Broad-spectrum antibiotics from the fluoroquinolone family have emerged as prominent water contaminants, among other pharmaceutical pollutants. In the present study, an antibacterial magnetic ...molecularly imprinted polymer (MMIP) composite was successfully fabricated using carboxy methyl dextrin grafted to poly(aniline-
-meta-phenylenediamine) in the presence of Fe
O
/CuO nanoparticles and ciprofloxacin antibiotic. The characteristics of obtained materials were investigated using FTIR, XRD, VSM, TGA, EDX, FE-SEM, zeta potential, and BETanalyses. Afterward, the MMIP's antibacterial activity and adsorption effectiveness for removing ciprofloxacin from aqueous solutions were explored. The results of the antibacterial tests showed that MMIP had an antibacterial effect against
, a Gram-negative pathogen (16 mm), and
, a Gram-positive pathogen (22 mm). Adsorption efficacy was evaluated under a variety of experimental conditions, including solution pH, adsorbent dosage, contact time, and initial concentration. The maximum adsorption capacity (Q
) of the MMIP for ciprofloxacin was determined to be 1111.1 mg/g using 3 mg of MMIP, with an initial concentration of 400 mg/L of ciprofloxacin at pH 7, within 15 min, and agitated at 25 °C, and the experimental adsorption results were well-described by the Freundlich isotherm model. The adsorption kinetic data were well represented by the pseudo-second-order model. Electrostatic interaction, cation exchange, π-π interactions, and hydrogen bonding were mostly able to adsorb the majority of the ciprofloxacin onto the MMIP. Adsorption-desorption experiments revealed that the MMIP could be retrieved and reused with no noticeable reduction in adsorption efficacy after three consecutive cycles.
Sulfonated polymer-based materials, among heterogeneous catalysts, are frequently utilized in chemical transformations due to their outstanding chemical and physical durability. In this regard, a ...magnetic sulfonated melamine–formaldehyde resin (MSMF) catalyst was successfully prepared from a mixture of sulfonated melamine–formaldehyde and Fe3O4 nanoparticles in two steps. MSMF was used as a heterogeneous catalyst for the one-pot, three-component condensation of benzyl pyrazolyl naphthoquinones in water as a green solvent and 4-(indol-3-yl)-arylmethyl-1-phenyl-3-methyl-5-pyrazolones. The antimicrobial and antioxidant activities of catalyst, benzyl pyrazolyl naphthoquinones, and 4-(indol-3-yl)-arylmethyl-1-phenyl-3-methyl-5-pyrazolones were evaluated using agar disk-diffusion and DPPH assays, respectively. The antioxidant activity of the catalyst and 4-(indol-3-yl)-arylmethyl-1-phenyl-3-methyl-5-pyrazolones was found to be 75% and 90%, respectively. Furthermore, catalyst, benzyl pyrazolyl naphthoquinones, and 4-(indol-3-yl)-arylmethyl-1-phenyl-3-methyl-5-pyrazolones exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli. In conclusion, MSMF is a superior catalyst for green chemical processes, owing to its high catalytic activity, stability, and reusability.
Early diagnosis is essential for the effective illness treatment, but traditional diagnostic approaches inevitably have major downsides. Recent advancements in nanoparticle-based biosensors have ...created new opportunities for accelerating diagnosis. High surface area, exceptional sensitivity, high specificity, and optical characteristics of metal and metal oxide nanoparticles have made it possible to detect a variety of health conditions and diseases immediately, including cancer, viral infection, biomarkers, and in-vivo imaging. Metal nanoparticles may be produced in a variety of ways, enabling the creation of innovative tools for chemical and biological sensing targets. The utilization of various metal nano-formulations, metal oxide nanoplatforms, and their composites in the early identification of illnesses is reported and summarized in this review. Additionally, the challenging corners in the use of metal oxide-based nano-scale diagnostic technologies in clinical applications are highlighted. The current work is believed to serve as a roadmap for in-depth research on inorganic nanomedicine, both in-vitro and in-vivo diagnosis of diseases and illnesses, especially pandemic infections like COVID-19.
