Short rotation poplar plantations grow on flat and even terrain, and the interrow spacing is wide enough for easy machine access. If the terrain is firm enough, one may consider moving the classic ...roadside chipping operation directly into the field (i.e., terrain chipping), thus saving on wood extraction cost. This study compared the efficiency and cost of roadside and terrain chipping conducted with exactly the same equipment, to assess the benefits offered by the versatile deployment of a standard chipping operation, whereby the operation can be moved inside the stand whenever terrain conditions are suitable. The study was conducted at 12 sample plots, containing about one truck load of chips each (i.e., approximately 11 bone-dry tons or BDT). Plots were arranged as alternate windrows on a 8.5 ha field. Data was collected for the whole supply chain, from field to factory. The factory was located 14 km from the field. Delivered cost was 53 € BDT-1 and 70 € BDT-1 for roadside and terrain chipping, respectively, i.e., terrain chipping was 1/3 more expensive than roadside chipping, even if the latter included the additional cost of forwarding the residues to the roadside. The chipper-truck used for the test could not cope with small scattered residue piles (32 BDT ha-1), and the cumbersome reposition maneuver became the main hurdle to efficient operation. Further improvements might be achieved by pre-bunching the residues, introducing a dedicated terrain chipper or bundling the residues and taking the bundles to the factory for centralized chipping.
The special extract ERr 731 from the roots of rhapontic rhubarb has been regularly prescribed for women with menopausal symptoms since 1993. As its constituents belong to the class of natural ...hydroxystilbenes, concerns have been raised about possible health risks similar to those known for the estrogenic diethylstilbestrol. To demonstrate the safety of the medical use of ERr 731, the extract was tested in long-term toxicity studies in dogs.
In two independent studies, male and female beagle dogs were treated with 100, 300 and 1000mg ERr 731/kg body weight (bw)/day and observed for 4 and 13 weeks followed by recovery periods. A histopathological examination of a full set of organs of all animals was examined.
In both studies, all animals survived the scheduled treatment and recovery periods. The administration of ERr 731 resulted in increased incidences of feces with white particles due to an incomplete absorption of the extract. In the 13-week study, a slight decrease in glucose levels was recorded in both sexes at 1000mg/kgbw/day. All other clinical changes were marginal and not related to ERr 731. Importantly, there was no increase in weight of organs of the genital tract due to ERr 731 intake. Based on these results, the no-observed-adverse-effect-level is 1000mg/kgbw/day. No pathological findings where detected following ERr 731 treatment demonstrating that the toxicological risk for women taking ERr 731 regularly is extremely low.
We established a straightforward experimental system to investigate directly the requirements for nucleocytoplasmic transport in live cells. For this purpose, substrates were created containing ...nuclear localization signals (NLS) or nuclear export signals (NES) linked to a chimeric protein composed of the glutathione S-transferase (GST) fused to the green fluorescent protein (GFP). The combination of GST/GFP-tagging allowed us to control protein expression in bacteria and to monitor protein purification during chromatography. Following microinjection into somatic cells, nuclear export/import of the highly fluorescent substrates could be observed directly by fluorescence microscopy. This system sets the stage to quantitate, in real time, the kinetics of nuclear import/export in living cells and to evaluate qualitative differences in various NLS/NES signals and pathways.
The most frequent complications following midline abdominal laparotomy include incisional hernias, which develop in 10-15 % of patients and surgical site infections in 15-25 % of cases; however, the ...risk of these complications can be reduced by the surgical technique and the use of special suture materials. In 2010, the INLINE meta-analysis performed by the Study Centre of the German Society of Surgery (SDGC) revealed that a continuous suture technique using slowly absorbable suture material resulted in the lowest risk of developing postoperative incisional hernia after elective midline laparotomy.
The aim of this study was to perform a systematic literature search to identify all randomized controlled trials (RCTs) that have been published since 2010 concerning conventional abdominal wall closure in order to update the 2010 INLINE meta-analysis and summarize current evidence.
On 28 January 2016, a systematic literature search was performed in MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL). All RCTs dealing with abdominal wall closure after midline laparotomy were identified and included for further analysis.
Since 2010 a total of 9 RCTs comparing different techniques of abdominal wall closure have been published. Three monocentric RCTs comparing different suture materials, showed no significant differences to the INLINE meta-analysis regarding incisional hernia development; therefore, slowly absorbable sutures using a continuous suture technique are still recommended for abdominal wall closure in elective cases. Furthermore, six RCTs were identified which investigated antimicrobial suture materials but failed to show an overall advantage for Triclosan-coated suture material with respect to surgical site infections.
Current evidence shows that slowly absorbable monofilament suture material using a continuous suture technique provides the best results with regard to incisional hernia rates after elective midline laparotomy. Triclosan-coated sutures cannot be recommended as a standard suture material as they failed to reduce surgical site infections. For emergency laparotomies no evidence exists to recommend a specific kind of suture technique or a special suture material.
Conflicting rules of the correct procedures of the Temple cult, whose significance demanded absolute exactitude and uniformity, precluded common public rituals and created the schism.
Eukaryotic initiation factor 5A (eIF-5A) is the only cellular protein known to contain the unusual amino acid hypusine. The exact in vivo function of eIF-5A, however, is to date unknown. The finding ...that eIF-5A is an essential cofactor of the human immunodeficiency virus type 1 (HIV-1) Rev RNA transport factor suggested that eIF-5A is part of a specific nuclear export pathway. In this study we used indirect immunofluorescence and immunogold electron microscopy to demonstrate that eIF-5A accumulates at nuclear pore-associated intranuclear filaments in mammalian cells and Xenopus oocytes. We are able to show that eIF-5A interacts with the general nuclear export receptor, CRM1. Furthermore, microinjection studies in somatic cells revealed that eIF-5A is transported from the nucleus to the cytoplasm, and that this nuclear export is blocked by leptomycin B. Our data demonstrate that eIF-5A is a nucleocytoplasmic shuttle protein.
This study argues that the source of the law constitutes the crucial ideological and practical difference between man-made and God-given codices. In the Mesopotamian codices, while the gods grant to ...the sovereign the authority to govern, it is he who ultimately creates the relevant laws. He is thus the source of the law and controls its application. God is the only source of biblical law, and is involved in its implementation. This crucial difference has far-reaching consequences. In particular, Mesopotamian laws focus on the redress of harm done to humans and on disruption of human order; further, legal procedures, sanctions and modes of compensation can be changed, forgiven or abolished. Biblical law regards some infractions as harms against humans, but others are also perceived as crimes against the Lord and a disruption of the divine order. Punishments are fixed by God in both cases, and are eternal and inalterable.
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