Accelerating MRI scans is one of the principal outstanding problems in the MRI research community. Towards this goal, we hosted the second fastMRI competition targeted towards reconstructing MR ...images with subsampled k-space data. We provided participants with data from 7,299 clinical brain scans (de-identified via a HIPAA-compliant procedure by NYU Langone Health), holding back the fully-sampled data from 894 of these scans for challenge evaluation purposes. In contrast to the 2019 challenge, we focused our radiologist evaluations on pathological assessment in brain images. We also debuted a new Transfer track that required participants to submit models evaluated on MRI scanners from outside the training set. We received 19 submissions from eight different groups. Results showed one team scoring best in both SSIM scores and qualitative radiologist evaluations. We also performed analysis on alternative metrics to mitigate the effects of background noise and collected feedback from the participants to inform future challenges. Lastly, we identify common failure modes across the submissions, highlighting areas of need for future research in the MRI reconstruction community.
Intracranial vessel wall imaging (VWI), which requires both high spatial resolution and high signal-to-noise ratio (SNR), is an ideal candidate for deep learning (DL)-based image quality improvement. ...Conventional VWI (Conv-VWI, voxel size 0.51 × 0.51 × 0.45 mm3) and denoised super-resolution DL-VWI (0.28 × 0.28 × 0.45 mm3) of 117 patients were analyzed in this retrospective study. Quality of the images were compared qualitatively and quantitatively. Diagnostic performance for identifying potentially culprit atherosclerotic plaques, using lesion enhancement and presence of intraplaque hemorrhage (IPH), was evaluated. DL-VWI significantly outperformed Conv-VWI in all image quality ratings (all P < .001). DL-VWI demonstrated higher SNR and contrast-to-noise ratio (CNR) than Conv-VWI, both in normal walls (basilar artery; SNR 4.83 ± 1.23 vs. 3.02 ± 0.59, P < .001) and lesions (contrast-enhanced images; SNR 22.12 ± 11.68 vs. 8.33 ± 3.26, P < .001). In the assessment of 86 lesions, DL-VWI showed higher confidence of detection (4.56 ± 0.55 vs. 2.62 ± 0.77, P < .001), more concordant IPH characterization (Cohen’s Kappa 0.85 vs. 0.59) and greater enhancement. For culprit plaque identification, IPH exhibited higher sensitivity in DL-VWI compared to Conv-VWI (70.6% vs. 23.5%) and excellent specificity (94.3% vs. 94.3%). Deep learning application of intracranial vessel wall images successfully improved the quality and resolution of the images. This aided in detecting vessel wall lesions and intraplaque hemorrhage, and in identifying potentially culprit atherosclerotic plaques.
Objectives
This study aimed to accelerate the 3D magnetization–prepared rapid gradient-echo (MPRAGE) sequence for brain imaging through the deep neural network (DNN).
Methods
This retrospective study ...used the k-space data of 240 scans (160 for the training set, mean ± standard deviation age, 93 ± 80 months, 94 males; 80 for the test set, 106 ± 83 months, 44 males) of conventional MPRAGE (C-MPRAGE) and 102 scans (77 ± 74 months, 52 males) of both C-MPRAGE and accelerated MPRAGE. All scans were acquired with 3T scanners. DNN was developed with simulated-acceleration data generated by under-sampling. Quantitative error metrics were compared between images reconstructed with DNN, GRAPPA, and E-SPIRIT using the paired
t
-test. Qualitative image quality was compared between C-MPRAGE and accelerated MPRAGE reconstructed with DNN (DNN-MPRAGE) by two readers. Lesions were segmented and the agreement between C-MPRAGE and DNN-MPRAGE was assessed using linear regression.
Results
Accelerated MPRAGE reduced scan times by 38% compared to C-MPRAGE (142 s vs. 320 s). For quantitative error metrics, DNN showed better performance than GRAPPA and E-SPIRIT (
p
< 0.001). For qualitative evaluation, overall image quality of DNN-MPRAGE was comparable (
p
> 0.999) or better (
p
= 0.025) than C-MPRAGE, depending on the reader. Pixelation was reduced in DNN-MPRAGE (
p
< 0.001). Other qualitative parameters were comparable (
p
> 0.05). Lesions in C-MPRAGE and DNN-MPRAGE showed good agreement for the dice similarity coefficient (= 0.68) and linear regression (
R
2
= 0.97;
p
< 0.001).
