The surface Resistive Plate Counter (sRPC) is a revolutionary RPC based on surface resistive electrodes realized with Diamond-Like-Carbon sputtered on Apical® foil. Exploiting high granularity ...current evacuation schemes developed for resistive MPGD and using electrodes with low surface resistivity (down to ∼100MΩ/□), sRPCs standing particle fluxes up to several hundreds kHz/cm2 should be easily developed. The scalability of the technology allows the construction of detectors for large area applications at future high luminosity colliders.
Background
Novel hormonal therapies have been recently investigated in non-metastatic castration-resistant prostate cancer (CRPC). We performed a meta-analysis to assess the efficacy and safety of ...novel hormonal therapies in non-metastatic CRPC.
Materials and methods
The primary outcome was metastasis-free survival (MFS). The secondary endpoints were overall survival (OS), time to PSA progression and safety. We planned a subgroup analysis according to the PSA doubling time (> 6 vs < 6 months), Eastern Cooperative Oncology Group (ECOG) performance status (1 vs 0) and concomitant use of bone-targeting agent (yes vs no).
Results
Pooled analysis of novel hormonal therapies revealed significantly increased MFS compared with placebo (hazard ratio (HR): HR = 0.32, 95% CI 0.25–0.41;
p
< 0.00001). The subgroup analysis showed a statistically significant MFS advantage in favour of men with the lower ECOG performance status. Other secondary endpoints favoured the novel hormonal therapies. The relative risk (RR) of grade ≥ 3 adverse events and ≥ 3 hypertension was 1.31 and 1.39, respectively.
Conclusions
This study confirmed the efficacy and safety of the novel hormonal therapies in non-metastatic CRPC.
The nature of quantum waves, whether they are real physical waves or, on the contrary, mere probability waves, has been a very controversial theme since the beginning of quantum theory. Here we ...present some possible experiments that may clarify the problem.
The surface Resistive Plate Counter (sRPC) is a new RPC based on surface resistive electrodes realized with Diamond-Like-Carbon (DLC) sputtered on Apical\protect \relax \special {t4ht=®} foil. ...Exploiting the high rate resistive MPGD technology, detectors able to stand several tens of kHz/cm2 can be easily developed. The scalability of the technology allows the construction of detectors for large area applications at future high luminosity colliders.
Performance of μ-RWELL detector vs resistivity of the resistive stage Bencivenni, G.; De Oliveira, R.; Felici, G. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2018, Letnik:
886
Journal Article
Recenzirano
Odprti dostop
The μ-RWELL is a compact spark-protected single amplification stage Micro-Pattern-Gaseous-Detector (MPGD). The detector amplification stage is realized with a polyimide structure, micro-patterned ...with a dense matrix of blind-holes, integrated into the readout structure. The anode is formed by a thin Diamond Like Carbon (DLC) resistive layer separated by an insulating glue layer from the readout strips. The introduction of the resistive layer strongly suppressing the transition from streamer to spark gives the possibility to achieve large gains (> 104), without significantly affecting the capability to be efficiently operated in high particle fluxes. In this work we present the results of a systematic study of the μ-RWELL performance as a function of the DLC resistivity. The tests have been performed either with collimated 5.9 keV X-rays or with pion and muon beams at the SPS Secondary Beamline H4 and H8 at CERN.
High space resolution μ-RWELL for high particle rate Bencivenni, G.; De Oliveira, R.; Felici, G. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2020, Letnik:
958
Journal Article
Recenzirano
Odprti dostop
The μ-RWELL is a single-amplification stage resistive MPGD. The amplification element, realized on a polyimide foil micro-patterned with a high density blind-holes (wells), is embedded through a thin ...resistive film, in the readout PCB. The introduction of the resistive layer affects the charge spread on the readout electrodes and suppresses the transition from streamer to spark giving the possibility to achieve large gains (>104). As a drawback the capability to stand high particle fluxes is reduced. In order to get rid of such a limitation different resistive layouts with prompt current evacuation schemes have been designed. In this work we present the study of the performance of the high rate layouts done at PSI, together with the measurement of the space resolution for orthogonal and inclined tracks performed at CERN.
The μ-RWELL is a new generation Micro-Pattern Gaseous Detector, composed of two elements: the cathode and the μ-RWELL_PCB including the amplification stage, realized with a polyimide structure ...micro-patterned with a blind-hole matrix, embedded through a Diamond-Like Carbon (DLC) resistive layer with the readout PCB. Different layouts of the resistive stage have been studied: the simplest one is based on a single DLC layer with edge grounding, suitable for low rate applications (30–40 kHz/cm2). More sophisticated schemes are under study for high-rate purposes (up to 2–3 MHz/cm2) in order to optimize the performance and the constructive process. For the phase-2 upgrade of the LHCb muon detector the experiment is targeting a luminosity of 2×1034 cm−2 s−1, with strong requirements on the robustness and detection efficiency of the muon system. We report on the ongoing R&D, showing also the latest measured performances of the new high-rate versions of the detector.
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