A
bstract
We consider the Banfi-Marchesini-Smye (BMS) equation which resums ‘non-global’ energy logarithms in the QCD evolution of the energy lost by a pair of jets via soft radiation at large ...angles. We identify a new physical regime where, besides the energy logarithms, one has to also resum (anti)collinear logarithms. Such a regime occurs when the jets are highly collimated (boosted) and the relative angles between successive soft gluon emissions are strongly increasing. These anti-collinear emissions can violate the correct time-ordering for time-like cascades and result in large radiative corrections enhanced by double collinear logs, making the BMS evolution unstable beyond leading order. We isolate the first such a correction in a recent calculation of the BMS equation to next-to-leading order by Caron-Huot. To overcome this difficulty, we construct a ‘collinearly-improved’ version of the leading-order BMS equation which resums the double collinear logarithms to all orders. Our construction is inspired by a recent treatment of the Balitsky-Kovchegov (BK) equation for the high-energy evolution of a space-like wavefunction, where similar time-ordering issues occur. We show that the conformal mapping relating the leading-order BMS and BK equations correctly predicts the physical time-ordering, but it fails to predict the detailed structure of the collinear improvement.
A high complete remission (CR) rate has been reported in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) following imatinib-based therapy. However, the overall ...effect of imatinib on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is undetermined. Between 2002 and 2005, 100 newly diagnosed adult patients with Ph+ALL were registered to a phase II study of imatinib-combined chemotherapy (Japan Adult Leukemia Study Group Ph+ALL202 study) and 97 patients achieved CR. We compared clinical outcomes of 51 patients who received allo-HSCT in their first CR (imatinib cohort) with those of 122 historical control patients in the pre-imatinib era (pre-imatinib cohort). The probability of overall survival at 3 years after allo-HSCT was 65% (95% confidence interval (CI), 49-78%) for the imatinib cohort and 44% (95% CI, 35-52%) for the pre-imatinib cohort. Multivariate analysis confirmed that this difference was statistically significant (adjusted hazard ratio, 0.44, P=0.005). Favorable outcomes of the imatinib cohort were also observed for disease-free survival (P=0.007) and relapse (P=0.002), but not for non-relapse mortality (P=0.265). Imatinib-based therapy is a potentially useful strategy for newly diagnosed patients with Ph+ALL, not only providing them more chance to receive allo-HSCT, but also improving the outcome of allo-HSCT.
We discuss the definition and the energy evolution of scattering amplitudes with
C-odd (“odderon”) quantum numbers within the effective theory for the color glass condensate (CGC) endowed with the ...functional, JIMWLK, evolution equation. We explicitly construct gauge-invariant amplitudes describing multiple odderon exchanges in the scattering between the CGC and two types of projectiles: a color-singlet quark–antiquark pair (or ‘color dipole’) and a system of three quarks in a colorless state. We deduce the energy evolution of these amplitudes from the general JIMWLK equation, which for this purpose is recast in a more synthetic form, which is manifestly infrared finite. For the dipole odderon, we confirm and extend the non-linear evolution equations recently proposed by Kovchegov, Szymanowski and Wallon, which couple the evolution of the odderon to that of the pomeron, and predict the rapid suppression of the odderon exchanges in the saturation regime at high energy. For the 3-quark system, we focus on the linear regime at relatively low energy, where our general equations are shown to reduce to the Bartels–Kwiecinski–Praszalowicz equation. Our gauge-invariant amplitudes, and the associated evolution equations, stay explicitly outside the Möbius representation, which is the Hilbert space where the BFKL Hamiltonian exhibits holomorphic separability.
Summary
Bioluminescence from cells is so dim that bioluminescence microscopy is performed using an ultra low‐light imaging camera. Although the image sensor of such cameras has been greatly improved ...over time, such improvements have not been made commercially available for microscopes until now. Here, we customized the optical system of a microscope for bioluminescence imaging. As a result, bioluminescence images of cells could be captured with a conventional objective lens and colour imaging camera. As bioluminescence microscopy requires no excitation light, it lacks the photo‐toxicity associated with fluorescence imaging and permits the long‐term, nonlethal observation of living cells. Thus, bioluminescence microscopy would be a powerful tool in cellular biology that complements fluorescence microscopy.
