•Winglets increase the efficiency of the partially shroud-covered axial fan.•Winglets decrease the efficiency of the 100% shroud-covered axial fan.•The fan efficiency is not the highest with 0 tip ...clearance in partial shroud.•The fan efficiency is the highest with certain tip clearance in partial shroud.
This study is concerned with the improvement in efficiency of axial flow fans that are being used in numerous fields including outdoor units of air conditioners. The tip leakage flow occurring between a blade tip and shroud is one of the major losses in the axial flow fan. A well-known method used to control such tip leakage flow is locating winglet on the suction side of blade tips. Only a few articles have studied the impact of tip clearance on the flow structure of tip leakage flow of axial flow fans with winglet. In this study, the flow structure occurring on the blade tip due to the location of a winglet was analyzed. We confirm the existence of an optimal tip clearance which results in the maximum efficiency for an axial flow fan with a shroud height measuring 30% of the axial chord length.
•The loss of the axial fan in an outdoor unit occurs mainly in the end-wall region.•The interaction between hub entrance vortex and a blade affects the fan efficiency.•The certain condition of ...cleaved hub vortex by a blade increases the fan efficiency.
The improvement in efficiency of axial flow fans is major concern in turbomachinery industries including outdoor units of air conditioners. The end wall region is responsible for losses in axial flow fan. Researches on the relationship between the efficiency and the vortex occurring on the hub with a short length have been little found in the literature. Variations of the vortical flow field and the effects on the efficiency have been investigated with the entrance hub length and corner shape of the axial flow fan. The losses and the efficiency were evaluated by the stagnation pressure loss coefficient distribution calculated using commercial CFD solver SC/Tetra v12. The results show the efficiency was improved at specific entrance hub length due to the interaction between the hub vortex and the blade.
Most multi-phase pumps used in crude oil production have been developed to satisfy certain pressure specifications. In the design of these pumps, the flow characteristics of the posterior stage are ...different from those of the prior stage. For this reason, the design of the second stage needs to be supplemented. To optimize performance in this stage, multi-objective optimization to simultaneously increase pressure and efficiency is reported in this article. Flow analyses of the single and multiple phases of the multi-phase pump were conducted by solving three-dimensional steady Reynolds-averaged Navier–Stokes equations. For the numerical optimization, two design variables related to the blade inlet angle were selected. The impeller and the diffuser blades were optimized using a systematic optimization technique combined with a central composite method and a hybrid multi-objective evolutionary algorithm coupled with a surrogate model. The selected optimal model yielded better hydrodynamic performance than the base model, and reasons for this are investigated through internal flow field analysis.
Doxorubicin, an anthracycline antitumor antibiotic, acts as a cancer treatment by interfering with the function of DNA. Herein, liquid chromatography-tandem mass spectrometry was for the first time ...developed and validated for the simultaneous determination of doxorubicin and its major metabolites doxorubicinol, doxorubicinone, doxorubicinolone, and 7-deoxydoxorubicinone in mouse plasma. The liquid-liquid extraction of a 10 μL mouse plasma sample with chloroform:methanol (4:1,
/
) and use of the selected reaction monitoring mode led to less matrix effect and better sensitivity. The lower limits of quantification levels were 0.5 ng/mL for doxorubicin, 0.1 ng/mL for doxorubicinol, and 0.01 ng/mL for doxorubicinone, doxorubicinolone, and 7-deoxydoxorubicinone. The standard curves were linear over the range of 0.5-200 ng/mL for doxorubicin; 0.1-200 ng/mL for doxorubicinol; and 0.01-50 ng/mL for doxorubicinone, doxorubicinolone, and 7-deoxydoxorubicinone in mouse plasma. The intra and inter-day relative standard deviation and relative errors for doxorubicin and its four metabolites at four quality control concentrations were 0.9-13.6% and -13.0% to 14.9%, respectively. This method was successfully applied to the pharmacokinetic study of doxorubicin and its metabolites after intravenous administration of doxorubicin at a dose of 1.3 mg/kg to female BALB/c nude mice.
