In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected ...only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F. tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor’s residence were positive by PCR for F. tularensis subsp. tularensis (clade A2). This investigation documents F. tularensis transmission by solid organ transplantation.
There is now clear evidence that the Complement anaphylatoxin C3a and C5a receptors (C3aR and C5aR) are expressed in glial cells, notably in astrocytes and microglia. In contrast, very few data are ...available concerning the possible expression of these receptors in neurons. Here, we show that transient expression of C3aR and C5aR occurs in cerebellar granule neurons in vivo with a maximal density in 12-day-old rat, suggesting a role of these receptors during development of the cerebellum. Expression of C3aR and C5aR mRNAs and proteins was also observed in vitro in cultured cerebellar granule cells. Quantification of the mRNAs by real-time reverse transcription-PCR showed a peak of expression at day 2 in vitro (DIV 2); the C3aR and C5aR proteins were detected by Western blot analysis at DIV 4 and by flow cytometry and immunocytochemistry in differentiating neurons with a maximum density at DIV 4-9. Apoptosis of granule cells plays a crucial role for the harmonious development of the cerebellar cortex. We found that, in cultured granule neurons in which apoptosis was induced by serum deprivation and low potassium concentration, a C5aR agonist promoted cell survival and inhibited caspase-3 activation and DNA fragmentation. The neuroprotective effect of the C5aR agonist was associated with a marked inhibition of caspase-9 activity and partial restoration of mitochondrial integrity. Our results provide the first evidence that C3aR and C5aR are both expressed in cerebellar granule cells during development and that C5a, but not C3a, is a potent inhibitor of apoptotic cell death in cultured granule neurons.
We measure the luminosity profiles of 16 brightest cluster galaxies (BCGs) at \(0.4 < z < 0.8\) using high resolution F160W NICMOS and F814W WFPC2 HST imaging. The heterogeneous sample is drawn from ...a variety of surveys: seven from clusters in the Einstein Medium Sensitivity Survey, five from the Las Campanas Distant Cluster Survey and its northern hemisphere precursor, and the remaining four from traditional optical surveys. We find that the surface brightness profiles of all but three of these BCGs are well described by a standard de Vaucouleurs (\(r^{1/4}\)) profile out to at least \(\sim2r_{e}\) and that the biweight-estimated NICMOS effective radius of our high redshift BCGs (\(r_{e} = 8.3\pm 1.4\) kpc for \(H_{0} = 80\) km s\(^{-1}\) Mpc\(^{-1}\), \(\Omega_{m} = 0.2, \Omega_\Lambda = 0.0\)) is \(\sim 2\) times smaller than that measured for a local BCG sample. If high redshift BCGs are in dynamical equilibrium and satisfy the same scaling relations as low redshift ones, this change in size would correspond to a mass growth of a factor of 2 since \(z \sim 0.5\). However, the biweight-estimated WFPC2 effective radius of our sample is 18 \(\pm \) 5.1 kpc, which is fully consistent with the local sample. While we can rule out mass accretion rates higher than a factor of 2 in our sample, the discrepancy between our NICMOS and WFPC2 results, which after various tests we describe appears to be physical, does not yet allow us to place strong constraints on accretion rates below that level.
We investigate the influence of environment on brightest cluster galaxy (BCG) evolution using a sample of 63 clusters at 0.3 < z < 0.9 drawn primarily from the Las Campanas Distant Cluster Survey and ...follow-up V, I, and K' photometry. The luminosity evolution of the entire BCG sample is not adequately described by a single evolutionary model. Using the integrated light from the cluster detection as a proxy for cluster Lx and the suggestion by Burke, Collins, & Mann, we set Lx = 2 x 10^{44} ergs/s to be the division between high and low luminosity clusters. At high redshift (z>0.6) BCGs from low-Lx clusters are fainter, on average, than those from high-Lx clusters and are best modeled as having constant luminosity with redshift. The BCGs from high-Lx cluster are best modeled as having a stellar population that formed at large redshift (z_form > 5) and is passively evolving. However, for the entire BCG population, the observed V-I and I-K' colors are well described by a single evolutionary model in which the stellar populations have z_form > 5 and subsequently passively evolve. We conclude that accretion is proportionally more significant for BCGs in lower mass clusters at these redshifts (factor of 2 to 4 increase in mass since z ~ 1 for the low Lx systems) and that the accreted matter is in the form of systems with evolved stellar populations.
