ACE (adverse childhood experience) studies typically examine the links between childhood stressors and adult health harming behaviours. Using an enhanced ACE survey methodology, we examine impacts of ...ACEs on non-communicable diseases and incorporate a proxy measure of premature mortality in England.
A nationally representative survey was undertaken (n = 3885, aged 18-69, April-July 2013). Socio-demographically controlled proportional hazards analyses examined the associations between the number of ACE categories (<18 years; e.g. child abuse and family dysfunction such as domestic violence) and cancer, diabetes, stroke, respiratory, liver/digestive and cardiovascular disease. Sibling (n = 6983) mortality was similarly analysed as a measure of premature mortality.
Of the total, 46.4% of respondents reported ≥1 and 8.3% ≥4 ACEs. Disease development was strongly associated with increased ACEs (e.g. hazard ratios, HR, 0 versus ≥4 ACEs; cancer, 2.38 (1.48-3.83); diabetes, 2.99 (1.90-4.72); stroke, 5.79 (2.43-13.80, all P < 0.001). Individuals with ≥4 ACEs (versus no ACEs) had a 2.76 times higher rate of developing any disease before age 70 years. Adjusted HR for mortality was strongly linked to ACEs (≥4 versus 0 ACEs; HR, 1.97 (1.39-2.79), P < 0.001).
Radically different life-course trajectories are associated with exposure to increased ACEs. Interventions to prevent ACEs are available but rarely implemented at scale. Treating the resulting health costs across the life course is unsustainable.
Mini Abstract: Pregnancy-associated osteoporosis (PAO) is a rare syndrome affecting women during late pregnancy and the early postpartum period. We set out to review the clinical features of ten ...cases of PAO from a single UK centre. Patients had attended the Royal National Hospital for Rheumatic Diseases, Bath (RNHRD) between January 2000 and June 2016. The principal criterion for inclusion was the occurrence of low trauma fractures either during pregnancy or the immediate post-partum period. Data were obtained from retrospective review of medical notes. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (Hologic ®Discovery system) at the lumbar spine and hip. Data pertaining to the pregnancy, as well as type and duration of treatment received, were reviewed. All ten cases presented with vertebral fractures. In four patients, no risk factors for fracture other than pregnancy or breastfeeding could be identified. Four patients were found to have vitamin D insufficiency at the time of diagnosis, and a further two patients had received treatment with low molecular weight heparin (LMWH). In one case, further investigation led to a diagnosis of osteogenesis imperfecta (OI) confirmed on genetic testing. In terms of treatment, eight out of the ten patients in this series received a bisphosphonate, most commonly risedronate due to its relatively short skeletal retention time. Clinicians should be aware of PAO, a rare but recognised complication of pregnancy. The condition should be especially considered in women presenting with new onset back pain in pregnancy or the postpartum period.
We present new results on the shock around the south-west radio lobe of Centaurus A using data from the Chandra Very Large Programme observations (740 ks total observing time). The X-ray spectrum of ...the emission around the outer south-western edge of the lobe is well described by a single power-law model with Galactic absorption – thermal models are strongly disfavoured, except in the region closest to the nucleus. We conclude that a significant fraction of the X-ray emission around the south-west part of the lobe is synchrotron, not thermal. We infer that in the region where the shock is strongest and the ambient gas density lowest, the inflation of the lobe is accelerating particles to X-ray synchrotron emitting energies, similar to supernova remnants such as SN1006. This interpretation resolves a problem of our earlier, purely thermal, interpretation for this emission, namely that the density compression across the shock was required to be much larger than the theoretically expected factor of 4. We describe a self-consistent model for the lobe dynamics and shock properties using the shell of thermal emission to the north of the lobe to estimate the lobe pressure. Based on this model, we estimate that the lobe is expanding to the south-west with a velocity of ∼2600 km s−1, roughly Mach 8 relative to the ambient medium. We discuss the spatial variation of spectral index across the shock region, concluding that our observations constrain γmax for the accelerated particles to be ∼108 at the strongest part of the shock, consistent with expectations from diffusive shock acceleration theory. Finally, we consider the implications of these results for the production of ultra-high energy cosmic rays (UHECRs) and TeV emission from Centaurus A, concluding that the shock front region is unlikely to be a significant source of UHECRs, but that TeV emission from this region is expected at levels comparable to current limits at TeV energies, for plausible assumed magnetic field strengths.
Super massive black holes at the centres of galaxies can cycle through periods of activity and quiescence. Characterising the duty cycle of active galactic nuclei (AGN) is crucial for understanding ...the impact of the energy they release on the host galaxy. For radio AGN, this can be done by identifying dying (remnant) and restarted radio galaxies from their radio spectral properties. Using the combination of the images at 1400 MHz produced by Apertif, the new phased-array feed receiver installed on the Westerbork Synthesis Radio Telescope, and images at 150 MHz provided by LOFAR, we have derived resolved spectral index images (at a resolution of ~15 arcsec) for all the sources within an approximately 6 deg
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area of the Lockman Hole region. In this way, we were able to select 15 extended radio sources with emission (partly or entirely) characterised by extremely steep spectral indices (steeper than 1.2). These objects represent cases of radio sources in the remnant or the restarted phases of their life cycle. Our findings confirm that these objects are not as rare as previously thought, suggesting a relatively fast cycle. They also show a variety of properties that can be relevant for modelling the evolution of radio galaxies. For example, the restarted activity can occur while the remnant structure from a previous phase of activity is still visible. This provides constraints on the duration of the “off” (dying) phase. In extended remnants with ultra-steep spectra at low frequencies, the activity likely stopped a few hundred megayears ago, and they correspond to the older tail of the age distribution of radio galaxies, in agreement with the results of simulations of radio source evolution. We find remnant radio sources with a variety of structures (from double-lobed to amorphous), possibly suggesting different types of progenitors. The present work sets the stage for exploiting the powerful tool of low-frequency spectral index studies of extended sources by taking advantage of the large areas common to the LOFAR and the Apertif surveys.
