A novel Schiff base ligand HL·CH3COOH with excited-state intramolecular proton transfer (ESIPT) and its zinc (Ⅱ) complex 1 were successfully synthesized, and both of them show high-contrast mechano- ...and acidochromic luminescence.
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A new Schiff base compound (HL·CH3COOH) with D-A structure and its zinc(II) complex (1) were successfully obtained. Due to the introduction of diethylamino and rotatable aromatic rings, both HL·CH3COOH and the complex adopt loosely packing patterns. HL·CH3COOH exhibits keto-form emission due to the excited-state intramolecular proton transfer (ESIPT) process, while complex 1 shows enol-form emission. They all show reversible mechanochromic luminescence (MCL) behavior, which is caused by the phase transformation from crystalline state to amorphous state revealed by Powder X-ray diffraction (PXRD) studies, and is accompanied by the departure of CH3COOH molecules for HL·CH3COOH. HL·CH3COOH and complex 1 can be protonated under the fumigation of HCl, resulting in the acidochromic properties, accompanied with the phase transformation. HCl also destroyed the interactions between CH3COOH and Schiff base molecules, leading to the departure of acetic acid molecules. More interestingly, HL·CH3COOH also exhibited NH3-stimuli response properties due to the prohibition of the ESIPT process.
Background:
The impact of obstructive sleep apnea (OSA) on subsequent cardiovascular events in patients with acute coronary syndrome (ACS) remains inconclusive.
Aim:
Our aim was to systematically ...assess the relationship between preexisting OSA and adverse cardiovascular events in patients with newly diagnosed ACS by conducting a systematic review and meta-analysis.
Methods:
We systematically searched PubMed, EMBASE, and Cochrane library for studies published up to May 1, 2020, that reported any association between OSA and cardiovascular events in patients with newly diagnosed ACS. The main outcomes were a composite of all-cause or cardiovascular death, recurrent myocardial infarction, stroke, repeat revascularization, or heart failure. We conducted a pooled analysis using the random-effects model. We also performed subgroup, sensitivity, heterogeneity analysis, and the assessment of publication bias.
Results:
We identified 10 studies encompassing 3350 participants. The presence of OSA was associated with increased risk of adverse cardiovascular events in newly prognosed ACS (risk ratio RR 2.18, 95% confidence interval CI: 1.45-3.26, P < .001, I2 = 64%). Between-study heterogeneity was partially explained by a multicenter study (9 single-center studies, RR 2.33 95% CI 1.69-3.19, I2 =18%), and I2 remarkably decreased from 64% to 18%. Moreover, OSA significantly increased the incidence of repeat revascularization (8 studies) and heart failure (6 studies) in patients with newly diagnosed ACS.
Conclusion:
Patients with preexisting OSA are at greater risk of subsequent cardiovascular events after onset of ACS. Further studies should investigate the treatment of OSA in patient with ACS.
Splenomegaly and pancytopenia are common in Wilson's disease (WD) and splenectomy is one of the conventional treatments for splenomegaly and the associated pancytopenia. However, splenectomy remained ...controversial for hypersplenism in WD as it was reported that splenectomy leaded to serious emotional and neurological deterioration in WD patients with hypersplenism. In the current study, we present our experiences in 70 WD patients with hypersplenism who had undergone splenectomy, outlining the safety and efficacy of splenectomy in WD. The clinical database of 70 WD patients with hypersplenism who had undergone splenectomy in our hospital between 2009 and 2013 were reviewed and followed-up regularly. Before splenectomy, all the patients accepted a short period of anti-copper treatment with intravenous sodium 2, 3-dimercapto-1-propane sulfonate (DMPS). All the patients demonstrated a marked improvement in platelet and leucocyte counts after splenectomy. No severe postoperative complication was observed. In particular, none of the 37 patients with mixed neurologic and hepatic presentations experienced neurological deterioration after splenectomy, and none of the patients with only hepatic presentations newly developed neurological symptoms. During the one year follow-up period, no patient presented hepatic failure or hepatic encephalopathy, no hepatic patient newly developed neurological presentations, and only 3 patients with mixed neurologic and hepatic presentations suffered neurological deterioration and these 3 patients had poor compliance of anti-copper treatment. Quantative analysis of the neurological symptoms in the 37 patients using the Unified Wilson's Disease Rating Scale (UWDRS) showed that the neurological symptoms were not changed in a short-term of one week after splenectomy but significantly improved in a long-term of one year after splenectomy. Additionally, compared to that before splenectomy, the esophageal gastric varices in most patients significantly improved one year after splenectomy. Thus, we may conclude that splenectomy is a safe and effective therapeutic measure for hypersplenism in WD patients who had been preoperatively treated with DMPS for powerful anti-copper therapy.