Conclusions
DNN-MPRAGE reduced acquisition time by 38% and revealed comparable image quality to C-MPRAGE.
Key Points
• DNN-MPRAGE reduced acquisition times by 38%
.
• DNN-MPRAGE outperformed conventional reconstruction on accelerated scans (SSIM of DNN-MPRAGE = 0.96, GRAPPA = 0.43, E-SPIRIT = 0.88; p < 0.001)
.
• Compared to C-MPRAGE scans, DNN-MPRAGE showed improved mean scores for overall image quality (2.46 vs. 2.52; p < 0.001) or comparable perceived SNR (2.56 vs. 2.58; p = 0.08).
OBJECTIVEThe aim of this study was to develop a deep neural network (DNN)-based parallel imaging reconstruction for highly accelerated 2D turbo spin echo (TSE) data in prostate MRI without quality ...degradation compared to conventional scans.METHODS155 participant data were acquired for training and testing. Two DNN models were generated according to the number of acquisitions (NAQ) of input images: DNN-N1 for NAQ = 1 and DNN-N2 for NAQ = 2. In the test data, DNN and TSE images were compared by quantitative error metrics. The visual appropriateness of DNN reconstructions on accelerated scans (DNN-N1 and DNN-N2) and conventional scans (TSE-Conv) was assessed for nine parameters by two radiologists. The lesion detection was evaluated at DNNs and TES-Conv by prostate imaging-reporting and data system.RESULTSThe scan time was reduced by 71% at NAQ = 1, and 42% at NAQ = 2. Quantitative evaluation demonstrated the better error metrics of DNN images (29-43% lower NRMSE, 4-13% higher structure similarity index, and 2.8-4.8 dB higher peak signal-to-noise ratio; p < 0.001) than TSE images. In the assessment of the visual appropriateness, both radiologists evaluated that DNN-N2 showed better or comparable performance in all parameters compared to TSE-Conv. In the lesion detection, DNN images showed almost perfect agreement (κ > 0.9) scores with TSE-Conv.CONCLUSIONSDNN-based reconstruction in highly accelerated prostate TSE imaging showed comparable quality to conventional TSE.ADVANCES IN KNOWLEDGEOur framework reduces the scan time by 42% of conventional prostate TSE imaging without sequence modification, revealing great potential for clinical application.
The aim of this study was to develop a deep neural network (DNN)-based parallel imaging reconstruction for highly accelerated 2D turbo spin echo (TSE) data in prostate MRI without quality degradation ...compared to conventional scans.
155 participant data were acquired for training and testing. Two DNN models were generated according to the number of acquisitions (NAQ) of input images: DNN-N1 for NAQ = 1 and DNN-N2 for NAQ = 2. In the test data, DNN and TSE images were compared by quantitative error metrics. The visual appropriateness of DNN reconstructions on accelerated scans (DNN-N1 and DNN-N2) and conventional scans (TSE-Conv) was assessed for nine parameters by two radiologists. The lesion detection was evaluated at DNNs and TES-Conv by prostate imaging-reporting and data system.
The scan time was reduced by 71% at NAQ = 1, and 42% at NAQ = 2. Quantitative evaluation demonstrated the better error metrics of DNN images (29-43% lower NRMSE, 4-13% higher structure similarity index, and 2.8-4.8 dB higher peak signal-to-noise ratio;
< 0.001) than TSE images. In the assessment of the visual appropriateness, both radiologists evaluated that DNN-N2 showed better or comparable performance in all parameters compared to TSE-Conv. In the lesion detection, DNN images showed almost perfect agreement (κ > 0.9) scores with TSE-Conv.
DNN-based reconstruction in highly accelerated prostate TSE imaging showed comparable quality to conventional TSE.
Our framework reduces the scan time by 42% of conventional prostate TSE imaging without sequence modification, revealing great potential for clinical application.
