In this paper, we present a relation between Jacobi–Reeb dynamics and the dynamics associated with a mechanical Hamiltonian system with respect to a linear Poisson structure on a vector bundle. For ...this purpose, we will use the so-called Jacobi bundle metrics induced by the mechanical Hamiltonian system. These constructions extend classical results on the relation between standard mechanical Hamiltonian systems on cotangent bundles and Reeb dynamics.
Aicardi Goutières Syndrome (AGS) is a heritable interferonopathy associated with systemic autoinflammation causing interferon (IFN) elevation, central nervous system calcifications, leukodystrophy ...and severe neurologic sequelae. An infant with TREX1 mutations was recently found to have abnormal C26:0 lysophosphatidylcholine (C26:0 Lyso-PC) in a newborn screening platform for X-linked adrenoleukodystrophy, prompting analysis of this analyte in retrospectively collected samples from individuals affected by AGS.
In this study, we explored C26:0 Lyso-PC levels and IFN signatures in newborn blood spots and post-natal blood samples in 19 children with a molecular and clinical diagnosis of AGS and in the blood spots of 22 healthy newborns. We used Nanostring nCounter™ for IFN-induced gene analysis and a high-performance liquid chromatography with tandem mass spectrometry (HPLC MS/MS) newborn screening platform for C26:0 Lyso-PC analysis.
Newborn screening cards from patients across six AGS associated genes were collected, with a median disease presentation of 2months. Thirteen out of 19 (68%) children with AGS had elevations of first tier C26:0 Lyso-PC (>0.4μM), that would have resulted in a second screen being performed in a two tier screening system for X-linked adrenoleukodystrophy (X-ALD). The median (95%CI) of first tier C26:0 Lyso-PC values in AGS individuals (0.43μM 0.37–0.48) was higher than that seen in controls (0.21μM 0.21–0.21), but lower than X-ALD individuals (0.72μM 0.59–0.84)(p<0.001). Fourteen of 19 children had elevated expression of IFN signaling on blood cards relative to controls (Sensitivity 73.7%, 95%CI 51–88%, Specificity 95%, 95% CI 78–99%) including an individual with delayed disease presentation (36months of age). All five AGS patients with negative IFN signature at birth had RNASEH2B mutations. Consistency of agreement between IFN signature in neonatal and post-natal samples was high (0.85).
This suggests that inflammatory markers in AGS can be identified in the newborn period, before symptom onset. Additionally, since C26:0 Lyso-PC screening is currently used in X-ALD newborn screening panels, clinicians should be alert to the fact that AGS infants may present as false positives during X-ALD screening.
•Aicardi Goutières Syndrome (AGS) is a heritable interferonopathy associated with systemic autoinflammation.•AGS results in interferon (IFN) elevation, CNS calcifications, leukodystrophy and severe neurologic sequelae.•An infant with TREX1 mutations was found to have abnormal C26:0 Lyso-PC on newborn screening.•This prompted analysis of this analyte in retrospectively collected samples from individuals affected by AGS.•Thirteen out of 19 (68%) children with AGS had elevations of first tier C26:0 Lyso-PC (>0.4µM).•This suggests that inflammatory markers in AGS can be identified in the newborn period, before symptom onset.•Additionally, clinicians should be alert that AGS infants may present as false positives during X-ALD screening.
Abstract Background Nowadays, contrast-induced nephropathy (CIN) is the third cause of acquired acute renal impairment in hospital. CIN is related to increased in-hospital morbidity, mortality, costs ...of medical care, and long admissions. Because of this, we hypothesized it would be useful to determine the risk of CIN with scores such as the Mehran score. The aim of this study was to validate the Mehran score in a contemporary cohort of Spanish patients with acute coronary syndrome (ACS). Methods We assessed the calibration and discriminatory capacity of Mehran score to predict CIN in a cohort of 1520 patients with a definitive diagnosis of ACS and who underwent coronary angiography between March 2008 and June 2012. We excluded patients on chronic dialysis and those without data of contrast volume. The calibration of the model was assessed with the Hosmer-Lemeshow goodness-of-fit test and discriminatory capacity was assessed by C-statistic, which is equivalent to the area under the receiver-operating characteristic curve. Results From the total group, 118 patients (7.8%) developed CIN. They were older, with higher rates of diabetes (DM) and hypertension and worse renal function and anemia ( p < 0.001). The odds ratios for different score components in Mehran's population versus our study were similar except for DM, hypotension, and intra-aortic balloon pump (1.6%, 2.68%, 2.55% vs 0.9%, 1.89%, and 2.86%, respectively). Calibration and discriminatory capacity of Mehran score were excellent with a Hosmer-Lemeshow p = 0.7, C-statistic value >0.8. Conclusions Mehran risk score has been validated in our study as a good score for predicting CIN in patients with ACS who underwent coronary angiography. According to this, we support its use in patients hospitalized for ACS in order to identify the ones at risk, and to optimize CIN prophylactic therapy prior to and after catheterization.
The main goal of this letter is the analysis of the multipactor effect within a coaxial waveguide structure when an external axial dc magnetic field is applied. We have designed and manufactured a ...coaxial waveguide sample that has been immersed within a long solenoid. Numerical and experimental results confirm a significant change in the RF breakdown behavior with regard to the case without the axial dc magnetic field, as well as the existence of single- and double-surface multipactor regimes. Good agreement between theory and experimental data has been found.
