The role of the orthodontist in the diagnosis of Gorlin’s syndrome Maroto, Martín Romero; Porras, Jose Luis Barrionuevo; Saez, Rafael Salvan ...
American journal of orthodontics and dentofacial orthopedics,
1999, 1999-Jan, 1999-1-00, 19990101, Letnik:
115, Številka:
1
Journal Article
Recenzirano
Gorlin’s syndrome is a relatively rare generalized disorder. Its diagnosis in childhood is usually through oral abnormalities. Some of the most frequent clinical features of this syndrome are ...discovered through radiographs commonly used in orthodontia. Thus, the orthodontist may be able to contribute to its diagnosis. The article shows three clinical cases that illustrate the role that the orthodontist may play in diagnosis of this syndrome. (Am J Orthod Dentofacial Orthop 1999;115:89-98)
Under normal conditions the blood circulates freely within the confines of the vascular system, carrying oxygen, nutrients, and hormonal information around the body and removing metabolic waste. If ...the blood gains access to extravascular sites or if the vasculature becomes pathologically challenged, the processes associated with hemostasis may be activated. Employing finely regulated positive- and negative-feedback loops, hemostasis represents the process responsible for both generating and regulating the plug that prevents blood loss following vessel injury. The components of hemostasis are both complex and heterogeneous, consisting of cell-associated and plasma-borne proteins, glycosaminoglycans, and platelets. To ensure the maintenance of both blood fluidity and yet also vascular integrity, the hemostatic response must be fast, and yet specifically localized to the site of vessel damage. In this way, the likelihood of further challenges being imposed upon the vascular system may be minimized. In the event of vascular injury, circulating platelets are rapidly recruited to the damaged region. These platelets become activated and aggregate, forming an unstable platelet plug (primary hemostasis) that immediately limits the loss of blood. The coagulation cascade is initiated simultaneously. Blood coagulation ultimately results in the deposition of fibrin, a molecular scaffold that consolidates the platelet plug and allows tissue repair mechanisms to act. This chapter focuses on the coagulation system and its regulation. An important protease generated during coagulation is thrombin, a serine protease with numerous substrates. As the physiological end points of coagulation are the fibrin clot and platelet activation, which are both determined by thrombin, regulation of coagulation can be viewed in its simplest form as the control of the generation and activities of thrombin.
En Amérique latine, depuis le début des années quatre-vingt, deux phénomènes majeurs, l'approfondissement de la crise financière-économique et l'évolution démocratique, ont renouvelé les termes et ...les enjeux d'un débat désormais généralisé sur les rapports entre pouvoirs centraux, pouvoirs régionaux et pouvoirs locaux. En France, dans la même période, mais dans un contexte politique différent, la discussion puis l'application des lois de décentralisation ont répondu à la volonté des sociétés locales de prendre une plus grande part dans la détermination de leur destin et de celui de leur territoire. Démocratisation et modernisation, modernisation et démocratisation sont ainsi devenues, tant en France (en Europe devrait-on dire) qu'en Amérique latine les mots-clés, les références incontournables pour toute réflexion sur les voies et moyens permettant d'affronter les mutations imposées par la compétition internationale.