To clarify the utility of contrast-enhanced ultrasonography (CEUS) for interim evaluation of response to chemotherapy in lymphoma treatment.
CEUS was performed both before (day 0) and after the ...treatment (7 and/or 14 days), and a time–intensity curve was obtained. The patients were divided into two groups (complete remission CR group and non-CR group) according to the results of conventional response evaluation, and peak enhancement (PE), time to peak enhancement, perfusion index (PI), the total area under the curve during wash-in (AUC-in), and the total AUC were compared between the groups.
Among 27 patients with various types of lymphoma, the median change ratio of PE and PI at day 7 evaluation were significantly different between the CR group and the non-CR group (0.81 versus 1.39, p=0.017 for PE and 0.92 versus 2.09, p=0.010 for PI). The change ratio of PE < 1.09 (specificity: 86%; sensitivity, 88%) and PI < 1.65 (specificity: 86%; sensitivity: 94%) distinguished CR from non-CR. Patients who achieved a PE change ratio <1.09 or a PI change ratio <1.65 had significantly better estimated progression-free survival (p<0.001).
The present study demonstrated that changes in tumour perfusion parameters evaluated with CEUS at 1 week after the treatment initiation were significantly different between lymphoma patients in CR group and non-CR group. Alterations in perfusion parameters evaluated via CEUS could impact the prognosis of lymphoma patients.
•Contrast-enhanced ultrasonography can evaluate treatment response in malignancies.•The significance of interim imaging analysis during the treatment of lymphomas.•Contrast-enhanced ultrasonography is useful to predict the prognosis of lymphoma.
We construct the effective Hamiltonian which governs the renormalization group flow of the gluon distribution with increasing energy and in the leading logarithmic approximation. This Hamiltonian ...defines a two-dimensional field theory which involves two types of Wilson lines: longitudinal Wilson lines which describe gluon recombination (or merging) and temporal Wilson lines which account for gluon bremsstrahlung (or splitting). The Hamiltonian is self-dual, i.e., it is invariant under the exchange of the two types of Wilson lines. In the high density regime where one can neglect gluon number fluctuations, the general Hamiltonian reduces to that for the JIMWLK evolution. In the dilute regime where gluon recombination becomes unimportant, it reduces to the dual partner of the JIMWLK Hamiltonian, which describes bremsstrahlung.
Using the AdS/CFT correspondence in the supergravity approximation, we compute the energy density radiated by a heavy quark undergoing some arbitrary motion in the vacuum of the strongly coupled
N
=
...4
supersymmetric Yang–Mills theory. We find that this energy is fully generated via backreaction from the near-boundary endpoint of the dual string attached to the heavy quark. Because of that, the energy distribution shows the same space–time localization as the classical radiation that would be produced by the heavy quark at weak coupling. We believe that this is an artifact of the supergravity approximation, which will be corrected after including string fluctuations. We discuss some other features of the result, like its anisotropy and the presence of regions with negative energy density. For the case where the quark trajectory is bounded, we also compute the radiated power, by integrating the energy density over the surface of a sphere at infinity. For sufficiently large times, we find agreement with a previous calculation by Mikhailov
hep-th/0305196.
We show that a source which radiates in the vacuum of the strongly coupled
SYM theory produces an energy distribution which, in the supergravity approximation, has the same space-time pattern as the ...corresponding classical distribution: the radiation propagates at the speed of light without broadening. We illustrate this on the basis of several examples: a small perturbation propagating down a steady string, a massless particle falling into AdS
5
, and the decay of a time-like wave-packet. A similar observation was made in
Phys. Rev. D81 (2010) 126001
for the case of a rotating string. In all these cases, the absence of broadening is related to the fact that the energy backreaction on the boundary arises exclusively from the bulk perturbation at, or near, the boundary. This is so since bulk sources which propagate in AdS
5
at the speed of light do not generate any energy on the boundary. We interpret these features as an artifact of the supergravity approximation, which fails to encode quantum mechanical fluctuations that should be present even in the strong coupling limit. We argue that such fluctuations should enter the dual string theory as longitudinal string fluctuations, which are not suppressed at strong coupling. We heuristically estimate the effects of such fluctuations and argue that they restore the broadening of the radiation, in agreement with expectations from both quantum mechanics and the ultraviolet/infrared correspondence.
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