BACKGROUNDCentral neurogenic hyperventilation (CNH) is increasingly reported in conscious patients with a CNS neoplasm. We aimed to synthesize the available data on the treatment of this condition to ...guide clinicians in their approach. METHODSWe describe the case of a 39-year-old conscious woman with CNH secondary to glioma brainstem infiltration for whom hyperventilation was aborted with hydromorphone, dexamethasone, and brainstem radiotherapy. We then performed a review of the literature on the treatment of CNH in conscious patients due to a CNS neoplasm. RESULTSA total of 31 studies reporting 33 cases fulfilled the selection criteria. The underlying neoplasm was lymphoma in 15 (45%) and glioma in 13 (39%) patients. Overall, CNH was aborted in 70% of cases. Opioids and sedatives overall seemed useful for symptom relief, but the benefit was often of short duration when the medication was administered orally or subcutaneously. Methadone and fentanyl were successful but rarely used. Chemotherapy was most effective in patients with lymphoma (89%), but not glioma (0%) or other neoplasms (0%). Patients with lymphoma (80%) and other tumors (100%) responded to radiotherapy more frequently than patients with glioma (43%). Corticosteroids were moderately effective. Subtotal surgical resection was successful in the 3 cases for which it was attempted. CONCLUSIONDefinitive treatment of the underlying neoplasm may be more successful in aborting hyperventilation. Variable rates of palliation have been observed with opioids and sedatives. Treatment of CNH is challenging but successful in a majority of cases.
Résumé Personne ne peut nier la trace indélébile que les technologies de l’information (TI) ont laissée sur l’organisation. Dans cet article de ce numéro spécial, les professeurs du Service de ...l’enseignement des technologies de l’information de HEC Montréal font le point sur l’introduction des TI dans l’organisation et sur les bouleversements qu’elles ont ensuite provoqués. Selon leurs propres points de vue et centres d’intérêt, ils y abordent les jalons importants de cette histoire : les événements marquants (comme l’introduction des ordinateurs au sein de l’organisation), les phénomènes qui nous accompagnent depuis plusieurs années et qui sont encore brûlants d’actualité (comme l’implantation ou la gestion de projets TI) et les courants qui sont apparus depuis quelques années, mais dont le potentiel reste encore à exploiter (par exemple, la gestion de la connaissance et l’intelligence d’affaires). Cette analyse montre bien l’éventail, la richesse et la complexité des facteurs à considérer lorsque l’organisation veut exploiter le potentiel des technologies de l’information.
In this paper, we present SimSo, a simulator that aims at facilitating the design of experimental evaluations for real-time scheduling algorithms. Currently, more than twentyfive algorithms were ...implemented. Special attention is paid to the execution time model of tasks. We show that the worst-case execution time for experimental simulation can introduce a bias in evaluation and we discuss as a work in progress how cache effects could be taken into consideration in the simulation.
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