Oxidative stress in malaria Percário, Sandro; Moreira, Danilo R; Gomes, Bruno A Q ...
International Journal of Molecular Sciences,
12/2012, Letnik:
13, Številka:
12
Journal Article, Book Review
Recenzirano
Odprti dostop
Malaria is a significant public health problem in more than 100 countries and causes an estimated 200 million new infections every year. Despite the significant effort to eradicate this dangerous ...disease, lack of complete knowledge of its physiopathology compromises the success in this enterprise. In this paper we review oxidative stress mechanisms involved in the disease and discuss the potential benefits of antioxidant supplementation as an adjuvant antimalarial strategy.
The structure-activity relationship has been used to study the determination of antioxidant pharmacophore for resveratrol using quantum chemistry calculations by the Functional of Density Theory ...method. According to the geometry obtained by using a B3LYP/6-31G(*), the HOMO, ionization potential, bond dissociation energies, stabilization energies, and spin density distribution, the electron or hydrogen abstraction in para position is more favored than in meta positions for resveratrol and related derivatives because of the resonance effects. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of resveratrol is 4-hydroxystilbene. Spin distribution showed that the pi-type electron system determines the stability of radicals and the unpaired electrons are mainly distributed to the O-atom in para position, double bond, and B-benzene ring. The antioxidant activity of resveratrol is related to the stabilization energy of 4-hydroxystilbene in resveratrol hydroxylated derivatives. Furthermore, the results explain the activity difference between resveratrol and its hydroxylated derivatives.
Attention can be “covertly” directed without eye movements; yet, even during fixation, there are continuous microsaccades (MSs). In areas V4 and IT of macaques, we found that firing rates and ...stimulus representations were enhanced by attention but only following a MS toward the attended stimulus. The onset of neural attentional modulations was tightly coupled to the MS onset. The results reveal a major link between the effects of covert attention on cortical visual processing and the overt movement of the eyes.
•Attentional modulation in V4 emerges only after microsaccades toward the stimulus•Onset of attention modulations is coupled to microsaccade onset•Object decoding is enhanced in V4 and IT after microsaccades toward the cued stimulus•Linkage between attention modulation and microsaccades is extra-retinal
Attention can be “covertly” directed without eye movements; yet, even during fixation, there are microsaccades. We found that neural activity was enhanced by attention, but only following a microsaccade toward the stimulus, revealing a major link between covert attention and the oculomotor system.
Alzheimer’s disease (AD) is a progressive and neurodegenerative disorder of the cortex and hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD remains unclear, ...the presence of β-amyloid (Aβ) peptides in these learning and memory regions is a hallmark of AD. Therefore, the inhibition of Aβ peptide aggregation has been considered the primary therapeutic strategy for AD treatment. Many studies have shown that resveratrol has antioxidant, anti-inflammatory, and neuroprotective properties and can decrease the toxicity and aggregation of Aβ peptides in the hippocampus of AD patients, promote neurogenesis, and prevent hippocampal damage. In addition, the antioxidant activity of resveratrol plays an important role in neuronal differentiation through the activation of silent information regulator-1 (SIRT1). SIRT1 plays a vital role in the growth and differentiation of neurons and prevents the apoptotic death of these neurons by deacetylating and repressing p53 activity; however, the exact mechanisms remain unclear. Resveratrol also has anti-inflammatory effects as it suppresses M1 microglia activation, which is involved in the initiation of neurodegeneration, and promotes Th2 responses by increasing anti-inflammatory cytokines and SIRT1 expression. This review will focus on the antioxidant and anti-inflammatory neuroprotective effects of resveratrol, specifically on its role in SIRT1 and the association with AD pathophysiology.
Transcatheter aortic valve implantation (TAVI) is an increasingly widespread procedure. Although this intervention is indicated for high and low surgical risk patients, some issues still remain, such ...as prosthesis positioning optimization in the aortic annulus. Coaxial positioning of the percutaneous prosthesis influences directly on the aortic wall stress map. The determination of the mechanical stress that acts on the vascular endothelium resulting from blood flow can be considered an important task, since TAVI positioning can lead to unfavorable hemodynamic patterns, resulting in changes in parietal stress, such as those found in post‐stenotic dilatation region. This research aims to investigate the influence of the prosthetic valve inclination angle in the mechanical stresses acting in the ascending aortic wall. Aortic compliance and blood flow during cardiac cycle were numerically obtained using fluid structure interaction. The aortic model was developed through segmentation of a computed tomography image of a specific patient submitted to TAVI. When compared to standard position (coaxiality match between the prosthesis and the aortic annulus), the inclination of 4° directed to the left main coronary artery decreased the aortic wall area with high values of wall shear stress and pressure. Coaxial positioning optimization of percutaneous aortic prosthesis may decrease the high mechanical stress area. These changes may be important to reduce the aortic remodeling process, vascular calcification or even the prosthesis half‐life. Computational fluid dynamics makes room for personalized medicine, with manufactured prosthesis tailored to each patient.