Abstract
Debris discs can be seen as the leftovers of giant planet formation and the possible nurseries of rocky planets. While M-type stars outnumber more massive stars we know very little about the ...time evolution of their circumstellar discs at ages older than ∼10 Myr. Sub-millimetre observations are best to provide first order estimates of the available mass reservoir and thus better constrain the evolution of such discs. Here, we present ALMA Cycle 3 Band 7 observations of the debris disc around the M2 star TWA 7, which had been postulated to harbour two spatially separated dust belts, based on unresolved far-infrared and sub-millimetre data. We show that most of the emission at wavelengths longer than ∼300 μm is in fact arising from a contaminant source, most likely a sub-mm galaxy, located at about 6.6 arcsec east of TWA 7 (in 2016). Fortunately, the high resolution of our ALMA data allows us to disentangle the contaminant emission from that of the disc and report a significant detection of the disc in the sub-millimetre for the first time with a flux density of 2.1 ± 0.4 mJy at 870 $\rm{\mu\,m}$. With this detection, we show that the spectral energy distribution can be reproduced with a single dust belt.
Context. The search for extrasolar planets has been limited so far to close orbit (typ. ≤5 au) planets around mature solar-type stars on the one hand, and to planets on wide orbits (≥10 au) around ...young stars on the other hand. To get a better view of the full giant planet population, we have started a survey to search for giant planets around a sample of carefully selected young stars. Aims. This paper aims at exploring the giant planet population around one of our targets, β Pictoris, over a wide range of separations. With a disk and a planet already known, the β Pictoris system is indeed a very precious system for studies of planetary formation and evolution, as well as of planet–disk interactions. Methods. We analyse more than 2000 HARPS high-resolution spectra taken over 13 years as well as NaCo images recorded between 2003 and 2016. We combine these data to compute the detection probabilities of planets throughout the disk, from a fraction of au to a few dozen au. Results. We exclude the presence of planets more massive than 3 MJup closer than 1 au and further than 10 au, with a 90% probability. 15+ MJup companions are excluded throughout the disk except between 3 and 5 au with a 90% probability. In this region, we exclude companions with masses larger than 18 (resp. 30) MJup with probabilities of 60 (resp. 90) %.
The present research has a double fold objective. Firstly, it aims at determining whether incorporating blow darts as part of a multidisciplinary rehabilitation program for people with spinal cord ...injuries (SCI) is feasible and safe. One secondary objective is to provide information regarding its effects on their respiratory function.
Fifteen people (ASIA Impairment Scale A–D) were assigned either to a blow darts group (intervention group IG, n=8, 44.3±8.0 years), or to a non-blow darts group (control group CG, n=7, 48.4±7.2 years). The IG completed a blow darts program based on the performance of 3 to 4 one-hour weekly sessions for 17 weeks, as part of their rehabilitation. The CG continued to receive the usual care. Feasibility of the program was recorded. Participants also performed spirometry to determine volumes and pulmonary flows and respiratory muscle strength tests to assess their maximum static mouth pressures.
Recruitment and completion rate for the IG were both 100%, whereas adherence to the program stood at 62.5%. After completing the program, neither group experienced significant changes in the variables assessed. However, the IG showed evidence for a possibly beneficial effect in peak expiratory flow (PEF) and maximal inspiratory pressures (MIP), with a large effect size (ηp2=0.377 and 0.199, respectively).
A 17-week blow darts program was a feasible rehabilitation approach in a group of SCI individuals. Further studies with greater statistical power are recommended to determine its impact on respiratory parameters.
La présente recherche a un double objectif. Premièrement, elle vise à déterminer si l’incorporation de fléchettes dans le cadre d’un programme de réadaptation multidisciplinaire pour les personnes atteintes d’une lésion de la moelle épinière est faisable et sûre. Un objectif secondaire est de fournir des informations concernant ses effets sur leur fonction respiratoire.
Quinze personnes (échelle de déficience ASIA A–D) ont été assignées soit à un groupe de fléchettes (groupe intervention IG, n=8, 44,3±8,0 ans), soit à un groupe sans fléchettes (groupe contrôle CG, n=7, 48,4±7,2 ans). Le groupe IG a suivi un programme de fléchettes soufflées basé sur l’exécution de 3 à 4 séances hebdomadaires d’une heure pendant 17 semaines, dans le cadre de leur rééducation. Les GC ont continué à recevoir les soins habituels. La faisabilité du programme a été enregistrée. Les participants ont également effectué une spirométrie pour déterminer les volumes et les flux pulmonaires et des tests de force des muscles respiratoires pour évaluer leurs pressions buccales statiques maximales.
Les taux de recrutement et d’achèvement de l’IG étaient tous deux de 100 %, tandis que l’adhésion au programme s’élevait à 62,5 %. Après avoir terminé le programme, aucun des deux groupes n’a connu de changements significatifs dans les variables évaluées. Cependant, l’IG a montré des preuves d’un effet bénéfique possible sur le débit expiratoire de pointe (DEP) et les pressions inspiratoires maximales (PIM), avec une taille d’effet importante (ηp2=0,377 et 0,199, respectivement).
Un programme de fléchettes de 17 semaines a été une approche de réadaptation réalisable dans un groupe de personnes atteintes d’une LM. D’autres études avec une plus grande puissance statistique sont recommandées pour déterminer son impact sur les paramètres respiratoires.
Genome-wide association studies (GWAS) for schizophrenia have identified over 100 loci encoding >500 genes. It is unclear whether any of these genes, other than dopamine receptor D
, are immediately ...relevant to antipsychotic effects or represent novel antipsychotic targets. We applied an in vivo molecular approach to this question by performing RNA sequencing of brain tissue from mice chronically treated with the antipsychotic haloperidol or vehicle. We observed significant enrichments of haloperidol-regulated genes in schizophrenia GWAS loci and in schizophrenia-associated biological pathways. Our findings provide empirical support for overlap between genetic variation underlying the pathophysiology of schizophrenia and the molecular effects of a prototypical antipsychotic.
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