Glucagon-Like Peptide-1 Giblett, Joel P., BM, BSc; Clarke, Sophie J., BSc; Dutka, David P., MD ...
JACC. Basic to translational science,
June 2016, Letnik:
1, Številka:
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Journal Article
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Summary Glucagon-like peptide-1-(7-36) amide (GLP-1) is a human incretin hormone responsible for the release of insulin in response to food. Pre-clinical and human physiological studies have ...demonstrated cardioprotection from ischemia-reperfusion injury. It can reduce infarct size, ischemic left ventricular dysfunction, and myocardial stunning. GLP-1 receptor agonists have also been shown to reduce infarct size in myocardial infarction. The mechanism through which this protection occurs is uncertain but may include hijacking the subcellular pathways of ischemic preconditioning, modulation of myocardial metabolism, and hemodynamic effects including peripheral, pulmonary, and coronary vasodilatation. This review will assess the evidence for each of these mechanisms in turn. Challenges remain in successfully translating cardioprotective interventions from bench-to-bedside. The window of cardioprotection is short and timing of cardioprotection in the appropriate clinical setting is critically important. We will emphasize the need for high-quality, well-designed research to evaluate GLP-1 as a cardioprotective agent for use in real-world practice.
We present a case of iatrogenic aortocoronary dissection sustained during routine percutaneous coronary intervention for stable angina. Careful wiring of the true lumen and stent implantation to seal ...off the dissection flap prevented immediate complications, and computed tomography aortography guided a conservative approach to manage the residual aortic dissection. (Level of Difficulty: Intermediate.)
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A patient with a history of coronary artery bypass graft presented with breathlessness and was found to have an 11 × 6 cm aneurysm in a distally occluded saphenous vein graft. This case describes the ...investigation, heart team discussion, and percutaneous closure of the aneurysm. (Level of Difficulty: Beginner.)
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A patient with a history of coronary artery bypass graft presented with breathlessness and was found to have an 11- × 6-cm aneurysm in a distally…
Transcatheter aortic valve replacement (TAVR) is an established therapy for patients with aortic stenosis (1). A conductance catheter (Millar Instruments, Houston, Texas) positioned at the RV apex ...recorded a family of pressure-volume loops during pre-load reduction with inferior vena cava balloon occlusion pre- and post-TAVR recorded a median time of 17 min (IQR: 12 to 23 min) after valve replacement.
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