Lycopene is a hydrocarbon phytochemical belonging to the tetraterpene carotenoid family and is found in red fruit and vegetables. Eleven conjugated double bonds predetermine the antioxidant ...properties of lycopene and its ability to scavenge lipid peroxyl radicals, reactive oxygen species, and nitric oxide. Lycopene has a low bioavailability rate and appears in the blood circulation incorporated into chylomicrons and other apo-B containing lipoproteins. The recent body of evidence suggests that plasma concentration of lycopene is not only a function of intestinal absorption rate but also lycopene breakdown via enzymatic and oxidative pathways in blood and tissues. Oxidative stress and the accumulation of reactive oxygen species and nitric oxide may represent a major cause of lycopene depletion in ageing, cardiovascular disease, and type 2 diabetes mellitus. It has been shown recently that low carotenoid levels, and especially decreased serum lycopene levels, are strongly predictive of all-cause mortality and poor outcomes of cardiovascular disease. However, there is a poor statistical association between dietary and serum lycopene levels which occurs due to limited bioavailability of lycopene from dietary sources. Hence, it is very unlikely that nutritional intervention alone could be instrumental in the correction of lycopene and carotenoid deficiency. Therefore, new nutraceutical formulations of carotenoids with enhanced bioavailability are urgently needed.
Objective To characterize the epidemiology of and identify risk factors for neonatal cardiac surgery–associated acute kidney injury (CS-AKI) and determine its impact on clinical outcomes. Study ...design Using secondary analysis of data from an ongoing multiprovincial prospective cohort study, we studied 264 neonates undergoing complex cardiac repair. CS-AKI was defined based on the Acute Kidney Injury Network (AKIN) definition. We used regression modeling and survival analysis (adjusting for covariates) to evaluate associations. Results CS-AKI occurred in 64% of the neonates in our study cohort. Lower age, longer cardiopulmonary bypass time, hypothermic circulatory arrest, type of repair, lower preoperative serum creatinine (SCr) level, lower gestational age, and preoperative ventilation were independent risk factors for developing CS-AKI. Neonates with CS-AKI had longer times to extubation, intensive care discharge, and hospital discharge, after adjusting for covariates. Mortality was significantly increased in neonates with AKIN stage 2 or higher CS-AKI. The neonates with CS-AKI had a lower z -score for height at 2-year follow-up and were seen by more specialists. Conclusion Neonatal CS-AKI is common and independently predicts important clinical outcomes, including mortality. Many risk factors are similar to those in older children, but some are unique to neonates. The observation that lower baseline SCr predicts CS-AKI merits further study. The AKIN definition, based on preoperative SCr value, is a reasonable method for defining CS-AKI in neonates. Many previous studies of CS-AKI have excluded neonates; we suggest that future intervention studies on approaches to reducing CS-AKI incidence and improving outcomes should include neonates.
The 4th World Symposium on Pulmonary Hypertension was the first international meeting to focus not only on pulmonary arterial hypertension (PAH) but also on the so-called non-PAH forms of pulmonary ...hypertension (PH). The term “non-PAH PH” summarizes those forms of PH that are found in groups 2 to 5 of the current classification of PH, that is, those forms associated with left heart disease, chronic lung disease, recurrent venous thromboembolism, and other diseases. Many of these forms of PH are much more common than PAH, but all of them have been less well studied, especially in terms of medical therapy. The working group on non-PAH PH focused mainly on 4 conditions: chronic obstructive lung disease, interstitial lung disease, chronic thromboembolic PH, and left heart disease. The medical literature regarding the role of PH in these diseases was reviewed, and recommendations regarding diagnosis and treatment of PH in these conditions are provided. Given the lack of robust clinical trials addressing PH in any of these conditions, it is important to conduct further studies to establish the role of medical therapy in non-PAH PH.
Defects in the repair of DNA interstrand crosslinks (ICLs) are associated with the genome instability syndrome Fanconi anemia (FA). Here we report that cells with mutations in RFWD3, an E3 ubiquitin ...ligase that interacts with and ubiquitylates replication protein A (RPA), show profound defects in ICL repair. An amino acid substitution in the WD40 repeats of RFWD3 (I639K) found in a new FA subtype abolishes interaction of RFWD3 with RPA, thereby preventing RFWD3 recruitment to sites of ICL-induced replication fork stalling. Moreover, single point mutations in the RPA32 subunit of RPA that abolish interaction with RFWD3 also inhibit ICL repair, demonstrating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair. We also report that unloading of RPA from sites of ICL induction is perturbed in RFWD3-deficient cells. These data reveal important roles for RFWD3 localization in protecting genome stability and preserving human health.
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•RFWD3-deficient human cells show profound defects in ICL repair•RFWD3 regulates RPA dynamics to promote homologous recombination•The FA-associated I639K mutation prevents RPA-dependent recruitment of RFWD3 to ICLs•RPA32 mutations that abolish interaction with RFWD3 also inhibit ICL repair
Feeney et al. show that the interaction of the E3 ubiquitin ligase RFWD3 with RPA plays a key role in the repair of DNA interstrand crosslinks, thereby preventing human disease. Loss of RFWD3 perturbs RPA dynamics at stalled replication forks and inhibits homologous recombination, a crucial step in ICL repair.
