Among the writers of the Syriac Christian tradition, none is as renowned as St. Ephrem of Nisibis (ca. 307–373), known to much of the later Christian world simply as “the Syrian.” The great majority ...of Ephrem’s works are poetry, with the madrāšē (“teaching songs”) especially prominent.
This volume presents English translations of four complete madrāšē cycles of Ephrem: On the Fast, On the Unleavened Bread, On the Crucifixion , and On the Resurrection . These collections include some of the most liturgically oriented songs in Ephrem’s corpus, and, as such, provide a window into the celebration of Lent and Easter in the Syriac-speaking churches of northern Mesopotamia in the fourth century. Even more significantly, they represent some of the oldest surviving poetry composed for these liturgical seasons in the entire Christian tradition. Not only are the liturgical occasions of the springtime months a source of colorful imagery in these texts, but Ephrem also employs traditional motifs of warm weather, spring rainstorms, and revived vegetation, which likely reflect Hellenistic literary influences.
Like all of Ephrem’s poetry, these songs express early Christian theology in language that is symbolic, terse, and vibrant. They are rich with biblical allusions and references, especially to the Exodus and Passion narratives. They also reveal a contested religious environment in which Ephrem strove to promote the Christian Pascha and Christian interpretations of Scripture over and against those of Jewish communities in the region, thus maintaining firm boundaries around the identity and practices of the churches.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when ...administered early. However, SARS-CoV-2 variants of concern (VOCs) have negatively affected therapeutic use of some authorized mAbs. Using a high-throughput B cell screening pipeline, we isolated LY-CoV1404 (bebtelovimab), a highly potent SARS-CoV-2 spike glycoprotein receptor binding domain (RBD)-specific antibody. LY-CoV1404 potently neutralizes authentic SARS-CoV-2, B.1.1.7, B.1.351, and B.1.617.2. In pseudovirus neutralization studies, LY-CoV1404 potently neutralizes variants, including B.1.1.7, B.1.351, B.1.617.2, B.1.427/B.1.429, P.1, B.1.526, B.1.1.529, and the BA.2 subvariant. Structural analysis reveals that the contact residues of the LY-CoV1404 epitope are highly conserved, except for N439 and N501. The binding and neutralizing activity of LY-CoV1404 is unaffected by the most common mutations at these positions (N439K and N501Y). The broad and potent neutralization activity and the relatively conserved epitope suggest that LY-CoV1404 has the potential to be an effective therapeutic agent to treat all known variants.
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•LY-CoV1404 potently neutralizes SARS-CoV-2 Omicron, BA.2 Omicron, and Delta variants•No loss of potency against currently circulating variants•Binding epitope on RBD of SARS-CoV-2 is rarely mutated based on current GISAID data•Breadth of neutralizing activity and potency supports clinical development
Westendorf et al. show that LY-CoV1404 is a potent SARS-CoV-2-binding antibody that neutralizes all known variants of concern and that its epitope is rarely mutated.
