Firearm purchasing increased within the U.S. during the coronavirus disease 2019 pandemic. While rates of firearm ownership and suicide are elevated among women Veterans compared to women ...non-Veterans, no studies have examined if and how firearm beliefs and behaviors changed among women Veterans during the pandemic. We examined women Veterans' changes in firearm beliefs and engagement in firearm behaviors during the early pandemic era.
3,000 post-9/11 era women Veterans were invited to participate in a survey. 501 respondents (May-December 2020) comprised the sample for this concurrent nested mixed-method analysis. Thematic analysis and log-binomial regression were used.
13.88% (n = 69) of women Veterans in our sample reported changes in their firearm beliefs; 22.15% (n = 109) reported engaging in firearm behaviors. The most prevalent reported behaviors were making household firearms more accessible (16.13%) and purchasing ammunition (11.97%). Smaller percentages reported carrying a firearm more frequently (6.71%), loading previously unloaded firearms (5.69%), or purchasing a firearm (4.24%). Thematic analysis suggested firearm behaviors were likely driven by a perceived increased need to protect oneself, family, and property due to: (1) uncertainties brought on by the pandemic; (2) pandemic-related threats necessitating self-defense, preparedness, and self-sufficiency; (3) political, social, and racial unrest and protests. PTSD symptom severity and military sexual assault history were associated with higher prevalence of changes in firearm beliefs and engagement in firearm behaviors during the pandemic.
Consideration of women Veterans' prior experiences and pandemic-related factors may be necessary to contextualize firearm discussions and inform future research. Given associations of military sexual assault and PTSD symptoms with firearm beliefs and behaviors, it may be crucial to ensure that such discussion are trauma-informed.
Institutional betrayal is defined as harm caused by an institution to an individual in the context of trust and dependence. High institutional betrayal is associated with poorer health outcomes, and ...high levels of trust, dependence, or identification with the institution (institutional closeness) may exacerbate the negative effects of institutional betrayal. While military sexual trauma is prevalent among women Veterans and associated with high rates of institutional betrayal, studies of the impact of military sexual trauma-related institutional betrayal have been limited in size and scope and have not examined the potential role of institutional closeness. We conducted a secondary analysis of national survey data collected from women Veterans who screened positive for military sexual trauma (n = 229). Hierarchical logistic and linear regression were used to examine associations between predictor variables (institutional betrayal, institutional closeness, and their interaction) and outcomes of interest and adjusted for age, education, and military sexual assault history. Institutional betrayal was associated with increased odds of suicidal ideation and suicide attempt during or following military service, as well as more severe symptoms of depression and posttraumatic stress disorder (PTSD). Institutional betrayal was not associated with non-suicidal self-injury or lifetime substance misuse. Counter to hypotheses, institutional closeness did not moderate relationships between institutional betrayal and mental health symptoms or self-directed violence. Results underscore the necessity of preventing and addressing institutional betrayal among women Veterans who experience military sexual trauma.
On the Magnetic Field of a Finite Solenoid Martin-Luna, P.; Gimeno, B.; Gonzalez-Iglesias, D. ...
IEEE transactions on magnetics,
04/2023, Letnik:
59, Številka:
4
Journal Article
The magnetostatic field of a finite solenoid with infinitely thin walls carrying a dc current oriented in the azimuthal direction is calculated everywhere in space in terms of complete elliptic ...integrals by direct integration of the Biot-Savart law. The solution is particularized near the solenoid axis and in the midplane perpendicular to the axis obtaining expressions that agree with some typical approximations that are made in introductory courses of electromagnetism or in the technical literature. The range of validity of these approximations has been studied comparing them with the obtained general expression.
Exocomets: A spectroscopic survey Rebollido, I.; Eiroa, C.; Montesinos, B. ...
Astronomy and astrophysics (Berlin),
07/2020, Letnik:
639
Journal Article, Web Resource
Recenzirano
Odprti dostop
Context.
While exoplanets are now routinely detected, the detection of small bodies in extrasolar systems remains challenging. Since the discovery of sporadic events, which are interpreted to be ...exocomets (falling evaporating bodies) around
β
Pic in the early 1980s, only ∼20 stars have been reported to host exocomet-like events.
Aims.
We aim to expand the sample of known exocomet-host stars, as well as to monitor the hot-gas environment around stars with previously known exocometary activity.
Methods.
We have obtained high-resolution optical spectra of a heterogeneous sample of 117 main-sequence stars in the spectral type range from B8 to G8. The data were collected in 14 observing campaigns over the course of two years from both hemispheres. We analysed the Ca
II
K&H and Na
I
D lines in order to search for non-photospheric absorptions that originated in the circumstellar environment and for variable events that could be caused by the outgassing of exocomet-like bodies.
Results.
We detected non-photospheric absorptions towards 50% of the sample, thus attributing a circumstellar origin to half of the detections (i.e. 26% of the sample). Hot circumstellar gas was detected in the metallic lines inspected via narrow stable absorptions and/or variable blue- and red-shifted absorption events. Such variable events were found in 18 stars in the Ca
II
and/or Na
I
lines; six of them are reported in the context of this work for the first time. In some cases, the variations we report in the Ca
II
K line are similar to those observed in
β
Pic. While we do not find a significant trend in the age or location of the stars, we do find that the probability of finding CS gas in stars with larger
v
sin
i
is higher. We also find a weak trend with the presence of near-infrared excess and with anomalous (
λ
Boo-like) abundances, but this would require confirmation by expanding the sample.
