposed. The effectiveness of the algorithm is analyzed through computational testing on a set of 19 school-bus routing benchmark problems from the literature, and on 9 hard real-world problem instances.
Abstract
Rickettsia helvetica
is an emerging pathogen of the Spotted Fever Group Rickettsia (SFGR) causing spotted fever diseases in various European countries. This tick-borne pathogen replicates in ...tick tissues such as the midgut and salivary gland, but its potential interactions with the vector microbiota is poorly characterized. The vector microbiome plays a pivotal role in tick-pathogen interactions, and some microbiota members facilitate or impede tick-borne pathogen infection. Manipulations of the tick microbiome have led to reduction in pathogen colonization in the tick vector. However, translating these findings into disease control applications requires a thorough characterization of vector microbiota response to different pathogens. In this study, we analyzed and compared the microbiota of
Ixodes ricinus
ticks attached on humans and collected in Serbia. Ticks were either infected with
R. helvetica
, or uninfected with major tick-borne pathogens (referred hereafter as ‘pathogen-free’). We used microbial co-occurrence network analysis to determine keystone taxa of each set of samples, and to study the interaction patterns of the microbial communities in response to pathogen infection. The inferred functional profiles of the tick microbiome in
R. helvetica
-positive and pathogen-free samples were also compared. Our results show that
R. helvetica
infection reduces significantly the diversity of the microbiota and the connectivity of the co-occurrence network. In addition, using co-occurrence network we identified bacterial taxa (i.e., Enterobacteriaceae, Comamonadaceae, and
Bacillus
) that were negatively associated with ‘
Rickettsia
’ in
R. helvetica
-infected ticks, suggesting competition between
R. helvetica
and some members of the tick microbiota. The reconstruction of microbial metabolic pathways shows that the presence of
R. helvetica
might have a major impact on the metabolic functions of the tick microbiome. These results can inform novel interventions for the prevention of
R. helvetica
, or other SFGR infections in humans.
A
bstract
Three different approaches to precisely describe the Adler function in the Euclidean regime at around 2 GeVs are available: dispersion relations based on the hadronic production data in
e
+
...e
−
annihilation, lattice simulations and perturbative QCD (pQCD). We make a comprehensive study of the perturbative approach, supplemented with the leading power corrections in the operator product expansion. All known contributions are included, with a careful assessment of uncertainties. The pQCD predictions are compared with the Adler functions extracted from
Δ
α
QED
had
(
Q
2
), using both the DHMZ compilation of
e
+
e
−
data and published lattice results. Taking as input the FLAG value of
α
s
, the pQCD Adler function turns out to be in good agreement with the lattice data, while the dispersive results lie systematically below them. Finally, we explore the sensitivity to
α
s
of the direct comparison between the data-driven, lattice and QCD Euclidean Adler functions. The precision with which the renormalisation group equation can be tested is also evaluated.
We present an improved version of FIT3D, a fitting tool for the analysis of the spectroscopic properties of the stellar populations and the ionized gas derived from moderate resolution spectra of ...galaxies. This tool was developed to analyze integral field spectroscopy data and it is the basis of P 3D, a pipeline used in the analysis of CALIFA, MaNGA, and SAMI data. We describe the philosophy and each step of the fitting procedure. We present an extensive set of simulations in order to estimate the precision and accuracy of the derived parameters for the stellar populations and the ionized gas. We report on the results of those simulations. Finally, we compare the results of the analysis using FIT3D with those provided by other widely used packages, and we find that the parameters derived by FIT3D are fully compatible with those derived using these other tools.