Based on asset pricing theory, we posit and find that equity markets and cryptocurrency markets share a common fundamental. Our cointegration tests show that the most important asset pricing ...primitive, consumption, can serve as the common fundamental. We further show that additional macroeconomic factors, as well as uncertainty and sentiment, all play a role in explaining the deviation from fundamentals. To understand the linkage between equity markets, cryptocurrency markets, and the macroeconomy, we suggest the following three channels: (i) portfolio allocation decisions, (ii) intermarket order flows, and (iii) technological adaption expectations.
Hair analysis receives a large amount of academic and commercial interest for wide-ranging applications. However, in many instances, especially for elemental or 'mineral' analysis, the degree of ...success of analytical interpretation has been quite minimal with respect to the extent of such endeavors. In this
critical review
we address the questions surrounding hair analysis with specific intent of discovering what hair concentrations can actually relate to in a biogenic sense. This is done from a chemistry perspective to explain why and how elements are incorporated into hair and their meaning. This includes an overview of variables attributed to altering hair concentrations, such as age, gender, melanin content, and other less reported factors. Hair elemental concentrations are reviewed with regard to morbidity, with specific examples of disease related effects summarized. The application of hair analysis for epidemiology and etiology studies is enforced. A section is dedicated specifically to the area of population studies with regards to mercury, which highlights how endogenous and exogenous incorporation relies on species dependant metabolism and metabolic products. Many of the considerations are relevant to other areas of interest in hair analysis, such as for drug and isotopic analysis. Inclusion of a table of elemental concentrations in hair should act as a valuable reference (298 references).
Exploring hair elemental analysis. How is it useful, what does it mean and how can it be applied?
The expression of plant resistance traits against arthropod herbivores often comes with costs to other essential plant functions such as growth and fitness. These trade‐offs are shaped by the ...allocation of limited resources. However, plants might also possess the capability to allocate resources to both resistance and growth, thereby ensuring their survival when under herbivore attacks. Additionally, the extent of damage caused by herbivores could vary across different years or seasons, subsequently impacting plant performance. In this study, we aimed to investigate how the annual variations in herbivore abundance and damage levels affect plant performance. We generated F2 progeny through a cross between two populations of the annual herb Datura stramonium (Solanaceae). These populations are known to have differing levels of chemical defense and herbivory. These F2 plants were cultivated in a common natural environment for two consecutive years (2017 and 2018). Our findings reveal that plants with higher resistance, attained higher seed production but this trend was evident only during 2018. This relationship coincided with a five‐fold increase in the abundance of Lema daturaphila (Chrysomelidae) larvae in 2018. Indeed, the plants experienced a 13‐fold increase in damage during this second year of study. Furthermore, our results indicated that there was no trade‐off between resistance, growth, and fitness in either of the 2 years. In contrast, during 2018, when plants faced stronger herbivore pressure, they allocated all available nutritional resources to enhance both resistance and growth. Our study highlights how the selection for plant resistance is dependent upon the inter‐annual variation in herbivore abundance.
The study underscores the influential role of specific herbivores in driving plant resistance and offers fresh insights into the inter‐annual evolutionary dynamics of plant resistance.
Minimally invasive stereotactic tumor ablation is a viable option for the treatment of benign and malignant intracranial lesions. Although surgical excision constitutes first-line therapy for various ...brain pathologies, it can cause irreversible neurologic deficits. Additionally, many patients who may benefit from surgery do not qualify as surgical candidates due to multiple comorbidities. Recent advancements in laser interstitial thermal therapy, namely the ability to monitor ablation in real-time under MR imaging, have improved the safety and efficacy of the procedure. MRI-guided laser interstitial thermal therapy is currently used as a minimally invasive treatment for brain metastases, radiation necrosis, glioma, and epilepsy. This article will discuss the principles, suggested indications, complications, and imaging characteristics of MRI-guided laser interstitial thermal therapy as they pertain to the treatment of brain pathology.
Unlike the well-known Mott's argument that extended and localized states should not coexist at the same energy in a generic random potential, we formulate the main principles and provide an example ...of a nearest-neighbor tight-binding disordered model which carries both localized and extended states without forming the mobility edge. Unexpectedly, this example appears to be given by a well-studied β ensemble with independently distributed random diagonal potential and inhomogeneous kinetic hopping terms. In order to analytically tackle the problem, we locally map the above model to the 1D Anderson model with matrix-size- and position-dependent hopping and confirm the coexistence of localized and extended states, which is shown to be robust to the perturbations of both potential and kinetic terms due to the separation of the above states in space. In addition, the mapping shows that the extended states are nonergodic and allows one to analytically estimate their fractal dimensions.
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