The hotel industry in modern business conditions, characterized by the networking of all key factors, is changing rapidly. Today, with „one-click― all information about hotels, tourist offer and ...price of services is available to tourists. The growth of megabrends through acquisitions, the growth of private rentals and the digitalization of consumer services are the trends that have been changing and shaping the hotel industry for the past few years. These trends affect hotel operators to develop new strategies for attracting consumers and retaining them. The aim of this paper is to explore what the key trends that have shaped and changed the hotel industry in recent years are, the changes that have occurred, what can be expected in the coming years and the ways hoteliers can adapt.
Over the last few decades there has been a tendency to use the word 'allergy' to describe all kinds of unexpected reactions to certain foods and food ingredients. The recent literature is plentiful ...and discusses food allergens and people who are hypersensitive to certain foods. The literature suggests the prevalence of food allergy to specific allergens to be changing with age. The aim of this empirical research was to examine the hypersensitivity to certain foods in relation to age and employment of the population consisting of customers on cruise ships. The study included 404 tourists on a cruise ship who voluntarily filled food sensitivity questionnaires and submitted them to the ship staff. These questionnaires were used to analyze the allergy trends and their connection to age and employment. The procedures of descriptive statistics and Chi-square test were used to process the obtained data. The results of the research suggested that there was a statistically significant relationship between the persons who were hypersensitive to certain foods relative to employment and age.
The hotel industry in modern business conditions, characterized by the networking of all key factors, is changing rapidly. Today, with „one-click? all information about hotels, tourist offer and ...price of services is available to tourists. The growth of megabrends through acquisitions, the growth of private rentals and the digitalization of consumer services are the trends that have been changing and shaping the hotel industry for the past few years. These trends affect hotel operators to develop new strategies for attracting consumers and retaining them. The aim of this paper is to explore what the key trends that have shaped and changed the hotel industry in recent years are, the changes that have occurred, what can be expected in the coming years and the ways hoteliers can adapt.
The hotel industry in modern business conditions, characterized by the networking of all key factors, is changing rapidly. Today, with „one-click― all information about hotels, tourist offer and ...price of services is available to tourists. The growth of megabrends through acquisitions, the growth of private rentals and the digitalization of consumer services are the trends that have been changing and shaping the hotel industry for the past few years. These trends affect hotel operators to develop new strategies for attracting consumers and retaining them. The aim of this paper is to explore what the key trends that have shaped and changed the hotel industry in recent years are, the changes that have occurred, what can be expected in the coming years and the ways hoteliers can adapt.
The hotel industry in modern business conditions, characterized by the networking of all key factors, is changing rapidly. Today, with „one-click? all information about hotels, tourist offer and ...price of services is available to tourists. The growth of megabrends through acquisitions, the growth of private rentals and the digitalization of consumer services are the trends that have been changing and shaping the hotel industry for the past few years. These trends affect hotel operators to develop new strategies for attracting consumers and retaining them. The aim of this paper is to explore what the key trends that have shaped and changed the hotel industry in recent years are, the changes that have occurred, what can be expected in the coming years and the ways hoteliers can adapt.
In the search for molecular candidates for targeted meningioma therapies, increasing attention has been paid to the role of signaling pathways in the development and progression of intracranial ...meningiomas. Although it is well known that the Wnt signaling pathway is involved in meningioma progression, the role of its central mediator, DVL1, is still unclear. In order to investigate the influence of
gene alterations on the progression of human intracranial meningioma, we focused on its central PDZ domain, which is responsible for DVL interaction with the Fzd receptor and the phosphorylation of DVL mediated through the casein kinases CK1 and CK2. A genetic analysis of genomic instability revealed the existence of microsatellite instability in 9.09% and the loss of heterozygosity in 6.06% of the samples. The sequencing of the PDZ gene region showed repetitive deletions of two bases located in intron 7 and exon 8, and a duplication in intron 8 in most samples, with different outcomes on the biological function of the DVL1 protein. Immunohistochemistry revealed that the nuclear expression of DVL1 was significantly correlated with a higher expression of active β-catenin (
= 0.029) and a higher meningioma grade (
= 0.030), which leads to the conclusion that it could be used as biomarker for meningioma progression and the activation of the Wnt signaling pathway.
Decompressive Craniectomy (DC) is a treatment option for severe brain injury (SBI). This method is applied when the growth of intracranial pressure (ICP) can no longer be controlled with conservative ...methods. DC belongs to class III "Guidelines"--"option" which has not clear clinical certainty. They do not correspond to "Standards" (class I) in treatment protocol for SBI, which is common in most neurotraumatological centers. We have analyzed retrospectively 95 patients with SBI who were admitted to the Clinical Hospital Centre Rijeka. All patients were managed based on a protocol of current Brain Trauma Foundations (BTF) Guidelines. 39 patients underwent DC while 34 patients underwent standard craniotomy. 22 patients did not undergo any surgical procedures. In each patient we analyzed ICP changes within the first 11 days and in that way we correlated them statistically with the initial Glasgow Coma Scale (GCS) and then with Glasgow Outcome Scale (GOS), after the end of the treatment. We particularly analyzed the outcome with reference to the time of the operation and the size of DC. The standard measurement of ICP shows statistical significance in recovery in the group without DC after 5 days of intensive treatment, when the pressure is stabilized between 20-25 mm Hg. The stabilization of ICP in the DC group is observed already after 3 days of intensive treatment. Furthermore, better functional recovery according to GOS, which is statistically significant, was observed in patients who underwent DC where the area of craniectomy was larger than 25 cm2, within the first 24 hours from the time of injury. The use of DC considerably reduces the need for CT check-ups. Increase in the number of encephalocele was noted, which is to be expected considering that dural decompression is used in DC procedure. The results of our study indicate that the utilization of DC is characterized with lower mortality and better functional recovery if it is applied at an early stage of treatment and if the size of DC is satisfactory.
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