We present new deep Chandra observations of the Centaurus A jet, with a combined on-source exposure time of 719 ks. These data allow detailed X-ray spectral measurements to be made along the jet out ...to its disappearance at 4.5 kpc from the nucleus. We distinguish several regimes of high-energy particle acceleration; while the inner part of the jet is dominated by knots and has properties consistent with local particle acceleration at shocks, the particle acceleration in the outer 3.4 kpc of the jet is likely to be dominated by an unknown distributed acceleration mechanism. In addition to several compact counterjet features, we detect probable extended emission from a counterjet out to 2.0 kpc from the nucleus and argue that this implies that the diffuse acceleration process operates in the counterjet as well. A preliminary search for X-ray variability finds no jet knots with dramatic flux density variations, unlike the situation seen in M87.
ABSTRACT
The Square Kilometre Array Observatory (SKAO) will explore the radio sky to new depths in order to conduct transformational science. SKAO data products made available to astronomers will be ...correspondingly large and complex, requiring the application of advanced analysis techniques to extract key science findings. To this end, SKAO is conducting a series of Science Data Challenges, each designed to familiarize the scientific community with SKAO data and to drive the development of new analysis techniques. We present the results from Science Data Challenge 2 (SDC2), which invited participants to find and characterize 233 245 neutral hydrogen (H i) sources in a simulated data product representing a 2000 h SKA-Mid spectral line observation from redshifts 0.25–0.5. Through the generous support of eight international supercomputing facilities, participants were able to undertake the Challenge using dedicated computational resources. Alongside the main challenge, ‘reproducibility awards’ were made in recognition of those pipelines which demonstrated Open Science best practice. The Challenge saw over 100 participants develop a range of new and existing techniques, with results that highlight the strengths of multidisciplinary and collaborative effort. The winning strategy – which combined predictions from two independent machine learning techniques to yield a 20 per cent improvement in overall performance – underscores one of the main Challenge outcomes: that of method complementarity. It is likely that the combination of methods in a so-called ensemble approach will be key to exploiting very large astronomical data sets.
Hyperphosphatemia is thought to underlie medial vascular calcification in advanced renal failure, but calcification can occur in other conditions in the absence of hyperphosphatemia, indicating that ...additional factors are important. To identify these factors, a model of medial calcification in rat aorta in vitro was developed. Aortic rings from rats were incubated in serum-free medium for 9 d, and calcification was measured as incorporation of (45)Ca and confirmed by histology and x-ray diffraction. No calcification occurred in normal vessels despite elevated free Ca(2+) and PO(4)(3-) concentrations of 1.8 mM and 3.8 mM, respectively, but mechanical injury resulted in extensive calcification in the media. Co-incubation studies revealed that normal aortas produced a soluble inhibitor of calcification in injured vessels that was destroyed by alkaline phosphatase. Culture of normal aortas with alkaline phosphatase resulted in calcification of the elastic lamina identified as hydroxyapatite by x-ray diffraction. This effect of alkaline phosphatase was not due to dephosphorylation of osteopontin (OPN), and calcification was not increased in aortas from OPN-deficient mice. The inhibitor was identified as pyrophosphate on the basis of the calcification induced in aortas cultured with inorganic pyrophosphatase, the inhibition of calcification in injured aortas by pyrophosphate, and the production of inhibitory levels of pyrophosphate by normal aortas. No calcification occurred under any conditions at a normal PO(4)(3-) concentration. It is concluded that elevated concentrations of Ca(2+) and PO(4)(3-) are not sufficient for medial vascular calcification because of inhibition by pyrophosphate. Alkaline phosphatase can promote calcification by hydrolyzing pyrophosphate, but OPN is not an endogenous inhibitor of calcification in rat aorta.
We report the discovery of a bright transient X-ray source, CXOU J132518.2-430304, toward Centaurus A (Cen A) using six new Chandra X-Ray Observatory observations in 2007 March-May. Between 2003 and ...2007, its flux has increased by a factor of >770. The source is likely a low-mass X-ray binary in Cen A with unabsorbed 0.3-10 keV band luminosities of (2-3) x 10 super(39)ergs s super(-1) and a transition from the steep-power-law state to the thermal state during our observations. CXOU J132518.2-430304 is the most luminous X-ray source in an early-type galaxy with extensive timing information that reveals transience and a spectral state transition. Combined with its luminosity, these properties make this source one of the strongest candidates to date for containing a stellar-mass black hole in an early-type galaxy. Unless this outburst lasts many years, the rate of luminous transients in Cen A is anomalously high compared to other early-type galaxies.
We present results from new Chandra, archival Hubble Space Telescope (HST), and VLA imaging observations of the circumnuclear extended emission in the nearby Type 2 Seyfert galaxy NGC 2110. We find ...resolved soft-band X-ray emission 64" (6160 pc) north of the nucleus, which is spatially coincident with O III emission, but lies just beyond the northern edge of the radio jet in the source. We find that shock heating of multiphase gas clouds can successfully account for this extended emission, although we cannot rule out alternative models, such as the scattering of nuclear radiation by ionized material, or pure photoionization from the nucleus. In addition, we detect kiloparsec-scale (630") extended soft-band X-ray emission south of the nucleus. Finally, we compare our results for NGC 2110 with the prototypical type 2 Seyfert galaxy NGC 1068, and suggest that different physical processes could produce extended circumnuclear X-ray emission in Seyfert galaxies.
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