Post‐translational modification of histones and DNA methylation are important components of chromatin‐level control of genome activity in eukaryotes. However, principles governing the combinatorial ...association of chromatin marks along the genome remain poorly understood. Here, we have generated epigenomic maps for eight histone modifications (H3K4me2 and 3, H3K27me1 and 2, H3K36me3, H3K56ac, H4K20me1 and H2Bub) in the model plant Arabidopsis and we have combined these maps with others, produced under identical conditions, for H3K9me2, H3K9me3, H3K27me3 and DNA methylation. Integrative analysis indicates that these 12 chromatin marks, which collectively cover ∼90% of the genome, are present at any given position in a very limited number of combinations. Moreover, we show that the distribution of the 12 marks along the genomic sequence defines four main chromatin states, which preferentially index active genes, repressed genes, silent repeat elements and intergenic regions. Given the compact nature of the Arabidopsis genome, these four indexing states typically translate into short chromatin domains interspersed with each other. This first combinatorial view of the Arabidopsis epigenome points to simple principles of organization as in metazoans and provides a framework for further studies of chromatin‐based regulatory mechanisms in plants.
This first comprehensive view of the Arabidopsis epigenome reveals that it is organized into four main chromatin types based on the integrative mapping of a broad set of 11 histone marks and DNA methylation in seedlings.
The High-Altitude Water Cherenkov (HAWC) observatory is a second-generation continuously operated, wide field-of-view, TeV gamma-ray observatory. The HAWC observatory and its analysis techniques ...build on experience of the Milagro experiment in using ground-based water Cherenkov detectors for gamma-ray astronomy. HAWC is located on the Sierra Negra volcano in México at an elevation of 4100 meters above sea level. The completed HAWC observatory principal detector (HAWC) consists of 300 closely spaced water Cherenkov detectors, each equipped with four photomultiplier tubes to provide timing and charge information to reconstruct the extensive air shower energy and arrival direction. The HAWC observatory has been optimized to observe transient and steady emission from sources of gamma rays within an energy range from several hundred GeV to several hundred TeV. However, most of the air showers detected are initiated by cosmic rays, allowing studies of cosmic rays also to be performed. This paper describes the characteristics of the HAWC main array and its hardware.
The close location of the HAWC observatory to the largest volcano in Mexico allows to perform a search for neutrino-induced horizontal muon and tau charged leptons. The section of the volcano located ...at the horizon reaches values of slant depth larger than 8 km of rock, making it an excellent shield for the cosmic ray horizontal background. We report the search method and background suppression technique developed for the detection of Earth-skimming neutrinos with HAWC, as well as a model that describes the remaining background produced by scattered muons. We show that by increasing the detection energy threshold we could use HAWC to search for neutrino-induced charged leptons.
We present new measurements of heavy cosmic-ray nuclei at high energies performed during the first flight of the balloon-borne cosmic-ray experiment Cosmic-Ray Energetics and Mass (CREAM). This ...instrument uses multiple charge detectors and a transition radiation detector to provide the first high accuracy measurements of the relative abundances of elements from boron to oxygen up to energies around 1
TeV/n. The data agree with previous measurements at lower energies and show a relatively steep decline (∼
E
−0.6 to
E
−0.5) at high energies. They further show the source abundance of nitrogen relative to oxygen is ∼10% in the TeV/n region.
Since summer 2021, the Radio Neutrino Observatory in Greenland (RNO-G) is searching for astrophysical neutrinos at energies
>
10
PeV by detecting the radio emission from particle showers in the ice ...around Summit Station, Greenland. We present an extensive simulation study that shows how RNO-G will be able to measure the energy of such particle cascades, which will in turn be used to estimate the energy of the incoming neutrino that caused them. The location of the neutrino interaction is determined using the differences in arrival times between channels and the electric field of the radio signal is reconstructed using a novel approach based on Information Field Theory. Based on these properties, the shower energy can be estimated. We show that this method can achieve an uncertainty of 13% on the logarithm of the shower energy after modest quality cuts and estimate how this can constrain the energy of the neutrino. The method presented in this paper is applicable to all similar radio neutrino detectors, such as the proposed radio array of IceCube-Gen2.
The High Altitude Water Cherenkov (HAWC) Gamma-Ray Observatory continuously detects TeV photons and particles within its large field of view, accumulating every day a deeper exposure of two-thirds of ...the sky. We analyzed 1523 days of HAWC live data acquired over four and a half years, in a follow-up analysis of 138 nearby (z < 0.3) active galactic nuclei from the Third Catalog of Hard Fermi-LAT sources culminating within 40° of the zenith at Sierra Negra, the HAWC site. This search for persistent TeV emission used a maximum-likelihood analysis assuming intrinsic power-law spectra attenuated by pair production of gamma-ray photons with the extragalactic background light. HAWC clearly detects persistent emission from Mkn 421 and Mkn 501, the two brightest blazars in the TeV sky, at 65 and 17 level, respectively. Marginal evidence, just above the 3 level, was found for three other known very high-energy emitters: the radio galaxy M87 and the BL Lac objects VER J0521+211 and 1ES 1215+303, the latter two at z ∼ 0.1. We find a 4.2 evidence for collective emission from the set of 30 previously reported very high-energy sources, with Mkn 421 and Mkn 501 excluded. Upper limits are presented for the sample under the power-law assumption and in the predefined (0.5-2.0), (2.0-8.0), and (8.0-32.0) TeV energy intervals.
Abstract
We report TeV gamma-ray observations of the ultra-high-energy source MGRO J1908+06 using data from the High Altitude Water Cherenkov Observatory. This source is one of the highest-energy ...known gamma-ray sources, with emission extending past 200 TeV. Modeling suggests that the bulk of the TeV gamma-ray emission is leptonic in nature, driven by the energetic radio-faint pulsar PSR J1907+0602. Depending on what assumptions are included in the model, a hadronic component may also be allowed. Using the results of the modeling, we discuss implications for detection prospects by multi-messenger campaigns.
The cosmic-ray energetics and mass (CREAM) investigation is designed to measure cosmic-ray composition to the supernova energy scale of 10
15 eV in a series of ultra long duration balloon (ULDB) ...flights. The first flight is planned to be launched from Antarctica in December 2004. The goal is to observe cosmic-ray spectral features and/or abundance changes that might signify a limit to supernova acceleration. The particle charge (
Z) measurements will be made with a timing-based charge detector and a pixelated silicon charge detector to minimize the effect of backscatter from the calorimeter. The particle energy measurements will be made with a transition radiation detector (TRD) for
Z>3 and a sampling tungsten/scintillator calorimeter for
Z⩾1 particles, allowing inflight cross calibration of the two detectors. The status of the payload construction and flight preparation are reported in this paper.
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