We present the results of a comparison between classical and newly identified EXor based on literature data and aimed at recognizing possible differences or similarities between the categories. ...Optical and near-IR two-color diagrams, modalities of fluctuations, and derived values of the mass accretion rates are indicative of strong similarities between the two samples. We demonstrate how the difference between the outburst and the quiescence spectral energy distribution of all EXor can be well fitted with a single blackbody, as if an additional thermal component appears during the outbursting phase. Temperatures of this additional component span between 1000 and 4500 K, while the radii of the emitting regions (assumed to be a uniform disk) span between 0.01 and 0.1 AU, sizes typical of the inner portions of the circumstellar disk. Spots persisting up to 50% of the outburst duration, not exceeding 10% of the stellar surface, and with temperatures compatible with the EXor mass accretion rates, are able to account for both the appearance of the additional thermal component and the dust sublimation in the inner structures of the disk. We also compare the EXor events with the most significant color and magnitude fluctuations of active T Tauri stars finding that (1) burst accretion phenomena should also be important for this latter class and (2) EXor events could be more frequent than those accidentally discovered. A remarkable case is that of the source V2493 Cyg, a T Tauri star recently identified as a strong outbursting object: New optical and near-IR photometric and spectroscopic data are presented in an attempt to clarify its EXor or FUor nature.
In pediatric patients with extrahepatic portal vein obstruction and complications of portal hypertension, but with normal liver function, a meso-Rex bypass (MRB) connecting the superior mesenteric ...vein to the intrahepatic left portal is the favored surgical management. Pediatric patients with a history of a partial liver transplant (LT), especially living donors, are at greater risk for portal vein complications. Hence, an adequate knowledge of this technique and its additional challenges in the post-LT patient setting is crucial. We provide an overview of the available literature on technical aspects for an MRB post-LT. Preoperative considerations are highlighted, along with intraoperative considerations and postoperative management. Special attention is given to the even-more-demanding aspect of performing an MRB post-liver transplantation with a left lateral segment. Surgical alternatives are also discussed. In addition, we report here a unique case in which this surgical technique was performed on a complex pediatric patient with a history of a living-donor LT with a left lateral segment graft over a decade ago.
Context. The near-Earth object (NEO) population is a window into the original conditions of the protosolar nebula, and has the potential to provide a key pathway for the delivery of water and ...organics to the early Earth. In addition to delivering the crucial ingredients for life, NEOs can pose a serious hazard to humanity since they can impact the Earth. To properly quantify the impact risk, physical properties of the NEO population need to be studied. Unfortunately, NEOs have a great variation in terms of mitigation-relevant quantities (size, albedo, composition, etc.) and less than 15% of them have been characterized to date. Aims. There is an urgent need to undertake a comprehensive characterization of smaller NEOs (D < 300 m) given that there are many more of them than larger objects; their small sizes make them intrinsically fainter and therefore harder to study. One of the main aims of the NEOShield-2 project (2015–2017), financed by the European Community in the framework of the Horizon 2020 program, is therefore to retrieve physical properties of a wide number of NEOs in order to design impact mitigation missions and assess the consequences of an impact on Earth. Methods. We carried out visible photometry of NEOs, making use of the DOLORES instrument at the Telescopio Nazionale Galileo (TNG, La Palma, Spain) in order to derive visible color indexes and the taxonomic classification for each target in our sample. Results. We attributed for the first time the taxonomical complex of 67 objects obtained during the first year of the project. While the majority of our sample belong to the S-complex, carbonaceous C-complex NEOs deserve particular attention. These NEOs can be located in orbits that are challenging from a mitigation point of view, with high inclination and low minimum orbit intersection distance (MOID). In addition, the lack of carbonaceous material we see in the small NEO population might not be due to an observational bias alone.