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In this work, magnetic poly(aniline-
co
-melamine) nanocomposite as an efficient heterogeneous polymer-based nanocatalyst was fabricated in two steps. First, poly(aniline-
co
-melamine) was ...synthesized through the chemical oxidation by ammonium persulfate, then the magnetic nanocatalyst was successfully prepared from the
in-situ
coprecipitation method in the presence of poly(aniline-
co
-melamine). The resulting poly(aniline-
co
-melamine)@MnFe
2
O
4
was characterized by FTIR, FESEM, XRD, VSM, EDX, TGA, and UV-vis analyses. The catalytic activity of poly(aniline-
co
-melamine)@MnFe
2
O
4
was investigated in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives, and new alkylene bridging bis 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives in excellent yields. The yield of 1,4-dihydropyrano2,3-cpyrazoles, 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), yields, and new alkylene bridging bis 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives were obtained 89%–96%, 90%–96%, and 92%–96%, respectively. The poly(aniline-
co
-melamine)@MnFe
2
O
4
nanocatalyst can be recycled without pre-activation and reloaded up to five consecutive runs without a significant decrease in its efficiency. In addition, the antioxidant activity of some derivatives was evaluated by DPPH assay. Results showed that the maximum antioxidant activity of 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives and 1,4-dihydropyrano2,3-
c
pyrazoles were 75% and 90%, respectively. Furthermore, 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives and 1,4-dihydropyrano2,3-
c
pyrazoles showed good potential for destroying colon cancer cell lines. Consequently, the poly(aniline-
co
-melamine)@MnFe
2
O
4
nanocomposite is an excellent catalyst for green chemical processes owing to its high catalytic activity, stability, and reusability.
Ionic liquids have developed as a new class of low-temperature molten salts which are formed of weakly corresponding cations and anions. Efforts to extend the ionic liquids applications across ...different research arenas have grown in recent years with growths in understanding and tailoring their physical, chemical, and biological properties. The use of ionic liquids as a source/media for the synthesis and stabilization of metal nanostructures has gained more popularity recently owing to their ability to be personalized in varying sizes, and morphologies. The metal nanostructures synthesized in the presence of ionic liquids are employed in cancer diagnosis and therapy. The current review describes the different ionic liquids and their role in the synthesis of metal nanostructures for cancer diagnosis and therapy. In the end, the perspective and new directions for developing ionic liquid-mediated synthesis of metal nanostructures for cancer diagnostic and therapy are highlighted.
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Lung cancer remains as the leading cause of cancer-related fatalities globally, posing significant challenges to conventional treatment methods, particularly in advanced stages where limitations and ...adverse effects are prevalent. Nanotechnology offers promising solutions to enhance lung cancer therapy. Inorganic nanomaterials, such as metal nanoparticles, rare earth elements, and carbonaceous materials, exhibit unique properties that can address these challenges. Metal nanoparticles facilitate targeted drug delivery, biosensing, and imaging, while rare earth elements demonstrate selective cytotoxic effects and imaging capabilities. Carbonaceous materials find applications in biosensing and drug delivery, including carbon ion radiotherapy. These advancements in inorganic nanomaterials present an opportunity to revolutionize lung cancer treatment, potentially leading to improved outcomes and better patient well-being. This paper focuses on recent progress in utilizing inorganic nanomaterials for treating lung cancer, aiming to provide a clearer understanding of their benefits compared to conventional treatments, along with an in-depth examination of their associated limitations and adverse effects.