Unusual flow characteristics such as reverse flow, rotating stalls, flow recirculation, and stationary vortexes can induce high dynamic forces and torque variations on the entire system, creating a ...positive slope in the discharge-head curve. To avoid these problems, the present study investigates the hydrodynamic characteristics of a lab-scale model of a Francis type pump-turbine unit in the transition region. To verify the simulation, its results were compared with those of a laboratory-scale experiment performed over various operating ranges. The differences between the experimental and numerical speed, discharge, and torque factors were compared. The numerical analysis was well-matched the experimental tendencies in the overall operating and transition regions. The reliability of the simulations was within 4%. The unsteady RANS equations in the SAS–SST model were discretized for a detailed analysis of the pressure and internal flow characteristics. Under the runaway condition and low-discharge conditions, the frequency spectra of the pressure fluctuations were remarkable at low-frequency related to the rotating stall and blade passing frequency. These results represent a rotating stall with a frequency propagation of approximately 60% of the rotational speed of the runner. In case of the internal flow field, some blade loading distributions developed a positive shape while others developed a negative shape under the runaway condition. Although a rotating stall formed under the low-discharge condition, the form under this condition differed from that developed under runaway conditions, owing to backflow and the single stall cell.
•The unstable S-shaped characteristics in a lab-scale model were studied.•The numerical results were validated in comparison to the experimental data.•The location and rotating speed of stall under the S-curve region were observed.•The unsteady pressure characteristics were analyzed with internal flow field.
APINACA (known as AKB48,
-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide), an indazole carboxamide synthetic cannabinoid, has been used worldwide as a new psychoactive substance. Drug abusers take ...various drugs concomitantly, and therefore, it is necessary to characterize the potential of APINACA-induced drug-drug interactions due to the modulation of drug-metabolizing enzymes and transporters. In this study, the inhibitory effects of APINACA on eight major human cytochrome P450s (CYPs) and six uridine 5'-diphospho-glucuronosyltransferases (UGTs) in human liver microsomes, as well as on the transport activities of six solute carrier transporters and two efflux transporters in transporter-overexpressed cells, were investigated. APINACA exhibited time-dependent inhibition of CYP3A4-mediated midazolam 1'-hydroxylation (
, 4.5 µM;
, 0.04686 min
) and noncompetitive inhibition of UGT1A9-mediated mycophenolic acid glucuronidation (
, 5.9 µM). APINACA did not significantly inhibit the CYPs 1A2, 2A6, 2B6, 2C8/9/19, or 2D6 or the UGTs 1A1, 1A3, 1A4, 1A6, or 2B7 at concentrations up to 100 µM. APINACA did not significantly inhibit the transport activities of organic anion transporter (OAT)1, OAT3, organic anion transporting polypeptide (OATP)1B1, OATP1B3, organic cation transporter (OCT)1, OCT2, P-glycoprotein, or breast cancer resistance protein at concentrations up to 250 μM. These data suggest that APINACA can cause drug interactions in the clinic via the inhibition of CYP3A4 or UGT1A9 activities.
The aim of this study was to determine pharmacokinetics of α-amanitin, a toxic bicyclic octapeptide isolated from the poisonous mushrooms, following intravenous (iv) or oral (po) administration in ...mice using a newly developed and validated liquid chromatography-high resolution mass spectrometry. The iv injected α-amanitin disappeared rapidly from the plasma with high a clearance rate (26.9-30.4 ml/min/kg) at 0.1, 0.2, or 0.4 mg/kg doses, which was consistent with a rapid and a major excretion of α-amanitin via the renal route (32.6%). After the po administration of α-amanitin at doses of 2, 5, or 10 mg/kg to mice, the absolute bioavailability of α-amanitin was 3.5-4.8%. Due to this low bioavailability, 72.5% of the po administered α-amanitin was recovered from the feces. When α-amanitin is administered po, the tissue to plasma area under the curve ratio was higher in stomach > large intestine > small intestine > lung ~ kidneys > liver but not detected in brain, heart, and spleen. The high distribution of α-amanitin to intestine, kidneys, and liver is in agreement with the previously reported major intoxicated organs following acute α-amanitin exposure. In addition, α-amanitin weakly or negligibly inhibited cytochrome P450 and 5′-diphospho-glucuronosyltransferase enzymes activity in human liver microsomes as well as major drug transport functions in mammalian cells overexpressing transporters. Data suggested remote drug interaction potential may be associated with α-amanitin exposure.
