We demonstrate measurement of uranium isotopes in femtosecond laser ablation plumes using two-dimensional fluorescence spectroscopy (2DFS). The high-resolution, tunable CW-laser spectroscopy ...technique clearly distinguishes atomic absorption from
U and
U in natural and highly enriched uranium metal samples. We present analysis of spectral resolution and analytical performance of 2DFS as a function of ambient pressure. Simultaneous measurement using time-resolved absorption spectroscopy provides information on temporal dynamics of the laser ablation plume and saturation behavior of fluorescence signals. The rapid, non-contact measurement is promising for in-field, standoff measurements of uranium enrichment for nuclear safety and security.
Spending time in natural environments can benefit health and well-being, but exposure-response relationships are under-researched. We examined associations between recreational nature contact in the ...last seven days and self-reported health and well-being. Participants (n = 19,806) were drawn from the Monitor of Engagement with the Natural Environment Survey (2014/15-2015/16); weighted to be nationally representative. Weekly contact was categorised using 60 min blocks. Analyses controlled for residential greenspace and other neighbourhood and individual factors. Compared to no nature contact last week, the likelihood of reporting good health or high well-being became significantly greater with contact ≥120 mins (e.g. 120-179 mins: ORs 95%CIs: Health = 1.59 1.31-1.92; Well-being = 1.23 1.08-1.40). Positive associations peaked between 200-300 mins per week with no further gain. The pattern was consistent across key groups including older adults and those with long-term health issues. It did not matter how 120 mins of contact a week was achieved (e.g. one long vs. several shorter visits/week). Prospective longitudinal and intervention studies are a critical next step in developing possible weekly nature exposure guidelines comparable to those for physical activity.
A Global Fireball Observatory Devillepoix, H.A.R.; Cupák, M.; Bland, P.A. ...
Planetary and space science,
10/2020, Letnik:
191
Journal Article
Recenzirano
Odprti dostop
The world’s meteorite collections contain a very rich picture of what the early Solar System would have been made of, however the lack of spatial context with respect to their parent population for ...these samples is an issue. The asteroid population is equally as rich in surface mineralogies, and mapping these two populations (meteorites and asteroids) together is a major challenge for planetary science. Directly probing asteroids achieves this at a high cost. Observing meteorite falls and calculating their pre-atmospheric orbit on the other hand, is a cheaper way to approach the problem. The Global Fireball Observatory (GFO) collaboration was established in 2017 and brings together multiple institutions (from Australia, USA, Canada, Morocco, Saudi Arabia, the UK, and Argentina) to maximise the area for fireball observation time and therefore meteorite recoveries. The members have a choice to operate independently, but they can also choose to work in a fully collaborative manner with other GFO partners. This efficient approach leverages the experience gained from the Desert Fireball Network (DFN) pathfinder project in Australia. The state-of-the art technology (DFN camera systems and data reduction) and experience of the support teams is shared between all partners, freeing up time for science investigations and meteorite searching. With all networks combined together, the GFO collaboration already covers 0.6% of the Earth’s surface for meteorite recovery as of mid-2019, and aims to reach 2% in the early 2020s. We estimate that after 5 years of operation, the GFO will have observed a fireball from virtually every meteorite type. This combined effort will bring new, fresh, extra-terrestrial material to the labs, yielding new insights about the formation of the Solar System.
•A large international collaboration is being set up to observe meteorite falls on Earth, aiming 2% Earth coverage.•The recovery of different types of fresh meteorites helps understanding the early Solar System.•The orbital origins of meteorites also inform us about the hazard posed by larger Near-Earth Objects.
Coulomb dissociation of 16O into 4He and 12C Göbel, Kathrin; Heil, Michael; Bott, Lukas ...
9th Nuclear Physics in Astrophysics, NPA 2019, Frankfurt, Germany,
10/2020, Letnik:
1668, Številka:
1
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
We measured the Coulomb dissociation of 16O into 4He and 12C at the R3B setup in a first campaign within FAIR Phase 0 at GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt. The goal was to ...improve the accuracy of the experimental data for the 12C(α,γ)16O fusion reaction and to reach lower center-ofmass energies than measured so far. The experiment required beam intensities of 109 16O ions per second at an energy of 500 MeV/nucleon. The rare case of Coulomb breakup into 12C and 4He posed another challenge: The magnetic rigidities of the particles are so close because of the same mass-to-charge-number ratio A/Z = 2 for 16O, 12C and 4He. Hence, radical changes of the R3B setup were necessary. All detectors had slits to allow the passage of the unreacted 16O ions, while 4He and 12C would hit the detectors' active areas depending on the scattering angle and their relative energies. We developed and built detectors based on organic scintillators to track and identify the reaction products with sufficient precision.
