Justice for terrorists Kent, F. Andrew
Commentary (New York),
06/2004, Letnik:
117, Številka:
6
Magazine Article
President Bush's first response to the enduring source of controversy on the treatment of accused terrorists in its custody was to authorize the creation of military tribunals to try those captured ...in the campaign in Afghanistan against al Qaeda and the Taliban regime. Here, Kent contends that after more than two-and-a-half years, the administration has yet use these tribunals, and has slated just six detainees for trial before them, only two of whom have been formally charged. Accounts detailing the hue and cry of libertarian critics on the Bush administration's efforts to restrict the usual workings of legal due process are also presented.
Prolonged trapezing during sailing often results in low back pain among elite sailors. Modifications of the trapeze harness have been proposed as one approach to ameliorating this problem. To ...evaluate six harnesses incorporating novel features that had tested well during pilot work, myoelectric activity was monitored at C5, T6, and L5 levels of sacrospinalis and at an abdominal site while five elite sailors wore the harnesses. Integrated EMG (IEMG) values were stored by a microcomputer at periodic intervals during each 10-min trial, as each subject maintained a static horizontal trapezing position in the laboratory. Factorial repeated-measures ANOVA indicated no change in IEMG values over time, but significant (
p
<0.001) differences among harnesses at all four electrode sites. Features of trapeze harness design that appear to minimize muscular tension include heavy, rigid padding throughout the harness, full-length shoulder-to-buttocks support of the trunk, and adjustable leg strap supports as opposed to a crotch strap.
Vaccination represents the best line of defense against infectious diseases and is crucial in curtailing pandemic spread of emerging pathogens to which a population has limited immunity. In recent ...years, mRNA vaccines have been proposed as the new frontier in vaccination, owing to their facile and rapid development while providing a safer alternative to traditional vaccine technologies such as live or attenuated viruses. Recent breakthroughs in mRNA vaccination have been through formulation with lipid nanoparticles (LNPs), which provide both protection and enhanced delivery of mRNA vaccines in vivo. In this review, current paradigms and state-of-the-art in mRNA-LNP vaccine development are explored through first highlighting advantages posed by mRNA vaccines, establishing LNPs as a biocompatible delivery system, and finally exploring the use of mRNA-LNP vaccines in vivo against infectious disease towards translation to the clinic. Furthermore, we highlight the progress of mRNA-LNP vaccine candidates against COVID-19 currently in clinical trials, with the current status and approval timelines, before discussing their future outlook and challenges that need to be overcome towards establishing mRNA-LNPs as next-generation vaccines.
With the recent success of mRNA vaccines developed by Moderna and BioNTech/Pfizer against COVID-19, mRNA technology and lipid nanoparticles (LNP) have never received more attention. This manuscript timely reviews the most advanced mRNA-LNP vaccines that have just been approved for emergency use and are in clinical trials, with a focus on the remarkable development of several COVID-19 vaccines, faster than any other vaccine in history. We aim to give a comprehensive introduction of mRNA and LNP technology to the field of biomaterials science and increase accessibility to readers with a new interest in mRNA-LNP vaccines. We also highlight current limitations and future outlook of the mRNA vaccine technology that need further efforts of biomaterials scientists to address.
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This article discusses ratings of visual discomfort from glare across different buildings located in Singapore. These data were used to determine if range effects influence the vertical illuminance ...values for the same ratings of visual discomfort when the category rating procedure is used. The effect occurs when maxima and minima vertical illuminance (i.e. the range) vary across buildings. Our analyses showed that with a higher vertical illuminance range in a building, the mean vertical illuminance value for the same criterion of visual discomfort also increased. The results suggest that the effect caused by different ranges of measured vertical illuminance present across the buildings biased the ratings of visual discomfort. Although these effects may be unavoidable in some buildings that have vastly different levels of light, the data suggest that the overall range of vertical illuminance must be carefully evaluated when predicting visual discomfort. Matching these conditions may enable vertical illuminance to provide more reliable evaluations of discomfort due to glare.
Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease that is characterized by the destruction of insulin-producing β cells in the pancreas. The administration to patients of ex ...vivo-differentiated FoxP3(+) regulatory T (Treg) cells or tolerogenic dendritic cells (DCs) that promote Treg cell differentiation is considered a potential therapy for T1D; however, cell-based therapies cannot be easily translated into clinical practice. We engineered nanoparticles (NPs) to deliver both a tolerogenic molecule, the aryl hydrocarbon receptor (AhR) ligand 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE), and the β cell antigen proinsulin (NPITE+Ins) to induce a tolerogenic phenotype in DCs and promote Treg cell generation in vivo. NPITE+Ins administration to 8-week-old nonobese diabetic mice suppressed autoimmune diabetes. NPITE+Ins induced a tolerogenic phenotype in DCs, which was characterized by a decreased ability to activate inflammatory effector T cells and was concomitant with the increased differentiation of FoxP3(+) Treg cells. The induction of a tolerogenic phenotype in DCs by NPs was mediated by the AhR-dependent induction of Socs2, which resulted in inhibition of nuclear factor κB activation and proinflammatory cytokine production (properties of tolerogenic DCs). Together, these data suggest that NPs constitute a potential tool to reestablish tolerance in T1D and potentially other autoimmune disorders.
The risk for venous thromboembolism during pregnancy or postpartum is uncertain.
To estimate the relative and absolute risk for deep venous thrombosis and pulmonary embolism during pregnancy and ...postpartum and to describe trends in incidence.
Population-based inception cohort study using the resources of the Rochester Epidemiology Project.
Olmsted County, Minnesota.
Women with deep venous thrombosis or pulmonary embolism first diagnosed between 1966 and 1995, including women with venous thromboembolism during pregnancy or the postpartum period (defined as delivery of a newborn no more than 3 months before the deep venous thrombosis or pulmonary embolism event date, including delivery of a stillborn infant after the first trimester).
The authors obtained yearly counts of live births in Olmsted County between 1966 and 1995 from the Minnesota Department of Health.
The relative risk (standardized incidence ratio) for venous thromboembolism among pregnant or postpartum women was 4.29 (95% CI, 3.49 to 5.22;P < 0.001), and the overall incidence of venous thromboembolism (absolute risk) was 199.7 per 100,000 woman-years. The annual incidence was 5 times higher among postpartum women than pregnant women (511.2 vs. 95.8 per 100,000), and the incidence of deep venous thrombosis was 3 times higher than that of pulmonary embolism (151.8 vs. 47.9 per 100,000). Pulmonary embolism was relatively uncommon during pregnancy versus the postpartum period (10.6 vs. 159.7 per 100,000). Over the 30-year study period, the incidence of venous thromboembolism during pregnancy remained relatively constant whereas the postpartum incidence of pulmonary embolism decreased more than 2-fold.
Because the Olmsted County population was 98% white and of non-Hispanic ethnicity, the results may not be generalizable to other ethnicities.
Among pregnant women, the highest risk period for venous thromboembolism and pulmonary embolism in particular is during the postpartum period. Any prophylaxis against these events should be particularly targeted to postpartum women. Although the incidence of pulmonary embolism has decreased over time, the incidence of deep venous thrombosis remains unchanged, indicating the need to better identify pregnant women at increased risk.
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ...ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.
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