Chronic arthritis (CA) represents a group of musculoskeletal diseases that require frequent physical therapy and a well-monitored medication regime to improve or maintain disease status. To support ...patients in this disease management, health apps may provide a solution. However, patients with CA differ in their disease trajectory, needs and preferences. There-fore, in this paper, we investigate the tailoring of motivational mHealth features for the heterogeneous group of patients with CA. An exploratory study was carried out, consisting of semi-structured interviews and focus groups with 34 patients with CA and six health professionals. Through qualitative analysis, we first derive a typology distinguishing patients of the Defeatist, Worrier, Warrior and Cruiser type. Each type is characterized by their own disease management needs and coping strategies. Next, we unveil how each patient type has different preferred motivational strategies. These findings may inform healthcare informatics researchers who wish to tailor mHealth applications and interventions to the diversity of patients characterized by musculoskeletal diseases and chronic pain.
Two distinct loci for the 24-kDa subunit of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain) were detected in the human genome: a transcribed gene from chromosome ...18 and an inactive locus on chromosome 19. Cosmid clones containing the functional gene (NDUFV2) and the pseudogene (NDUFV2P1) were isolated. The NDUFV2 gene spans approximately 20 kb and contains 8 exons. Refined mapping of both NDUFV2 genes by FISH resulted in an assignment of the NDUFV2 gene to 18p11.2–p11.31 and of the NDUFV2P1 gene to 19q13.3-qter. The nucleotide sequence of the NDUFV2P1 pseudogene differs from the cDNA sequence by the lack of the methionine initiator codon, an additional 165 bp of the first intron sequence, and a 1-nucleotide deletion.
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