Today, individual's self-disclosure on the social network sites (SNS) have become a prevalent phenomenon. This study proposes a research model for investigating the beneficial effects of individual's ...self-disclosure on the social network sites (SNS). In this study, social support and online social well-being are seen as the beneficial effects of individual's self-disclosure on the SNS. Furthermore, this study examines whether self-disclosure increases social support and online social well-being. For developing a more parsimonious research model, this study chose self-disclosure and social support as second-order constructs. Self-disclosure is devised as a formative second-order construct that includes five components: amount, depth, honesty, intent, and valence. Social support is used as a reflective second-order construct comprising two factors: informational support and emotional support. In addition, this research also proposes that social support increase online social well-being. Further, online social well-being is hypothesized to positively affect the continuance intention in relation to the SNS. Data collected from 333 Facebook users provided support for all the hypotheses. Implications for theory and practice are discussed, and suggestions are made for future research.
•This research proposes two beneficial effects of individual's self-disclosure: social support and online social well-being.•Self-disclosure has a positive, significant effect on social support and online social well-being.•Social support has a significant, positive effect on online social well-being.•Online social well-being has a strong effect on the individual's continuance intention toward the SNS.
Customer loyalty or repeat purchasing is critical for the survival and success of any store. By focusing on online stores, this study investigates the repeat purchase intention of experienced online ...buyers based on means‐end chain theory and prospect theory. In the research model, both utilitarian value and hedonic value are hypothesised to affect repeat purchase intention positively. Perceived risk is hypothesised to affect repeat purchase intention negatively and moderate the effects of utilitarian and hedonic values on repeat purchase intention. Utilitarian value is proposed as a formative second‐order construct formed by product offerings, product information, monetary savings and convenience. Hedonic value is also proposed as a formative second‐order construct formed by the six hedonic benefits that have been identified in prior research. Data collected from 782 Yahoo!Kimo customers provide strong support for the research model. The results indicate that both the utilitarian value and hedonic value are positively associated with buyers' repeat purchase intention. A higher level of perceived risk reduces the effect of utilitarian value and increases the effect of hedonic value on repeat purchase intention. Implications for theory and practice and suggestions for future research are provided.
User loyalty or continued use is critical to the survival and development of any website. Focusing on the social network services (SNSs) context, this study proposes a research model for ...investigating individuals' use motivations and the moderating role of habit with regard to gratification and continuance intention. This research integrates two influential media communication theories, media system dependency (MSD) and uses and gratifications, to examine SNSs-related behaviors. To comprehend online users' motivations in depth, three motivations derived from MSD (understanding, orientation and play dependency relations) are operationalized as reflective, second-order constructs. The three motivations are theorized to affect parasocial interaction positively, and parasocial interaction is hypothesized to positively affect the gratification that individuals derive from SNSs usage. Furthermore, this study hypothesizes that gratification positively affects individuals' continuance intention. Finally, we theorize that habit moderates the impact of gratification on continuance intention. Data collected from 657 Facebook users provide strong support for all six hypotheses. The results indicate that individuals' motivations (i.e., the understanding, orientation and play dependency relations) positively affect parasocial interaction, which in turn has a positive effect on gratification, and subsequently continuance intention. In addition, the results show that habit has a small but negative moderating effect on the relationship between gratification and continuance intention. Implications for theory and practice are discussed, and suggestions are made for future research.
► Perceived network size negatively affect a member's social network site (SNS) identification. ► Perceived external prestige positively affect a member's identification with the SNS. ► Perceived ...complementarity has a stronger effect than compatibility on user satisfaction. ► Satisfaction has a stronger effect than SNS identification on subjective well-being (SWB). ► Satisfaction is the strongest antecedent of loyalty, followed by SWB and SNS identification.
This study aims to investigate users’ subjective well-being and loyalty towards social network sites (SNSs). Despite the growing role of network externalities in SNS continuance decisions, the SNS usage literature has paid scant attention to the relationship between network externalities, SNS identification, and users’ subjective well-being. In this study, we identify four components of network externalities: perceived network size, external prestige, compatibility, and complementarity. In the research model, both network size and external prestige are hypothesized positively to affect SNS identification. Perceived compatibility and perceived complementarity are hypothesized positively to affect user satisfaction. Satisfaction and SNS identification are hypothesized positively to affect user subjective well-being and loyalty towards the SNS. Users’ subjective well-being is hypothesized positively to affect their loyalty towards the SNS. Data collected from 615 valid users of Facebook provide strong support for most of these hypotheses. The findings indicate that perceived network size negatively affects users’ SNS identifications. Other components of network externalities have positive effects on SNS identification and satisfaction, which in turn have positive effects on users’ subjective well-being and loyalty towards SNS. Implications for theory and practice and suggestions for future research are also discussed.
