Transgenic maize engineered to express insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) has become widely adopted in U.S. agriculture. In 2009, Bt maize was planted on more than ...22.2 million hectares, constituting 63% of the U.S. crop. Using statistical analysis of per capita growth rate estimates, we found that areawide suppression of the primary pest Ostrinia nubilalis (European corn borer) is associated with Bt maize use. Cumulative benefits over 14 years are an estimated $3.2 billion for maize growers in Illinois, Minnesota, and Wisconsin, with more than $2.4 billion of this total accruing to non-Bt maize growers. Comparable estimates for Iowa and Nebraska are $3.6 billion in total, with $1.9 billion for non-Bt maize growers. These results affirm theoretical predictions of pest population suppression and highlight economic incentives for growers to maintain non-Bt maize refugia for sustainable insect resistance management.
Abstract
The HUGO Gene Nomenclature Committee (HGNC) based at EMBL’s European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 42,000 approved gene ...symbols in our current database of which over 19 000 are for protein-coding genes. While we still update placeholder and problematic symbols, we are working towards stabilizing symbols where possible; over 2000 symbols for disease associated genes are now marked as stable in our symbol reports. All of our data is available at the HGNC website https://www.genenames.org. The Vertebrate Gene Nomenclature Committee (VGNC) was established to assign standardized nomenclature in line with human for vertebrate species lacking their own nomenclature committee. In addition to the previous VGNC core species of chimpanzee, cow, horse and dog, we now name genes in cat, macaque and pig. Gene groups have been added to VGNC and currently include two complex families: olfactory receptors (ORs) and cytochrome P450s (CYPs). In collaboration with specialists we have also named CYPs in species beyond our core set. All VGNC data is available at https://vertebrate.genenames.org/. This article provides an overview of our online data and resources, focusing on updates over the last two years.
We present the results of models that were designed to study all possible water maser transitions in the frequency range 0–1.91 THz, with particular emphasis on maser transitions that may be ...generated in evolved-star envelopes and observed with the ALMA and SOFIA telescopes. We used tens of thousands of radiative transfer models of both spin-species of H2O, spanning a considerable parameter space in number density, kinetic temperature and dust temperature. Results, in the form of maser optical depths, have been summarized in a master table. Maser transitions identified in these models were grouped according to loci of inverted regions in the density/kinetic temperature plane, a property clearly related to the dominant mode of pumping. A more detailed study of the effect of dust temperature on maser optical depth enabled us to divide the maser transitions into three groups: those with both collisional and radiative pumping schemes (22, 96, 209, 321, 325, 395, 941 and 1486 GHz), a much larger set that are predominantly radiatively pumped, and another large group with a predominantly collisional pump. The effect of accelerative and decelerative velocity shifts of up to 5 km s−1 was found to be generally modest, with the primary effect of reducing computed maser optical depths. More subtle asymmetric effects, dependent on line overlap, include maximum gains offset from zero shift by >1 km s−1, but these effects were predominantly found under conditions of weak amplification. These models will allow astronomers to use multitransition water maser observations to constrain physical conditions down to the size of individual masing clouds (size of a few astronomical units).
This paper is the first in a series in which we perform an extensive comparison of various galaxy-based cluster mass estimation techniques that utilize the positions, velocities and colours of ...galaxies. Our primary aim is to test the performance of these cluster mass estimation techniques on a diverse set of models that will increase in complexity. We begin by providing participating methods with data from a simple model that delivers idealized clusters, enabling us to quantify the underlying scatter intrinsic to these mass estimation techniques. The mock catalogue is based on a Halo Occupation Distribution (HOD) model that assumes spherical Navarro, Frenk and White (NFW) haloes truncated at R
200, with no substructure nor colour segregation, and with isotropic, isothermal Maxwellian velocities. We find that, above 1014M⊙, recovered cluster masses are correlated with the true underlying cluster mass with an intrinsic scatter of typically a factor of 2. Below 1014M⊙, the scatter rises as the number of member galaxies drops and rapidly approaches an order of magnitude. We find that richness-based methods deliver the lowest scatter, but it is not clear whether such accuracy may simply be the result of using an over-simplistic model to populate the galaxies in their haloes. Even when given the true cluster membership, large scatter is observed for the majority non-richness-based approaches, suggesting that mass reconstruction with a low number of dynamical tracers is inherently problematic.
Major sudden stratospheric warmings (SSWs), vortex formation, and final breakdown dates are key highlight points of the stratospheric polar vortex. These phenomena are relevant for ...stratosphere‐troposphere coupling, which explains the interest in understanding their future changes. However, up to now, there is not a clear consensus on which projected changes to the polar vortex are robust, particularly in the Northern Hemisphere, possibly due to short data record or relatively moderate CO2 forcing. The new simulations performed under the Coupled Model Intercomparison Project, Phase 6, together with the long daily data requirements of the DynVarMIP project in preindustrial and quadrupled CO2 (4xCO2) forcing simulations provide a new opportunity to revisit this topic by overcoming the limitations mentioned above. In this study, we analyze this new model output to document the change, if any, in the frequency of SSWs under 4xCO2 forcing. Our analysis reveals a large disagreement across the models as to the sign of this change, even though most models show a statistically significant change. As for the near‐surface response to SSWs, the models, however, are in good agreement as to this signal over the North Atlantic: There is no indication of a change under 4xCO2 forcing. Over the Pacific, however, the change is more uncertain, with some indication that there will be a larger mean response. Finally, the models show robust changes to the seasonal cycle in the stratosphere. Specifically, we find a longer duration of the stratospheric polar vortex and thus a longer season of stratosphere‐troposphere coupling.