Silica-supported TiO(2) powders were synthesized by a wet method under mild conditions. The aim of the work was the preparation of TiO(2)/SiO(2) additives for photocatalytic cements. Three types of ...commercial SiO(2) were used as supports: Cabot, Axim and Fly Ash. Cabot silica was ultra-pure whereas the other two silica contained different percentages of various oxides. The TiO(2)/SiO(2) samples, denoted TiO(2)/Cabot, TiO(2)/Axim and TiO(2)/Fly Ash, were prepared by boiling suspensions obtained by addition of silica to a solution of TiCl(4) in water (volume ratio 1:10). The photocatalytic activity was evaluated in a gas-solid system both in batch and in continuous reactors using 2-propanol as probe molecule. SEM-EDX analysis revealed that titanium dioxide was quantitatively deposited on silica. TiO(2)/Axim and TiO(2)/Fly Ash were scarcely active whereas a good photoactivity was exhibited by the TiO(2)/Cabot sample both in the batch and in the continuous system. Consequently only the last sample was tested for both NO(x) abatement and for 4-nitrophenol photodegradation in a liquid-solid system.
Aims. With an observed and rest-frame duration of <2 s and <0.5 s, respectively, GRB 090426 could be classified as a short GRB. The prompt detection, both from space and ground-based telescopes, of a ...bright optical counterpart to this GRB offered a unique opportunity to complete a detailed study. Methods. Based on an extensive ground-based observational campaign, we obtained the spectrum of the optical afterglow of GRB 090426, measuring its redshift and obtaining information about the medium in which the event took place. We completed follow-up observations of the afterglow optical light curve down to the brightness level of the host galaxy that we firmly identified and studied. We also retrieved and analyzed all the available high-energy data of this event, and compared the results with our findings in the optical. This represents one of the most detailed studies of a short-duration event presented so far. Results. The time properties qualify GRB 090426 as a short burst. In this case, its redshift of $z = 2.61$ would be the highest yet found for a GRB of this class. On the other hand, the spectral and energy properties are more similar to those of long bursts. LBT late-time deep imaging identifies a star-forming galaxy at a redshift consistent with that of the GRB. The afterglow lies within the light of its host and shows evidence of local absorption.
To better understand how climate change might influence global canola production, scientists from six countries have completed the first inter-comparison of eight crop models for simulating growth ...and seed yield of canola, based on experimental data from six sites across five countries. A sensitivity analysis was conducted with a combination of five levels of atmospheric CO
2
concentrations, seven temperature changes, five precipitation changes, together with five nitrogen application rates. Our results were in several aspects different from those of previous model inter-comparison studies for wheat, maize, rice, and potato crops. A partial model calibration only on phenology led to very poor simulation of aboveground biomass and seed yield of canola, even from the ensemble median or mean. A full calibration with additional data of leaf area index, biomass, and yield from one treatment at each site reduced simulation error of seed yield from 43.8 to 18.0%, but the uncertainty in simulation results remained large. Such calibration (with data from one treatment) was not able to constrain model parameters to reduce simulation uncertainty across the wide range of environments. Using a multi-model ensemble mean or median reduced the uncertainty of yield simulations, but the simulation error remained much larger than observation errors, indicating no guarantee that the ensemble mean/median would predict the correct responses. Using multi-model ensemble median, canola yield was projected to decline with rising temperature (2.5–5.7% per °C), but to increase with increasing CO
2
concentration (4.6–8.3% per 100-ppm), rainfall (2.1–6.1% per 10% increase), and nitrogen rates (1.3–6.0% per 10% increase) depending on locations. Due to the large uncertainty, these results need to be treated with caution. We further discuss the need to collect new data to improve modelling of several key physiological processes of canola for increased confidence in future climate impact assessments.