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A magnetic poly (1,8-diaminonaphthalene)-nickel (PDAN-Ni@Fe3O4) composite as a multifunctional nanocatalyst was prepared in several steps including (I) synthesis of poly (1,8-diaminonaphthalene) ...(PDAN), (II) modification of PDAN with NiSO4 (PDAN-Ni) and (III) preparation of magnetic nanocatalyst by iron (I and II) salts in the existence of PDAN-Ni complex (PDAN-Ni@Fe3O4). Fourier-transform infrared spectroscopy (FTIR), elemental analysis (CHNSO), vibrating-sample magnetometer (VSM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), field emission scanning electron microscope (FESEM), ultraviolet–visible (UV–vis), and thermogravimetric analysis (TGA) were applied to characterize the prepared nanocatalyst. The PDAN-Ni@Fe3O4 was applied as an environmentally friendly nanocatalyst for the isoxazole-5(4H)-ones synthesis via a one-pot reaction between aryl/heteroaryl aldehyde, hydroxylamine hydrochloride, and β-ketoester. The nanocomposite was also used for the synthesis of some new alkylene bridging bis 4-benzylidene-3-methyl isoxazole-5(4H)-ones. The catalyst's reusability, and the antioxidant and antibacterial activities of both catalyst and products, were studied. Results showed that the nanocatalyst and isoxazole-5(4H)-ones have antioxidant activity of 75% and 92%, respectively. In addition, the antibacterial test showed that the nanocatalyst and isoxazole-5(4H)-ones have highly active versus Staphylococcus aureus and Escherichia coli bacteria. The reusability and stability of the nanocatalyst, a medium to higher product yield and conversion, a faster reaction time, and the use of green solvents were a few benefits of this study.
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•A magnetic bionanocomposite based on carboxymethyl dextrin was fabricated.•Bionanocomposite showed good antibacterial and antioxidant activities and low toxicity.•Bionanocomposite ...showed good physicochemical properties such as solubility and conductivity.•Bionanocomposite can have good potential applications in biomedical applications.
Nowadays, nanocomposites based on carbohydrate polymers owing to good physicochemical and biological properties have found promising applications in various fields especially biomedical applications. In the current study, a bioactive nanocomposite based on carboxymethyl dextrin-grafted-poly(aniline-co-meta-phenylenediamine) and iron oxide/copper oxide (CMD-g-PACPD@Fe3O4/CuO) was prepared by an in-situ copolymerization method. Several analyses such as FT-IR, NMR, EDX, BET, XRD, UV–vis, FE-SEM, TGA, VSM, and DLS were employed for the characterization of prepared materials. The NMR spectroscopy confirmed the preparation of carboxymethyl dextrin. The FTIR and EDX analysis showed that the CMD-g-PACPD@Fe3O4/CuO nanocomposite was prepared successfully. The specific surface area of about 11.30 m2/g was obtained for CMD-g-PACPD@Fe3O4/CuO nanocomposite by using BET analysis. The specific conductivity values of CMD-g-PACPD@Fe3O4/CuO were obtained in a range of 0.3 to 102 µS/cm in various solvents. The solubility test showed that the best solvent for the dispersion of the CMD-g-PACPD@Fe3O4/CuO was dimethyl sulfoxide. A superparamagnetic property of the CMD-g-PACPD@Fe3O4/CuO with saturation magnetism (MS) of 16.49 emu/g was obtained by VSM analysis. The CMD-g-PACPD@Fe3O4/CuO nanocomposite had good antioxidant (54 %) and antibacterial (against Escherichia coli and Staphylococcus aureus) activities and low toxicity at high concentrations (500 mg/mL). The current work may shed light on the potential applications of CMD-g-PACPD@Fe3O4/CuO in biomedical applications.