Undesirable flow phenomena in Francis turbines are caused by pressure fluctuations induced under conditions of low flow rate; the resulting vortex ropes with precession in the draft tube (DT) can ...degrade performance and increase the instability of turbine operations. To suppress these DT flow instabilities, flow deflectors, grooves, or other structures are often added to the DT into which air or water is injected. This preliminary study investigates the effects of anti-cavity fins on the suppression of vortex ropes in DTs without air injection. Unsteady-state Reynolds-averaged Navier–Stokes analyses were conducted using a scale-adaptive simulation shear stress transport turbulence model to observe the unsteady internal flow and pressure characteristics by applying anti-cavity fins in the DT of a Francis turbine model. A vortex rope with precession was observed in the DT under conditions of low flow rate, and the anti-cavity fins were confirmed to affect the mitigation of the vortex rope. Moreover, at the low flow rate conditions under which the vortex rope developed, the application of anti-cavity fins was confirmed to reduce the maximum unsteady pressure.
The importance of renewable energy will increase rapidly due to the global regulation of carbon dioxide emissions to cope with global warming. However, renewable energy has a high output variation ...because of the fluctuating characteristics of the energy source. Therefore, pumped-storage power stations require high flexibility and reliability in operation under off-design conditions, especially in the pump mode. When a pump-turbine operates under various part load conditions in pump mode, highly dynamic phenomenon such as stationary vortex and rotating stall occur. The performance characteristics in pump mode are vital for the safe and effective operation. A number of studies have been conducted to investigate the flow characteristics in a turbine or pump mode under different GVOs through numerical simulations. However, the studies about the influence of the position of the interface and the steady and unsteady interface condition on the pump characteristics of pump-turbines have been not completely clear. In this paper, the three-dimensional steady and unsteady Reynolds-averaged Navier–Stokes equations were solved for a detailed analysis of the influence of interface conditions with various guide vane opening conditions in pump mode. To ensure the reliability of the numerical analysis, the numerical results were validated in comparison with the experimental data.
•The effect of interface conditions with various guide vane openings was studied.•The numerical results were validated in comparison to the experimental data.•The dynamic flow phenomenon and hysteresis characteristics were investigated.•The location and magnitude of vortex under the hump region were observed.•The unsteady pressure characteristics were analyzed with internal flow field.
Due to increasing safety and intracellular delivery concerns about hydrophilic polymers in amphiphilic polymer-based nanoparticles (NPs), this study investigates small hydrophilic molecule-stabilized ...NPs for effective intracellular delivery with multiorganelle targetability and dual responsiveness to acidic pH/glutathione (GSH). In the construction of small hydrophilic molecule-stabilized NP (MSPCL-NP), the A-B-A-type amphiphilic polymer (MSPCL-P) is composed of two short hydrophilic carboxylate-capped disulfide derivatives (A) that replace hydrophilic polymers and assist in providing colloidal stability and preventing antibody (e.g., at least anti-PEG antibody)-mediated specific interactions and complement activation in the plasma and a hydrophobic multiple disulfide-containing poly(ε-caprolactone) block (B) that carries hydrophobic drugs. The carboxylates on the surface of MSPCL-NP target the acidic extratumoral/endolysosomal milieu by sensing and buffering acidic pH values, and the hydrophobic carboxylic acids improve adsorptive endocytosis and effective endosomal escape. Multiple disulfide linkages selectively target cytosolic GSH, resulting in rapid drug release from the destroyed MSPCL-NP via the cleavage of disulfide bonds in MSPCL-P. Doxorubicin (DOX)-loaded NP (DOX@MSPCL-NP) exerts strong effects on killing cells in vitro and inhibits tumor growth in HCT116 xenograft tumor-bearing mice. In conclusion, the multifunctionality and multispatial targetability of MSPCL-NP might effectively overcome various sequential drug delivery hurdles, ranging from blood circulation to drug release. Furthermore, the introduction of small hydrophilic molecules represents a potential strategy to make self-assembled NPs without the use of hydrophilic polymers.
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