We aimed to investigate the correlation of homocysteine (Hcy) level with clinical characteristics, and explore its predictive value for major adverse cardiovascular events (MACE) risk in female ...patients with premature acute coronary syndrome (ACS).The serum Hcy level was detected from 1299 female patients with premature ACS. According to the tertile of Hcy level, patients were divided into 3 groups: lowest tertile group (≤9.1 μmol/L), middle tertile group (9.2-11.6 μmol/L) and highest tertile group (>11.6 μmol/L). MACE incidence was recorded and MACE-free survival was caculated with the median follow-up duration of 28.3 months.Increased Hcy correlated with older age (P < .001), higher creatinine level (P < .001), and enhanced uric acid level (P = .001), while reduced fasting glucose concentration (P < .001). MACE incidence was 10.7% and it was highest in highest tertile group (22.1%), followed by middle tertile group (7.7%) and lowest tertile group (2.4%) (P < .001). Receiver operating characteristic curve showed that Hcy distinguished MACE patients from non-MACE patients with the area under the curve of 0.789 (95% CI: 0.742-0.835). Kaplan-Meier curves revealed that MACE-free survival was shortest in Hcy highest tertile group, followed by middle tertile group and lowest tertile group (P < .001). Multivariate Cox analyses further showed that higher Hcy level was an independent predictive factor for poor MACE-free survival (middle tertile vs lowest tertile (P = .001, HR: 3.615, 95% CI: 1.661-7.864); highest tertile vs lowest tertile (P < .001, HR: 11.023, 95% CI: 5.356-22.684)).Hcy serves as a potential predictive factor for increased MACE risk in female patients with premature ACS.
We demonstrate here that the nanostructure of poly(3-hexylthiophene) and 6,6-phenyl-C61-butyric acid methyl ester (P3HT/PCBM) bulk heterojunction (BHJ) can be tuned by inorganic nanoparticles (INPs) ...for enhanced solar cell performance. The self-organized nanostructural evolution of P3HT/PCBM/INPs thin films was investigated by using simultaneous grazing-incidence small-angle X-ray scattering (GISAXS) and grazing-incidence wide-angle X-ray scattering (GIWAXS) technique. Including INPs into P3HT/PCBM leads to (1) diffusion of PCBM molecules into aggregated PCBM clusters and (2) formation of interpenetrating networks that contain INPs which interact with amorphous P3HT polymer chains that are intercalated with PCBM molecules. Both of the nanostructures provide efficient pathways for free electron transport. The distinctive INP-tuned nanostructures are thermally stable and exhibit significantly enhanced electron mobility, external quantum efficiency, and photovoltaic device performance. These gains over conventional P3HT/PCBM directly result from newly demonstrated nanostructure. This work provides an attractive strategy for manipulating the phase-separated BHJ layers and also increases insight into nanostructural evolution when INPs are incorporated into BHJs.
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•Allulose mitigates lysosomal dysfunction in damaged colon cells.•Negative correction of allulose contents is observed in IBD patients.•Allulose mitigates the breakdown of epithelial ...tight junctions.
Metabolic changes have been linked to the development of inflammatory bowel disease (IBD), which includes colitis. Allulose, an endogenous bioactive monosaccharide, is vital to the synthesis of numerous compounds and metabolic processes within living organisms. Nevertheless, the precise biochemical mechanism by which allulose inhibits colitis remains unknown. Allulose is an essential and intrinsic protector of the intestinal mucosal barrier, as it maintains the integrity of tight junctions in the intestines, according to the current research. It is also important to know that there is a link between the severity of inflammatory bowel disease (IBD) and colorectal cancer (CRC), chemically-induced colitis in rodents, and lower levels of allulose in the blood. Mice with colitis, either caused by dextran sodium sulphate (DSS) or naturally occurring colitis in IL-10-/- mice, had less damage to their intestinal mucosa after being given allulose. Giving allulose to a colitis model starts a chain of reactions because it stops cathepsin B from ejecting and helps lysosomes stick together. This system effectively stops the activity of myosin light chain kinase (MLCK) when intestinal epithelial damage happens. This stops the breakdown of tight junction integrity and the start of mitochondrial dysfunction. To summarise, the study's findings have presented data that supports the advantageous impact of allulose in reducing the advancement of colitis. Its ability to stop the disruption of the intestinal barrier enables this. Therefore, allulose has potential as a medicinal supplement for treating colitis.
Multifunctional stimuli-responsive materials with room-temperature phosphorescence (RTP) has been demonstrated to be one of the most important members of the stimuli-responsive material family and ...their development remains a great challenge at this stage. Herein, we successfully synthesized two coordination polymers (CPs), formulated as {M(cbbpy)(HBTC)(H
2
O)·2H
2
O}
n
(M = Zn (
1
) and Cd (
2
)), using a viologen ligand 1-(3-carboxybenzyl)-4,4′-bipyridinium chloride (Hcbbpy) and trimesic acid (H
3
BTC) by tuning different metal ions. Complexes
1
and
2
show excellent chromic behavior in response to X-ray and UV light. In particular, complex
1
exhibits thermochromism. Moreover, complexes
1
and
2
exhibit dual fluorescence and RTP emissions in the solid state, emitting yellow afterglow of 1.5 s and 1 s at room temperature (297 K) and cyan afterglow of 6.5 s and 5 s at a low temperature (77 K), respectively, when turning off the UV lamp. A hypothetical mechanism is proposed
via
theoretical calculations that the fluorescence corresponds to the transfer of electrons from the viologen-based moiety to O1 and O2 of complexes. And the phosphorescence corresponds to the intersystem crossing (ISC) process with electrons being transferred from the viologen moiety through the metal atom to the carboxyl group of trimesic acid in an excited triplet state and then transition back to the ground state. In addition, multiple encryption and
anti
-counterfeiting were successfully designed through photochromism, fluorescence and RTP of these complexes. This work not only provides a new strategy for the design and synthesis of multifunctional materials, but also develops a new dynamic photo-controlled afterglow switching.