MicroRNAs (miRNAs) play important roles in the development of various cancers including lung cancer which is one of the devastating diseases worldwide. How miRNAs function in de novo lung ...tumorigenesis remains largely unknown. We here developed a CRISPR/Cas9-mediated dual guide RNA (dgRNA) system to knockout miRNAs in genetically engineered mouse model (GEMM). Through bioinformatic analyses of human lung cancer miRNA database, we identified 16 downregulated miRNAs associated with malignant progression and performed individual knockout with dgRNA system in KrasG12D/Trp53L/L (KP) mouse model. Using this in vivo knockout screening, we identified miR-30b and miR-146a, which has been previously reported as tumor suppressors and miR-190b, a new tumor-suppressive miRNA in lung cancer development. Over-expression of miR-190b in KP model as well as human lung cancer cell lines significantly suppressed malignant progression. We further found that miR-190b targeted the Hus1 gene and knockout of Hus1 in KP model dramatically suppressed lung tumorigenesis. Collectively, our study developed an in vivo miRNA knockout platform for functionally screening in GEMM and identified miR-190b as a new tumor suppressor in lung cancer.
Objective
This study aimed to examine associations of maternal folic acid supplementation (FAS) during pregnancy with childhood overweight or obesity (OWO) or adiposity.
Methods
In a population‐based ...cohort of 1479 children, maternal FAS during pregnancy was assessed retrospectively by questionnaires. BMI and body fat percentages were measured at a mean age of 6.4 years. Pertinent factors were accounted for in data analyses.
Results
Maternal FAS during pregnancy was negatively associated with OWO (adjusted odds ratio: 0.70; 95% CI: 0.50 to 0.99). There were inverse associations of maternal FAS during pregnancy with BMI z score (β: −0.22; 95% CI: −0.39 to −0.05), whole body fat percentage (β: −1.28; 95% CI: −2.27 to −0.30), trunk fat percentage (β: −1.41; 95% CI: −2.78 to −0.04), and limb fat percentage (β: −1.31; 95% CI: −2.32 to −0.30). Stratified analyses found inverse associations of FAS during pregnancy with OWO, BMI z score, and body fat percentages predominantly among children without breastfeeding and whose parents had a below‐tertiary educational level.
Conclusions
This study provides novel evidence that maternal FAS during pregnancy was significantly associated with a decreased risk of childhood OWO and adiposity, particularly among children with no breastfeeding and lower parental educational level.
Cytokine signaling is responsible for coordinating conserved epithelial regeneration and immune responses in the digestive tract. In the Drosophila midgut, Upd3 is a major cytokine, which is induced ...in enterocytes (EC) and enteroblasts (EB) upon oral infection, and initiates intestinal stem cell (ISC) dependent tissue repair. To date, the genetic network directing upd3 transcription remains largely uncharacterized. Here, we have identified the key infection-responsive enhancers of the upd3 gene and show that distinct enhancers respond to various stresses. Furthermore, through functional genetic screening, bioinformatic analyses and yeast one-hybrid screening, we determined that the transcription factors Scalloped (Sd), Mothers against dpp (Mad), and D-Fos are principal regulators of upd3 expression. Our study demonstrates that upd3 transcription in the gut is regulated by the activation of multiple pathways, including the Hippo, TGF-β/Dpp, and Src, as well as p38-dependent MAPK pathways. Thus, these essential pathways, which are known to control ISC proliferation cell-autonomously, are also activated in ECs to promote tissue turnover the regulation of upd3 transcription.
SSIM-Based Perceptual Rate Control for Video Coding Tao-Sheng Ou; Yi-Hsin Huang; Chen, Homer H
IEEE transactions on circuits and systems for video technology,
05/2011, Letnik:
21, Številka:
5
Journal Article
Recenzirano
The quality of video is ultimately judged by human eye; however, mean squared error and the like that have been used as quality metrics are poorly correlated with human perception. Although the ...characteristics of human visual system have been incorporated into perceptual-based rate control, most existing schemes do not take rate-distortion optimization into consideration. In this paper, we use the structural similarity index as the quality metric for rate-distortion modeling and develop an optimum bit allocation and rate control scheme for video coding. This scheme achieves up to 25% bit-rate reduction over the JM reference software of H.264. Under the rate-distortion optimization framework, the proposed scheme can be easily integrated with the perceptual-based mode decision scheme. The overall bit-rate reduction may reach as high as 32% over the JM reference software.
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