The formation of p-hydroxytranylcypromine from intraperitoneally injected tranylcypromine was confirmed using two types of experiments. In the first, tranylcypromine levels were shown to be increased ...in brains of rats pretreated with agents known to be inhibitors of ring hydroxylation compared to rats pretreated with physiological saline. For the second set of experiments, p-hydroxytranylcypromine was identified in brain and urine (following intraperitoneal injection) by derivatizing with perfluoroacylating reagents and analyzing by electron-capture gas chromatography and by combined gas chromatography-mass spectrometry. In experiments in vitro, p-hydroxytranylcypromine was demonstrated to inhibit monoamine oxidase, although it was weaker than TCP in this regard and was a much stronger inhibitor of MAO-A than of MAO-B.
In a series of 760 patients with adenocarcinoma of the colon and rectum, 103 patients presented with acute obstruction requiring urgent surgical decompression. Obstructed patients were slightly older ...and had slightly more advanced tumors than the total group. Obstructing lesions of the left colon treated primarily by staged procedures had relatively low mortality and five year survival figures comparable to unobstructed cases. Obstructing lesions of the right colon had a much poorer absolute five year survival rate, mainly because of the high operative mortality associated with primary resection in our institution. Five year survival after curative resection in patients with obstructing tumors of the right colon was considerably less than in patients with nonobstructing tumors. A suggestion is made for consideration of proximal external bowel decompression in association with resection of the right colon.
The rapid and accurate detection of influenza A and B in a hospital setting is useful to confirm infection, exclude other diseases and assist in the management of patient illness including the ...possible use of specific antiviral therapy. We evaluated the use of the Directigen Flu A+B in a paediatric hospital laboratory in comparison with the established diagnostic tests direct immunofluorescence, viral culture and reverse transcriptase-polymerase chain reaction. A total of 193 respiratory specimens were examined and the Directigen test detected positive samples with an 80.8 per cent sensitivity and a specificity of 100 per cent. This study confirms other paediatric studies which have found the Directigen Flu A+B to be less sensitive than traditional laboratory tests but nevertheless to have a potential role in patient management especially when a positive result is obtained.
A near-bottom turbidity zone, related to tidal and storm resuspension of bottom muds, is described for Central Long Island Sound. The turbidity layer exists in the deeper parts of the Sound and ...extends over an area of ca. 1,000 km2. This phenomenon may be widespread among
estuaries and embayments. Suspended seston loads change with the stage of the tide, vary seasonally and are concentrated within the lower 6-9 m of the water column. Bottom turbidity increases in the spring, reaching maximum values in May, June, and July (10-40 mg-1)
as measured 1 m above the bottom. Resuspension during this period may be facilitated by intensive bioturbation of the seafloor. Concentrations decrease in late summer, often falling below 10 mg-1. Bottom resuspension may also increase in the fall, related to plankton blooms
or storm mixing of the water column. Earlier studies in Buzzards Bay, Massachusetts have shown that POC, PON, and chlorophyll a are frequently higher in the near-bottom turbidity layer than in surface water. Bottom concentrations are apparently correlated with surface production.
The potential of the PON contained in the turbidity zone to support growth of commercially important molluscan species is evaluated in terms of a simulation model of Mytilus edulis deployed on bottom racks. The output of this model closely predicts the measured growth rate of an actual
M. edulis deployment in the turbidity zone of Buzzards Bay, Massachusetts. The simulation model predicts that 1.5 to 3.8 g (dry wt) mussels can be obtained if 0.3 g (dry wt) spat are placed into the turbidity zone in May and cropped in late December. This range of mussel weight depends
on the assigned assimilation efficiency which could range between 52 to 100%.
Food was given to pigs before weaning to determine whether a hypersensitive response to dietary antigen might be a predisposing factor to postweaning diarrhea. Small amounts of food increased the ...severity and accelerated the onset of postweaning diarrhea. Postweaning diarrhea was dependent on the presence within the diet of antigenic material (bovine casein). A weaning diet, containing little antigenic material (hydrolyzed casein), had less effect on sucrase concentration in intestinal brush borders than did diets rich in antigens (native casein). Seemingly, immune-mediated intestinal damage may predispose the pig to postweaning diarrhea.
Neck injury is an all too frequent accompaniment to a military fast jet flying career. The incidence of neck injury within the RAAF was last formally reviewed in 1997. Over the succeeding ten year ...period to date, although the fast jet inventory within RAAF has not appreciably changed, the fast jet flying environment has changed significantly, with introduction of new technology such as Night Vision Goggles and the Joint Helmet Mounted Cueing Systems into service, with even greater changes planned for the near future. A current review of neck injury patterns was therefore undertaken as part of a comprehensive education package delivered to all fast jet squadrons within RAAF during 2007. This paper will discuss various factors associated with neck injury occurrence within RAAF. Information derived from this review has been utilised to guide holistic preventive and management activities into the future.
Monitoring of a large piggery in Victoria demonstrated that the rate of carriage by wild rats as detected by bacterial culture was 2.3 percent. The results indicated that adequate control of wild ...rats on piggeries should be an essential element of all attempts to control or eradicate swine dysentery.
The Oxford Biomedical Research Centre (BRC) was established in April 2007. OHE and RAND Europe were commissioned by the Oxford BRC to undertake a programme of top-down evaluations of aspects of the ...impact of the BRC since its inception. This programme of research has looked at the health, economic and scientific impact of Oxford BRC's research activity, whether achieved directly from the outcomes of the many specific pieces of BRC-supported research, or indirectly due to the BRC's impact on research activity/awareness/culture in health services and industry. Overall this programme of research indicated that the Oxford BRC has had a number of positive impacts on health care provided at OUH, through both direct and indirect effects. It is clear that Oxford BRC research plays a major role within the totality of research activity at OUH. In particular, Oxford BRC has - - Added positively to the reputation of OUH, and has facilitated collaboration between OUH clinical staff and academic researchers; - Had a positive effect on commercial activity; - Been associated with an increase in the number of publications and collaborations amongst relevant institutions within the Oxford region Please note a chapter of this report( https://health-policy-systems.biomedcentral.com/articles/10.1186/s12961-016-0163-7) has also been published in Health Research Policy and Systems.
The 1997-98 influenza season was dominated by the influenza A (H3N2) virus for the second consecutive year. Outbreaks of influenza B virus were reported in Japan and the People's Republic of China ...but worldwide, most isolates were influenza A virus. Two related viruses circulated during this time: A/Wuhan/359/95 and A/Sydney/5/97. The influenza season began in early December and peaked in early February. In May, the first case of influenza A (H5N1) occurred in Hong Kong, and was followed by 17 additional cases in November and December. The 1998-99 vaccine will contain A/Sydney/5/97 (H3N2), A/Beijing/262/95 (H1N1) and B/Beijing/184/93 viruses.
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