Neurogenesis occurs in the olfactory system of the adult brain throughout life, in both invertebrates and vertebrates, but its physiological regulation is not understood. We show that the production ...of neuronal progenitors is stimulated in the forebrain subventricular zone of female mice during pregnancy and that this effect is mediated by the hormone prolactin. The progenitors then migrate to produce new olfactory interneurons, a process likely to be important for maternal behavior, because olfactory discrimination is critical for recognition and rearing of offspring. Neurogenesis occurs even in females that mate with sterile males. These findings imply that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy.
Abstract
We present a new pipeline based on the Support Vector Machine algorithm to confirm the detection and perform classification of small solar system objects by serendipitous stellar ...occultations. This pipeline is designed to analyze light curves and to identify the occultation events and the classification of the occulting bodies according to their size, typically from a fraction to a few kilometers, and their distance from the Sun, typically a few tens of astronomical units. The input light curves for this pipeline were obtained from the event simulator for the Trans-Neptunian Automated Occultation Survey (TAOS II). We explore parameters affecting occultation light curves such as spectral type, apparent magnitude and finite angular size of the occulted star, angle from opposition, and readout cadence for the observations; also we assumed a Poisson noise distribution as expected from the TAOS II project. We find that occultation events, especially by trans-Neptunian objects with diameters ≥2 km are detected with 99.99%, 99.53%, and 86% efficiency for stars with a visual apparent magnitude of 12, 14, and 16, respectively at 0.05 s of exposure time. In terms of size and distance classification the overall accuracy is 94%. However, for smaller objects the confirmation and classification depends mostly upon the signal-to-noise ratio.
We present a new occultation event simulator for the Trans-Neptunian Automated Occultation Survey (TAOS II). We have developed a method to compute occultation shadows by small objects with ...non-circular apparent shapes (as may result from an intrinsic morphology or from the projection of a contact binary). The new simulator calculates diffraction features in the occultation shadows, as well as resulting light curves as would be measured by the TAOS II survey system. We include effects such as the spectral type and finite angular size of the occulted star. We find that occultation events, especially by Trans-Neptunian Objects with diameters ∼3 km may be misidentified or mischaracterized when not taking non-spherical shapes into account.
In the solar system, the planets' compositions vary with orbital distance, with rocky planets in close orbits and lower-density gas giants in wider orbits. The detection of close-in giant planets ...around other stars was the first clue that this pattern is not universal and that planets' orbits can change substantially after their formation. Here, we report another violation of the orbit-composition pattern: two planets orbiting the same star with orbital distances differing by only 10% and densities differing by a factor of 8. One planet is likely a rocky "super-Earth," whereas the other is more akin to Neptune. These planets are 20 times more closely spaced and have a larger density contrast than any adjacent pair of planets in the solar system.
Feral cats (Felis catus) have devastated wildlife globally. In Australia, feral cats are implicated in most recent mammal extinctions and continue to threaten native species. Cat control is a ...high-profile priority for Australian policy, research and management. To develop the evidence-base to support this priority, we first review information on cat presence/absence on Australian islands and mainland cat-proof exclosures, finding that cats occur across >99.8% of Australia's land area. Next, we collate 91 site-based feral cat density estimates in Australia and examine the influence of environmental and geographic influences on density. We extrapolate from this analysis to estimate that the feral cat population in natural environments fluctuates between 1.4 million (95% confidence interval: 1.0–2.3 million) after continent-wide droughts, to 5.6 million (95% CI: 2.5–11 million) after extensive wet periods. We estimate another 0.7 million feral cats occur in Australia's highly modified environments (urban areas, rubbish dumps, intensive farms). Feral cat densities are higher on small islands than the mainland, but similar inside and outside conservation land. Mainland cats reach highest densities in arid/semi-arid areas after wet periods. Regional variation in cat densities corresponds closely with attrition rates for native mammal fauna. The overall population estimate for Australia's feral cats (in natural and highly modified environments), fluctuating between 2.1 and 6.3 million, is lower than previous estimates, and Australian feral cat densities are lower than reported for North America and Europe. Nevertheless, cats inflict severe impacts on Australian fauna, reflecting the sensitivity of Australia's native species to cats and reinforcing that policy, research and management to reduce their impacts is critical.