The androgen receptor (AR) is a key driver of prostate cancer (PC), even in the state of castration-resistant PC (CRPC) and frequently even after treatment with second-line hormonal therapies such as ...abiraterone and enzalutamide. The persistence of AR activity via both ligand-dependent and ligand-independent mechanisms (including constitutively active AR splice variants) highlights the unmet need for alternative approaches to block AR signaling in CRPC. We investigated the transcription factor GATA-binding protein 2 (GATA2) as a regulator of AR signaling and an actionable therapeutic target in PC. We demonstrate that GATA2 directly promotes expression of both full-length and splice-variant AR, resulting in a strong positive correlation between GATA2 and AR expression in both PC cell lines and patient specimens. Conversely, GATA2 expression is repressed by androgen and AR, suggesting a negative feedback regulatory loop that, upon androgen deprivation, derepresses GATA2 to contribute to AR overexpression in CRPC. Simultaneously, GATA2 is necessary for optimal transcriptional activity of both full-length and splice-variant AR. GATA2 colocalizes with AR and Forkhead box protein A1 on chromatin to enhance recruitment of steroid receptor coactivators and formation of the transcriptional holocomplex. In agreement with these important functions, high GATA2 expression and transcriptional activity predicted worse clinical outcome in PC patients. A GATA2 small molecule inhibitor suppressed the expression and transcriptional function of both full-length and splice-variant AR and exerted potent anticancer activity against PC cell lines. We propose pharmacological inhibition of GATA2 as a first-in-field approach to target AR expression and function and improve outcomes in CRPC.
Significance Androgen receptor (AR) signaling is a key driver of prostate cancer (PC), even in the context of resistance to current therapies, creating an unmet need for novel approaches to inhibit AR. We demonstrate that the transcription factor GATA-binding protein 2 (GATA2) is critical for both AR expression and optimal transcriptional activity. GATA2 colocalizes with AR and Forkhead box protein A1 on chromatin to enhance recruitment of steroid receptor coactivators and formation of the transcriptional holocomplex. A GATA2 inhibitor suppressed the expression and transcriptional function of AR (including the constitutively active splice variants) and exerted potent anticancer activity against PC cells. We propose GATA2 inhibition as a previously unexplored approach to extinguish both ligand-dependent and ligand-independent AR transcriptional activity and to improve clinical outcomes for PC patients.
In 1991, a group of expert scientists at a Wingspread work session on endocrine-disrupting chemicals (EDCs) concluded that “Many compounds introduced into the environment by human activity are ...capable of disrupting the endocrine system of animals, including fish, wildlife, and humans. Endocrine disruption can be profound because of the crucial role hormones play in controlling development.” Since that time, there have been numerous documented examples of adverse effects of EDCs in invertebrates, fish, wildlife, domestic animals, and humans. Hormonal systems can be disrupted by numerous different anthropogenic chemicals including antiandrogens, androgens, estrogens, AhR agonists, inhibitors of steroid hormone synthesis, antithyroid substances, and retinoid agonists. In addition, pathways and targets for endocrine disruption extend beyond the traditional estrogen/androgen/thyroid receptor–mediated reproductive and developmental systems. For example, scientists have expressed concern about the potential role of EDCs in increasing trends in early puberty in girls, obesity and type II diabetes in the United States and other populations. New concerns include complex endocrine alterations induced by mixtures of chemicals, an issue broadened due to the growing awareness that EDCs present in the environment include a variety of potent human and veterinary pharmaceutical products, personal care products, nutraceuticals and phytosterols. In this review we (1) address what have we learned about the effects of EDCs on fish, wildlife, and human health, (2) discuss representative animal studies on (anti)androgens, estrogens and 2,3,7,8-tetrachlorodibenzo-p-dioxin–like chemicals, and (3) evaluate regulatory proposals being considered for screening and testing these chemicals.
On June 19, 2020 at 20:05:07 UTC, a fireball lasting 5.5s was observed above Western Australia by three Desert Fireball Network observatories. The meteoroid entered the atmosphere with a speed of ...14.00±0.17 km s‐1 and followed a 58° slope trajectory from a height of 75 km down to 18.6 km. Despite the poor angle of triangulated planes between observatories (29°) and the large distance from the observatories, a well‐constrained kilo‐size main mass was predicted to have fallen just south of Madura in Western Australia. However, the search area was predicted to be large due to the trajectory uncertainties. Fortunately, the rock was rapidly recovered along the access track during a reconnaissance trip. The 1.072 kg meteorite called Madura Cave was classified as an L5 ordinary chondrite. The calculated orbit is of Aten type (mostly contained within the Earth’s orbit), only the second time a meteorite was observed on such an orbit, after Bunburra Rockhole. Dynamical modeling shows that Madura Cave has been in near‐Earth space for a very long time. The dynamical lifetime in near‐Earth space for the progenitor meteoroid is predicted to be ~87 Myr. This peculiar orbit also points to a delivery from the main asteroid belt via the ν6 resonance, and therefore an origin in the inner belt. This result contributes to drawing a picture for the existence of a present‐day L chondrite parent body in the inner belt.
