First-line immunotherapy in non-small-cell lung cancer largely improved patients’ survival. PD-L1 testing is required before immune checkpoint inhibitor initiation. However, this biomarker fails to ...accurately predict patients’ response. On the other hand, immunotherapy exposes patients to immune-related toxicity, the mechanisms of which are still unclear. Hence, there is an unmet need to develop clinically approved predictive biomarkers to better select patients who will benefit the most from immune checkpoint inhibitors and improve risk management. Single-cell technologies provide unprecedented insight into the tumor and its microenvironment, leading to the discovery of immune cells involved in immune checkpoint inhibitor response or toxicity. In this review, we will underscore the potential of the single-cell approach to identify candidate biomarkers improving non-small-cell lung cancer patients’ care.
The XENON100 dark matter experiment Aprile, E.; Arisaka, K.; Arneodo, F. ...
Astroparticle physics,
April 2012, 2012-4-00, 20120401, Letnik:
35, Številka:
9
Journal Article
Recenzirano
Odprti dostop
► XENON100 is currently one of the most sensitive experiments to detect WIMP dark matter. ► Detector design and active/passive shielding reduce the radioactive background level. ► The event vertex of ...an interaction is reconstructed with a few mm precision. ► All position dependent signal corrections are presented in the paper. ► An energy scale exploiting the light-charge anti-correlation leads to an energy resolution competitive with NaI(Tl) crystals.
The XENON100 dark matter experiment uses liquid xenon (LXe) in a time projection chamber (TPC) to search for xenon nuclear recoils resulting from the scattering of dark matter Weakly Interacting Massive Particles (WIMPs). In this paper we present a detailed description of the detector design and present performance results, as established during the commissioning phase and during the first science runs.
The active target of XENON100 contains 62kg of LXe, surrounded by an LXe veto of 99kg, both instrumented with photomultiplier tubes (PMTs) operating inside the liquid or in xenon gas. The LXe target and veto are contained in a low-radioactivity stainless steel vessel, embedded in a passive radiation shield and is installed underground at the Laboratori Nazionali del Gran Sasso (LNGS), Italy. The experiment has recently published results from a 100 live-days dark matter search. The ultimate design goal of XENON100 is to achieve a spin-independent WIMP-nucleon scattering cross section sensitivity of σ=2×10−45cm2 for a 100GeV/c2 WIMP.
A 7-year-old neutered female Doberman pinscher was presented with a palpebral nodule on the haired eyelid of the left eye. The nodule was removed surgically. Microscopically, the nodule was ...consistent with eyelid melanocytoma. The tumour was characterized by the presence of numerous lacunar and slit-like spaces filled by erythrocytes and interspersed throughout the neoplastic melanocytes. Immunohistochemically, these spaces were lined by cells expressing PNL2 and factor VIII, but the cells were negative for CD31. These findings were consistent with neoplastic melanocytes without endothelial cell participation. This feature was interpreted as ‘vasculogenic mimicry’, a mechanism of tumour angiogenesis that is well-recognized in human melanomas, but has not yet been reported in melanomas in animals.
► Material selection based on their intrinsic radioactive contaminations is crucial for low background experiments. ► We present detailed results from the material screening and selection campaign ...for the XENON100 dark matter experiment. ► The measurements were performed using low background gamma-ray spectrometry and mass spectrometry.
Results of the extensive radioactivity screening campaign to identify materials for the construction of XENON100 are reported. This dark matter search experiment is operated underground at Laboratori Nazionali del Gran Sasso (LNGS), Italy. Several ultra sensitive High Purity Germanium detectors (HPGe) have been used for gamma ray spectrometry. Mass spectrometry has been applied for a few low mass plastic samples. Detailed tables with the radioactive contaminations of all screened samples are presented, together with the implications for XENON100.
The XENON100 experiment, situated in the Laboratori Nazionali del Gran Sasso, aims at the direct detection of dark matter in the form of weakly interacting massive particles (WIMPs), based on their ...interactions with xenon nuclei in an ultra low background dual-phase time projection chamber. This paper describes the general methods developed for the analysis of the XENON100 data. These methods have been used in the 100.9 and 224.6 live days science runs from which results on spin-independent elastic, spin-dependent elastic and inelastic WIMP-nucleon cross-sections have already been reported.
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