•A collation of 91 studies was used to estimate Australia's feral cat population.•Feral cats are present on >>99.8% of Australia's land area.•Feral cat numbers in Australia fluctuate (2.1–6.3 million) with antecedent rainfall.•Feral cat density is higher on small islands, and in arid/semi-arid areas after rain.•Feral cat impacts on Australian biodiversity have been particularly severe.
The population size of feral cats in natural environments in Australia fluctuates between 1.4 and 5.6 million, depending on rainfall. An additional 0.7 million feral cats live in heavily modified environments like towns and intensive farms. The maps show the model predictions for cat density in natural environments across Australia during dry-average rainfall conditions (on the left) and after extensive rainfall events (on the right). They show that cat density is fairly uniform across the continent during average-dry conditions, but extensive rainfall events cause an increase in feral cat density in the inland of Australia. As predictors, the regression model includes mean annual rainfall, mean annual temperature, tree cover, ruggedness and fox presence/absence. For islands smaller than Tasmania, island area was also included as a predictor of density (small islands have higher cat densities). The dashed lines indicate the Tropic of Capricorn. Display omitted
Abstract Purpose Patients with febrile neutropaenia (FN) can be stratified according to their risk of significant complications, allowing reduced intensity therapy for low risk (LR) episodes. Serious ...events are very rare in low risk episodes making randomised trials difficult. Introduction of new evidence-based guidelines followed by re-auditing of the outcome is an alternative strategy. Methods New guidelines for the management of LR FN were implemented in 4 specialist paediatric oncology centres (POCs) and in their associated shared care units (POSCUs). All patients commenced empirical intravenous antibiotic therapy and after 48 h those with blood culture negative episodes designated LR were eligible for discharge on oral co-amoxiclav. Prospective data collection on FN episodes in all treatment centres was undertaken over a 1-year period. Results Seven hundred and sixty two eligible episodes of FN were recorded in 368 patients; 213 episodes were initiated in POCs and 549 episodes were initiated in POSCUs. In 40% of episodes no clinical or microbiological focus of infection was found. At 48 h, 212 (27%) episodes were classified as LR and 143 of these (19%) were managed on the LR protocol. There was a low hospital readmission rate (8/143 episodes; 5.6%), no intensive care admissions and no deaths in LR episodes. Almost all LR episodes (209/212) occurred in the shared care setting. Conclusions Rapid step-down to oral antibiotics was a feasible and safe management strategy for LR FN in the shared care setting in England.
The two rings of (50000) Quaoar Pereira, C. L.; Sicardy, B.; Morgado, B. E. ...
Astronomy and astrophysics (Berlin),
05/2023, Letnik:
673
Journal Article
Recenzirano
Odprti dostop
Context.
Quaoar is a classical trans-Neptunian object (TNO) with an area-equivalent diameter of 1100 km and an orbital semi-major axis of 43.3 astronomical units. Based on stellar occultations ...observed between 2018 and 2021, an inhomogeneous ring (Q1R, i.e., Quaoar’s first ring) has been detected around this body.
Aims.
A new stellar occultation by Quaoar was observed on August 9, 2022, with the aim of improving Quaoar’s shape models and the physical parameters of Q1R, while searching for additional material around the body.
Methods.
The occultation provided nine effective chords across Quaoar, pinning down its size, shape, and astrometric position. Large facilities, such as Gemini North and the Canada-France-Hawaii Telescope (CFHT), were used to obtain high acquisition rates and signal-to-noise ratios. The light curves were also used to characterize the Q1R ring (radial profiles and orbital elements).
Results.
