The preparation of high‐quality perovskite films is important for achieving high‐performance perovskite solar cells (PSCs). The effective balance between solvent and antisolvent is an essential ...factor for regulating high‐quality perovskite film during the spin‐coating and thermal‐annealing steps. In this work, a greener, nonhalogenated, nontoxic bifunctional (anti)solvent, methyl benzoate (MB), is developed not only as an antisolvent to rapidly generate crystal seeds at the perovskite spin‐coating step, but also as a digestive‐ripening solvent for the perovskite precursors, which can prevent the loss of organic components during the thermal‐annealing stage and effectively suppress the formation of miscellaneous lead halide phases. As a result, this novel bifunctional (anti)solvent is employed in planar n–i–p PSCs for engineering high‐quality perovskite layers and thus achieving a power conversion efficiency up to 22.37% with negligible hysteresis and >1300 h stability. Moreover, due to the high boiling point and low‐volatility characteristic of MB, high‐performance PSCs are achieved reproducibly at different operating temperatures (22–34 °C). Therefore, this developed bifunctional solvent system can provide a promising platform toward globally upscaling and commercializing PSCs in all seasons and regions.
A novel bifunctional (anti)solvent system is developed for regulating the perovskite crystallization procedure. It can perform not only as an antisolvent at the spin‐coating step to rapidly generate crystal seeds, but also as a solvent for ripening the precursors to large crystal grains during the thermal‐annealing process. Therefore, it can significantly enhance the efficiency, stability, and reproducibility of perovskite solar cells.
Ram air turbines are used in the power generation systems of hypersonic vehicles, which can address the problem of the high power consumption of weapon systems. However, high incoming air ...temperatures can cause the turbine blades of power generation to ablate. At this point, the incoming air can no longer be used as a cooling source to cool the turbine blades. To prevent the ablation of the turbine blades of the hypersonic vehicle power generation, hydrocarbon fuel carried by the hypersonic vehicle itself is used to cool the turbine blades. Hence, hydrocarbon fuels under rotating conditions are investigated. The results show that the rotation leads to a strong pressure gradient that causes the density and dynamic viscosity of hydrocarbon fuel to increase dramatically. Compared to the static condition, the density and dynamic viscosity of the hydrocarbon fuel increase by a maximum of 65.1% and 405%, respectively, under the rotating condition. This leads to an obvious reduction in velocity. The comprehensive influence of the physical properties of the fuel, centrifugal force, and Coriolis force causes the convective heat transfer coefficient and Nusselt number of the channel to first increase and then decrease with the increase in the rotational speed. Compared to the static condition, the convective heat transfer coefficient and Nusselt number increase by a maximum of 69.7% and 45.6%, respectively, under the rotating condition. The critical rotational speed of the Nusselt number from rise to fall is 20,000 rpm for different inlet temperature conditions.
For the problem of power generation turbine blade ablation in hypersonic vehicles, hydrocarbon fuel carried by the vehicle is used to cool the turbine blades. In order to fully utilize the cooling ...capacity of hydrocarbon fuel, the structure of the cooling channels needs to be optimized. In this study, a variable clearance hydrocarbon fuel cooling channel is applied for the first time to the rotating turbine blades of a hypersonic vehicle to enhance the heat transfer ability of hydrocarbon fuel. The effect of clearance size on the heat transfer performance of hydrocarbon fuel under rotating conditions is investigated. The accuracy of the calculations is verified by comparison with experimental data. The results of the study show that the heat transfer performance can be significantly improved by changing the clearance of the turning section. The clearance size 2.5 D channel has the highest thermal performance with a maximum improvement of 1.8 times. The law of change of thermal performance is affected by crossing the critical temperature point, as it is different before and after the crossing. Thermal performance changes from decreasing then increasing to increasing then decreasing as the clearance size increases for high rotation speed conditions as the temperature of the entrance straddles the critical temperature. The Nusselt number first increases and then decreases for all channels with different clearance sizes with an increasing rotational speed. The friction factor changes from first increasing and then decreasing to decreasing and then increasing as the clearance size increases for high rotation speed conditions as the temperature of the entrance straddles the critical temperature.
Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing ...HIF-1α-mediated transactivation and glycolysis. Mechanistically, HIFAL recruits prolyl hydroxylase 3 (PHD3) to pyruvate kinase 2 (PKM2) to induce its prolyl hydroxylation and introduces the PKM2/PHD3 complex into the nucleus via binding with heterogeneous nuclear ribonucleoprotein F (hnRNPF) to enhance HIF-1α transactivation. Reciprocally, HIF-1α induces HIFAL transcription, which forms a positive feed-forward loop to maintain the transactivation activity of HIF-1α. Clinically, high HIFAL expression is associated with aggressive breast cancer phenotype and poor patient outcome. Furthermore, HIFAL overexpression promotes tumor growth in vivo, while targeting both HIFAL and HIF-1α significantly reduces their effect on cancer growth. Overall, our results indicate a critical regulatory role of HIFAL in HIF-1α-driven transactivation and glycolysis, identifying HIFAL as a therapeutic target for cancer treatment.