A new strategy for the synthesis of multifunctional stimuli-responsive room-temperature phosphorescent materials and their application in multiple dynamic encryption was reported.
Actin cytoskeleton dynamic rearrangement is required for tumor cell metastasis and is a key characteristic of
(
)-infected host cells. Actin cytoskeleton modulation is coordinated by multiple ...actin-binding proteins (ABP). Through Kyoto encyclopedia of gene and genomes database, GEPIA website, and real-time PCR data, we found that
infection significantly induced L-plastin, a key ABP, in gastric cancer cells. We further explored the regulation and function of L-plastin in
-associated gastric cancer and found that, mechanistically,
infection induced gastric cancer cells to express L-plastin via
-activated ERK signaling pathway to mediate SP1 binding to L-plastin promoter. Moreover, this increased L-plastin promoted gastric cancer cell proliferation and migration
and facilitated the growth and metastasis of gastric cancer
. Finally, we detected the expression pattern of L-plastin in gastric cancer tissues, and found that L-plastin was increased in gastric cancer tissues and that this increase of L-plastin positively correlated with
infection status. Overall, our results elucidate a novel mechanism of L-plastin expression induced by
, and a new function of L-plastin-facilitated growth and metastasis of gastric cancer, and thereby implicating L-plastin as a potential therapeutic target against gastric cancer. IMPLICATIONS: Our results elucidate a novel mechanism of L-plastin expression induced by
in gastric cancer, and a new function of L-plastin-facilitated gastric cancer growth and metastasis, implicating L-plastin as a potential therapeutic target against gastric cancer.
•PHPG is applied as a novel nanoscale initiator for hydrocarbon fuels.•Decomposition of PHPG starts above 200°C.•The cracking conversion and the heat sink of fuels are promoted in the presence of ...PHPG.
One of hyperbranched polymers is developed as a novel nanoscale initiator to enhance the heat sink of endothermic hydrocarbon fuels to meet the great cooling requirement of hypersonic aircrafts. In this work, the hyperbranched polyglycerol (HPG) is treated with palmitoyl chloride to obtain a fuel-soluble product, palmitoyl-hyperbranched polyglycerol (PHPG). The thermogravimetric analyses show that the long-alkyl chains rupture first from the matrix at about 200°C, and then the HPG core breaks around 400°C during the cracking of PHPG, which indicates a high decomposition temperature for this “macroinitiator”. The cracking processes of n-tridecane with PHPG in different molecular weights and addition quantities are performed in an electrically heated tube reactor under supercritical conditions (3.5MPa, and 600–720°C). PHPG can promote the cracking of n-tridecane with significant improvements of the conversion and heat sink. The conversion of n-tridecane is improved as high as 17.6% at 690°C, and the corresponding heat sink is improved from 3.0MJ/kg to 3.5MJ/kg. Furthermore, the optimum addition quantity and molecular weight range of PHPG are chosen for the practical application to an aviation kerosene under 600–700°C, and the increases of heat sink in comparison with those from the thermal cracking confirm the potential application of PHPG to endothermic hydrocarbon fuels.
The effect of Fe(III) on Cr(VI) reduction by organic reducing substances in sugarcane molasses was investigated under different conditions i.e., Fe(III) concentration, pH, and temperature using batch ...experiments. Results indicated that Fe(III) can accelerate Cr(VI) reduction by sugarcane molasses over a wide pH range. The catalytic mechanism of the reaction involved the formation of organic reducing substance complexes with both Fe(III) and Cr(VI) that decrease the reaction activation energy of Cr(VI) reduction and accelerate electron transfer between Cr(VI) and organic reducing substances. The reaction could be described by a pseudo-first-order kinetic model with respect to Cr(VI) concentration. Increasing the Fe(III) concentration could promote Cr(VI) reduction. At pH 2.5, 3.0, 3.5, 4.0, 5.6, and 8.0, the initial reaction rates (vᵢₙᵢₜᵢₐₗ) increased by 0.68, 0.84, 1.38, 1.39, 0.89, and 0.29 times, respectively, in the presence of Fe(III) compared with those obtained without Fe(III). The vᵢₙᵢₜᵢₐₗ increased by 0.87 times in the presence of Fe(III) compared with that without Fe(III) at 10 °C (pH 2.5).
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