Quaoar’s elliptical fit to the occultation chords yields the limb with an apparent semi-major axis of 579.5 ± 4.0 km, apparent oblateness of 0.12 ± 0.01, and area-equivalent radius of 543 ± 2 km. Quaoar’s limb orientation is consistent with Q1R and Weywot orbiting in Quaoar’s equatorial plane. The orbital radius of Q1R is refined to a value of 4057 ± 6 km. The radial opacity profile of the more opaque ring profile follows a Lorentzian shape that extends over 60 km, with a full width at half maximum (FWHM) of ∼5 km and a peak normal optical depth of 0.4. Besides the secondary events related to the already reported rings, new secondary events detected during the August 2022 occultation in three different data sets are consistent with another ring around Quaoar with a radius of 2520 ± 20 km, assuming the ring is circular and co-planar with Q1R. This new ring has a typical width of 10 km and a normal optical depth of ∼0.004. Just as Q1R, it also lies outside Quaoar’s classical Roche limit.
Crossbred, multiparous beef cows (n = 178 in Year 1; n = 148 in Year 2) were used to evaluate the effects of Cu, Zn, and Mn supplementation and source on reproduction, mineral status, and performance ...in grazing cattle in eastern Colorado over a 2-yr period. Cows were stratified by expected calving date, age, BW, BCS, and liver mineral status and assigned to the following treatments: 1) control (no supplemental Cu, Zn, or Mn); 2) organic (ORG; 50% organic and 50% inorganic Cu, Zn, and Mn); and 3) inorganic (ING; 100% inorganic CuSO4, ZnSO4, and MnSO4). Free-choice mineral feeders were used to provide current NRC-recommended concentrations of Cu, Zn, and Mn from 82 d (Year 1) and 81 d (Year 2) before the average calving date of the herd through 110 d (Year 1) and 135 d (Year 2) after calving. At the end of Year 1, supplemented cows had greater liver Cu (P < 0.01), Zn (P < 0.05), and Mn (P < 0.01) concentrations compared with controls, whereas liver Cu concentration was greater (P < 0.01) in ORG vs. ING cows. At the end of Year 2, supplemented cows had greater (P < 0.01) liver Cu concentrations relative to controls, whereas control cows had greater (P < 0.02) liver Mn concentration than did supplemented cows. In Year 1, pregnancy rate to AI in control cows did not differ (P = 0.47) from supplemented cows, but there was a trend (P < 0.08) for pregnancy rate to be higher for ORG than ING cows. In Year 2, supplemented cows had a higher (P < 0.02) pregnancy rate to AI than controls. In both years, when cows were inseminated after an observed estrus, supplemented cows had a higher (P < 0.04) pregnancy rate than did controls. Also, for both years, overall 60-d pregnancy rate tended (P = 0.10) to be higher for supplemented cows than for controls. In Year 1, kilograms of calf weaned per cow exposed was greater (P < 0.02) in controls than in supplemented cows, and kilograms of calf weaned per cow exposed was greater (P < 0.01) in ING than ORG treatments. However, in Year 2, kilograms of calf weaned per cow exposed was greater (P < 0.02) in controls than in supplemented cows, and tended (P = 0.09) to be greater in ORG than ING treatments. Results indicate that supplementation and source of trace minerals affected mineral status and kilograms of calf weaned per cow exposed in grazing beef cows. Supplementation also improved pregnancy rate to AI compared with cows not supplemented with Cu, Zn, or Mn for more than 1 yr. Furthermore, mineral source may influence pregnancy rate to AI.
We present a new occultation event simulator for the Trans-Neptunian Automated Occultation Survey (TAOS II). We have developed a method to compute occultation shadows by small objects with ...non-circular apparent shapes (as may result from an intrinsic morphology or from the projection of a contact binary). The new simulator calculates diffraction features in the occultation shadows, as well as resulting light curves as would be measured by the TAOS II survey system. We include effects such as the spectral type and finite angular size of the occulted star. We find that occultation events, especially by Trans-Neptunian Objects with diameters ∼3 km may be misidentified or mischaracterized when not taking non-spherical shapes into account.
PDF