Background The association between gastrointestinal cancer and types of meat consumption, including red meat, processed meat, or a combination of both, remains disputable. Therefore, we performed a ...systematic review and meta-analysis of prospective cohort studies to estimate the association between meat consumption and gastrointestinal cancer risk. Methods PubMed, EmBase, and the Cochrane library databases were searched systematically for eligible studies that investigated the relation between meat consumption and the risk of developing gastrointestinal cancers, including esophageal cancer (EC), gastric cancer (GC), colorectal cancer (CRC), colon cancer (CC), rectal cancer (RC), pancreatic cancer (PC), and hepatocellular carcinoma (HCC) throughout February, 2023. The pooled relative risk (RR) with 95% confidence interval (CI) was assigned as an effect estimate and calculated using a random-effects model with inverse variance weighting. Results Forty cohorts comprising 3,780,590 individuals were selected for the final quantitative analysis. The summary results indicated that a higher red meat consumption was associated with an increased risk of CRC (RR: 1.09; 95% CI: 1.02-1.16; P = 0.007) and CC (RR: 1.13; 95% CI: 1.03-1.25; P = 0.011). Moreover, a higher processed meat consumption was associated with an increased risk of CRC (RR: 1.19; 95% CI: 1.13-1.26; P < 0.001), CC (RR: 1.24; 95% CI: 1.13-1.26; P < 0.001), and RC (RR: 1.24; 95% CI: 1.08-1.42; P = 0.002). Furthermore, a higher total consumption of red and processed meat was associated with an increased risk of CRC (RR: 1.13; 95% CI: 1.06-1.20; P < 0.001), CC (RR: 1.17; 95% CI: 1.04-1.33; P = 0.012), and RC (RR: 1.20; 95% CI: 1.04-1.39; P = 0.016). Finally, the strength of higher consumption of total red and processed meat with the risk of GC, and higher consumption of red meat with the risk of RC in subgroup of high adjusted level was lower than subgroup of moderate adjusted level, while the strength of higher consumption of processed meat with the risk of RC and HCC in subgroup of follow-up greater than or equal to 10.0 years was higher than subgroup of follow-up < 10.0 years. Conclusions This study found that meat consumption was associated with an increased risk of CRC, CC, and RC, and dietary intervention could be considered an effective strategy in preventing CRC.
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause ...cell death. Entosis is one mechanism proposed to mediate the engulfment and killing of live tumor cells by their neighbors, an activity often referred to as cell cannibalism. Here we report that the expression of exogenous epithelial cadherin proteins (E- or P-cadherin) in human breast tumor cells lacking endogenous expression of epithelial cadherins induces entosis and inhibits transformed growth. Entosis induced by cadherin expression is associated with the polarized distribution of Rho and Rho-kinase (ROCK) activity within entotic cells, which is dependent on p190A RhoGAP activity. ROCK inhibition or downregulation of p190A RhoGAP expression reduces entosis and increases the transformed growth of epithelial cadherin-expressing tumor cells. These data define new cell systems for the study of entosis, and identify entosis as a mechanism of cell cannibalism that is induced by the establishment of epithelial adhesion and inhibits transformed growth.
In this paper, the flow and heat dissipation performance of 0.1–0.5 vol per cent of Al2O3 -water nanofluid through serpentine micro-channel was experimentally studied in the Reynolds range 124–1000. ...By analyzing the experimental results of nanofluid flow and heat dissipation: In the experiment, the Nusselt number of nanofluids is 1.12–1.66 times that of deionized water, which indicates that Al2O3 -water nanofluids have significant heat transfer enhancement effect. Nanofluid flow resistance is 1.02–1.80 times that of deionized water, this indicates that Al2O3 -water nanofluid has the disadvantage of increasing energy consumption. From a comprehensive performance point of view: all the nanofluids used in the experiment have enhanced heat transfer factors more significant than one, and the enhanced heat transfer effect is better than that of deionized water, this suggests that Al2O3 -water nanofluid has the drawback of rising energy consumption. All the nanofluids used in the experiment have enhanced heat transfer factors more significant than one, and the enhanced heat transfer effect is better than that of deionized water. Nano-fluids, with a volume fraction of 0.4%, have an average increased heat transfer factor of 1.4, which is the best overall performance.
Long-chain ω-3 polyunsaturated fatty acids (ω3-PUFAs), including eicosapentaenoic acid (EPA) (20:5ω-3), docosapentaenoic acid (DPA) (22:5ω-3), and docosahexaenoic acid (DHA) (22:6ω-3), have been ...shown to reduce cardiovascular risk, but effects on cause-specific and total mortality and potential dose-responses remain controversial. Most observational studies have assessed self-reported dietary intake and most randomized trials have tested effects of adding supplements to dietary intake and evaluated secondary prevention, thus limiting inference for dietary ω3-PUFAs or primary prevention.