For the anatomy studied, aiming to diminish the aortic remodeling process, a tilt angle of 4° LCA presents an optimize condition. This position decreased the regions with high mechanical stresses (WSS and pressure) in the aortic wall. It was shown that a numerical simulation of the blood flow for a specific anatomy could be a viable tool to assist the TAVI procedure planning, aiming to ensure physiological flow patterns in the ascending aorta.
Transcatheter aortic valve implantation (TAVI) has become the alternative procedure to high-risk patients who are diagnosed with aortic valve stenosis. Differently from the traditional open-chest ...surgical procedure, a small variation on the prosthetic aortic valve deployment angle is expected with the TAVI procedure. The hemodynamic patterns of the blood flow in the ascending aorta are related to the development of many cardiovascular diseases. There are, however, few data available in the literature correlating the aortic valve tilt angle to hemodynamic effects. In this work, a 3D printed aorta model made of a transparent silicon resin was produced, based on the anatomy of a specific patient submitted to a TAVI procedure. The stereoscopic Particle Image Velocimetry technique was employed to measure three-component velocity fields at closely spaced cross-sectional planes, along the ascending aorta. The measurements were performed for a constant flow rate corresponding to the peak of the systolic phase of the cardiac cycle. Averaged velocity fields and turbulent quantities were determined for both, the base case, with no valve tilt, and for cases with an inclination of 4° and 8°, oriented at the four anatomical directions of the human body reference system, namely anterior, posterior, right and left. The results revealed the dominant flow patterns in the ascending aorta formed by a jet-like inlet flow impinging on the curved aorta right wall, inducing a significant eccentricity on the axial velocity profile. Regions of reverse flow were identified and linked to the abrupt area change associated with the typical reduced inlet diameter of TAVI implants. The impinging flow and wall curvature effects established circulation patterns defining a helical flow structure. The influence of the inlet flow orientation on the flow turbulent characteristics was assessed by the spatial evolution of the turbulent kinetic energy (TKE), Reynolds and viscous stresses. The maximum values of TKE were found around the inlet jet boundaries and concentrated in the neighborhood of the right aorta wall where the eccentric axial flow prevailed. Spatial distributions of the maximum Reynolds stresses were similar to the TKE distributions and presented maximum stresses typically one order of magnitude higher than the maximum average viscous shear stresses. Maximum average viscous stress distributions were revealed at the jet-like flow boundaries and in the vicinity of the right wall, displaying moderate stress levels that, according to the literature, can be sufficient to produce cell damage and platelet activation. The complex nature of the flow field was revealed by streamlines obtained from the measured flow fields, allowing the identification of the influence of the inlet flow orientation and tilt angle on the position of the stagnation point on the aorta right wall, as well as the angle of incidence of the jet-like flow on the wall. A simple model based on momentum balance was used to estimate the pressure increment on the wall due to flow impingement. The model captured the influence of the inlet flow orientation, indicating that pressure increases of the order of 40% in relation to the base case condition were obtained for the 8°, left inlet flow orientation.
Graphic abstract
Grounding-line fans and their associated supercritical-flow bedforms are still poorly recognized in the upper Paleozoic glacial record. In order to fill this gap and to explore the products of the ...transition between upper and lower flow regimes, we examined a gravel-rich succession composed of conglomerates, sandstones, and diamictites deposited during the Late Paleozoic Ice Age (LPIA) in southeastern Paraná Basin, Brazil. To investigate this succession, we described the main bedforms and associated facies in laterally persistent outcrops and measured several vertical logs that were subsequently merged into a composite log. From base to top, the succession is composed of a muddy glacitectonized substrate, and a subglacial to ice-marginal facies association including a basal, boulder-rich, subglacial lag of local extent, and submarine deposits belonging to a grounding-line fan. In the grounding-line fan association, we identified bedforms related to concentrated flows that represent the complete spectrum of flow regime transition from supercritical to subcritical in a waning wall jet model. The proximal zone was dominated by highly turbulent supercritical flows, resulting in highly scoured conglomerates and deposition of unstable and stable antidunes. A transitional zone under transcritical flow conditions resulted in deposits represented by humpback dunes. In the distal zone, the flow behaved as subcritical, resulting in the deposition of dunes and climbing ripples. Debris flows were also active. These cohesive flows underwent dilution by water entrainment and erosion of the head, leading to the generation of turbulent portions in the head of the debris flows. This bipartite behavior of the flows resulted in thin sandstones capping diamictites, which compose the fabric of the glacigenic debrites observed in the study area. The described facies and bedforms point to the existence of a grounded ice margin at the final stages of the LPIA in the SE portion of the Paraná Basin.