In this research study, a novel method, an in-situ growth approach, to incorporate metal-organic framework (MOF) into carrageenan-grafted- polyacrylamide-Fe3O4 substrate was introduced. ...Carrageenan-grafted-polyacrylamide-Fe3O4/MOF nanocomposite (kC-g-PAAm@Fe3O4-MOF-199) was fabricated utilizing three stages. In this way, the polyacrylamide (PAAm) was grafted onto the carrageenan (kC) backbone via free radical polymerization in the presence of methylene bisacrylamide (MBA) as cross-linker and Fe3O4 magnetic nanoparticles. Next, the kC-g-PAAm@Fe3O4 was modified by MOF-199 via an in-situ solvothermal approach. Several analyses such as Fourier transform infrared spectroscopy (FT-IR), X-Ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-Dispersive X-ray Spectroscopy (EDX), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), Brunauer-Emmett-Teller (BET) demonstrated the successful synthesis of kC-g-PAAm@Fe3O4-MOF-199 magnetic hydrogel nanocomposite. The XRD pattern of magnetic hydrogel nanocomposite illustrated characteristic peaks of Fe3O4, neat kC, and MOF-199 with enhanced crystallinity in comparison with kC-g-PAAm@Fe3O4. TGA showed it has a char yield of 24 wt% at 800 °C. VSM confirmed its superparamagnetic behavior (with Ms of 8.04 emu g−1), and the BET surface area of kC-g-PAAm@Fe3O4-MOF-199 was measured at 64.864 m2 g−1, which was higher than that of kC-g-PAAm@Fe3O4 due to the highly porous MOF-199 incorporation with a BET surface area of 905.12 m2 g−1). The adsorption effectiveness of kC-g-PAAm@Fe3O4-MOF-199 for eliminating cephalosporin and quinolones antibiotics, i.e., Cefixime (CFX) and Levofloxacin (LEV) from the aquatic area was considered. Several experimental setups were used to evaluate the efficacy of adsorption, such as solution pH, amount of adsorbent, contact duration, and initial concentration. The maximum adsorption capacity (Qmax) of the prepared magnetic hydrogel nanocomposite was found to be 2000 and 1666.667 mg−1 for LEV and CFX using employing 0.0025 g of adsorbent. The Freundlich isotherm model well described the experimental adsorption data with R2CFX = 0.9986, and R2LEV = 0.9939. And the adsorption kinetic data were successfully represented by the pseudo-second-order model with R2LEV = 0.9949 and R2CFX = 0.9906. Hydrogen bonding, π-π interaction, diffusion, and entrapment in the hydrogel network all contributed to the successful adsorption of both antibiotics onto the kC-g-PAAm@Fe3O4-MOF-199 adsorbent. Other notable physicochemical properties include the three-dimensional structure and availability of the reactive adsorption sites. Moreover, the adsorption/desorption efficacy of magnetic hydrogel nanocomposites was not significantly diminished after four cycles of recovery.
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•A MOF-199 was prepared via in situ method onto carrageenan-grafted polyacrylamide hydrogel.•High adsorption capacity (2000 and 1666.667 mg/g) of LEV and CFX was achieved.•Adsorption data were fitted by Freundlich isotherms and pseudo second-order kinetics.•The kC-g-PAAm@Fe3O4-MOF-199 nanoadsorbent reused at least four times.
Developing new and efficient technologies for environmental remediation is becoming significant due to the increase in global concerns such as climate change, severe epidemics, and energy crises. Air ...pollution, primarily due to increased levels of H2S, SOx, NH3, NOx, CO, volatile organic compounds (VOC), and particulate matter (PM) in the atmosphere, has a significant impact on public health, and exhaust gases harm the natural sulfur, nitrogen, and carbon cycles. Similarly, wastewater discharged to the environment with metal ions, herbicides, pharmaceuticals, personal care products, dyes, and aromatics/organic compounds is a risk for health since it may lead to an outbreak of waterborne pathogens and increase the exposure to endocrine-disrupting agents. Therefore, developing new and efficient air and water quality management systems is critical. Metal-organic frameworks (MOFs) are novel materials for which the main application areas include gas storage and separation, water harvesting from the atmosphere, chemical sensing, power storage, drug delivery, and food preservation. Due to their versatile structural motifs that can be modified during synthesis, MOFs also have a great promise for green applications including air and water pollution remediation. The motivation to use MOFs for environmental applications prompted the modification of their structures via the addition of metal and functional groups, as well as the creation of heterostructures by mixing MOFs with other nanomaterials, to effectively remove hazardous contaminants from wastewater and the atmosphere. In this review, we focus on the state-of-the-art environmental applications of MOFs, particularly for water treatment and air pollution, by highlighting the groundbreaking studies in which MOFs have been used as adsorbents, membranes, and photocatalysts for the abatement of air and water pollution. We finally address the opportunities and challenges for the environmental applications of MOFs.
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•Developing new and efficient technologies for environmental remediation is becoming significant.•MOFs hold great promise for environmental applications due to their versatile structural motifs.•The state-of-the-art environmental applications of MOFs for water treatment and air pollution described.•We addressed opportunities and challenges for the environmental applications of MOFs.