Objective
The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces ...cohort treated with hydroxychloroquine (HCQ).
Methods
SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer thickness (GCLT) and qualitative data of retinal pigment epithelium (RPE) and external retina (ExtR) were collected prospectively. We compared data from 2012 (first) and 2017 (second) SD-OCT.
Results
We studied 110 patients and 195 eyes. No cases of HCQ toxicity were detected. At the time of the second SD-OCT, 99% patients had taken a daily dose of HCQ ≤5 mg/kg/day. The median time on HCQ was 133 months. The mean AMT and GCLT were significantly lower in both eyes at the second SD-OCT; however, all the differences were clinically insignificant at less than 1%. Qualitative analysis of RPE and ExtR showed no significant changes. Similar results were found among patients with risk factors for retinopathy. The comparison of patients with and without risk factors showed no differences.
Conclusions
This study shows clinically irrelevant retinal changes in an SLE cohort on HCQ treatment over a five-year follow-up. Our findings support the safety of long-term HCQ at doses ≤5 mg/kg/day.
The biochemistry of somatic hypermutation Peled, Jonathan U; Kuang, Fei Li; Iglesias-Ussel, Maria D ...
Annual review of immunology,
01/2008, Letnik:
26
Journal Article
Recenzirano
Affinity maturation of the humoral response is mediated by somatic hypermutation of the immunoglobulin (Ig) genes and selection of higher-affinity B cell clones. Activation-induced cytidine deaminase ...(AID) is the first of a complex series of proteins that introduce these point mutations into variable regions of the Ig genes. AID deaminates deoxycytidine residues in single-stranded DNA to deoxyuridines, which are then processed by DNA replication, base excision repair (BER), or mismatch repair (MMR). In germinal center B cells, MMR, BER, and other factors are diverted from their normal roles in preserving genomic integrity to increase diversity within the Ig locus. Both AID and these components of an emerging error-prone mutasome are regulated on many levels by complex mechanisms that are only beginning to be elucidated.
X-band RF photoinjector design for the CompactLight project González-Iglesias, D.; Aksoy, A.; Esperante, D. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
10/2021, Letnik:
1014
Journal Article
Recenzirano
Odprti dostop
RF photoinjectors have been under development for several decades to provide the high-brightness electron beams required for X-ray Free Electron Lasers. This paper proposes a photoinjector design ...that meets the Horizon 2020 CompactLight design study requirements. It consists of a 5.6-cell, X-band (12 GHz) RF gun, an emittance-compensating solenoid and two X-band traveling-wave structures that accelerate the beam out of the space-charge-dominated regime. The RF gun is intended to operate with a cathode gradient of 200 MV/m, and the TW structures at a gradient of 65 MV/m. The shape of the gun cavity cells was optimized to reduce the peak electric surface field. An assessment of the gun RF breakdown likelihood is presented as is a multipacting analysis for the gun coaxial coupler. RF pulse heating on the gun inner surfaces is also evaluated and beam dynamics simulations of the 100MeV photoinjector are summarized.
The negative strand of HIV-1 encodes a highly hydrophobic antisense protein (ASP) with no known homologs. The presence of humoral and cellular immune responses to ASP in HIV-1 patients indicates that ...ASP is expressed
, but its role in HIV-1 replication remains unknown. We investigated ASP expression in multiple chronically infected myeloid and lymphoid cell lines using an anti-ASP monoclonal antibody (324.6) in combination with flow cytometry and microscopy approaches. At baseline and in the absence of stimuli, ASP shows polarized subnuclear distribution, preferentially in areas with low content of suppressive epigenetic marks. However, following treatment with phorbol 12-myristate 13-acetate (PMA), ASP translocates to the cytoplasm and is detectable on the cell surface, even in the absence of membrane permeabilization, indicating that 324.6 recognizes an ASP epitope that is exposed extracellularly. Further, surface staining with 324.6 and anti-gp120 antibodies showed that ASP and gp120 colocalize, suggesting that ASP might become incorporated in the membranes of budding virions. Indeed, fluorescence correlation spectroscopy studies showed binding of 324.6 to cell-free HIV-1 particles. Moreover, 324.6 was able to capture and retain HIV-1 virions with efficiency similar to that of the anti-gp120 antibody VRC01. Our studies indicate that ASP is an integral protein of the plasma membranes of chronically infected cells stimulated with PMA, and upon viral budding, ASP becomes a structural protein of the HIV-1 envelope. These results may provide leads to investigate the possible role of ASP in the virus replication cycle and suggest that ASP may represent a new therapeutic or vaccine target.
The HIV-1 genome contains a gene expressed in the opposite, or antisense, direction to all other genes. The protein product of this antisense gene, called ASP, is poorly characterized, and its role in viral replication remains unknown. We provide evidence that the antisense protein, ASP, of HIV-1 is found within the cell nucleus in unstimulated cells. In addition, we show that after PMA treatment, ASP exits the nucleus and localizes on the cell membrane. Moreover, we demonstrate that ASP is present on the surfaces of viral particles. Altogether, our studies identify ASP as a new structural component of HIV-1 and show that ASP is an accessory protein that promotes viral replication. The presence of ASP on the surfaces of both infected cells and viral particles might be exploited therapeutically.
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