•The first paper proposing a detailed investigation for the characterization of upper-flow regime bedforms in LPIA deposits.•Froude supercritical flow bedforms deposited under glacimarine wall jet density flows.•The grounding-line fan exhibits a distinct bimodal sedimentation pattern.•Debris flow dilution leads to the generation of turbidity currents.•Existence of a grounded ice margin at the final stages of the LPIA in the SE Paraná Basin.
Bio-based materials, such as wood bio-concrete (WBC), hold promise in reducing energy consumption and carbon footprint of the construction industry. However, the durability of these materials is not ...well understood and can be negatively affected by the high water absorption capacity of wood bio-aggregates. In the field of cement composites, for example, silane–siloxane-based water repellent has been used to protect such materials from natural environmental attack. Nevertheless, there is still a limited understanding of various aspects related to this type of treatment, including its performance when applied to the bio-concrete substrate. This research aimed to investigate the influence of silane–siloxane on the rheology and hydration of cementitious paste through isothermal calorimetry and thermogravimetric analysis. Additionally, the impact of silane–siloxane on the physical and mechanical properties of WBCs was examined by conducting tests at fresh state (flow table and entrained air content) and hardened state (compressive strength and capillary water absorption). The composites were produced with a volumetric fraction of 45% of wood shavings while the cement matrix consisted of a combination of cement, rice husk ash, and fly ash. Silane–siloxane was applied in three ways: as coating, incorporated as an admixture, and in a combination of both methods. The results indicated that by incorporating silane in the cementitious pastethe viscosity increased by 40% and the hydration was delayed by approximately 6 h when compared to the reference. In addition, silane improved the compressive strength of WBCs by 24% when incorporated into the mixture, expressively reduced the water sorptivity of WBCs (93%), and was more effective if used as coating.
Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) is a polyphagous pest with a wide geographic distribution. This pest first arrived in Brazil in 2013, and since then studies on possible control ...methods for it have been necessary. A possible method for the control of H. armigera is using the egg parasitoid Trichogramma pretiosum Riley (Hymenoptera: Trichogrammatidae). Therefore, the objective of this study was to evaluate the performance of T. pretiosum on H. armigera eggs, which are known to represent suitable hosts for the development of this parasitoid species in the laboratory. Parasitism and emergence rates and the duration of the egg-to-adult period of T. pretiosum were investigated following 24- and 48-h exposures of this parasitoid to H. armigera and Corcyra cephalonica (Stainton) (Lepidoptera: Pyralidae) eggs. The longevity of offspring after the 24-h exposure was studied, as well as the frequency of parasitism and emergence, host preference, and the emergence of offspring from eggs of different ages or oviposited by lepidopterans on different days. Parasitism was 14.4 and 34.9% more frequent on C. cephalonica than on H. armigera after 24 and 48 h of exposure, respectively. In C. cephalonica, parasitism was 27.2% higher after 48 h. Parasitism was more frequent on C. cephalonica eggs collected on the second day of oviposition (76.2%), and on H. armigera on the third day of oviposition (71.1%). Parasitism frequency was lower on 2-day-old C. cephalonica eggs (63.3%) and on 3-day-old H. armigera eggs (41.3%). When tested with a chance of choice between hosts, T. pretiosum preferred H. armigera, while in the test with no chance of choice there was no difference in preference. Thus, T. pretiosum may be considered a tool for the Integrated Pest Management (IPM) of H. armigera.
The heart and brain are reciprocally interconnected and engage in two-way communication for homeostatic regulation. Epilepsy is considered a network disease that also affects the autonomic nervous ...system (ANS). The neurovisceral integration model (NVM) proposes that cardiac vagal tone, indexed by heart rate variability (HRV), can indicate the functional integrity of cognitive neural networks. ANS activity and the pattern of oscillatory EEG activity covary during the transition of arousal states and associations between cortical and autonomic activity are reflected by HRV. Cognitive dysfunction is one of the common comorbidities that occur in epilepsy, including memory, attention, and processing difficulties. Recent studies have shown evidence for the active involvement of alpha activity in cognitive processes through its active role in the control of neural excitability in the cortex through top-down modulation of cortical networks. In the present pilot study, we evaluated the association between resting EEG oscillatory behavior and ANS function in patients with refractory epilepsy. Our results show: (1) In patients with refractory epilepsy, there is a strong positive correlation between HRV and the power of cortical oscillatory cortical activity in all studied EEG bands (delta, theta, alpha, and beta) in all regions of interest in both hemispheres, the opposite pattern found in controls which had low or negative correlation between these variables; (2) higher heartbeat evoked potential amplitudes in patients with refractory epilepsy than in controls. Taken together, these results point to a significant alteration in heart-brain interaction in patients with refractory epilepsy.
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