To investigate associations of plasma phospholipid EPA, DPA, DHA, and total ω3-PUFA levels with total and cause-specific mortality among healthy older adults not receiving supplements.
Prospective cohort study.
4 U.S. communities.
2692 U.S. adults aged 74 years (±5 years) without prevalent coronary heart disease (CHD), stroke, or heart failure at baseline.
Phospholipid fatty acid levels and cardiovascular risk factors were measured in 1992. Relationships with total and cause-specific mortality and incident fatal or nonfatal CHD and stroke through 2008 were assessed.
During 30 829 person-years, 1625 deaths (including 570 cardiovascular deaths), 359 fatal and 371 nonfatal CHD events, and 130 fatal and 276 nonfatal strokes occurred. After adjustment, higher plasma levels of ω3-PUFA biomarkers were associated with lower total mortality, with extreme-quintile hazard ratios of 0.83 for EPA (95% CI, 0.71 to 0.98; P for trend = 0.005), 0.77 for DPA (CI, 0.66 to 0.90; P for trend = 0.008), 0.80 for DHA (CI, 0.67 to 0.94; P for trend = 0.006), and 0.73 for total ω3-PUFAs (CI, 0.61 to 0.86; P for trend < 0.001). Lower risk was largely attributable to fewer cardiovascular than noncardiovascular deaths. Individuals in the highest quintile of phospholipid ω3-PUFA level lived an average of 2.22 more years (CI, 0.75 to 3.13 years) after age 65 years than did those in the lowest quintile.
Temporal changes in fatty acid levels and misclassification of causes of death may have resulted in underestimated associations, and unmeasured or imperfectly measured covariates may have caused residual confounding.
Higher circulating individual and total ω3-PUFA levels are associated with lower total mortality, especially CHD death, in older adults.
National Institutes of Health.
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•Spatial distribution of soil enzyme activities was visualized by direct zymography.•Decreased soil pH induced increased acid soluble chromium (Cr)•Enzyme activity hotspots in the ...rhizosphere were larger than hotspots in bulk soil.•Biochar led to a larger maize performance index and greater shoot/root ratio.•Manure addition narrowed enzyme activity zones more strongly than biochar.
Chromium (Cr) contamination is especially hazardous to soil biota. Application of manure and biochar has been frequently proposed to remediate Cr-contaminated soil. However, the understanding of mechanisms behind manure and biochar impacts on soil enzyme activities requires advanced visualization technologies. For the first time, we compared manure and its biochar influence on the spatial distribution of β-glucosidase, N-acetyl-glucosaminidase and phosphomonoesterase activities in Cr-contaminated soil using direct zymography. Maize was planted for 45 days in (a) soil mixed with manure, (b) soil mixed with manure-derived biochar and (c) soil without any addition. Soil pH decreased over 45 days, inducing an increase in acid soluble Cr. The concomitant decrease in β-glucosidase and N-acetyl-glucosaminidase activities explained the narrowing rhizosphere extent of enzyme activities by 13–44%, indicating that increased Cr bioavailability decreases microbial activities. A larger maize performance index and the greatest plant shoot/root ratio after biochar application suggested enhanced maize growth (p < 0.05). In contrast, manure induced the narrowest extent of β-glucosidase and phosphomonoesterase activities due to the addition of labile organic compounds and nutrients following its application. Our study emphasizes the importance of pH on Cr bioavailability and enzyme activities and demonstrates that biochar application is more ideally suited for remediating Cr-contaminated soil.
Freezing of gait (FOG) is common in neurodegenerative forms of atypical parkinsonism, but few studies have examined FOG in multiple system atrophy (MSA). In this study, we examined the prevalence of ...freezing of gait and its relationship to clinical features in a large cohort of Chinese MSA patients.
This exploratory study included 202 Chinese patients with probable MSA. FOG was defined as a score ≥ 1 on item 14 of the Unified Parkinson's Disease Rating Scale. Patients with or without FOG were compared in terms of the Unified MSA Rating Scale (UMSARS) as well as cognitive and neuropsychiatric assessments.
The frequency of FOG was 48.0, 52.1, and 38.7% in MSA, MSA with predominant parkinsonism (MSA-P), and MSA with predominant cerebellar ataxia (MSA-C), respectively. FOG was associated with worse subscores on parts I, II and IV of the UMSARS as well as worse total UMSARS score; greater likelihood of speech difficulties, falls, gait impairment and balance disorder; more severe symptoms of anxiety and depression; and lower activities of daily living. The binary logistic regression model indicated that higher total UMSARS scores were associated with FOG in MSA, MSA-P, and MSA-C patients.
Freezing of gait may be common among Chinese MSA patients, FOG may correlate with severe motor symptoms, anxiety, depression and activities of daily living. Total UMSARS score may be an independent risk factor for FOG.
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