ABSTRACT
We report the results we derived analyzing photometric measurements obtained at different phase angles for 15 Near-Earth Objects (NEOs), observed from Campo Imperatore observatory, and ...Observatório Astronômico do Sertão de Itaparica (OASI). The performed analysis allows us to taxonomically classify them using several independent techniques, thus constraining their surface composition. The majority of this sample is in agreement with a pristine carbonaceous composition (C-complex/D-type asteroids), while few NEOs are composed of more evolved (e.g. S/M/E-type bodies) material. With this work we made evident that a comprehensive characterization of a NEO can be achieved through the coupling of spectrophotometric data and phase curve assessment. This is crucial in case these objects become target of future rendez-vous, sample-return or mitigation missions.
Essentials
Signaling by Gas6 through Tyro3/Axl/Mer receptors is essential for stable platelet aggregation.
UNC2025 is a small molecule inhibitor of the Mer tyrosine kinase.
UNC2025 decreases platelet ...activation in vitro and thrombus formation in vivo.
UNC2025's anti‐platelet effect is synergistic with inhibition of the ADP receptor, P2Y12.
Summary
Background
Growth arrest‐specific protein 6 signals through the TAM (TYRO‐3–AXL–MERTK) receptor family, mediating platelet activation and thrombus formation via activation of the aggregate‐stabilizing αIIbβ3 integrin.
Objective
To describe the antithrombotic effects mediated by UNC2025, a small‐molecule MERTK tyrosine kinase inhibitor.
Methods
MERTK phosphorylation and downstream signaling were assessed by immunoblotting. Light transmission aggregometry, flow cytometry and microfluidic analysis were used to evaluate the impact of MERTK inhibition on platelet activation and stability of aggregates in vitro. The effects of MERTK inhibition on arterial and venous thrombosis, platelet accumulation at microvascular injury sites and tail bleeding times were determined with murine models. The effects of combined treatment with ADP–P2Y1&12 pathway antagonists and UNC2025 were also evaluated.
Results and Conclusions
Treatment with UNC2025 inhibited MERTK phosphorylation and downstream activation of AKT and SRC, decreased platelet activation, and protected animals from pulmonary embolism and arterial thrombosis without increasing bleeding times. The antiplatelet effect of UNC2025 was enhanced in combination with ADP–P2Y1&12 pathway antagonists, and a greater than additive effect was observed when these two agents with different mechanisms of inhibition were coadministered. TAM kinase signaling represents a potential therapeutic target, as inhibition of this axis, especially in combination with ADP–P2Y pathway antagonism, mediates decreased platelet activation, aggregate stability, and thrombus formation, with less hemorrhagic potential than current treatment strategies. The data presented here also demonstrate antithrombotic activity mediated by UNC2025, a novel translational agent, and support the development of TAM kinase inhibitors for clinical applications.
We present low-resolution spectroscopy in the near-IR (0.8-2.5 mm) of the EXor variables. These are the initial results (obtained during the period 2007-2008) from a long-term photometric and ...spectroscopic program aimed to study the variability in the accretion processes of pre-main-sequence stars, by correlating the continuum fluctuations with the spectroscopic properties. Eight sources have been observed in different epochs, for a total of 25 acquired spectra. EXor spectra show a wide variety of emission features dominated by H I recombination (Paschen and Brackett series). We have investigated whether line and continuum variability could be due to a variable extinction, but such a hypothesis is applicable only to the peculiar source PV Cep. By comparing the observed spectra with a wind model, mass loss rates in the range (2-10) X 10-8 M yr-1 are derived, along with other wind parameters. Consistent results are also obtained by assuming that H I lines are due to accretion. A CO overtone is also detected in the majority of the sources both in absorption and in emission. It appears to come from regions more compact than winds, likely the stellar photosphere (when in absorption) and the circumstellar disk (when in emission). Na I and Ca I IR lines behave as the CO does, thus they are thought to arise in the same locations. For some targets multiple spectra correspond to different activity stages of the source. Those exhibiting the largest continuum variation at 2 mm (K 1 mag) present a significant line flux fading during the continuum declining phases. In particular, CO absorption (emission) appears associated with inactive (active) stages, respectively.
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