Recent technological advancements have revolutionized routine brain magnetic resonance imaging (MRI) sequences, offering enhanced diagnostic capabilities in intracranial disease evaluation. This ...review explores 2 pivotal breakthrough areas: deep learning reconstruction (DLR) and quantitative MRI techniques beyond conventional structural imaging. DLR using deep neural networks facilitates accelerated imaging with improved signal-to-noise ratio and spatial resolution, enhancing image quality with short scan times. DLR focuses on supervised learning applied to clinical implementation and applications. Quantitative MRI techniques, exemplified by 2D multidynamic multiecho, 3D quantification using interleaved Look-Locker acquisition sequences with T2 preparation pulses, and magnetic resonance fingerprinting, enable precise calculation of brain-tissue parameters and further advance diagnostic accuracy and efficiency. Potential DLR instabilities and quantification and bias limitations will be discussed. This review underscores the synergistic potential of DLR and quantitative MRI, offering prospects for improved brain imaging beyond conventional methods.ABSTRACTRecent technological advancements have revolutionized routine brain magnetic resonance imaging (MRI) sequences, offering enhanced diagnostic capabilities in intracranial disease evaluation. This review explores 2 pivotal breakthrough areas: deep learning reconstruction (DLR) and quantitative MRI techniques beyond conventional structural imaging. DLR using deep neural networks facilitates accelerated imaging with improved signal-to-noise ratio and spatial resolution, enhancing image quality with short scan times. DLR focuses on supervised learning applied to clinical implementation and applications. Quantitative MRI techniques, exemplified by 2D multidynamic multiecho, 3D quantification using interleaved Look-Locker acquisition sequences with T2 preparation pulses, and magnetic resonance fingerprinting, enable precise calculation of brain-tissue parameters and further advance diagnostic accuracy and efficiency. Potential DLR instabilities and quantification and bias limitations will be discussed. This review underscores the synergistic potential of DLR and quantitative MRI, offering prospects for improved brain imaging beyond conventional methods.
We introduce a novel, all-in-one deep learning framework for MR image reconstruction, enabling a single model to enhance image quality across multiple aspects of k-space sampling and to be effective ...across a wide range of clinical and technical scenarios. This DICOM-based algorithm serves as the core of SwiftMR (AIRS Medical, Seoul, Korea), which is FDA-cleared, CE-certified, and commercially available. We first detail the comprehensive development process of the model, including data collection, training pair preparation, model architecture design, and DICOM inference. We then assess the model's capability to enhance image quality in a multi-dimensional manner, specifically across various aspects of k-space sampling. Subsequently, we evaluate several features of the multi-dimensional enhancement: the accuracy of tunable denoising, the effectiveness of super-resolution in each encoding direction, and the reduction of artifacts that become more prominent at lower spatial resolutions. Additionally, we assess its compatibility with various scan parameter sets and its generalizability across scanner vendors not seen during training. Finally, we present specific cases demonstrating the model's utility in reducing scan time across anatomical regions in conjunction with protocol optimization. The proposed model is compatible with a broad spectrum of scenarios, including various vendors, pulse sequences, scan parameters, and anatomical regions. Its DICOM-based operation particularly enhances its applicability for real-world applications. Given its demonstrated effectiveness and versatility, we expect its use to expand in the field of clinical MRI.
Accelerating MRI scans is one of the principal outstanding problems in the MRI research community. Towards this goal, we hosted the second fastMRI competition targeted towards reconstructing MR ...images with subsampled k-space data. We provided participants with data from 7,299 clinical brain scans (de-identified via a HIPAA-compliant procedure by NYU Langone Health), holding back the fully-sampled data from 894 of these scans for challenge evaluation purposes. In contrast to the 2019 challenge, we focused our radiologist evaluations on pathological assessment in brain images. We also debuted a new Transfer track that required participants to submit models evaluated on MRI scanners from outside the training set. We received 19 submissions from eight different groups. Results showed one team scoring best in both SSIM scores and qualitative radiologist evaluations. We also performed analysis on alternative metrics to mitigate the effects of background noise and collected feedback from the participants to inform future challenges. Lastly, we identify common failure modes across the submissions, highlighting areas of need for future research in the MRI reconstruction community.
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