SCOPE: Urolithins are bioactive metabolites produced by the gut microbiota from ellagitannins (ETs) and ellagic acid (EA). We investigated whether urolithins could be detected in colon tissues from ...colorectal cancer (CRC) patients after pomegranate extract (PE) intake. METHODS AND RESULTS: CRC patients (n = 52) were divided into controls and PEs consumers (900 mg/day for 15 days) before surgical resection. PEs with low (PE‐1) and high (PE‐2) punicalagin:EA ratio were administered. Twenty‐three metabolites, but no ellagitannins, were detected in urine, plasma, normal (NT) or malignant (MT) colon tissues using UPLC‐ESI‐QTOF‐MS/MS (UPLC, ultra performance liquid chromatography; QTOF, quadrupole TOF). Free EA, five EA conjugates, gallic acid and 12 urolithin derivatives were found in colon tissues. Individual and total metabolites levels were higher in NT than in MT, independently of the PE consumed. The maximal mean concentration (1671 ± 367 ng/g) was found in NT after consumption of PE‐1 and the lowest concentration (42.4 ± 10.2 ng/g) in MT with PE‐2. Urolithin A or isourolithin A were the main urolithins produced (54 and 46% patients with urolithin A or isourolithin A phenotype, respectively). High punicalagin content (PE‐2) hampered urolithins formation. CONCLUSION: Significant levels of EA derivatives and urolithins are found in human colon tissues from CRC patients after consumption of pomegranate. Further studies are warranted to elucidate their biological activity.
This paper introduces a problem that can be seen as a combination of the traveling salesman problem with profits and the traveling repairman problem with profits, coined as the multi‐objective ...traveling salesman–repairman problem with profits (Mo‐TSRPP). The objective of the Mo‐TSRPP is to simultaneously optimize three objectives: the total cost, total latency, and total profit. Indirectly, the number of nodes visited is also considered although not as an objective itself since it is determined by the size of every efficient solution in the Pareto front. The Mo‐TSRPP emerges as a real‐world problem in which a freelancer, which repairs appliances, wants to plan the daily route. Moreover, the daily plan does not require to visit all customers. To solve the problem, first, a greedy randomized adaptive procedure is designed to generate a set of high‐quality nondominated solutions and then, a variable neighborhood descent algorithm is applied for further improving the initial set. This procedure allows us to attain a good approximation of the Pareto front. To prove the performance of the proposal a comparison is done against three well‐known evolutionary algorithms: NSGA‐II, SPEA‐2, and MOEA/D. Finally, a realistic problem is shown and solved to illustrate the potential of the algorithm.
Abstract
We report an ultrabright lensed submillimeter galaxy at
z
spec
= 1.4796, identified as a result of a full-sky cross-correlation of the AllWISE and Planck compact source catalogs aimed at ...searching for bright submillimeter galaxies at
z
∼ 1.5–2.8. Atacama Pathfinder Experiment (APEX)/LABOCA observations of the candidate galaxy reveal a source with flux
S
870
μ
m
= 54 ± 8 mJy. The position of the APEX source coincides with the position of the AllWISE mid-IR source and with the Einstein ring GAL-CLUS-022058s, observed with the Hubble Space Telescope. Archival VLT/FORS observations reveal the redshift of this Einstein ring,
z
spec
= 1.4796, and the detection of the CO(5–4) line at
z
spec
= 1.4802 with APEX/nFLASH230 confirms the redshift of the submillimeter emission. The lensed source appears to be gravitationally magnified by a massive foreground galaxy cluster lens at
z
= 0.36. We use Lenstool to model the gravitational lensing, which is close to a “fold arc” configuration for an elliptical mass distribution of the central halo, where four images of the lensed galaxy are seen; the mean magnification is
μ
L
= 18 ± 4. We have determined an intrinsic rest-frame infrared luminosity of
L
IR
≈10
12
L
⊙
and a likely star formation rate of ∼70–170
M
⊙
yr
−1
. The molecular gas mass is
M
mol
∼ 2.6 × 10
10
M
⊙
and the gas fraction is
f
= 0.34 ± 0.07. We also obtain a stellar mass log (
M
*
/
M
⊙
) = 10.7 ± 0.1 and a specific star formation rate log (sSFR/Gyr
−1
) = 0.15 ± 0.03. This galaxy lies on the so-called main sequence of star-forming galaxies at this redshift.
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