Gastrointestinal diseases are very common worldwide. Patients with gastroesophageal reflux disease, functional dyspepsia, irritable bowel syndrome, and inflammatory bowel diseases frequently recur to ...complementary medicine, including acupuncture, likely because of the recurrence of symptoms and the sometimes lack of efficacy of conventional treatments. Acupuncture is a medical practice used in Asian country with benefits for thousands years. In the last decades, growing attention has been given to acupuncture also in Western countries and many studies have investigated the role of acupuncture in gastroenterology. This review provided an overview of the effectiveness and potential mechanisms of action of acupuncture for the treatment of gastrointestinal diseases.
Conventional therapies (CTs), pharmacological (PH) and non–pharmacological (NPH), do not always achieve benefits in the treatment of chronic low back pain (CLBP). We assessed efficacy and safety of ...acupuncture for CLBP as alternative or addition to CT.
We included randomised controlled trials (RCTs) comparing acupuncture alone or in combination with CT to CT. We searched Medline, Cochrane Library, Embase up to May 2022. We assessed risk of bias with the original Cochrane tool and GRADE certainty of evidence. Results were pooled through meta-analysis.
Ten RCTs (2122 participants) were included comparing acupuncture versus CT and 4 RCTs (374 participants) were comparing acupuncture plus CT to CT alone. In terms of comparing acupuncture with NPH or PH, no differences were found for pain and disability. Comparing acupuncture with PH and NPH combined, pain and disability were reduced (SMD=-0.50, 95% CI -0.62 to -0.37; SMD=-0.71, 95% CI -1.17 to -0.24). Comparing acupuncture plus NPH with NPH alone, pain and disability were reduced (SMD=-0.70, 95% CI -0.94 to -0.46; SMD=-0.95, 95% CI -1.36 to -0.54). Comparing acupuncture plus PH with PH alone, pain and disability were reduced (MD=-0.21, 95% CI -433.28 to -10.42; MD=-3.1, 95% CI -4.87 to -1.83). Comparing acupuncture plus combined treatment versus combined treatment alone, no differences were found in pain, while disability was reduced (MD=-3.40 95% CI -5.17 to -1.63). No studies assessed adverse event. Certainty of evidence ranged from moderate to very low.
We are uncertain whether acupuncture is more effective and safer than CT. In the comparisons without estimates’ imprecision, acupuncture showed promising results. Acupuncture could be an option based on patients’ preferences.
Migraine is a chronic paroxymal neurological disorder characterized by attacks of moderate to severe headache and reversible neurological and systemic symptoms. Treatment of migraine includes acute ...therapies, that aim to reduce the intensity of pain of each attack, and preventive therapies that should decrease the frequency of headache recurrence. The objective of this systematic review was to assess the efficacy and safety of acupuncture for the prophylaxis of episodic or chronic migraine in adult patients compared to pharmacological treatment.
We included randomized-controlled trials published in western languages that compared any treatment involving needle insertion (with or without manual or electrical stimulation) at acupuncture points, pain points or trigger points, with any pharmacological prophylaxis in adult (≥18 years) with chronic or episodic migraine with or without aura according to the criteria of the International Headache Society.
Nine randomized trials were included encompassing 1,484 patients. At the end of intervention we found a small reduction in favor of acupuncture for the number of days with migraine per month: (SMD: -0.37; 95% CI -1.64 to -0.11), and for response rate (RR: 1.46; 95% CI 1.16-1.84). We found a moderate effect in the reduction of pain intensity in favor of acupuncture (SMD: -0.36; 95% CI -0.60 to -0.13), and a large reduction in favor of acupuncture in both the dropout rate due to any reason (RR 0.39; 95% CI 0.18 to 0.84) and the dropout rate due to adverse event (RR 0.26; 95% CI 0.09 to 0.74). Quality of evidence was moderate for all these primary outcomes. Results at longest follow-up confirmed these effects.