Key Points
The tropospheric signal of sudden stratospheric warming (SSWs) in the North Atlantic does not change under 4xCO2 forcing
There is high uncertainty in changes of SSW frequency under 4xCO2 forcing; single models show the rate to be significantly halved or doubled
The boreal polar vortex will form earlier and disappear later under increased CO2, extending the season of stratosphere‐troposphere coupling
The implementation of novel therapeutic interventions has improved the survival rates of melanoma patients with metastatic disease. Nonetheless, only 33% of treated cases exhibit long term responses. ...Circulating tumor cell (CTC) measurements are currently of clinical value in breast, prostate and colorectal cancers. However, the clinical utility of melanoma CTCs (MelCTCs) is still unclear due to challenges that appear intrinsic to MelCTCs (i.e. rarity, heterogeneity) and a lack of standardization in their isolation, across research laboratories. Here, we review the latest developments, pinpoint the challenges in MelCTC isolation and address their potential role in melanoma management.
•This review discusses Melanoma CTCs (MelCTCs).•MelCTCs are promising liquid biopsy biomarkers in melanoma.•They are heterogeneous with no common marker for their detection, unlike epithelial cancers.•Label-independent methods are preferred for isolation of diverse MelCTCs.•Identification of MelCTC subtypes provides significant clinical utility.
As genomic sequencing expands, so does our knowledge of the link between genetic variation and disease. Deeper catalogs of variant frequencies improve identification of benign variants, while ...sequencing affected individuals reveals disease‐associated variation. Accumulation of human genetic data thus makes reanalysis a means to maximize the benefits of clinical sequencing. We implemented pipelines to systematically reassess sequencing data from 494 individuals with developmental disability. Reanalysis yielded pathogenic or likely pathogenic (P/LP) variants that were not initially reported in 23 individuals, 6 described here, comprising a 16% increase in P/LP yield. We also downgraded 3 LP and 6 variants of uncertain significance (VUS) due to updated population frequency data. The likelihood of identifying a new P/LP variant increased over time, as ~22% of individuals who did not receive a P/LP variant at their original analysis subsequently did after 3 years. We show here that reanalysis and data sharing increase the diagnostic yield and accuracy of clinical sequencing.
The dual protein kinase-transcription factor, ERK5, is an emerging drug target in cancer and inflammation, and small-molecule ERK5 kinase inhibitors have been developed. However, selective ERK5 ...kinase inhibitors fail to recapitulate ERK5 genetic ablation phenotypes, suggesting kinase-independent functions for ERK5. Here we show that ERK5 kinase inhibitors cause paradoxical activation of ERK5 transcriptional activity mediated through its unique C-terminal transcriptional activation domain (TAD). Using the ERK5 kinase inhibitor, Compound 26 (ERK5-IN-1), as a paradigm, we have developed kinase-active, drug-resistant mutants of ERK5. With these mutants, we show that induction of ERK5 transcriptional activity requires direct binding of the inhibitor to the kinase domain. This in turn promotes conformational changes in the kinase domain that result in nuclear translocation of ERK5 and stimulation of gene transcription. This shows that both the ERK5 kinase and TAD must be considered when assessing the role of ERK5 and the effectiveness of anti-ERK5 therapeutics.
The primary difficulty in measuring dynamical masses of galaxy clusters from galaxy data lies in the separation between true cluster members from interloping galaxies along the line of sight. We ...study the impact of membership contamination and incompleteness on cluster mass estimates obtained with 25 commonly used techniques applied to nearly 1000 mock clusters with precise spectroscopic redshifts. We show that all methods overestimate or underestimate cluster masses when applied to contaminated or incomplete galaxy samples, respectively. This appears to be the main source of the intrinsic scatter in the mass scaling relation. Applying corrections based on a prior knowledge of contamination and incompleteness can reduce the scatter to the level of shot noise expected for poorly sampled clusters. We establish an empirical model quantifying the effect of imperfect membership on cluster mass estimation and discuss its universal and method-dependent features. We find that both imperfect membership and the response of the mass estimators depend on cluster mass, effectively causing a flattening of the estimated–true mass relation. Imperfect membership thus alters cluster counts determined from spectroscopic surveys, hence the cosmological parameters that depend on such counts.
We describe the HadGEM2 family of climate configurations of the Met Office Unified Model, MetUM. The concept of a model "family" comprises a range of specific model configurations incorporating ...different levels of complexity but with a common physical framework. The HadGEM2 family of configurations includes atmosphere and ocean components, with and without a vertical extension to include a well-resolved stratosphere, and an Earth-System (ES) component which includes dynamic vegetation, ocean biology and atmospheric chemistry. The HadGEM2 physical model includes improvements designed to address specific systematic errors encountered in the previous climate configuration, HadGEM1, namely Northern Hemisphere continental temperature biases and tropical sea surface temperature biases and poor variability. Targeting these biases was crucial in order that the ES configuration could represent important biogeochemical climate feedbacks. Detailed descriptions and evaluations of particular HadGEM2 family members are included in a number of other publications, and the discussion here is limited to a summary of the overall performance using a set of model metrics which compare the way in which the various configurations simulate present-day climate and its variability.
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