We report the discovery of a galaxy cluster at z = 1.41. ISCS J143809+341419 was found in the Spitzer/IRAC Shallow Survey of the Bootes field in the NOAO Deep Wide-Field Survey carried out by IRAC. ...The cluster candidate was initially identified as a high density region of objects with photometric redshifts in the range 1.3 < z < 1.5. Optical spectroscopy of a limited number of objects in the region shows that 5 galaxies within a ~120 arcsec diameter region lie at z = 1.41 +/- 0.01. Most of these member galaxies have broad--band colors consistent with the expected spectral energy distribution of a passively--evolving elliptical galaxy formed at high redshift. The redshift of ISCS J143809+341419 is the highest currently known for a spectroscopically-confirmed cluster of galaxies.
(Abridged) We analyze photometry and spectroscopy of a sample of 63 clusters at 0.3<z<0.9 drawn from the Las Campanas Distant Cluster Survey to empirically constrain models of cluster galaxy ...evolution. Specifically, by combining data on our clusters with those from the literature we parametrize the redshift dependence of 1) M*_I in the observed frame; 2) the V-I color of the E/S0 red sequence in the observed frames; and 3) the I-K' color of the E/S0 red sequence in the observed frame. Using the peak surface brightness of the cluster detection, S, as a proxy for cluster mass, we find no correlation between S and M* or the location of the red envelope in V-I. We suggest that these observations can be explained with a model in which luminous early type galaxies (or more precisely, the progenitors of current day luminous early type galaxies) form the bulk of their stellar populations at high redshift (>~ 5) and in which many of these galaxies, if not all, accrete mass either in the form of evolved stellar populations or gas that causes only a short term episode of star formation at lower redshifts (1.5 < z < 2). Our data are too crude to reach conclusions regarding the evolutionary state of any particular cluster or to investigate whether the morphological evolution of galaxies matches the simple scenario we discuss, but the statistical nature of this study suggests that the observed evolutionary trends are universal in massive clusters.
We present our study of the evolution of brightest cluster galaxies based on data from the Las Campanas Distant Cluster Survey (Gonzalez et al. 2001) and HST optical and IR imaging. We briefly ...discuss the technique that enabled us to use short (~ 3 min) exposures and a small (1m) telescope to efficiently survey about 130 sq. deg. of sky for high-z galaxy clusters. Follow-up imaging is used to construct a sample of several tens of BCGs at 0.3 < z < 0.9 with which to explore their evolution. In particular, we examine the luminosity and color evolution of these galaxies. We confirm the previous results that 1) BCGs in different environments evolve differently (eg. Burke et al 2000), 2) BCGs, particularly those in low-mass clusters, must be accreting significantly since z ~ 1 (Aragon-Salamanca et al. 1998). From measurments of the colors vs. redshift, we conclude that this accretion must consist of old stellar populations. Using HST NICMOS and WFPC2 images, we find preliminary evidence for evolution in the sizes of BCGs that is consistent with the accretion model presented in standard hierarchical models (Aragon-Salamanca et al. 1998), but puzzling differences between NICMOS and WFPC2 scale lengths precludes a definitive conclusion.
We present the Las Campanas Distant Cluster Survey, which has produced over a thousand galaxy cluster candidates at 0.35 < z < 1.1 (see Gonzalez et al. 2001 for the full catalog). We discuss the ...technique that enabled us to use short (~ 3 min) exposures and a small (1m) telescope to efficiently survey ~ 130 sq. deg. of sky. Follow-up imaging and spectroscopy using a wide array of telescopes including the Keck and VLT suggest that the bona-fide cluster fraction is ~70%. We construct methods to estimate both the redshift and cluster mass from the survey data themselves and discuss our first result on large-scale structure, the dependence of the cluster correlation length with mean cluster separation at z ~ 0.5 (Gonzalez, Zaritsky, & Wechsler 2001).
Here, we present the complete chloroplast genomes of
,
, and
from California. The genomes are 161,119 to 161,130 bp and encode 132 genes.
and
are identical in sequence but differ from
by three indels ...and eight SNPs.
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