Adipose tissue quantity and quality both affect oocyte quality and endometrial factors required for reproductive success.Within adipose tissue (WAT), adipocytes produce and secrete bioactive ...molecules, known as adipokines, that exert endocrine and paracrine effects on various reproductive processes.WAT is highly dynamic and changes at the whole organ and cellular level in response to reproductive hormone fluctuations during menarche, pregnancy, and menopause.Metabolic studies should always include the use of females, with a proper study design that considers menstrual/estrous cycle stage and hormone levels.
Body composition impacts female fertility and there are established relationships between adipose tissue and the reproductive system. Maintaining functional adipose tissue is vital for meeting the energetic demands during the reproductive process, from ovulation to delivery and lactation. White adipose tissue (WAT) shows plastic responses to daily physiology and secretes diverse adipokines that affect the hypothalamic–pituitary–ovarian axis, but many other interorgan interactions remain to be determined. This Review summarizes the current state of research on the dialogue between WAT and the female reproductive system, focusing on the impact of this crosstalk on ovarian and endometrial factors essential for fecundity.
Body composition impacts female fertility and there are established relationships between adipose tissue and the reproductive system. Maintaining functional adipose tissue is vital for meeting the energetic demands during the reproductive process, from ovulation to delivery and lactation. White adipose tissue (WAT) shows plastic responses to daily physiology and secretes diverse adipokines that affect the hypothalamic–pituitary–ovarian axis, but many other interorgan interactions remain to be determined. This Review summarizes the current state of research on the dialogue between WAT and the female reproductive system, focusing on the impact of this crosstalk on ovarian and endometrial factors essential for fecundity.
Arpu Kuilpu: An H5 from the outer main belt Shober, Patrick M.; Devillepoix, Hadrien A. R.; Sansom, Eleanor K. ...
Meteoritics & planetary science,
June 2022, 2022-06-00, 20220601, Letnik:
57, Številka:
6
Journal Article
Recenzirano
Odprti dostop
On June 1, 2019, just before 7:30 p.m. local time, the Desert Fireball Network (DFN) detected a −9.3 magnitude fireball over South Australia near the Western Australia border. The event was observed ...by six fireball observatories, and lasted for 5 s. One station was nearly directly underneath the trajectory, greatly constraining the trajectory solution. This trajectory's backward numerical integrations indicate that the object originated from the outer main belt with a semimajor axis of 2.75 au. A light curve was also extracted and showed that the body experienced very little fragmentation during its atmospheric passage. A search campaign was conducted with several DFN team members and other volunteers. One 42 g fragment was recovered within the predicted fall area based on the dark flight model. Based on measurements of short‐lived radionuclides, the fragment was confirmed to be a fresh fall. The meteorite, Arpu Kuilpu, has been classified as an H5 ordinary chondrite. This marks the fifth fall recovered in Australia by the DFN, and the smallest meteoroid (≃2 kg) to ever survive entry and be recovered as a meteorite.
Data demonstrate numerous per- and polyfluoroalkyl substances (PFAS) activate peroxisome proliferator-activated receptor alpha (PPARα), however, additional work is needed to characterize PFAS ...activity on PPAR gamma (PPARγ) and other nuclear receptors. We utilized
in vitro
assays with either human or rat PPARα or PPARγ ligand binding domains to evaluate 16 PFAS (HFPO-DA, HFPO-DA-AS, NBP2, PFMOAA, PFHxA, PFOA, PFNA, PFDA, PFOS, PFBS, PFHxS, PFOSA, EtPFOSA, and 4:2, 6:2 and 8:2 FTOH), 3 endogenous fatty acids (oleic, linoleic, and octanoic), and 3 pharmaceuticals (WY14643, clofibrate, and the metabolite clofibric acid). We also tested chemicals for human estrogen receptor (hER) transcriptional activation. Nearly all compounds activated both PPARα and PPARγ in both human and rat ligand binding domain assays, except for the FTOH compounds and PFOSA. Receptor activation and relative potencies were evaluated based on effect concentration 20% (EC
20
), top percent of max fold induction (pmax
top
), and area under the curve (AUC). HFPO-DA and HFPO-DA-AS were the most potent (lowest EC
20
, highest pmax
top
and AUC) of all PFAS in rat and human PPARα assays, being slightly less potent than oleic and linoleic acid, while NBP2 was the most potent in rat and human PPARγ assays. Only PFHxS, 8:2 and 6:2 FTOH exhibited hER agonism >20% pmax.
In vitro
measures of human and rat PPARα and PPARγ activity did not correlate with oral doses or serum concentrations of PFAS that induced increases in male rat liver weight from the National Toxicology Program 28-d toxicity studies. Data indicate that both PPARα and PPARγ activation may be molecular initiating events that contribute to the
in vivo
effects observed for many PFAS.
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