Based on moderate certainty of evidence, we conclude that acupuncture is mildly more effective and much safer than medication for the prophylaxis of migraine.
We present the catalog of ∼31,500 extragalactic H i line sources detected by the completed Arecibo Legacy Fast ALFA (ALFALFA) survey out to z < 0.06, including both high signal-to-noise ratio (>6.5) ...detections and ones of lower quality that coincide in both position and recessional velocity with galaxies of known redshift. We review the observing technique, data reduction pipeline, and catalog construction process, focusing on details of particular relevance to understanding the catalog's compiled parameters. We further describe and make available the digital H i line spectra associated with the cataloged sources. In addition to the extragalactic H i line detections, we report nine confirmed OH megamasers (OHMs) and 10 OHM candidates at 0.16 < z < 0.22 whose OH line signals are redshifted into the ALFALFA frequency band. Because of complexities in data collection and processing associated with the use of a feed-horn array on a complex single-dish antenna in the terrestrial radio frequency interference environment, we also present a list of suggestions and caveats for consideration by users of the ALFALFA extragalactic catalog for future scientific investigations.
Aims. We determine the mass distribution of stars, gas, and dark matter in M 33 to test cosmological models of galaxy formation and evolution. Methods. We map the neutral atomic gas content of M 33 ...using high resolution Very Large Array and Green Bank Telescope observations of the 21 cm HI line emission. A tilted ring model is fitted to the HI datacube to determine the varying spatial orientation of the extended gaseous disk and the rotation curve. We derive the stellar mass surface density map of M 33’s optical disk via pixel-SED fitting methods based on population synthesis models that allow for positional changes in star formation history. Stellar and gas maps are used in the dynamical analysis of the rotation curve to constrain the dark halo properties. Results. The disk of M 33 warps from 8 kpc outward without substantial change of its inclination with respect to the line of sight; the line of nodes rotates clockwise toward the direction of M 31. Rotational velocities rise steeply with radius in the inner disk, reaching 100 km s-1 in 4 kpc, then the rotation curve becomes more perturbed and flatter with velocities as high as 120–130 km s-1 out to 2.7 R25. The stellar surface density map highlights a star-forming disk with a varying mass-to-light ratio. At larger radii, a dynamically relevant fraction of the baryons are in gaseous form. A dark matter halo with a Navarro-Frenk-White density profile, as predicted by hierarchical clustering and structure formation in a ΛCDM cosmology, provides the best fits to the rotation curve. Dark matter is relevant at all radii in shaping the rotation curve and the most likely dark halo has a concentration C ≃ 9.5 and a total mass of 4.3(±1.0) × 1011 M⊙. This imples a baryonic fraction of order 0.02 and the evolutionary history of this galaxy should therefore account for loss of a large fraction of its original baryonic content.
A large corpus of evidence has reported encouraging results for acupuncture as a prophylaxis therapy for migraine. However, trials that investigated the efficacy of acupuncture in comparison with ...pharmacological treatment in episodic migraine showed conflicting results. The study aimed to evaluate if acupuncture is as effective as evidence-based pharmacological drugs in episodic migraine prophylaxis.
This is a randomized controlled clinical study. Patients suffering from migraine without preventive treatment in the past 3 months were recruited. After the run-in period, episodic migraineurs were assigned randomly to two groups: the acupuncture group (A) was treated with 12 sessions of acupuncture, and the pharmacological group (B) was treated with the most appropriate medication for each patient. Headache frequency was compared at baseline and at the end of treatment. Both groups were evaluated 3 and 6 months after treatment.
