Additionally, she contributed to an equally vast trove of collectively authored, unattributed, and unsigned opinion pieces, critical treatises, collaborative essays, and speeches, as well as ...countless personal, private letters of support, encouragement, guidance, and meticulous editorial critiques (both solicited and unsolicited)—all gifted with joy, hope, and love—to generations of activists, scholars, community members, and young people. Martínez spoke and wrote in a style meant to energize and inspire all who crossed paths with her to join "La Lucha/the struggle" and work for meaningful social change in whatever capacity they could. Since her passing on June 29, 2021, countless odes, memorial events, and tributes have been organized to honor her vast contributions to many social movements, which she always considered as interrelated—their successes interdependent. ...the Elizabeth Betita Martínez Memorial Committee is currently launching a digital database and ofrenda webpage that aims to house a meticulously curated selection of her writings, speeches, interviews, and videos that can be accessed at www.elizabethbetitamartinez.squarespace.com. Furthermore, Martínez provides an effective prescription for global action grounded in the belief that resistance can be encoded in the practices of remembering (collective memory) as well as documenting/writing (alternative histories). ...Martínez's writings range from her very first collaborative translation of a French novel with a socialist bent in the early 1960s to many unsigned collaborations in the form of editorial treatises that at one point are described as having the goal of "envisioning a liberation politics for the 21st century.
The treatment paradigm for metastatic hormone-sensitive prostate cancer (mHSPC) patients is evolving. PET/CT now offers improved sensitivity and accuracy in staging. Recent randomized trial data ...supports escalated hormone therapy, local primary tumor therapy, and metastasis-directed therapy. The impact of combining such therapies into a multimodal approach is unknown. This Phase II single-arm clinical trial sponsored and funded by Veterans Affairs combines local, metastasis-directed, and systemic therapies to durably render patients free of detectable disease off active therapy.
Patients with newly-diagnosed M1a/b prostate cancer (PSMA PET/CT staging is permitted) and 1-5 radiographically visible metastases (excluding pelvic lymph nodes) are undergoing local treatment with radical prostatectomy, limited duration systemic therapy for a total of six months (leuprolide, abiraterone acetate with prednisone, and apalutamide), metastasis-directed stereotactic body radiotherapy (SBRT), and post-operative fractionated radiotherapy if pT ≥ 3a, N1, or positive margins are present. The primary endpoint is the percent of patients achieving a serum PSA of < 0.05 ng/mL six months after recovery of serum testosterone ≥150 ng/dL. Secondary endpoints include time to biochemical progression, time to radiographic progression, time to initiation of alternative antineoplastic therapy, prostate cancer specific survival, health related quality-of-life, safety and tolerability.
To our knowledge, this is the first trial that tests a comprehensive systemic and tumor directed therapeutic strategy for patients with newly diagnosed oligometastatic prostate cancer. This trial, and others like it, represent the critical first step towards curative intent therapy for a patient population where palliation has been the norm.
Clinicaltrials.gov identifier: NCT03298087 (registration date: September 29, 2017).
The study carried out in the Department of Gynecology and Obstetrics of the Edgardo Rebagliati Martins National Hospital (HNERM) aimed to analyze the vertical transmission of the SARS-CoV-2 virus in ...pregnant women with COVID-19. Twelve pregnant women who met the established inclusion criteria were included. Real-time PCR (RT-PCR) diagnostic testing for SARS-CoV-2 was performed during the admission of each pregnant patient, and placenta samples were collected for pathological evaluation. The results showed that vertical transmission of the virus was rare, with an overall low positivity rate in newborns. Although the study has limitations, such as the small number of cases and the lack of electron microscope analysis, it constitutes the first attempt in Peru to evaluate vertical transmission. It is concluded that more research is needed to better understand the relationship between COVID-19 infection and complications during pregnancy.
Se realizó un estudio en el departamento de Ginecología y Obstetricia del Hospital Nacional Edgardo RebagliatiMartins (HNERM) con el objetivo analizar la transmisión vertical del SARS-CoV-2 en mujeres embarazadas con COVID-19. Se incluyeron 12 gestantes que cumplían con los criterios de inclusión. Se realizaron pruebas diagnósticas de PCR en tiempo real (RT-PCR) para SARS-CoV-2 durante la admisión de cada gestante y se recolectaron muestras de placenta para su evaluación anatomopatológica. Los resultados mostraron que la transmisión vertical del virus fue poco común, con una tasa general de positividad baja en los recién nacidos. Aunque el estudio presenta limitaciones, como el número reducido de casos y la falta de análisis con microscopio electrónico, constituye el primer intento en Perú de evaluar la transmisión vertical. Se concluye que se necesita más investigación para comprender mejor la relación entre la infección por la COVID-19 y las complicaciones durante el embarazo.
SÍNTESIS DE SACARINATOCOBRE(I) Ceroni Galloso, Mario; Angulo Cornejo, Jorge R.; Lino Pacheco, María N. ...
Revista de la Sociedad Química del Perú,
09/2017, Letnik:
83, Številka:
3
Journal Article
Odprti dostop
Se ha obtenido el compuesto de coordinación sacarinatocobre(I), Cu2(C7H4SO3N)2n, por reacción de reducción de sulfato de cobre con ácido ascórbico y adición de sacarinato de sodio en medio acuoso. La ...caracterización se realizó por análisis elemental, espectroscopia fotoelectrónica de rayos X, espectrofotometría infrarroja y voltametría cíclica.
Objetivos: Implementar el ensayo PCR-RFLP-ITS2 para diferenciar especies del género Anopheles presentes en distintas localidades del Perú. Diseño: Descriptivo, observacional. Institución: D. A. ...Microbiología Médica, Facultad de Medicina, UNMSM; Centro de Biotecnología, Universidad Iberoamericana de Ciencias y Tecnología; Laboratorio Entomología Médica, Sección Parasitología, Instituto de Salud Pública; Laboratorio de Entomología Médica, Laboratorio de Referencia Regional, Gerencia Regional de Salud La Libertad; Dirección Ejecutiva de Salud Ambiental, Sub Región de Salud “Luciano Castillo Colonna”, DIRESA Piura. Material biológico: Mosquitos del género Anopheles. Intervenciones: Extracción de ADN de Anopheles Principales medidas de resultados: Se utilizó 79 ejemplares del género Anopheles de cinco departamentos del país. Se extrajo ADN de una parte de cada mosquito, el que fue utilizado como molde para la amplificación de la región ITS2, producto que fue digerido con dos enzimas de restricción. Resultados: La digestión de la región ITS2, con las enzimas AluI y BclI, permitió diferenciar entre especies de este género de mosquitos, al generarse patrones de bandeo diferentes en cada una de las especies. Conclusiones: La región ITS2 es un marcador molecular que varía en las distintas especies de este género, por lo cual mediante la utilización de este marcador se puede identificar especies tanto en este género de mosquito, como en otros géneros pertenecientes a la misma familia.
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