A total of 148 patients (24 males and 124 females) were enrolled in the study. Out of these, 69 were randomized to A and 66 to B. At baseline, no significant differences were found between the two groups. Of the patients, 15.5% (21/135) interrupted the treatment, especially those randomized to B. After 4 months, migraine frequency decreased from 8.58 ± 3.21 to 6.43 ± 3.45 in A and from 8.29 ± 2.72 to 6.27 ± 4.01 in B. Headache frequency decreased significantly after treatment without differences between the two groups (time-effect:
< 0.001; group effect:
= 0.332; interaction time-group effects:
= 0.556). Approximately 34% of patients showed a reduction of headache days by at least 50% after the treatment. The improvements observed at the end of treatment persisted in 57.3% (59/103) after 3 months and 38.8% (40/103) after 6 months, especially in patients randomized to A.
Our trial is the first one comparing acupuncture with the more appropriate pharmacological treatment for migraine prophylaxis. Data suggested that acupuncture could be adopted as migraine prophylaxis and seem to be slightly superior to pharmacological treatment in compliance and rate of adverse events.
Acupuncture in Italy: state of the art Giovanardi, Carlo Maria; Mazzanti, Umberto; Poini, Alessandra
Integrative medicine research,
03/2020, Letnik:
9, Številka:
1
Journal Article
We carried out deep searches for CO line emission in the outer disk of M 33, at R > 7 kpc, and examined the dynamical conditions that can explain variations in the mass distribution of the molecular ...cloud throughout the disk of M 33. We used the IRAM-30 m telescope to search for CO lines in the outer disk toward 12 faint mid-infrared (MIR) selected sources and in an area of the southern outer disk hosting MA1, a bright HII region. We detect narrow CO lines at the location of two MIR sources at galactocentric distances of about 8 kpc that are associated with low-mass young stellar clusters, and at four locations in the proximity of MA1. The paucity of CO lines at the location of weak MIR-selected sources probably arises because most of them are not star-forming sites in M 33, but background sources. Although very uncertain, the total molecular mass of the detected clouds around MA1 is lower than expected given the stellar mass of the cluster, because dispersal of the molecular gas is taking place as the HII region expands. The mean mass of the giant molecular clouds (GMCs) in M 33 decreases radially by a factor 2 from the center out to 4 kpc, then it stays constant until it drops at R > 7 kpc. We suggest that GMCs become more massive toward the center because of the fast rotation of the disk, which drives mass growth by coalescence of smaller condensations as they cross the arms. The analysis of both HI and CO spectral data gives the consistent result that corotation of the two main arms in this galaxy is at a radius of 4.7 ± 0.3 kpc, and spiral shock waves become subsonic beyond 3.9 kpc. Perturbations are quenched beyond 6.5 kpc, where CO lines have been detected only around sporadic condensations associated with UV and MIR emission.
We carried out deep searches for CO line emission in the outer disk of M33, at R>7 kpc, and examined the dynamical conditions that can explain variations in the mass distribution of the molecular ...cloud throughout the disk of M33. We used the IRAM-30~m telescope to search for CO lines in the outer disk toward 12 faint mid-infrared (MIR) selected sources and in an area of the southern outer disk hosting MA1, a bright HII region. We detect narrow CO lines at the location of two MIR sources at galactocentric distances of about 8 kpc that are associated with low-mass young stellar clusters, and at four locations in the proximity of MA1. The paucity of CO lines at the location of weak MIR-selected sources probably arises because most of them are not star-forming sites in M33, but background sources. Although very uncertain, the total molecular mass of the detected clouds around MA1 is lower than expected given the stellar mass of the cluster, because dispersal of the molecular gas is taking place as the HII region expands. The mean mass of the giant molecular clouds (GMCs) in M33 decreases radially by a factor 2 from the center out to 4 kpc, then it stays constant until it drops at R>7 kpc. We suggest that GMCs become more massive toward the center because of the fast rotation of the disk, which drives mass growth by coalescence of smaller condensations as they cross the arms. The analysis of both HI and CO spectral data gives the consistent result that corotation of the two main arms in this galaxy is at a radius of 4.7+-0.3 kpc, and spiral shock waves become subsonic beyond 3.9 kpc. Perturbations are quenched beyond 6.5 kpc, where CO lines have been detected only around sporadic condensations associated with UV and MIR emission.
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